Publication Information

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'https://openalex.org/W2069603831', 'https://openalex.org/W2070196678', 'https://openalex.org/W2083768931', 'https://openalex.org/W2089814223', 'https://openalex.org/W2093383843', 'https://openalex.org/W2094517427', 'https://openalex.org/W2096644570', 'https://openalex.org/W2099384461', 'https://openalex.org/W2105300849', 'https://openalex.org/W2110910879', 'https://openalex.org/W2143937232', 'https://openalex.org/W2146083400', 'https://openalex.org/W2147241123', 'https://openalex.org/W2162382085'], 'related_works': ['https://openalex.org/W4229738240', 'https://openalex.org/W2412864637', 'https://openalex.org/W2165499430', 'https://openalex.org/W2053211371', 'https://openalex.org/W2029101025', 'https://openalex.org/W2022751822', 'https://openalex.org/W2001525537', 'https://openalex.org/W2000304408', 'https://openalex.org/W1988350384', 'https://openalex.org/W1988110468'], 'abstract_inverted_index': {'Na+/Cl–-dependent': [0, 246, 664], 'neurotransmitter': [1, 247, 642, 665, 1888], 'transporters': [2, 248, 643, 648, 666, 1889, 2152, 2265, 2390, 2979, 3626, 3776, 3837], 'form': [3, 249, 671, 1172, 3661], 'constitutive': [4, 250, 672, 2619], 'oligomers.': [5, 251], 'The': [6, 222, 252, 468, 624, 891, 973, 1030, 1360, 1422, 1662, 1838, 1885, 2068, 2142, 2697, 2787, 3016, 3089, 3186, 3286, 3319, 3909, 4072, 4268, 4297], 'topological': [7, 253, 892], 'arrangement': [8, 254], 'is': [9, 231, 255, 477, 566, 572, 578, 638, 863, 899, 995, 1010, 1052, 1890, 1897, 1937, 2677, 2704, 2745, 2882, 2958, 3031, 3055, 3166, 3565, 3580, 3620, 3960], 'not': [10, 256, 900, 1891, 1898, 2416, 2489, 2521, 2529, 2543, 2572, 2794, 2804, 2884, 3167, 3257, 3366, 3566, 4070, 4175], 'known,': [11, 257], 'but': [12, 258], 'a': [13, 23, 113, 192, 259, 269, 359, 438, 864, 1022, 1026, 1037, 1046, 1049, 1055, 1471, 1549, 1620, 1811, 1856, 1977, 2437, 2539, 2618, 2668, 2709, 2725, 2728, 2753, 2826, 3010, 3145, 3209, 3348, 3571, 3766, 3871, 3882, 3951, 4088, 4092, 4286], 'leucine': [14, 260], 'heptad': [15, 261], 'repeat': [16, 262], 'in': [17, 26, 92, 97, 125, 161, 238, 263, 272, 338, 343, 371, 407, 484, 674, 874, 902, 925, 984, 989, 1006, 1021, 1063, 1086, 1176, 1205, 1303, 1393, 1554, 1619, 1677, 1690, 1816, 1835, 1845, 1852, 1855, 1894, 1910, 1942, 2071, 2094, 2107, 2119, 2124, 2131, 2218, 2428, 2471, 2574, 2687, 2694, 2701, 2752, 2756, 2763, 2774, 2779, 2796, 2842, 2864, 2894, 2928, 2992, 3050, 3154, 3169, 3189, 3214, 3261, 3277, 3377, 3559, 3609, 3637, 3666, 3749, 3765, 3811, 3995, 4025, 4064, 4078, 4118, 4170, 4232, 4272, 4307, 4324, 4377], 'transmembrane': [18, 264, 512, 632], 'domain': [19, 116, 265, 362, 3600], '(TM)': [20, 266], '2': [21, 267, 1565, 1632], 'and': [22, 88, 121, 138, 171, 200, 268, 334, 367, 384, 417, 446, 518, 521, 591, 644, 653, 918, 1078, 1142, 1184, 1190, 1202, 1283, 1293, 1319, 1356, 1375, 1386, 1477, 1497, 1513, 1541, 1552, 1568, 1645, 1652, 1684, 1698, 1723, 1736, 1776, 1781, 1785, 1787, 1814, 1831, 1883, 1893, 1962, 1972, 2140, 2167, 2176, 2195, 2209, 2223, 2231, 2263, 2364, 2399, 2507, 2557, 2568, 2581, 2603, 2615, 2715, 2739, 2759, 2834, 2852, 2854, 2869, 2890, 2913, 2924, 2940, 2955, 2976, 2982, 2996, 3005, 3109, 3144, 3223, 3232, 3243, 3247, 3462, 3479, 3508, 3520, 3538, 3577, 3612, 3630, 3706, 3730, 3732, 3747, 3774, 3777, 3799, 3832, 3898, 3926, 4017, 4056, 4105, 4158, 4164, 4166, 4215, 4225, 4240, 4260, 4357], 'glycophorin-like': [24, 270], 'motif': [25, 271], 'TM6': [27, 273], 'have': [28, 274, 667, 1121, 1168, 1390, 3119, 3987], 'been': [29, 275, 557, 668, 1220, 1391, 3120], 'proposed': [30, 276], 'to': [31, 65, 78, 105, 210, 277, 311, 324, 351, 456, 670, 1012, 1034, 1135, 1171, 1194, 1258, 1275, 1530, 1659, 1725, 1732, 1931, 1940, 2020, 2192, 2196, 2236, 2456, 2484, 2590, 2611, 2689, 2722, 2817, 2886, 3034, 3129, 3135, 3140, 3184, 3310, 3391, 3468, 3480, 3527, 3539, 3569, 3582, 3595, 3714, 3901, 4058, 4144, 4177, 4185, 4198, 4263, 4303], 'stabilize': [32, 278], 'the': [33, 37, 43, 80, 84, 86, 98, 100, 109, 126, 136, 150, 169, 279, 283, 289, 326, 330, 332, 344, 346, 355, 372, 382, 396, 415, 495, 548, 560, 573, 580, 675, 844, 858, 869, 895, 903, 913, 919, 930, 978, 990, 998, 1001, 1015, 1137, 1169, 1177, 1198, 1260, 1300, 1304, 1387, 1482, 1531, 1649, 1678, 1691, 1713, 1727, 1795, 1846, 1905, 1911, 1923, 1949, 1963, 1967, 1981, 1991, 1994, 2002, 2008, 2015, 2021, 2038, 2074, 2095, 2115, 2129, 2132, 2145, 2149, 2188, 2198, 2203, 2229, 2238, 2268, 2402, 2409, 2412, 2423, 2445, 2451, 2457, 2460, 2485, 2493, 2499, 2513, 2526, 2536, 2650, 2658, 2673, 2683, 2713, 2719, 2737, 2740, 2749, 2767, 2775, 2780, 2812, 2818, 2821, 2836, 2840, 2843, 2848, 2861, 2867, 2877, 2898, 2910, 2920, 2931, 2944, 2950, 2961, 2965, 2968, 2972, 2990, 3000, 3026, 3035, 3038, 3044, 3048, 3058, 3061, 3093, 3097, 3105, 3112, 3116, 3124, 3130, 3136, 3149, 3152, 3158, 3161, 3170, 3173, 3216, 3221, 3226, 3235, 3266, 3271, 3281, 3297, 3306, 3311, 3324, 3352, 3357, 3362, 3370, 3378, 3387, 3394, 3406, 3425, 3442, 3446, 3492, 3501, 3518, 3525, 3551, 3556, 3610, 3616, 3628, 3656, 3673, 3687, 3690, 3707, 3719, 3724, 3733, 3736, 3740, 3756, 3761, 3781, 3794, 3800, 3807, 3816, 3824, 3842, 3850, 3855, 3862, 3866, 3896, 3903, 3917, 3920, 3935, 3968, 3971, 3992, 3996, 4004, 4020, 4029, 4035, 4046, 4049, 4065, 4122, 4128, 4132, 4136, 4178, 4204, 4210, 4226, 4233, 4250, 4255, 4265, 4304, 4316, 4320, 4326, 4332, 4335, 4368, 4375], 'oligomer.': [34, 280, 3379], 'To': [35, 281, 1461, 2896], 'determine': [36, 282, 4199], 'topology,': [38, 284], 'we': [39, 187, 285, 433, 1120, 1147, 1163, 1469, 1719, 2532, 2596, 2653, 2904, 3008, 3205, 3590, 3751], 'generated': [40, 286, 1766, 1956, 4148], 'versions': [41, 287, 1129, 2478], 'of': [42, 