Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2909523539', 'doi': 'https://doi.org/10.1002/9780470015902.a0026795', 'title': 'Human Topoisomerase <scp>I</scp> Inhibitors', 'display_name': 'Human Topoisomerase <scp>I</scp> Inhibitors', 'publication_year': 2016, 'publication_date': '2016-08-16', 'ids': {'openalex': 'https://openalex.org/W2909523539', 'doi': 'https://doi.org/10.1002/9780470015902.a0026795', 'mag': '2909523539'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/9780470015902.a0026795', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4363604175', 'display_name': 'Encyclopedia of Life Sciences', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'other', 'type_crossref': 'other', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5019534523', 'display_name': 'Alessandro Desideri', 'orcid': 'https://orcid.org/0000-0003-1541-4217'}, 'institutions': [{'id': 'https://openalex.org/I116067653', 'display_name': 'University of Rome Tor Vergata', 'ror': 'https://ror.org/02p77k626', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I116067653']}], 'countries': ['IT'], 'is_corresponding': True, 'raw_author_name': 'Alessandro Desideri', 'raw_affiliation_strings': ['University of Roma Tor Vergata, Roma, Italy'], 'affiliations': [{'raw_affiliation_string': 'University of Roma Tor Vergata, Roma, Italy', 'institution_ids': ['https://openalex.org/I116067653']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5019534523'], 'corresponding_institution_ids': ['https://openalex.org/I116067653'], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 66}, 'biblio': {'volume': None, 'issue': None, 'first_page': '1', 'last_page': '8'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11845', 'display_name': 'Cancer therapeutics and mechanisms', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11845', 'display_name': 'Cancer therapeutics and mechanisms', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13188', 'display_name': 'Synthesis and bioactivity of alkaloids', 'score': 0.9921, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13105', 'display_name': 'Synthesis and pharmacology of benzodiazepine derivatives', 'score': 0.9885, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/camptothecin', 'display_name': 'Camptothecin', 'score': 0.95396924}, {'id': 'https://openalex.org/keywords/topotecan', 'display_name': 'Topotecan', 'score': 0.59999657}, {'id': 'https://openalex.org/keywords/topoisomerase-inhibitor', 'display_name': 'Topoisomerase inhibitor', 'score': 0.47727484}], 'concepts': [{'id': 'https://openalex.org/C147897179', 'wikidata': 'https://www.wikidata.org/wiki/Q407828', 'display_name': 'Topoisomerase', 'level': 3, 'score': 0.95863247}, {'id': 'https://openalex.org/C2779682216', 'wikidata': 'https://www.wikidata.org/wiki/Q419964', 'display_name': 'Camptothecin', 'level': 2, 'score': 0.95396924}, {'id': 'https://openalex.org/C158456008', 'wikidata': 'https://www.wikidata.org/wiki/Q412639', 'display_name': 'DNA supercoil', 'level': 4, 'score': 0.766081}, {'id': 'https://openalex.org/C2781209748', 'wikidata': 'https://www.wikidata.org/wiki/Q419953', 'display_name': 'Topotecan', 'level': 3, 'score': 0.59999657}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.5632677}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.49334446}, {'id': 'https://openalex.org/C2778616834', 'wikidata': 'https://www.wikidata.org/wiki/Q281044', 'display_name': 'Topoisomerase inhibitor', 'level': 4, 'score': 0.47727484}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.44034824}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.4379925}, {'id': 