Publication Information

{'id': 'https://openalex.org/W1988110468', 'doi': 'https://doi.org/10.1126/science.2147779', 'title': 'Sequence Requirements for Coiled-Coils: Analysis with λ Repressor-GCN4 Leucine Zipper Fusions', 'display_name': 'Sequence Requirements for Coiled-Coils: Analysis with λ Repressor-GCN4 Leucine Zipper Fusions', 'publication_year': 1990, 'publication_date': '1990-12-07', 'ids': {'openalex': 'https://openalex.org/W1988110468', 'doi': 'https://doi.org/10.1126/science.2147779', 'mag': '1988110468', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/2147779'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1126/science.2147779', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S3880285', 'display_name': 'Science', 'issn_l': '0036-8075', 'issn': ['0036-8075', '1095-9203'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315823', 'host_organization_name': 'American Association for the Advancement of Science', 'host_organization_lineage': ['https://openalex.org/P4310315823'], 'host_organization_lineage_names': ['American Association for the Advancement of Science'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5089370746', 'display_name': 'James C. Hu', 'orcid': 'https://orcid.org/0000-0001-9016-2684'}, 'institutions': [{'id': 'https://openalex.org/I63966007', 'display_name': 'Massachusetts Institute of Technology', 'ror': 'https://ror.org/042nb2s44', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I63966007']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'James C. Hu', 'raw_affiliation_strings': ['*Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139;'], 'affiliations': [{'raw_affiliation_string': '*Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139;', 'institution_ids': ['https://openalex.org/I63966007']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033920261', 'display_name': 'Erin K. O’Shea', 'orcid': 'https://orcid.org/0000-0002-2649-1018'}, 'institutions': [{'id': 'https://openalex.org/I63966007', 'display_name': 'Massachusetts Institute of Technology', 'ror': 'https://ror.org/042nb2s44', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I63966007']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': "Erin K. O'Shea", 'raw_affiliation_strings': ['Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, and Whitehcad Institute for Biomedical Research, Cambridge, MA 02142.'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, and Whitehcad Institute for Biomedical Research, Cambridge, MA 02142.', 'institution_ids': ['https://openalex.org/I63966007']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100672876', 'display_name': 'Peter S. Kim', 'orcid': 'https://orcid.org/0000-0001-6503-4541'}, 'institutions': [{'id': 'https://openalex.org/I4210157710', 'display_name': 'Whitehead Institute for Biomedical Research', 'ror': 'https://ror.org/04vqm6w82', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210157710', 'https://openalex.org/I63966007']}, {'id': 'https://openalex.org/I63966007', 'display_name': 'Massachusetts Institute of Technology', 'ror': 'https://ror.org/042nb2s44', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I63966007']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Peter S. Kim', 'raw_affiliation_strings': ['Department of Biology Massachusetts Institute of Technology, Cambridge, 02139, and Whitehead Institute for Biomedical Research, Cambridge, MA 02142.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biology Massachusetts Institute of Technology, Cambridge, 02139, and Whitehead Institute for Biomedical Research, Cambridge, MA 02142.', 'institution_ids': ['https://openalex.org/I4210157710', 'https://openalex.org/I63966007']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5011979076', 'display_name': 'Robert T. Sauer', 'orcid': 'https://orcid.org/0000-0002-1719-5399'}, 'institutions': [{'id': 'https://openalex.org/I63966007', 'display_name': 'Massachusetts Institute of Technology', 'ror': 'https://ror.org/042nb2s44', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I63966007']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Robert T. Sauer', 'raw_affiliation_strings': ['*Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139;'], 'affiliations': [{'raw_affiliation_string': '*Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139;', 'institution_ids': ['https://openalex.org/I63966007']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 11.384, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 379, 'citation_normalized_percentile': {'value': 0.956876, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '250', 'issue': '4986', 'first_page': '1400', 'last_page': '1403'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10521', 'display_name': 'RNA and protein synthesis mechanisms', 'score': 0.998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10521', 'display_name': 'RNA and protein synthesis mechanisms', 'score': 