129, 141, 214, 235, 244, 288, 375, 387, 460, 481, 490, 551, 567, 575, 582, 586, 627, 630, 659, 848, 894, 907, 1000, 1039, 1130, 1140, 1180, 1197, 1362, 1606, 1610, 1623, 1654, 1680, 1687, 1729, 1757, 1798, 1848, 1859, 1880, 1887, 1926, 1952, 1966, 1980, 1993, 2007, 2013, 2098, 2134, 2144, 2201, 2228, 2240, 2411, 2420, 2449, 2479, 2525, 2538, 2585, 2605, 2675, 2736, 2769, 2789, 2800, 2829, 2900, 2974, 3012, 3025, 3037, 3047, 3060, 3104, 3115, 3151, 3163, 3172, 3212, 3218, 3268, 3338, 3351, 3389, 3397, 3419, 3448, 3460, 3506, 3517, 3615, 3625, 3658, 3675, 3686, 3735, 3755, 3760, 3768, 3847, 3852, 3868, 3885, 3893, 3906, 3911, 3919, 3937, 3945, 3955, 3973, 3978, 3991, 4019, 4023, 4041, 4045, 4067, 4074, 4076, 4095, 4112, 4127, 4139, 4156, 4189, 4219, 4270, 4289, 4322, 4365], 'human': [44, 290, 507, 543, 985, 4005], 'serotonin': [45, 291, 496, 504, 597], 'transporter': [46, 153, 292, 399, 497, 1043, 1201, 2720, 3321, 3573, 3738, 3994], '(hSERT)': [47, 293, 987], 'that': [48, 176, 294, 422, 555, 856, 860, 976, 997, 1014, 1155, 1165, 1334, 1759, 1908, 1984, 1990, 2393, 2408, 2432, 2496, 2535, 2613, 2672, 2682, 2748, 2814, 2949, 2987, 3024, 3092, 3103, 3160, 3198, 3224, 3291, 3369, 3384, 3415, 3579, 3592, 3633, 3679, 3770, 3791, 3813, 3838, 3943, 3962, 3970, 4061, 4135, 4150], 'carried': [49, 295, 1665, 3207], 'cyan': [50, 296, 522], 'or': [51, 297, 1069, 1213, 1277, 1315, 1326, 2054, 2217, 2463, 2501, 2791, 3139, 3796], 'yellow': [52, 298, 520], 'fluorescent': [53, 299, 523, 1199, 1369, 1921, 1969, 1995, 2016, 2413, 2452, 3353], 'proteins': [54, 300, 655, 1730, 1959, 2392], 'at': [55, 217, 301, 463, 1084, 1149, 1215, 1279, 1289, 1295, 1577, 1670, 1824, 1865, 1869, 2401, 3605, 4010, 4308], 'their': [56, 302, 2856], 'amino': [57, 87, 110, 172, 303, 333, 356, 418, 1141, 1217, 1291, 1924, 2022, 2230, 2458, 2714, 2758, 2870, 2878, 2954, 3001, 3106, 3137, 3143, 3312, 3342], 'and/or': [58, 304], 'carboxyl': [59, 89, 101, 170, 305, 335, 347, 416, 1143, 1281, 1297, 2039, 2232, 2461, 2716, 2760, 2868, 2956, 3098, 3131, 3146, 3336, 3363, 4012], 'terminus.': [60, 306, 3147], 'Appropriate': [61, 307], 'pairs': [62, 308, 2936, 2973], 'were': [63, 144, 309, 390, 1332, 1544, 1573, 1701, 1765, 1792, 1806, 1820, 1833, 1985, 2214, 2481, 2509, 2937, 2984, 3127, 3192, 3308, 3403, 3417, 3878, 4174], 'coexpressed': [64, 151, 310, 397, 2781, 3702], 'measure': [66, 312, 1462], 'fluorescence': [67, 313, 527, 2606, 2770, 2906, 3449, 4211], 'resonance': [68, 314, 528, 2592, 3052, 3248, 3262], 'energy': [69, 315, 529, 1935, 1945, 2593, 2801, 2815, 2892, 2902, 3053, 3249, 3263], 'transfer': [70, 316, 1936, 1946, 2802, 2816, 2893, 3054, 3250, 3264], '(FRET).': [71, 317], 'Donor': [72, 318, 1431, 2806], 'photobleaching': [73, 198, 319, 444, 1432, 1467, 1480, 2663, 2807, 3412], 'FRET': [74, 199, 320, 445, 1433, 1506, 2577, 2808, 2830, 3030, 3292, 3326], 'microscopy': [75, 321, 1434, 2809], 'was': [76, 132, 207, 322, 378, 453, 1256, 1366, 1426, 1435, 1503, 1617, 1664, 1675, 1685, 1843, 1872, 2010, 2018, 2085, 2153, 2186, 2434, 2441, 2454, 2466, 2520, 2771, 3100, 3228, 3251, 3256, 3273, 3294, 3422, 3451, 3804, 3820, 3913, 3931, 3948, 3999, 4083, 4115, 4183, 4277, 4299, 4329, 4370], 'employed': [77, 323, 1257, 2597], 'deduce': [79, 325], 'following': [81, 327, 1261, 1532, 4317], 'arrangement:': [82, 328], 'within': [83, 329, 2512, 3405, 3806, 4048, 4331], 'monomer,': [85, 331], 'termini': [90, 102, 173, 336, 348, 419, 1925, 2233, 2761, 2871, 2957, 3099, 3132, 3138, 3313, 3364], 'are': [91, 103, 337, 349, 853, 923, 981, 1019, 1252, 1771, 1928, 2234, 2394, 2587, 2685, 2762, 2872, 3497, 3664, 3680, 3839, 3965], 'close': [93, 339, 1138, 1929, 2764], 'vicinity.': [94, 340, 2765], 'In': [95, 341, 1045, 1117, 1145, 2182, 2491, 2649, 3175, 3203, 3439, 3789, 3809, 4253], 'addition,': [96, 342, 1146, 3051, 3204, 3750], 'oligomer,': [99, 345], 'closer': [104, 350], 'each': [106, 352, 1363, 3141, 3608, 3712, 4193], 'other': [107, 353, 647, 1065, 2966, 4256], 'than': [108, 354, 988, 1075, 2778, 2876, 2942, 2960, 2986, 3102, 3134, 3304, 3598], 'termini.': [111, 357, 1144, 2717, 2879, 3107], 'Hence,': [112, 167, 358, 413, 3356, 4181], 'separate': [114, 360, 3210], 'interaction': [115, 225, 361, 471, 2239, 3564, 3698], '(i.e.': [117, 363, 3003], 'distinct': [118, 364, 1090], 'from': [119, 365, 868, 1657, 2114, 3182, 3500, 3627, 3672, 4245], 'TM2': [120, 366], 'TM6)': [122, 368], 'must': [123, 369, 1072, 1082], 'reside': [124, 370], 'carboxyl-terminal': [127, 139, 373, 385, 920, 1324, 2210, 2502, 3371, 3395, 3493, 3521, 3557, 3613, 3797, 3927, 4036, 4137], 'half': [128, 374, 3396, 3553, 3558, 4040, 4138], 'hSERT.': [130, 142, 376, 388, 1007, 1131], 'This': [131, 230, 377, 476, 1132, 2110, 2465, 2517, 2947, 3421, 3669, 3710, 3763, 3998, 4110, 4313], 'confirmed': [133, 379, 3290], 'by': [134, 154, 196, 380, 400, 442, 563, 640, 645, 1054, 1125, 1368, 1505, 1511, 1548, 1575, 1703, 1767, 1810, 1822, 2105, 2523, 2547, 3057, 3194, 3253, 3333, 3682, 3854, 3870, 3933, 3967, 4002, 4086, 4192, 4280, 4334, 4367, 4373], 'expressing': [135, 381, 3441, 4080, 4221, 4274], 'amino-': [137, 383, 2500, 2975, 3519, 3611, 3795], 'halves': [140, 386, 3465, 3522, 3614], 'These': [143, 389, 3401, 3495], 'retained': [145, 149, 391, 395, 2511, 3404, 3665, 3721, 3805, 4330], 'intracellularly;': [146, 392], 'they': [147, 393, 599, 3416, 4173], 'also': [148, 208, 394, 454, 579, 1265, 2467, 2533, 3206, 3289, 3858, 4084, 4116, 4278, 4371], 'full-length': [152, 398, 1200, 1642, 1695, 2151, 2438, 2477, 3704, 3737, 3773, 3779, 3801, 3817, 3889, 3993, 4205, 4228, 4243, 4266, 4327], 'forming': [155, 401], 'export-deficient': [156, 402], 'oligomers': [157, 237, 403, 483, 673], 'and,': [158, 404, 2915], 'when': [159, 405, 1918], 'cotransfected': [160, 406], 