'https://openalex.org/C2780259306', 'wikidata': 'https://www.wikidata.org/wiki/Q412197', 'display_name': 'Irinotecan', 'level': 4, 'score': 0.42984045}, {'id': 'https://openalex.org/C143425029', 'wikidata': 'https://www.wikidata.org/wiki/Q5205747', 'display_name': 'DNA damage', 'level': 3, 'score': 0.4242277}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.40849036}, {'id': 'https://openalex.org/C73573662', 'wikidata': 'https://www.wikidata.org/wiki/Q130996', 'display_name': 'DNA replication', 'level': 3, 'score': 0.39425403}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.14623496}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.10191664}, {'id': 'https://openalex.org/C526805850', 'wikidata': 'https://www.wikidata.org/wiki/Q188874', 'display_name': 'Colorectal cancer', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/9780470015902.a0026795', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4363604175', 'display_name': 'Encyclopedia of Life Sciences', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 62, 'referenced_works': ['https://openalex.org/W1196185908', 'https://openalex.org/W1530307268', 'https://openalex.org/W1535509076', 'https://openalex.org/W1536538430', 'https://openalex.org/W1541204074', 'https://openalex.org/W1558058463', 'https://openalex.org/W1639589518', 'https://openalex.org/W1871475547', 'https://openalex.org/W1911947704', 'https://openalex.org/W1953653486', 'https://openalex.org/W1966421179', 'https://openalex.org/W1966861299', 'https://openalex.org/W1968293348', 'https://openalex.org/W1979316449', 'https://openalex.org/W1979632053', 'https://openalex.org/W1985336260', 'https://openalex.org/W1987486924', 'https://openalex.org/W1988695114', 'https://openalex.org/W1993676097', 'https://openalex.org/W2001570602', 'https://openalex.org/W2006758809', 'https://openalex.org/W2014014132', 'https://openalex.org/W2020926770', 'https://openalex.org/W2022515199', 'https://openalex.org/W2027095809', 'https://openalex.org/W2031733136', 'https://openalex.org/W2038692006', 'https://openalex.org/W20400739', 'https://openalex.org/W2041079014', 'https://openalex.org/W2056013470', 'https://openalex.org/W2062954993', 'https://openalex.org/W2063732648', 'https://openalex.org/W2067332276', 'https://openalex.org/W2068577449', 'https://openalex.org/W2069204351', 'https://openalex.org/W2070498380', 'https://openalex.org/W2074686601', 'https://openalex.org/W2076418100', 'https://openalex.org/W2089202243', 'https://openalex.org/W2092243276', 'https://openalex.org/W2098549100', 'https://openalex.org/W2106190585', 'https://openalex.org/W2106834985', 'https://openalex.org/W2120463045', 'https://openalex.org/W2121310433', 'https://openalex.org/W2121999441', 'https://openalex.org/W2124624490', 'https://openalex.org/W2127767958', 'https://openalex.org/W2129507023', 'https://openalex.org/W2135768192', 'https://openalex.org/W2139472764', 'https://openalex.org/W2143257102', 'https://openalex.org/W2146274229', 'https://openalex.org/W2154144066', 'https://openalex.org/W2156741483', 'https://openalex.org/W2168026882', 'https://openalex.org/W2283538748', 'https://openalex.org/W2319272555', 'https://openalex.org/W4237529838', 'https://openalex.org/W4242256765', 'https://openalex.org/W4250968935', 'https://openalex.org/W82016181'], 'related_works': ['https://openalex.org/W3094291022', 'https://openalex.org/W2429529028', 'https://openalex.org/W2400832343', 'https://openalex.org/W2118553080', 'https://openalex.org/W2104743561', 'https://openalex.org/W2098393177', 