Publication Information

{'id': 'https://openalex.org/W1541204074', 'doi': None, 'title': 'Protein-linked DNA strand breaks induced in mammalian cells by camptothecin, an inhibitor of topoisomerase I.', 'display_name': 'Protein-linked DNA strand breaks induced in mammalian cells by camptothecin, an inhibitor of topoisomerase I.', 'publication_year': 1989, 'publication_date': '1989-09-15', 'ids': {'openalex': 'https://openalex.org/W1541204074', 'mag': '1541204074', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/2548707'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/2548707', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5034690406', 'display_name': 'Joseph M. Covey', 'orcid': 'https://orcid.org/0000-0002-5696-8999'}, 'institutions': [{'id': 'https://openalex.org/I4210140884', 'display_name': 'National Cancer Institute', 'ror': 'https://ror.org/040gcmg81', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'J M Covey', 'raw_affiliation_strings': ['Laboratory of Molecular Pharmacology, National Cancer Institute, Bethesda, Maryland 20892.'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Molecular Pharmacology, National Cancer Institute, Bethesda, Maryland 20892.', 'institution_ids': ['https://openalex.org/I4210140884']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056095784', 'display_name': 'Christine Jaxel', 'orcid': 'https://orcid.org/0000-0002-1387-4458'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'C Jaxel', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008633409', 'display_name': 'Kurt W. Kohn', 'orcid': 'https://orcid.org/0000-0002-5125-6271'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'K W Kohn', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5016113672', 'display_name': 'Y Pommier', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Y Pommier', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 3.208, 'has_fulltext': False, 'cited_by_count': 243, 'citation_normalized_percentile': {'value': 0.999958, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '49', 'issue': '18', 'first_page': '5016', 'last_page': '22'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11845', 'display_name': 'Cancer therapeutics and mechanisms', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11845', 'display_name': 'Cancer therapeutics and mechanisms', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10123', 'display_name': 'DNA Repair Mechanisms', 'score': 0.9922, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13188', 'display_name': 'Synthesis and bioactivity of alkaloids', 'score': 0.9898, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/camptothecin', 'display_name': 'Camptothecin', 'score': 0.97774994}, {'id': 'https://openalex.org/keywords/amsacrine', 'display_name': 'Amsacrine', 'score': 0.48738986}, {'id': 'https://openalex.org/keywords/sodium-dodecyl-sulfate', 'display_name': 'Sodium dodecyl sulfate', 'score': 0.45202187}, {'id': 'https://openalex.org/keywords/topoisomerase-inhibitor', 'display_name': 'Topoisomerase inhibitor', 'score': 0.44758314}], 'concepts': [{'id': 'https://openalex.org/C2779682216', 'wikidata': 'https://www.wikidata.org/wiki/Q419964', 'display_name': 'Camptothecin', 'level': 2, 'score': 0.97774994}, {'id': 'https://openalex.org/C147897179', 'wikidata': 'https://www.wikidata.org/wiki/Q407828', 'display_name': 'Topoisomerase', 'level': 3, 'score': 0.9410876}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.69150895}, {'id': 'https://openalex.org/C57409179', 'wikidata': 'https://www.wikidata.org/wiki/Q1218293', 'display_name': 'Lysis', 'level': 2, 'score': 0.6796209}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.6160188}, {'id': 'https://openalex.org/C2780500152', 'wikidata': 'https://www.wikidata.org/wiki/Q2784004', 'display_name': 'Amsacrine', 'level': 4, 'score': 0.48738986}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.48595703}, {'id': 'https://openalex.org/C2778913249', 'wikidata': 'https://www.wikidata.org/wiki/Q422241', 'display_name': 'Sodium dodecyl sulfate', 'level': 2, 'score': 0.45202187}, {'id': 'https://openalex.org/C2778616834', 'wikidata': 'https://www.wikidata.org/wiki/Q281044', 'display_name': 'Topoisomerase inhibitor', 'level': 4, 'score': 0.44758314}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.43882114}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.43247765}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.39256787}], 'mesh': [{'descriptor_ui': 'D002166', 'descriptor_name': 'Camptothecin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D004249', 'descriptor_name': 'DNA Damage', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D004277', 'descriptor_name': 'DNA, Single-Stranded', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D059004', 'descriptor_name': 'Topoisomerase I Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002166', 'descriptor_name': 'Camptothecin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004277', 'descriptor_name': 