'all': [162, 408, 641, 1064, 2476], 'possible': [163, 409, 2885, 4184], 'combinations,': [164, 410], 'supported': [165, 411], 'FRET.': [166, 412, 1933], 'both': [168, 414, 2055, 2994, 3772, 4081, 4275], 'contain': [174, 420, 3596], 'elements': [175, 421], 'drive': [177, 227, 423, 473, 1195, 1726], 'oligomerization.': [178, 424], 'By': [179, 425], 'employing': [180, 426], 'fragments': [181, 427, 1203, 1331, 1734, 2213, 3985, 4149, 4224, 4257, 4369], 'comprising': [182, 428, 1317, 1328, 1960, 4237], 'two': [183, 219, 429, 465, 908, 926, 1151, 1307, 1336, 1761, 2598, 2935, 3125, 4152], 'neighboring': [184, 430, 1337, 1762, 4153], 'TM': [185, 431, 897, 916, 979, 1017, 1338, 1763, 2504, 2734, 3372, 4154], 'helices,': [186, 432], 'unequivocally': [188, 434], 'identified': [189, 224, 435, 470, 1148], 'TM11/12': [190, 436, 4241], 'as': [191, 437, 1437, 1509, 2267, 2436, 2916, 3430, 3432, 3696, 3785, 3861, 3916, 4195], 'new': [193, 439], 'contact': [194, 440, 1080, 1153], 'site': [195, 441, 581], 'donor': [197, 443, 532, 1463, 1472, 2609, 2662, 2822, 2853, 2995, 3222, 3411, 3443], 'β-lactamase': [201, 447, 1714, 1733], 'protein': [202, 448, 1715, 1996, 2017, 2080, 2453, 3354, 3974], 'fragment': [203, 449, 1716, 4194, 4201], 'complementation': [204, 450, 1717], 'assay.': [205, 451, 3699], 'TM1/2': [206, 452], 'found': [209, 455], 'self-associate.': [211, 457], 'Thus,': [212, 458, 993, 2743, 3550, 3849], 'oligomerization': [213, 459, 849, 3635], 'hSERT': [215, 461, 1183, 1185, 1302, 1758, 1882, 1927, 1961, 1982, 2000, 2079, 2241, 2433, 2480, 2548, 3339, 3398, 3593, 3659, 3705, 3803, 3819, 3853, 4024, 4042, 4140, 4157, 4191, 4244, 4366], 'involves': [216, 462], 'least': [218, 464, 1085, 1150, 3606, 4309], 'discontinuous': [220, 466, 1152, 3683], 'interfaces.': [221, 467], 'currently': [223, 469], 'sites': [226, 472, 1081, 1154], 'homophilic': [228, 474, 1060, 1157], 'interactions.': [229, 475, 1061, 1158], 'consistent': [232, 478], 'with': [233, 479, 1312, 1323, 1794, 1920, 1944, 1948, 1999, 2391, 2418, 2579, 3043, 3296, 3555, 3723, 3739, 3881, 4014, 4121, 4203, 4301], 'assembly': [234, 480], 'SERT': [236, 482, 565, 628, 986, 1166, 1643, 2185, 2421], 'an': [239, 485, 1173, 1269, 1875, 2917, 3142, 3697, 3786, 4059, 4142, 4196, 4282], 'array-like': [240, 486, 1174], 'structure': [241, 487, 906, 1024, 1032, 1051, 1175, 1907, 2755], 'containing': [242, 488, 1556, 1626], 'multimers': [243, 489], 'dimers.': [245, 491], 'Under': [492], 'physiological': [493], 'conditions,': [494], '(SERT)': [498], '1The': [499], 'abbreviations': [500], 'used': [501, 1187, 1427, 1720, 3752], 'are:': [502], 'SERT,': [503], 'transporter;': [505], 'hSERT,': [506, 2177, 3890], 'SERT;': [508], '5-HT,': [509], '5-hydroxytryptamine;': [510], 'TM,': [511], 'domain;': [513], 'ER,': [514, 3629], 'endoplasmic': [515, 870], 'reticulum;': [516], 'YFP': [517, 1212, 1276, 1294, 1314, 1325, 1483, 2540, 3741, 4214], 'CFP,': [519], 'protein,': [524, 1970, 2439], 'respectively;': [525, 2178], 'FRET,': [526], 'transfer;': [530], 'DRAP,': [531], 'recovery': [533, 1464], 'after': [534, 1465, 1478, 2608, 2661], 'acceptor': [535, 1466, 2819, 2851, 2997, 3164, 3201, 3227, 3272], 'photobleaching;': [536], '[3H]β-CIT,': [537], '(1R,2S,3S,5S)-3-(4-iodophenyl)-8-[3H]methyl-8-azabicyclo[3.2.1]octane-2-carboxylic': [538], 'acid,': [539], 'methyl': [540], 'ester;': [541], 'hD2,': [542], 'dopamine': [544, 2333, 4006], 'D2': [545, 4007], 'receptor.': [546], 'mediates': [547], 'selective': [549], 're-uptake': [550], '5-hydroxytryptamine': [552], '(5-HT;': [553], 'serotonin)': [554], 'has': [556, 1219, 2721, 3594], 'released': [558], 'into': [559, 1904, 2398, 2422, 2444, 3823, 3841, 4249], 'synaptic': [561], 'cleft': [562], 'neurons.': [564], 'clinical': [568], 'relevance': [569], 'because': [570, 598, 2664], 'it': [571, 994, 1009, 1896, 2440, 2707, 2744, 2881, 3041, 3467, 3959, 4182], 'target': [574], 'antidepressants.': [576], 'It': [577], 'action': [583], 'for': [584, 866, 1036, 1268, 1383, 1428, 1485, 1581, 1641, 1648, 1667, 1694, 1828, 1862, 2004, 2073, 2104, 2148, 2172, 2396, 2555, 2564, 2667, 2691, 2706, 2724, 2733, 2909, 2933, 2943, 2971, 2989, 3019, 3196, 3280, 3347, 3386, 3424, 3433, 3491, 3602, 3622, 4098, 4292, 4319], 'drugs': [585], 'abuse,': [587], 'viz.': [588, 2600, 3604, 3718], 'ecstasy': [589], '(methylenedioxymetamphetamine)': [590], 'its': [592, 1216, 1280, 1290, 1296, 4011], 'congeners;': [593], 'these': [594, 1079, 1123, 1161, 2934, 3588, 3663], 'compounds': [595], 'release': [596], 'induce': [600], 'reverse': [601, 2921], 'transport': [602, 2006, 2193, 2546, 4328], '(1Scholze': [603], 'P.': [604, 681, 1096, 2624], 'Zwach': [605], 'J.': [606, 615, 690, 716, 811, 833, 881, 934, 959, 1101, 1233, 1406, 1441, 1585, 2248, 2277, 2317, 2347, 2382, 2633, 3645], 'Kattinger': [607], 'A.': [608, 715, 748, 767, 779, 788, 800, 806, 1232, 1405, 1516, 1739, 2306, 2312, 2371], 'Pifl': [609], 'C.': [610, 804, 2304], 'Singer': [611, 686, 2629], 'E.A.': [612, 687, 2630], 'Sitte': [613, 688, 1099, 2631, 3076], 'H.H.': [614, 689, 877, 1100, 2632, 3077, 3641], 'Pharmacol.': [616, 882, 3646], 'Exp.': [617], 'Ther.': [618], '2000;': [619, 749, 768, 1521, 2295], '293:': [620], '870-878PubMed': [621], 'Google': [622, 704, 730, 755, 774, 795, 825, 841, 889, 952, 971, 1115, 1247, 1420, 1459, 1527, 1603, 1754, 2261, 2283, 2301, 2331, 2362, 2388, 2647, 3072, 3087, 3653], 'Scholar).': [623, 842, 890, 972, 1116, 1248, 1421, 1460, 1604, 1755, 2648, 3088, 3654], 'hydrophobic': [625, 1002], 'core': [626, 1003], 'consists': [629], '12': [631, 896, 1016], 'domains': [633], '(TMs);': [634], 'this': [635, 1118, 2665, 3020, 3563], 'structural': [636], 'feature': [637], 'shared': [639], 'many': [646, 854], '(e.g.': [649, 656, 1067, 2832, 2980], 