Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2050951907', 'doi': 'https://doi.org/10.1016/j.bmc.2004.11.011', 'title': 'On the role of E-ring oxygen atoms in the binding of camptothecin to the topoisomerase I–DNA covalent binary complex', 'display_name': 'On the role of E-ring oxygen atoms in the binding of camptothecin to the topoisomerase I–DNA covalent binary complex', 'publication_year': 2004, 'publication_date': '2004-12-16', 'ids': {'openalex': 'https://openalex.org/W2050951907', 'doi': 'https://doi.org/10.1016/j.bmc.2004.11.011', 'mag': '2050951907', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15670945'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.bmc.2004.11.011', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S10422866', 'display_name': 'Bioorganic & Medicinal Chemistry', 'issn_l': '0968-0896', 'issn': ['0968-0896', '1464-3391'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5104831804', 'display_name': 'Nicolas J. Rahier', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I51556381', 'display_name': 'University of Virginia', 'ror': 'https://ror.org/0153tk833', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I51556381']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Nicolas J. Rahier', 'raw_affiliation_strings': ['Department of Chemistry and Department of Biology, University of Virginia, Charlottesville, Virginia 22901, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry and Department of Biology, University of Virginia, Charlottesville, Virginia 22901, USA', 'institution_ids': ['https://openalex.org/I51556381']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051498727', 'display_name': 'Brian M. Eisenhauer', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I51556381', 'display_name': 'University of Virginia', 'ror': 'https://ror.org/0153tk833', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I51556381']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Brian M. Eisenhauer', 'raw_affiliation_strings': ['Department of Chemistry and Department of Biology, University of Virginia, Charlottesville, Virginia 22901, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry and Department of Biology, University of Virginia, Charlottesville, Virginia 22901, USA', 'institution_ids': ['https://openalex.org/I51556381']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101743626', 'display_name': 'Rong Gao', 'orcid': 'https://orcid.org/0000-0002-5495-2889'}, 'institutions': [{'id': 'https://openalex.org/I51556381', 'display_name': 'University of Virginia', 'ror': 'https://ror.org/0153tk833', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I51556381']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Rong Gao', 'raw_affiliation_strings': ['Department of Chemistry and Department of Biology, University of Virginia, Charlottesville, Virginia 22901, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry and Department of Biology, University of Virginia, Charlottesville, Virginia 22901, USA', 'institution_ids': ['https://openalex.org/I51556381']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080345639', 'display_name': 'Shannon J. Thomas', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I51556381', 'display_name': 'University of Virginia', 'ror': 'https://ror.org/0153tk833', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I51556381']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Shannon J. Thomas', 'raw_affiliation_strings': ['Department of Chemistry and Department of Biology, University of Virginia, Charlottesville, Virginia 22901, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry and Department of Biology, University of Virginia, Charlottesville, Virginia 22901, USA', 'institution_ids': ['https://openalex.org/I51556381']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5006249781', 'display_name': 'Sidney M. Hecht', 'orcid': 'https://orcid.org/0000-0002-5429-2462'}, 'institutions': [{'id': 'https://openalex.org/I51556381', 'display_name': 'University of Virginia', 'ror': 'https://ror.org/0153tk833', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I51556381']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sidney M. Hecht', 'raw_affiliation_strings': ['Department of Chemistry and Department of Biology, University of Virginia, Charlottesville, Virginia 22901, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry and Department of Biology, University of Virginia, Charlottesville, Virginia 22901, USA', 'institution_ids': ['https://openalex.org/I51556381']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3690, 'currency': 'USD', 'value_usd': 3690, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.475, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 14, 'citation_normalized_percentile': {'value': 0.633607, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 83, 'max': 84}, 'biblio': {'volume': '13', 'issue': '4', 'first_page': '1381', 'last_page': '1386'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11845', 'display_name': 'Cancer therapeutics