'https://openalex.org/W2062114187', 'https://openalex.org/W1988529521', 'https://openalex.org/W1981866275', 'https://openalex.org/W1573325703'], 'abstract_inverted_index': {'Abstract': [0], 'Topoisomerases': [1, 111], 'are': [2, 48, 112, 213], 'ubiquitous': [3], 'enzymes': [4, 114, 229], 'that': [5], 'solve': [6], 'topological': [7], 'problems': [8], 'due': [9], 'to': [10, 80, 160, 208], 'DNA': [11, 62, 76, 128, 232], '(deoxyribonucleic': [12], 'acid)': [13], 'supercoiling': [14], 'occurring': [15], 'during': [16, 97], 'the': [17, 31, 59, 64, 71, 74, 117, 147, 154, 169, 197, 200, 223, 244], 'replication,': [18], 'transcription,': [19], 'recombination': [20], 'and': [21, 46, 61, 68, 94, 172, 178, 181, 187, 199], 'chromatin': [22], 'remodelling': [23], 'processes.': [24], 'Human': [25, 122], 'topoisomerase': [26, 123, 144, 203, 236], 'IB': [27, 83, 124, 145, 237], '(Topo': [28], 'IB)': [29], 'is': [30, 84, 137, 146], 'selective': [32], 'target': [33], 'of': [34, 73, 89, 100, 119, 141, 219, 225, 235, 247, 249], 'camptothecin,': [35], 'a': [36, 126, 131, 138, 240], 'natural': [37, 139], 'compound': [38, 140], 'from': [39], 'which': [40, 142], 'two': [41], 'powerful': [42], 'anticancer': [43], 'drugs,': [44], 'topotecan': [45, 175], 'irinotecan,': [47], 'produced.': [49], 'Camptothecin': [50, 136, 151, 186], 'acts': [51], 'as': [52, 191], 'an': [53], 'interfacial': [54, 192], 'inhibitor': [55], 'interacting': [56, 194], 'with': [57, 195, 252], 'both': [58, 196], 'enzyme': [60, 198], 'stabilising': [63], 'covalent': [65], 'enzyme–DNA': [66, 133, 155], 'complex,': [67], 'slowing': [69], 'down': [70], 'religation': [72], 'broken': [75], 'strands': [77], 'brings': [78], 'cells': [79, 159], 'death.': [81, 161], 'Topo': [82], 'also': [85, 239], 'important': [86], 'for': [87, 106, 176, 183], 'transcription': [88], 'genes': [90, 250], 'involved': [91, 230], 'in': [92, 116, 222, 231], 'neurodevelopment,': [93], 'its': [95, 188], 'inhibition': [96], 'critical': [98], 'stages': [99], 'brain': [101], 'development': [102], 'may': [103, 205], 'be': [104], 'responsible': [105], 'neurodevelopmental': [107], 'disorders.': [108], 'Key': [109], 'Concepts': [110], 'crucial': [113], 'essential': [115], 'relaxation': [118], 'supercoiled': [120], 'DNA.': [121, 201], 'cuts': [125], 'single': [127], 'strand': [129], 'forming': [130], 'transient': [132], 'cleavage': [134, 156], 'complex.': [135], 'human': [143], 'only': [148], 'cellular': [149], 'target.': [150], 'can': [152], 'trap': [153], 'complex': [157], 'bringing': [158], 'Two': [162], 'camptothecin': [163, 220], 'derivatives': [164, 189, 212], 'have': [165], 'been': [166], 'approved': [167], 'by': [168], 'US': [170], 'Food': [171], 'Drug': [173], 'Administration:': [174], 'ovarian': [177], 'lung': [179], 'cancers': [180], 'irinotecan': [182], 'colorectal': [184], 'cancer.': [185], 'act': [190], 'inhibitors': [193], 'Single': [202], 'mutation': [204], 'induce': [206], 'resistance': [207], 'camptothecin.': [209], 'New': [210], 'non‐camptothecin': [211], 'under': [214], 'development.': [215], 'The': [216], 'cytotoxic': [217], 'activity': [218], 'increases': [221], 'presence': [224], 'other': [226], 'compounds': [227], 'inhibiting': [228], 'repair.': [233], 'Inhibition': [234], 'has': [238], 'strong': [241], 'influence': [242], 'on': [243], 'modulation': [245], 'expression': [246], 'groups': [248], 'associated': [251], 'autism.': [253]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2909523539', 'counts_by_year': [], 'updated_date': '2024-12-07T03:44:06.604226', 'created_date': '2019-01-25'}