'P-glycoprotein-like': [650], 'efflux': [651], 'pumps)': [652], 'membrane': [654, 677, 1839, 2447, 3561, 3826, 3844], 'mammalian': [657, 1206], 'isoforms': [658], 'membrane-bound': [660], 'adenylyl': [661], 'cyclase).': [662], 'Several': [663], 'shown': [669, 2427, 2573, 2863, 2927], 'plasma': [676, 1912, 2403, 2424, 2446, 3825, 3843, 4179, 4251], '(2Schmid': [678, 2621], 'J.A.': [679, 781, 2622, 3075], 'Scholze': [680, 2623], 'Kudlacek': [682, 2625], 'O.': [683, 2246, 2626], 'Freissmuth': [684, 878, 1097, 2627, 3642], 'M.': [685, 735, 879, 961, 1098, 1741, 2310, 2628, 3643], 'Biol.': [691, 717, 812, 1102, 1234, 1407, 2318, 2634], 'Chem.': [692, 718, 813, 1103, 1235, 1408, 2319, 2635], '2001;': [693, 789, 2351, 2636], '276:': [694, 2637], '3805-3810Abstract': [695, 2638], 'Full': [696, 698, 722, 724, 817, 819, 1107, 1109, 1239, 1241, 1412, 1414, 2323, 2325, 2354, 2356, 2639, 2641], 'Text': [697, 699, 723, 725, 818, 820, 1108, 1110, 1240, 1242, 1413, 1415, 2324, 2326, 2355, 2357, 2640, 2642], 'PDF': [700, 726, 821, 1111, 1243, 1416, 2327, 2358, 2643], 'PubMed': [701, 727, 752, 771, 792, 822, 838, 886, 949, 968, 1112, 1244, 1417, 1456, 1524, 1600, 1751, 2258, 2282, 2298, 2328, 2359, 2387, 2644, 3084, 3650], 'Scopus': [702, 728, 753, 772, 793, 823, 839, 887, 950, 969, 1113, 1245, 1418, 1457, 1525, 1601, 1752, 2259, 2299, 2329, 2360, 2645, 3070, 3085, 3651], '(168)': [703, 2646], 'Scholar,': [705, 731, 756, 775, 796, 826, 953, 2284, 2302, 3073], '3Sorkina': [706], 'T.': [707, 1224, 1397, 3064], 'Doolen': [708, 1225, 1398], 'S.': [709, 733, 747, 766, 787, 944, 1226, 1399, 1451, 1595, 2369, 2377], 'Galperin': [710, 1227, 1400], 'E.': [711, 1228, 1401], 'Zahniser': [712, 1229, 1402], 'N.R.': [713, 1230, 1403], 'Sorkin': [714, 1231, 1404], '2003;': [719, 814, 835, 883, 946, 965, 1236, 1409, 1453, 1597, 2384, 3081, 3647], '278:': [720, 815, 1237, 1410], '28274-28283Abstract': [721, 1238, 1411], '(160)': [729, 1246, 1419], '4Eskandari': [732], 'Kreman': [734], 'Kavanaugh': [736], 'M.P.': [737], 'Wright': [738], 'E.M.': [739, 2274], 'Zampighi': [740], 'G.A.': [741], 'Proc.': [742, 761, 782], 'Natl.': [743, 762, 783], 'Acad.': [744, 763, 784], 'Sci.': [745, 764, 785], 'U.': [746, 765, 786, 2243, 2367], '97:': [750, 769], '8641-8646Crossref': [751], '(109)': [754], '5Kilic': [757], 'F.': [758, 832], 'Rudnick': [759, 829], 'G.': [760, 830, 940, 1447, 1591, 2316], '3106-3111Crossref': [770], '(190)': [773], '6Hastrup': [776], 'H.': [777, 2250, 2341], 'Karlin': [778], 'Javitch': [780], '98:': [790], '10055-10060Crossref': [791], '(174)': [794], '7Torres': [797], 'G.E.': [798, 2335], 'Carneiro': [799], 'Seamans': [801], 'K.': [802], 'Fiorentini': [803], 'Sweeney': [805], 'Yao': [807, 2336], 'W.D.': [808, 2337], 'Caron': [809, 2348], 'M.G.': [810, 2349], '2731-2739Abstract': [816], '(218)': [824], '8Kocabas': [827], 'A.M.': [828], 'Kilic': [831], 'Neurochem.': [834], '85:': [836], '1513-1520Crossref': [837], '(51)': [840], 'Although': [843, 3655], 'precise': [845], 'biological': [846], 'role': [847], 'remains': [850], 'enigmatic,': [851], 'there': [852, 1071], 'arguments': [855], 'support': [857, 1156, 1932, 2237, 3374, 3845], 'conjecture': [859], 'oligomer': [861, 2620, 4145], 'formation': [862, 3619], 'prerequisite': [865], 'export': [867, 3624, 3677], 'reticulum': [871], '(ER)': [872], '(reviewed': [873], 'Ref.': [875], '9Sitte': [876], 'Eur.': [880, 3644], '479:': [884, 3648], '229-236Crossref': [885, 3649], '(47)': [888, 3652], 'arrangements': [893], 'helices': [898, 917, 922, 980, 1018, 1764, 2750], 'known;': [901, 1892], 'recently': [904], 'solved': [905], 'distantly': [909], 'related': [910, 2264], 'bacterial': [911, 991], 'transporters,': [912], 'first': [914], 'six': [915, 921, 2503], 'arranged': [924, 1020], 'pseudosymmetrical': [927], 'lobes': [928], 'around': [929, 1025], 'central': [931, 1027], 'pore': [932], '(10Abramson': [933, 1440, 1584], 'Smirnova': [935, 1442, 1586], 'I.': [936, 1443, 1587], 'Kasho': [937, 1444, 1588], 'V.': [938, 1445, 1589, 2375], 'Verner': [939, 1446, 1590], 'Kaback': [941, 1448, 1592], 'H.R.': [942, 1449, 1593], 'Iwata': [943, 1450, 1594], 'Science.': [945, 964, 1452, 1596], '301:': [947, 966, 1454, 1598], '610-615Crossref': [948, 1455, 1599], '(1240)': [951, 1458, 1602], '11Huang': [954], 'Y.': [955], 'Lemieux': [956], 'M.J.': [957, 2314], 'Song': [958], 'Auer': [960], 'Wang': [962], 'D.N.': [963], '616-620Crossref': [967], '(866)': [970], 'connecting': [974], 'loops': [975], 'connect': [977], 'substantially': [982, 1005, 2772], 'shorter': [983, 2941], 'transporters.': [992, 3015, 3029], 'likely': [996], 'topology': [999, 1886], 'differs': [1004], 'However,': [1008, 1062, 2718, 2880, 3148, 3958], 'reasonable': [1011], 'predict': [1013], 'ring-like': [1023, 1031, 2754], 'substrate-binding': [1028], 'cavity.': [1029], 'ought': [1033], 'allow': [1035], 'number': [1038, 2674], 'contacts': [1040], 'between': [1041, 1089, 2712, 2850, 2888, 2953, 3096, 3230, 3361], 'individual': [1042, 1901, 4222], 'monomers.': [1044], 'dimeric': [1047], 'arrangement,': [1048], 'self-limiting': [1050], 'achieved': [1053], 'symmetric': [1056], 'interface,': [1057, 1077], 'i.e.': [1058, 1092, 2727, 3040], 'via': [1059], 'instances': [1066], 'trimers': [1068], 'tetramers),': [1070], 'be': [1073, 2102, 2112, 3694, 3715, 3859], 'more': [1074, 2746, 2873, 3121, 3597], 'one': [1076, 3599, 3607], 'represent,': [1083], 'part,': [1087], 'interactions': [1088, 1094], 'segments,': [1091], 'heterophilic': [1093], '(12Scholze': [1095], '2002;': [1104, 1748, 2255], '277:': [1105], '43682-43690Abstract': [1106], '(98)': [1114], 'work,': [1119], 'examined': [1122], 'predictions': [1124], 'generating': [1126], 'several': [1127, 2588], 'tagged': [1128, 1919, 2150, 2978, 3014, 3028, 