0.998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10184', 'display_name': 'Plant Molecular Biology Research', 'score': 0.9968, 'subfield': {'id': 'https://openalex.org/subfields/1110', 'display_name': 'Plant Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10303', 'display_name': 'Photosynthetic Processes and Mechanisms', 'score': 0.9958, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/heptad-repeat', 'display_name': 'Heptad repeat', 'score': 0.8601547}, {'id': 'https://openalex.org/keywords/siphoviridae', 'display_name': 'Siphoviridae', 'score': 0.6340513}, {'id': 'https://openalex.org/keywords/atf3', 'display_name': 'ATF3', 'score': 0.520994}, {'id': 'https://openalex.org/keywords/zipper', 'display_name': 'Zipper', 'score': 0.4849639}, {'id': 'https://openalex.org/keywords/bzip-domain', 'display_name': 'bZIP domain', 'score': 0.45252767}], 'concepts': [{'id': 'https://openalex.org/C156860981', 'wikidata': 'https://www.wikidata.org/wiki/Q2565229', 'display_name': 'Leucine zipper', 'level': 4, 'score': 0.9328011}, {'id': 'https://openalex.org/C122146531', 'wikidata': 'https://www.wikidata.org/wiki/Q16920125', 'display_name': 'Heptad repeat', 'level': 4, 'score': 0.8601547}, {'id': 'https://openalex.org/C2778303719', 'wikidata': 'https://www.wikidata.org/wiki/Q6808', 'display_name': 'Siphoviridae', 'level': 5, 'score': 0.6340513}, {'id': 'https://openalex.org/C2779546866', 'wikidata': 'https://www.wikidata.org/wiki/Q531306', 'display_name': 'Dimer', 'level': 2, 'score': 0.55794716}, {'id': 'https://openalex.org/C515207424', 'wikidata': 'https://www.wikidata.org/wiki/Q8066', 'display_name': 'Amino acid', 'level': 2, 'score': 0.5505302}, {'id': 'https://openalex.org/C2776580952', 'wikidata': 'https://www.wikidata.org/wiki/Q483745', 'display_name': 'Leucine', 'level': 3, 'score': 0.55002254}, {'id': 'https://openalex.org/C157880135', 'wikidata': 'https://www.wikidata.org/wiki/Q17832633', 'display_name': 'ATF3', 'level': 5, 'score': 0.520994}, {'id': 'https://openalex.org/C105782903', 'wikidata': 'https://www.wikidata.org/wiki/Q6577686', 'display_name': 'Zipper', 'level': 2, 'score': 0.4849639}, {'id': 'https://openalex.org/C167625842', 'wikidata': 'https://www.wikidata.org/wiki/Q899763', 'display_name': 'Peptide sequence', 'level': 3, 'score': 0.4733798}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.46206105}, {'id': 'https://openalex.org/C202908374', 'wikidata': 'https://www.wikidata.org/wiki/Q4867030', 'display_name': 'Basic helix-loop-helix leucine zipper transcription factors', 'level': 5, 'score': 0.46176854}, {'id': 'https://openalex.org/C158448853', 'wikidata': 'https://www.wikidata.org/wiki/Q425218', 'display_name': 'Repressor', 'level': 4, 'score': 0.45373905}, {'id': 'https://openalex.org/C19408993', 'wikidata': 'https://www.wikidata.org/wiki/Q24784063', 'display_name': 'bZIP domain', 'level': 5, 'score': 0.45252767}, {'id': 'https://openalex.org/C88045685', 'wikidata': 'https://www.wikidata.org/wiki/Q174576', 'display_name': 'Activator (genetics)', 'level': 3, 'score': 0.43878615}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.42419183}, {'id': 'https://openalex.org/C547475151', 'wikidata': 'https://www.wikidata.org/wiki/Q25419', 'display_name': 'Escherichia coli', 'level': 3, 'score': 0.41706142}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4008442}, {'id': 'https://openalex.org/C2776441376', 'wikidata': 'https://www.wikidata.org/wiki/Q165028', 'display_name': 'Bacteriophage', 'level': 4, 'score': 0.38755974}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.22198334}, {'id': 'https://openalex.org/C94966510', 'wikidata': 'https://www.wikidata.org/wiki/Q2252764', 'display_name': 'DNA-binding protein', 'level': 4, 'score': 0.18977991}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.14807823}, {'id': 'https://openalex.org/C101762097', 'wikidata': 'https://www.wikidata.org/wiki/Q224093', 'display_name': 'Promoter', 'level': 4, 'score': 0.10196763}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C11413529', 'wikidata': 'https://www.wikidata.org/wiki/Q8366', 'display_name': 'Algorithm', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D010582', 'descriptor_name': 'Bacteriophage lambda', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D004926', 'descriptor_name': 'Escherichia coli', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D005656', 'descriptor_name': 'Fungal Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D016350', 'descriptor_name': 'Leucine Zippers', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D011494', 'descriptor_name': 'Protein Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D029701', 'descriptor_name': 'Saccharomyces cerevisiae Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010582', 'descriptor_name': 'Bacteriophage lambda', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004926', 'descriptor_name': 'Escherichia