and mechanisms', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11845', 'display_name': 'Cancer therapeutics and mechanisms', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12172', 'display_name': 'Neutropenia and Cancer Infections', 'score': 0.9951, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12334', 'display_name': 'Lung Cancer Research Studies', 'score': 0.9894, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/camptothecin', 'display_name': 'Camptothecin', 'score': 0.9530394}, {'id': 'https://openalex.org/keywords/ternary-complex', 'display_name': 'Ternary complex', 'score': 0.52753806}], 'concepts': [{'id': 'https://openalex.org/C147897179', 'wikidata': 'https://www.wikidata.org/wiki/Q407828', 'display_name': 'Topoisomerase', 'level': 3, 'score': 0.9665134}, {'id': 'https://openalex.org/C2779682216', 'wikidata': 'https://www.wikidata.org/wiki/Q419964', 'display_name': 'Camptothecin', 'level': 2, 'score': 0.9530394}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.87008274}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.63675797}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.6263467}, {'id': 'https://openalex.org/C180577832', 'wikidata': 'https://www.wikidata.org/wiki/Q127920', 'display_name': 'Covalent bond', 'level': 2, 'score': 0.53912824}, {'id': 'https://openalex.org/C86756495', 'wikidata': 'https://www.wikidata.org/wiki/Q7702931', 'display_name': 'Ternary complex', 'level': 3, 'score': 0.52753806}, {'id': 'https://openalex.org/C109316439', 'wikidata': 'https://www.wikidata.org/wiki/Q246181', 'display_name': 'Cytotoxicity', 'level': 3, 'score': 0.43608022}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.33000547}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.28597546}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.17483059}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.11583686}], 'mesh': [{'descriptor_ui': 'D002166', 'descriptor_name': 'Camptothecin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D004264', 'descriptor_name': 'DNA Topoisomerases, Type I', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D010100', 'descriptor_name': 'Oxygen', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D001345', 'descriptor_name': 'Autoradiography', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002166', 'descriptor_name': 'Camptothecin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018360', 'descriptor_name': 'Crystallography, X-Ray', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004264', 'descriptor_name': 'DNA Topoisomerases, Type I', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009682', 'descriptor_name': 'Magnetic Resonance Spectroscopy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010100', 'descriptor_name': 'Oxygen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D021241', 'descriptor_name': 'Spectrometry, Mass, Electrospray Ionization', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.bmc.2004.11.011', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S10422866', 'display_name': 'Bioorganic & Medicinal Chemistry', 'issn_l': '0968-0896', 'issn': ['0968-0896', '1464-3391'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/15670945', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Clean water and sanitation', 'id': 'https://metadata.un.org/sdg/6', 'score': 0.76}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 29, 'referenced_works': ['https://openalex.org/W1536538430', 'https://openalex.org/W1541204074', 'https://openalex.org/W1823160408', 'https://openalex.org/W1871475547', 'https://openalex.org/W1923310201', 'https://openalex.org/W1966990845', 'https://openalex.org/W1975985891', 'https://openalex.org/W1979194751', 'https://openalex.org/W1981987977', 'https://openalex.org/W1991902444', 'https://openalex.org/W1997361520', 'https://openalex.org/W2016256393', 'https://openalex.org/W2018185888', 'https://openalex.org/W2021325933', 'https://openalex.org/W2026709688', 'https://openalex.org/W2031733136', 'https://openalex.org/W2040955353', 'https://openalex.org/W2051557244', 'https://openalex.org/W2056249358', 'https://openalex.org/W2066588134', 'https://openalex.org/W2070534090', 'https://openalex.org/W2073898802', 'https://openalex.org/W2074325268', 'https://openalex.org/W2089217892', 'https://openalex.org/W2094337350', 'https://openalex.org/W2100113089', 'https://openalex.org/W2159921901', 'https://openalex.org/W2179029723', 'https://openalex.org/W4297069849'], 'related_works': ['https://openalex.org/W2909523539', 'https://openalex.org/W2429529028', 'https://openalex.org/W2409654774', 'https://openalex.org/W2159921901', 'https://openalex.org/W2074902034', 'https://openalex.org/W2050951907', 'https://openalex.org/W2025290139', 'https://openalex.org/W2003849230', 'https://openalex.org/W1968975825', 'https://openalex.org/W1541204074'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2050951907', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 2}], 'updated_date': '2024-12-16T05:39:49.409985', 'created_date': '2016-06-24'}