3299, 4009], 'allowed': [1133, 3385], 'us': [1134], 'confirm': [1136], 'proximity': [1139], 'Based': [1159, 2859, 3586], 'on': [1160, 2656, 2811, 2847, 2855, 2860, 2999, 3157, 3504, 3587, 3865], 'observations,': [1162], 'propose': [1164], 'may': [1167, 3118, 3345, 3981, 3986], 'propensity': [1170], 'membrane.': [1178, 1913, 2404, 2425, 4180, 4252], 'Construction': [1179], 'Fluorescently': [1181], 'Tagged': [1182, 1881, 2583], 'Fragments—We': [1186], 'plasmids': [1188, 1721, 1799], 'pECFP-N1/pEYFP-N1': [1189], 'pECFP-C1/': [1191], 'pEYFP-C1': [1192], '(Clontech)': [1193], 'expression': [1196, 1728, 2108, 2470, 3178, 3388, 3759, 3918, 4169], 'thereof': [1204], 'cells.': [1207, 4027], 'YFP/CFP-hSERT': [1208], '(hSERT': [1209, 1272, 1285, 1310, 1321, 1341, 1344, 1347, 1350, 1354, 1358, 1778, 1783, 1789], 'Met1–Val630': [1210, 1273, 1286], 'carrying': [1211, 1287], 'CFP': [1214, 1278, 1288, 1971, 2833, 3725, 4015, 4216], 'terminus)': [1218, 1282], 'described': [1221, 1392, 1438, 1510], 'previously': [1222, 1439], '(3Sorkina': [1223, 1396], 'PCR': [1249, 1768], '2Primer': [1250, 1769], 'sequences': [1251, 1770], 'available': [1253, 1772], 'upon': [1254, 1773, 2469], 'request.': [1255], 'generate': [1259], 'additional': [1262, 1957], 'constructs': [1263, 1644, 1983, 3383, 4082, 4236, 4276], '(see': [1264], 'Fig.': [1266, 1974, 2120, 2429, 2575, 2702, 2865, 2929, 3190, 3278, 4207], '1A': [1267, 1975, 2703], 'overview):': [1270], 'hSERT-YFP/CFP': [1271], 'fused': [1274, 1731, 2455], 'CFP-hSERT-YFP': [1284, 2777], 'terminus': [1292, 2023, 2040, 3002, 3337, 4013], 'terminus).': [1298], 'Severing': [1299], 'double-tagged': [1301, 2776, 2945, 3320], 'middle': [1305], 'yielded': [1306], 'constructs:': [1308], 'YFP/CFP-hSERT-N-term': [1309], 'Met1–Asn356': [1311], 'amino-terminal': [1313, 2204, 3464, 3552, 3921, 4030], 'CFP)': [1316, 1327], 'TM1–6': [1318], 'hSERT-C-term-YFP/CFP': [1320], 'Cys357–Val630': [1322], 'TM7–12.': [1329], 'YFP-labeled': [1330, 3463, 4021], 'created': [1333], 'comprised': [1335, 1760, 2497, 4151], 'helices:': [1339], 'YFP-hSERT-TM1/2': [1340], 'Met1–Ile150),': [1342], 'YFP-hSERT-TM3/4': [1343], 'Trp151–Gly278),': [1345], 'YFP-hSERT-TM5/6': [1346], 'Lys275–Asn357),': [1348], 'YFP-hSERT-TM7/8': [1349], 'Cys357–Leu451),': [1351], 'YFP-hSERT-TM': [1352], '9/10': [1353], 'Asp452–Arg523),': [1355], 'hSERT-TM11/12-YFP': [1357], 'Lys526–Val630).': [1359], 'integrity': [1361], 'engineered': [1364, 3382], 'construct': [1365], 'verified': [1367, 2407, 2534], 'sequencing.': [1370], 'Cell': [1371], 'Transfection,': [1372], 'Uptake': [1373], 'Experiments,': [1374], 'Fluorescence': [1376], 'Resonance': [1377, 1934], 'Energy': [1378], 'Transfer': [1379], '(FRET)': [1380], 'Microscopy—The': [1381], 'conditions': [1382], 'cell': [1384, 1637, 2514, 3183, 3407, 3874, 4050, 4333], 'culture': [1385], 'uptake': [1388, 2099, 2135, 3846, 3867, 3910, 3947], 'experiments': [1389, 1915, 3213, 3413], 'detail': [1394], 'elsewhere': [1395], 'calcium': [1423], 'phosphate': [1424], 'method': [1425], 'transient': [1429, 3176], 'transfection.': [1430], 'performed': [1436], '(DRAP),': [1468], 'acquired': [1470], '(CFP)': [1473], 'image': [1474], 'before': [1475], '(Ib)': [1476], '(Ia)': [1479], 'using': [1481, 1800, 1874], 'setting': [1484], '90': [1486], 's': [1487, 3455, 3472, 3484, 3531, 3543], '(excitation': [1488], '=': [1489, 1494, 1499, 1535, 2026, 2032, 2043, 2049, 2058, 2064, 2091, 2157, 2180, 2550, 2559, 3457, 3474, 3486, 3533, 3545], '500': [1490], 'nm,': [1491, 1496], 'dichroic': [1492], 'mirror': [1493], '525': [1495], 'emission': [1498], '535': [1500], 'nm).': [1501], 'DRAP': [1502, 3287], 'quantified': [1504, 3860, 4085, 4279], 'efficiency': [1507, 3293, 3327], '(E)': [1508], 'Miyawaki': [1512], 'Tsien': [1514, 1517], '(14Miyawaki': [1515], 'R.Y.': [1518], 'Methods': [1519], 'Enzymol.': [1520], '327:': [1522], '472-500Crossref': [1523], '(387)': [1526], 'Scholar)': [1528, 2262, 2389], 'according': [1529], 'equation:': [1533], 'E': [1534], '(Ia': [1536], '–': [1537], 'Ib)/Ia.': [1538], 'Membrane': [1539], 'Preparation': [1540], 'Radioligand': [1542], 'Binding—Cells': [1543], 'detached': [1545, 1807], 'mechanically,': [1546, 1808], 'lysed': [1547, 1809], 'freeze-thaw': [1550, 1812], 'cycle,': [1551, 1813], 'homogenized': [1553, 1815], 'buffer': [1555], '20': [1557, 1582, 1627, 1829], 'mm': [1558, 1563, 1566, 1570, 1628, 1633], 'Tris-HCl': [1559], '(pH': [1560, 1630], '8),': [1561], '1': [1562], 'EDTA,': [1564, 1636], 'MgCl2,': [1567, 1634], '300': [1569], 'sucrose.': [1571], 'Membranes': [1572, 1819], 'sedimented': [1574, 1821], 'centrifugation': [1576, 1823], '50,000': [1578, 1825], '×': [1579, 1826], 'g': [1580, 1827], 'min': [1583, 1669, 1864], 'Binding': [1605], '[3H]β-CIT': [1607, 1655], '(specific': [1608], 'activity': [1609], '∼50': [1611], 'Ci/mmol;': [1612], 'Tocris,': [1613], 'Bristol,': [1614], 'United': [1615], 'Kingdom)': [1616], 'determined': [1618, 1676, 2070, 2905, 3018, 3252], 'final': [1621], 'volume': [1622, 1858], '40': [1624], 'μl': [1625, 1861], 'Hepes-NaOH': [1629], '7.4),': [1631], '1mm': [1635], 'membranes': [1638], '(10': [1639], 'μg': [1640, 1647, 3977], '50': [1646], 'severed': [1650, 2494, 3775], 'transporters),': [1651], 'concentrations': [1653], 'ranging': [1656], '0.25': [1658], '10': [1660], 'nm.': [1661], 'reaction': [1663], 'out': [1666, 1989, 3208, 4001], '60': [1668], 'room': [1671], 'temperature.': [1672], 'Nonspecific': [1673], 'binding': [1674, 1689], 'presence': [1679, 1847, 2410, 2537], '3': [1681], 'μm': [1682, 1850, 2089, 2554, 2563], 'paroxetine': [1683], '<10%': [1686], 'total': [1688, 1857, 3904], 'KD': [1692], 'range': [1693, 3954], 'constructs.': [1696], 'Bound': [1697], 'free': [1699], 'radioligands': [1700], 'separated': [1702], 