coli', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005656', 'descriptor_name': 'Fungal Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014644', 'descriptor_name': 'Genetic Variation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016350', 'descriptor_name': 'Leucine Zippers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008958', 'descriptor_name': 'Models, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016297', 'descriptor_name': 'Mutagenesis, Site-Directed', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010641', 'descriptor_name': 'Phenotype', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011487', 'descriptor_name': 'Protein Conformation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011897', 'descriptor_name': 'Random Allocation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011993', 'descriptor_name': 'Recombinant Fusion Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011993', 'descriptor_name': 'Recombinant Fusion Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1126/science.2147779', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S3880285', 'display_name': 'Science', 'issn_l': '0036-8075', 'issn': ['0036-8075', '1095-9203'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315823', 'host_organization_name': 'American Association for the Advancement of Science', 'host_organization_lineage': ['https://openalex.org/P4310315823'], 'host_organization_lineage_names': ['American Association for the Advancement of Science'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/2147779', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 31, 'referenced_works': ['https://openalex.org/W1510499038', 'https://openalex.org/W1970492002', 'https://openalex.org/W1974574324', 'https://openalex.org/W1975511017', 'https://openalex.org/W1980581336', 'https://openalex.org/W1990882655', 'https://openalex.org/W1992829924', 'https://openalex.org/W1999200731', 'https://openalex.org/W1999602995', 'https://openalex.org/W2002866511', 'https://openalex.org/W2005393972', 'https://openalex.org/W2007385914', 'https://openalex.org/W200996029', 'https://openalex.org/W2016705724', 'https://openalex.org/W2020552893', 'https://openalex.org/W2022064097', 'https://openalex.org/W2038352589', 'https://openalex.org/W2039839088', 'https://openalex.org/W2045315686', 'https://openalex.org/W2045412127', 'https://openalex.org/W2049158685', 'https://openalex.org/W2053621664', 'https://openalex.org/W2055257235', 'https://openalex.org/W2064089886', 'https://openalex.org/W2069587384', 'https://openalex.org/W2073548049', 'https://openalex.org/W2081643570', 'https://openalex.org/W2085087848', 'https://openalex.org/W2213239053', 'https://openalex.org/W2329508872', 'https://openalex.org/W967642706'], 'related_works': ['https://openalex.org/W2432170829', 'https://openalex.org/W2352023249', 'https://openalex.org/W2267454943', 'https://openalex.org/W2108839301', 'https://openalex.org/W2091477850', 'https://openalex.org/W2058215940', 'https://openalex.org/W2015278341', 'https://openalex.org/W1989443065', 'https://openalex.org/W1988350384', 'https://openalex.org/W1988110468'], 'abstract_inverted_index': {'A': [0], 'genetic': [1], 'system': [2, 26], 'was': [3, 27], 'developed': [4], 'in': [5, 103, 114], 'Escherichia': [6], 'coli': [7], 'to': [8, 29, 98, 109], 'study': [9], 'leucine': [10, 49, 115], 'zippers': [11], 'with': [12], 'the': [13, 31, 34, 44, 48, 53, 72, 104], 'amino-terminal': [14], 'domain': [15], 'of': [16, 33, 47, 93], 'bacteriophage': [17], 'λ': [18], 'repressor': [19], 'as': [20], 'a': [21, 111], 'reporter': [22], 'for': [23], 'dimerization.': [24, 117], 'This': [25], 'used': [28], 'analyze': [30], 'importance': [32], 'amino': [35, 60], 'acid': [36, 61], 'side': [37], 'chains': [38], 'at': [39, 71], 'eight': [40], 'positions': [41], 'that': [42], 'form': [43], 'hydrophobic': [45, 69, 94], 'interface': [46], 'zipper': [50, 116], 'dimer': [51, 73], 'from': [52], 'yeast': [54], 'transcriptional': [55], 'activator,': [56], 'GCN4.': [57], 'When': [58], 'single': [59], 'substitutions': [62], 'were': [63, 96, 107], 'analyzed,': [64], 'most': [65, 76], 'functional': [66], 'variants': [67, 79], 'contained': [68, 80], 'residues': [70, 95], 'interface,': [74], 'while': [75], 'nonfunctional': [77], 'sequence': [78], 'strongly': [81], 'polar': [82], 'or': [83], 'helix-breaking': [84], 'residues.': [85], 'In': [86], 'multiple': [87], 'randomization': [88], 'experiments,': [89], 'however,': [90], 'many': [91], 'combinations': [92], 'found': [97], 'be': [99], 'nonfunctional,': [100], 'and': [101], 'leucines': [102], 'heptad': [105], 'repeat': [106], 'shown': [108], 'have': [110], 'special': [112], 'function': [113]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1988110468', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 7}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2024-12-08T07:49:13.789349', 'created_date': '2016-06-24'}