'DNA, Single-Stranded', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004278', 'descriptor_name': 'DNA, Superhelical', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D004278', 'descriptor_name': 'DNA, Superhelical', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013816', 'descriptor_name': 'Thermodynamics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/2548707', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 23, 'referenced_works': ['https://openalex.org/W1497508512', 'https://openalex.org/W1536538430', 'https://openalex.org/W1704248043', 'https://openalex.org/W1900905714', 'https://openalex.org/W1980353627', 'https://openalex.org/W1982075384', 'https://openalex.org/W2004211331', 'https://openalex.org/W2023407704', 'https://openalex.org/W2028541172', 'https://openalex.org/W2029117724', 'https://openalex.org/W2054823832', 'https://openalex.org/W2069396614', 'https://openalex.org/W2077757406', 'https://openalex.org/W2080010039', 'https://openalex.org/W2125397490', 'https://openalex.org/W2143897649', 'https://openalex.org/W2147515565', 'https://openalex.org/W2154654003', 'https://openalex.org/W2155007470', 'https://openalex.org/W2402286038', 'https://openalex.org/W2409350485', 'https://openalex.org/W2416485676', 'https://openalex.org/W50560755'], 'related_works': ['https://openalex.org/W2404444211', 'https://openalex.org/W2328369261', 'https://openalex.org/W2118553080', 'https://openalex.org/W2083302591', 'https://openalex.org/W2076763254', 'https://openalex.org/W2057945316', 'https://openalex.org/W1973255116', 'https://openalex.org/W1946967684', 'https://openalex.org/W1936342525', 'https://openalex.org/W1541204074'], 'abstract_inverted_index': {'Camptothecin': [0], 'was': [1, 67, 88, 111, 119, 199, 229], 'recently': [2], 'identified': [3], 'as': [4, 131], 'an': [5, 255], 'inhibitor': [6], 'of': [7, 14, 96, 124, 136, 160, 173, 183, 224], 'mammalian': [8, 28, 250], 'topoisomerase': [9, 15, 37, 147, 184, 209, 234, 258], 'I.': [10, 235, 259], 'Similar': [11], 'to': [12, 102, 121, 157, 207, 254], 'inhibitors': [13], 'II,': [16], 'camptothecin': [17, 77, 225, 248], 'produces': [18], 'DNA': [19, 62, 137, 142], 'single-strand': [20], 'breaks': [21], '(SSB)': [22], 'and': [23, 49, 56, 72, 98, 214, 244], 'DNA-protein': [24], 'cross-links': [25], '(DPC)': [26], 'in': [27, 51, 205, 249], 'cells.': [29], 'However,': [30], 'their': [31, 57], 'one-to-one': [32], 'association,': [33], 'expected': [34], 'for': [35, 84], 'trapped': [36, 208], 'complexes,': [38, 211], 'has': [39], 'not': [40], 'previously': [41], 'been': [42], 'demonstrated.': [43], 'We': [44], 'have': [45], 'studied': [46], 'camptothecin-induced': [47, 126, 203], 'SSB': [48, 71, 97, 127, 174, 243], 'DPC': [50, 73, 99, 176, 245], 'Chinese': [52], 'hamster': [53], 'DC3F': [54], 'cells': [55, 251], 'isolated': [58, 196], 'nuclei,': [59, 197], 'using': [60, 195], 'the': [61, 70, 81, 93, 116, 125, 134, 152, 161, 202, 239, 242], 'alkaline': [63], 'elution': [64, 138], 'technique.': [65], 'It': [66], 'found': [68, 200], 'that': [69, 151, 181, 201, 241], 'frequencies': [74, 95], 'detected': [75], 'following': [76], 'treatment': [78], 'depend': [79], 'upon': [80], 'conditions': [82, 167], 'used': [83], 'lysis.': [85], 'When': [86], 'lysis': [87, 166], 'with': [89, 145, 190, 232], 'sodium': [90, 107], 'dodecyl': [91, 108], 'sulfate,': [92], 'observed': [94], 'were': [100, 128], '2-': [101], '3-fold': [103], 'greater': [104], 'than': [105], 'when': [106], 'sarkosinate': [109], '(Sarkosyl)': [110], 'used.': [112], 'In': [113, 164, 193], 'either': [114, 191], 'case,': [115], 'SSB:DPC': [117], 'ratio': [118], 'close': [120], '1.': [122], 'All': [123], 'protein': [129], 'linked,': [130], 'indicated': [132, 150], 'by': [133, 178, 247], 'absence': [135], 'under': [139], 'nondeproteinizing': [140], 'conditions.': [141], 'cleavage': [143], 'assays': [144], 'purified': [146, 233], 'I': [148], 'also': [149, 230], 'weaker': [153], 'Sarkosyl': [154], 'detergent': [155], 'fails': [156], 'trap': [158], 'all': [159], 'enzyme-DNA': [162], 'complexes.': [163], 'contrast,': [165], 'had': [168], 'little': [169], 'effect': [170], 'on': [171, 257], 'levels': [172], 'or': [175], 'produced': [177], "4'-(9-acridinylamino)-methanesulfon-m-anisidide,": [179], 'suggesting': [180], 'trapping': [182], 'II': [185, 210], 'complexes': [186], 'occurs': [187], 'equally': [188], 'well': [189], 'detergent.': [192], 'experiments': [194], 'it': [198], 'SSB,': [204], 'contrast': [206], 'can': [212], 'form': [213], 'reverse': [215], 'within': [216], 'minutes': [217], 'at': [218, 226], '4': [219], 'degrees': [220], 'C.': [221], 'The': [222], 'activity': [223], 'low': [227], 'temperature': [228], 'seen': [231], 'These': [236], 'results': [237], 'support': [238], 'hypothesis': [240], 'induced': [246], 'are': [252], 'due': [253], 'action': [256]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1541204074', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2024-12-07T23:22:05.649363', 'created_date': '2016-06-24'}