'filtration': [1704], 'over': [1705, 3950], 'glass-fiber': [1706], 'filters.': [1707], 'β-Lactamase': [1708], 'Protein': [1709], 'Fragment': [1710], 'Complementation': [1711], 'Assay—For': [1712], 'assay,': [1718], 'pcDNA3.1-Zeo+/F[I]m182T': [1722], 'pcDNA3.1-Zeo+/F[II]': [1724], 'F[I]': [1735], 'F[II]': [1737], '(15Galarneau': [1738], 'Primeau': [1740], 'Trudeau': [1742], 'L.E.': [1743], 'Michnick': [1744], 'S.W.': [1745], 'Nat.': [1746, 2293], 'Biotechnol.': [1747], '20:': [1749], '619-622Crossref': [1750], '(355)': [1753], 'Constructs': [1756], 'request.:': [1774], 'F[I]-TM1/2': [1775], 'F[II]-TM1/2': [1777], 'Gly83–Gly146),': [1779], 'F[I]-TM5/6': [1780], 'F[II]-TM5/6': [1782], 'Val274–Asn356),': [1784], 'F[I]-': [1786], 'F[II]-TM11/12': [1788], 'Phe536–Thr600).': [1790], 'Cells': [1791], 'transfected': [1793, 3873, 3880, 4096, 4120, 4290], 'indicated': [1796, 3091], 'combinations': [1797, 3236], 'LipofectAMINE.': [1801], 'After': [1802], '24–48': [1803], 'h,': [1804], 'cells': [1805, 3197, 3440, 3769, 3783, 3790, 3812, 3877, 4079, 4097, 4119, 4220, 4273, 4291, 4323], 'phosphate-buffered': [1817, 1836, 1853], 'saline.': [1818, 1837], 'min,': [1830], 'pellets': [1832], 'resuspended': [1834], 'suspension': [1840], '(20-μl': [1841], 'aliquot)': [1842], 'incubated': [1844], '100': [1849], 'nitrocefin': [1851], 'saline': [1854], '200': [1860], '45': [1863], '37': [1866], '°C.': [1867], 'Absorption': [1868], '492': [1870], 'nm': [1871, 2171], 'measured': [1873], 'automated': [1876], 'plate': [1877], 'reader.': [1878], 'Characterization': [1879], 'Half-molecules—': [1884], 'particular,': [1895], 'clear': [1899], 'how': [1900], 'monomers': [1902], 'assemble': [1903], 'oligomeric': [1906], 'resides': [1909], 'Previous': [1914], 'showed': [1916, 3323, 3414], 'that,': [1917], 'proteins,': [1922], 'enough': [1930, 2679, 3568], 'exquisitely': [1938, 3032], 'sensitive': [1939, 3033], 'variation': [1941], 'distance,': [1943], 'declining': [1947], 'sixth': [1950, 3045], 'power': [1951, 3046], 'distance.': [1953, 2963], 'We': [1954, 1987, 2405, 3380, 3700, 3941, 4147], 'therefore': [1955, 2406, 3381, 3701, 3879], 'fusion': [1958], 'spectral': [1964], 'variants': [1965], 'green': [1968], 'YFP.': [1973], 'shows': [1976, 4209], 'schematic': [1978], 'rendering': [1979], 'employed.': [1986], 'ruled': [1988, 4000], 'position': [1992], 'tag': [1997, 2414], 'interfered': [1998], 'function:': [2001], 'Km': [2003, 2025, 2042, 2057, 2069, 2558], 'inward': [2005], 'substrate': [2009, 2194, 2738], 'comparable': [2011, 3953], 'regardless': [2012, 2200, 2448], 'whether': [2014, 2202, 2450], 'attached': [2019, 3128, 3309], '(CFP-hSERT;': [2024], '1.5': [2027, 2059, 2161], '±': [2028, 2045, 2060, 2087, 2159, 2162, 2165, 2169, 2552, 2561, 3453, 3470, 3482, 3529, 3541, 4338, 4342, 4346, 4350, 4354, 4359], '0.7': [2029], 'μm,': [2030, 2047], 'n': [2031, 2048, 2063, 2179], '3)': [2033, 2050, 2065], '(Fig.': [2034, 2081, 2136, 2205, 2220, 2515, 2784, 3317, 3408, 3437, 3574, 3727, 3744, 3829, 3922, 4032, 4038, 4053, 4295], '1B,': [2035, 2082, 2206], 'closed': [2036, 2052, 2225, 3924], 'squares),': [2037], '(hSERT-CFP;': [2041], '2.5': [2044], '0.8': [2046], '(inverted': [2051], 'triangles),': [2053], '(CFP-hSERT-YFP;': [2056], '0.6': [2061, 2088], 'μm;': [2062], '(closed': [2066], 'circles).': [2067], 'parallel': [2072, 2688], 'transiently': [2075, 3872], 'expressed': [2076, 2215, 2435, 3771, 3792, 3814, 4231], 'untagged': [2077], 'wild-type': [2078], 'open': [2083, 2207], 'triangles)': [2084, 3929], '2.6': [2086, 3483], '(n': [2090, 3456, 3473, 3485, 3532, 3544], '3).': [2092, 2181], 'Differences': [2093], 'maximum': [2096, 2710], 'velocity': [2097, 2133], '(Vmax)': [2100], 'can': [2101, 2111, 3693, 3857], 'accounted': [2103], 'variations': [2106, 2693], 'levels.': [2109], 'gauged': [2113], 'saturation': [2116], 'experiment': [2117, 3288], 'depicted': [2118, 2700], '1C,': [2121], 'where': [2122, 2475], 'differences': [2123, 3153], 'Bmax': [2125], 'levels': [2126, 3179], 'essentially': [2127], 'reflect': [2128], 'variability': [2130], '1,': [2137, 2221, 3575], 'compare': [2138], 'B': [2139, 2222, 3576, 3729], 'C).': [2141, 3833], 'affinity': [2143], 'inhibitor': [2146, 2199, 2566], 'β-CIT': [2147], 'virtually': [2154, 2938], 'identical': [2155, 2939], '(KD': [2156], '1.2': [2158, 3454, 3471], '0.2,': [2160], '0.3,': [2163], '2.1': [2164], '1.7,': [2166], '1.3': [2168], '0.2': [2170, 2553], 'CFP-hSERT-YFP,': [2173], 'CFP-hSERT,': [2174], 'hSERT-CFP,': [2175], 'contrast,': [2183, 2492, 3810, 4254], 'if': [2184, 3123, 3265, 3305, 3393], 'severed,': [2187], 'resulting': [2189], 'half-molecules': [2190, 2527, 3390, 3657, 3856, 3930, 4022, 4068], 'failed': [2191, 4262], 'bind': [2197], 'circles)': [2208, 3925], '(open': [2211, 3928], 'squares)': [2212], 'alone': [2216, 3444], 'combination': [2219, 2911, 2991, 3021, 3282, 3300, 3426], 'C,': [2224], 'diamonds).': [2226], 'Segments': [2227], 'thought': [2235], '(16Jess': [2242], 'El': [2244], 'Far': [2245], 'Kirsch': [2247], 'Betz': [2249], 'Biochem.': [2251], 'Biophys.': [2252], 'Res.': [2253], 'Commun.': [2254], '294:': [2256], '272-279Crossref': [2257], '(40)': [2260], 'such': [2266], 'γ-aminobutyric': [2269], 'acid': [2270], '(17Beckman': [2271], 'M.L.': [2272, 2288], 'Bernstein': [2273], 'Quick': [2275, 2291, 2378], 'M.W.': [2276, 2292, 2379], 'Neurosci.': [2278, 2294, 2383], '1998;': [2279], '18:': [2280], '6103-6112Crossref': [2281], '18Deken': [2285], 'S.L.': [2286], 'Beckman': [2287], 'Boos': [2289], 'L.': [2290], '3:': [2296], '998-1003Crossref': [2297], '(137)': [2300], '19Perego': [2303], 'Bulbarelli': [2305], 'Longhi': [2307], 'R.': [2308], 'Caimi': [2309], 'Villa': [2311], 'Caplan': [2313], 'Pietrini': [2315], '1997;': [2320], '272:': [2321], '6584-6592Abstract': [2322], '(60)': [2330], 'Scholar),': [2332, 2363], '(20Torres': [2334], 'Mohn': [2338], 'A.R.': [2339], 'Quan': [2340], 'Kim': [2342], 'K.M.': [2343, 2373], 'Levey': [2344], 'A.I.': [2345], 'Staudinger': [2346], 'Neuron.': [2350], '30:': [2352], '121-134Abstract': [2353], '(282)': [2361], 'norepinephrine': [2365], '(21Sung': [2366], 'Apparsundaram': [2368], 'Galli': [2370], 'Kahlig': [2372], 'Savchenko': [2374], 'Schroeter': [2376], 'Blakely': [2380], 'R.D.': [2381], '23:': [2385], '1697-1709Crossref': [2386], 'important': [2395, 3601], 'insertion': [2397, 2419], 'retention': [2400, 2519, 3639, 3692, 3851, 3990, 4063, 4075, 4114, 4188, 4271, 4294, 4364], 'did': [2415, 2542, 2793], 'interfere': [2417], 'As': [2426, 2926], '1D,': [2430], 'provided': [2431, 2671, 2681], 'efficiently': [2442, 2482, 3821], 'inserted': [2443, 3822, 3840, 4248], 'terminus,': [2459, 2462], 'both.': [2464], 'seen': [2468], 'differentiated': [2472], 'PC12': [2473], 'cells,': [2474, 4172], 'transported': [2483], 'extending': [2486], 'neurite': [2487], '(data': [2488, 2528, 2571, 2803, 4069], 'shown).': [2490, 2530, 2805, 4071], 'half-transporters': [2495, 3402], 'only': [2498, 3815, 3835], 'segments': [2505, 3373, 4155], '(CFP-hSERT-N-term': [2506, 3476, 3535], 'hSERT-C-term-CFP)': [2508], 'invariably': [2510], '1D).': [2516, 3409], 'intracellular': [2518, 3335, 3560, 3584, 3638, 3667, 3691, 4099, 4113, 4187, 4293, 4363], 'overcome': [2522, 3583], 'coexpression': [2524], 'Finally,': [2531, 3007], 'moiety': [2541], 'affect': [2544], '5-HT': [2545], '(Km': [2549], '0.9': [2551], 'YFP-hSERT,': [2556, 3239], '1.1': [2560], '0.3': [2562], 'hSERT-YFP),': [2565, 3246], 'binding,': [2567], 'subcellular': [2569], 'localization': [2570], '1).': [2576], 'Microscopy': [2578], 'Amino-': [2580], 'Carboxyl-terminally': [2582], 'Versions': [2584], 'hSERT—There': [2586], 'ways': [2589], 'assess': [2591, 2897], 'transfer.': [2594], 'Previously,': [2595], 'methods,': [2599], 'ratio': [2601, 3217], 'imaging,': [2602], 'determination': [2604], 'decay': [2607, 2659, 2768, 2844, 2907, 3450], 'photobleaching,': [2610], 'demonstrate': [2612, 4134], 'YFP-hSERT': [2614, 2912, 2981, 3004], 'CFP-hSERT': [2616, 2923, 3237, 3240, 3283], 'formed': [2617, 3681], 'present': [2651], 'study,': [2652], 'relied': [2654], 'primarily': [2655], 'measuring': [2657, 4374], 'lifetimes': [2660, 2908, 2932, 2969, 3155], 'allows': [2666, 2732, 3711], 'statistical': [2669], 'comparison': [2670], 'measurements': [2676, 2684], 'large': [2678], '(and': [2680, 2838], 'done': [2686], 'account': [2690], 'inherent': [2692], 'lamp': [2695], 'intensity).': [2696], 'serpentine': [2698], 'diagram': [2699], 'misleading,': [2705], 'suggests': [2708], 'distance': [2711, 2849, 2952, 3036, 3095, 3360], 'provide': [2723, 3346], 'pore,': [2726], 'hydrophilic': [2729], 'channel,': [2730], 'which': [2731, 2757, 2993, 3215, 3344, 4200, 4325], 'permeation': [2735], 'cotransported': [2741], 'ions.': [2742], 'plausible': [2747], 'arrange': [2751], 'Accordingly,': [2766], 'slower': [2773], 'pair': [2782, 2828, 3011], 'CFP-hSERT/hSERT-YFP': [2783], '2,': [2785], 'A–C).': [2786], 'addition': [2788], 'substrates': [2790], 'inhibitors': [2792], 'result': [2795, 3636], 'any': [2797, 3258, 3375], 'appreciable': [2798, 3259], 'change': [2799], 'relies': [2810, 3156], 'fact': [2813, 3969], 'protects': [2820], 'against': [2823], 'bleaching.': [2824], 'For': [2825], 'given': [2827], 'fluorophores': [2831, 3062, 3126, 3307], 'YFP),': [2835], 'protection': [2837], 'hence,': [2839], 'increase': [2841], 'lifetime)': [2845], 'depends': [2846], 'relative': [2857, 3113], 'orientation.': [2858], 'data': [2862, 3187], '2C,': [2866, 2930], 'closely': [2874], 'associated': [2875], 'obviously': [2883], 'differentiate': [2887], 'intra-': [2889], 'intermolecular': [2891, 2901, 2962, 3094, 3359], 'CFP-hSERT-YFP.': [2895, 2946], 'contribution': [2899], 'transfer,': [2903], 'hSERT-CFP': [2914, 3244], 'internal': [2918, 3787], 'control,': [2919], 'pair,': [2922], 'hSERT-YFP.': [2925], 'indicates': [2948], 'intramolecular': [2951], 'smaller': [2959, 3101], 'On': [2964], 'hand,': [2967], 'obtained': [2970, 2988, 3193], 'carboxyl-terminally': [2977, 3013, 3298], 'hSERT-CFP)': [2983], 'longer': [2985], 'resided': [2998], 'CFP-hSERT).': [3006], 'tested': [3009], 'lifetime': [3017, 3447, 3526], 'again': [3022], 'exceeded': [3023, 4062], 'amino-terminally': [3027], 'fluorophore,': [3039], 'declines': [3042], 'distance;': [3049], 'affected': [3056], 'orientation': [3059, 3114], '(22Förster': [3063], 'Ann.': [3065], 'Physik.': [3066], '1948;': [3067], '2:': [3068], '55-75Crossref': [3069], '(5083)': [3071], '23Schmid': [3074], 'Curr.': [3078], 'Opin.': [3079], 'Oncol.': [3080], '15:': [3082], '55-64Crossref': [3083], '(45)': [3086], 'observations': [3090], 'Alternatively,': [3108, 4362], 'less': [3110], 'likely,': [3111], 'dipoles': [3117], 'favorable': [3122], 'rather': [3133], 'interpretation': [3150], 'assumption': [3159], 'amount': [3162, 3267, 3884, 3905, 3936, 3972], 'fluorophore': [3165], 'limiting': [3168, 3753], 'vicinity': [3171], 'donor.': [3174], 'transfection,': [3177], 'vary': [3180, 3982], 'widely': [3181], 'cell.': [3185, 3808], 'displayed': [3188, 3199], '2C': [3191], 'selecting': [3195], 'bright': [3200], 'fluorescence.': [3202], 'series': [3211], 'plasmid': [3219, 3269, 3757, 3886, 3900, 3939, 3956, 3979], 'encoding': [3220, 3225, 3270, 3888, 3895], 'varied': [3229], '1:1': [3231], '1:4': [3233], '(using': [3234, 4213], '+': [3238, 3241, 3245, 3284, 3302, 3315, 3428, 3435, 3477, 3489, 3536, 3548, 4102, 4107], 'hSERT-YFP,': [3242], 'DRAP.': [3254], 'There': [3255], 'difference': [3260], 'increased': [3274, 3466], '4-fold': [3275], '(shown': [3276], '2D': [3279], 'YFP-hSERT).': [3285], 'higher': [3295], '(hSERT-CFP': [3301], 'hSERT-YFP)': [3303, 3316], '(CFP-hSERT': [3314], '2D).': [3318], '(CFP-hSERT-YFP)': [3322], 'highest': [3325], '(p': [3328, 3513], '<': [3329, 3514], '0.001).': [3330], 'Oligomer': [3331, 3618], 'Formation': [3332], 'Half-molecules—The': [3334], 'comprises': [3340], '35': [3341], 'acids,': [3343], 'flexible': [3349], 'tether': [3350], 'tag.': [3355], 'short': [3358], 'does': [3365], 'necessarily': [3367], 'indicate': [3368], 'association': [3376], 'test': [3392, 3512], 'supports': [3399], 'self-association.': [3400, 3420], 'Nevertheless,': [3410], 'capable': [3418], 'true': [3423], 'CFP-hSERT-N-term': [3427], 'YFP-hSERT-N-term': [3429], 'well': [3431], 'hSERT-C-term-CFP': [3434], 'hSERT-C-term-YFP': [3436], '2C).': [3438], '(CFP-hSERT-N-term),': [3445], '19.1': [3452], '42).': [3458], 'Coexpression': [3459], 'CFP-': [3461], '21.9': [3469], '30)': [3475], 'YFP-hSERT-N-term)': [3478], '25.3': [3481], '25)': [3487], '(hSERT-C-term-CFP': [3488, 3547], 'hSERT-C-term-YFP)': [3490, 3537], 'halves.': [3494], 'values': [3496], 'significantly': [3498], 'different': [3499], 'reference': [3502], 'based': [3503], 'analysis': [3505], 'variance': [3507], "Scheffé's": [3509], 'post': [3510], 'hoc': [3511], '0.05).': [3515], 'Expression': [3516], 'together': [3523], 'prolonged': [3524], '23.5': [3528], '2.3': [3530, 3542], '22)': [3534], '24.4': [3540], '31)': [3546], 'YFP-hSERT-N-term).': [3549], 'interacts': [3554], 'compartments;': [3562], 'strong': [3567], 'reconstitute': [3570], 'functional': [3572], 'C)': [3578], 'able': [3581], 'retention.': [3585], 'data,': [3589], 'conclude': [3591], 'oligomerization,': [3603], 'transporter.': [3617, 4206, 4229, 4267], 'required': [3621], 'efficient': [3623], 'point': [3631], 'mutations': [3632], 'suppress': [3634], '(9Sitte': [3640], 'do': [3660], 'oligomers,': [3662], 'compartments.': [3668], 'presumably': [3670], 'arises': [3671], 'disruption': [3674], 'ER': [3676], 'signals': [3678], 'segments.': [3684], 'Regardless': [3685], 'underlying': [3688], 'basis,': [3689], 'exploited': [3695], 'YFP-tagged': [3703, 4223], 'CFP-tagged': [3708, 4190, 4227], 'half-molecules.': [3709], 'molecule': [3713], 'visualized': [3716], 'individually,': [3717], 'intracellularly': [3720], 'half-molecule': [3722, 3798], 'filter': [3726, 3742, 4217], '3,': [3728, 3745, 3830, 4054], 'D)': [3731], 'fate': [3734], 'set': [3743], 'A': [3746, 3831], 'B);': [3748], 'amounts': [3754, 3892], 'driving': [3758], 'half-molecule.': [3762], 'resulted': [3764], 'mixture': [3767], 'exclusively': [3778], 'hSERT;': [3780], 'latter': [3782], 'served': [3784], 'control.': [3788], 'either': [3793, 4018], 'transporter,': [3802, 3818], '(YFP': [3827], 'filter)': [3828, 4052], 'Obviously,': [3834], 'those': [3836], 'substrate.': [3848], 'average': [3863], 'effect': [3864], '[3H]5-HT': [3869, 3912, 3946], 'population.': [3875], 'HEK293': [3876, 4026, 4171], 'constant': [3883], 'DNA': [3887, 3894, 3907, 3980], 'increasing': [3891], 'half-molecules,': [3897], 'empty': [3899], 'keep': [3902], 'constant.': [3908], 'progressively': [3914], 'reduced': [3915], '3E,': [3923], 'forced': [3932], 'raising': [3934], 'cognate': [3938], 'DNA.': [3940, 3957], 'noted': [3942], 'inhibition': [3944], 'observed': [3949, 4117], 'reasonably': [3952], 'self-evident': [3961], 'quantitative': [3963], 'interpretations': [3964], 'limited': [3966], 'produced': [3975], 'per': [3976], 'considerably.': [3983], 'Aggregated': [3984], 'caused': [3988, 4043], 'nonspecific': [3989], 'ER.': [3997], 'coexpressing': [4003], 'receptor': [4008, 4047, 4123], '(hD2-CFP)': [4016], 'Neither': [4028], '(YFP-hSERT-N-term)': [4031], '3G)': [4033], 'nor': [4034], '(hSERT-C-term-YFP)': [4037], '3I)': [4039], 'accumulation': [4044], '(CFP': [4051], 'F': [4055], 'H)': [4057], 'extent': [4060, 4073, 4111, 4269], 'absence': [4066], 'hD2-CFP': [4077], 'having': [4087, 4281], 'blinded': [4089, 4300], 'observer': [4090, 4284, 4298], 'score': [4091, 4285], 'random': [4093, 4287], 'selection': [4094, 4288], 'retention:': [4100], 'CFP-hD2': [4101, 4106], 'YFP-hSERT-N-term,': [4103], '16%;': [4104], 'hSERT-C-term-YFP,': [4108], '10%.': [4109], 'alone.': [4124], 'Discontinuous': [4125], 'Nature': [4126], 'Oligomeric': [4129], 'Interface—Taken': [4130], 'together,': [4131], 'findings': [4133], 'contributes': [4141], 'interface': [4143], 'formation.': [4146], 'YFP:': [4159], 'YFP-hSERT-TM1/2,': [4160], '-TM3/4,': [4161], '-TM5/6,': [4162], '-TM7/8,': [4163], '-TM9/10': [4165], 'hSERT-TM11/12-YFP.': [4167], 'Upon': [4168], 'delivered': [4176], 'exploit': [4186], 'assay': [4197], 'interacted': [4202], '4A': [4208], 'micrographs': [4212], 'sets)': [4218], 'When': [4230], 'same': [4234], 'cell,': [4235], 'TM1/2,': [4238], 'TM5/6,': [4239], 'prevented': [4242], 'being': [4246], 'correctly': [4247], '(TM3/4,': [4258], 'TM7/8,': [4259], 'TM9/10)': [4261], 'retain': [4264], 'unbiased': [4283], '4B).': [4296], 'respect': [4302], 'transfection': [4305], 'protocol': [4306], 'three': [4310], 'independent': [4311], 'transfections.': [4312], 'quantification': [4314], 'gave': [4315], 'estimates': [4318], 'proportion': [4321], 'fragment:': [4336], '82': [4337], '7%': [4339], '(TM1/2),': [4340], '16': [4341], '8%': [4343, 4355], '(TM3/4),': [4344], '91': [4345], '6%': [4347, 4360], '(TM5/6),': [4348], '30': [4349], '5%': [4351], '(TM7/8),': [4352], '15': [4353], '(TM9/10),': [4356], '94': [4358], '(TM11/12).': [4361], 'assessed': [4372], 'decline': [4376], 'cellular': [4378], '5-[3H]HT': [4379], 'u': [4380]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2087277719', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-12-08T17:43:43.932459', 'created_date': '2016-06-24'}