Publication Information

{'id': 'https://openalex.org/W2165499430', 'doi': 'https://doi.org/10.1126/science.8248779', 'title': 'A Switch Between Two-, Three-, and Four-stranded Coiled Coils in GCN4 Leucine Zipper Mutants', 'display_name': 'A Switch Between Two-, Three-, and Four-stranded Coiled Coils in GCN4 Leucine Zipper Mutants', 'publication_year': 1993, 'publication_date': '1993-11-26', 'ids': {'openalex': 'https://openalex.org/W2165499430', 'doi': 'https://doi.org/10.1126/science.8248779', 'mag': '2165499430', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/8248779'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1126/science.8248779', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S3880285', 'display_name': 'Science', 'issn_l': '0036-8075', 'issn': ['0036-8075', '1095-9203'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315823', 'host_organization_name': 'American Association for the Advancement of Science', 'host_organization_lineage': ['https://openalex.org/P4310315823'], 'host_organization_lineage_names': ['American Association for the Advancement of Science'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5069719269', 'display_name': 'Pehr B. Harbury', 'orcid': 'https://orcid.org/0000-0002-3657-5485'}, 'institutions': [{'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'P B Harbury', 'raw_affiliation_strings': ['Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115.', 'institution_ids': ['https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100375841', 'display_name': 'Tao Zhang', 'orcid': 'https://orcid.org/0000-0002-7897-0205'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'T Zhang', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100672876', 'display_name': 'Peter S. Kim', 'orcid': 'https://orcid.org/0000-0001-6503-4541'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'P S Kim', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5070022547', 'display_name': 'Tom Alber', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'T Alber', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 18.577, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 1456, 'citation_normalized_percentile': {'value': 0.999964, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '262', 'issue': '5138', 'first_page': '1401', 'last_page': '1407'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10521', 'display_name': 'RNA and protein synthesis mechanisms', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10521', 'display_name': 'RNA and protein synthesis mechanisms', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10044', 'display_name': 'Protein Structure and Dynamics', 'score': 0.9977, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11162', 'display_name': 'Enzyme Structure and Function', 'score': 0.9955, 'subfield': {'id': 'https://openalex.org/subfields/2505', 'display_name': 'Materials Chemistry'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/coiled-coil', 'display_name': 'Coiled coil', 'score': 0.89923346}, {'id': 'https://openalex.org/keywords/heptad-repeat', 'display_name': 'Heptad repeat', 'score': 0.8939035}, {'id': 'https://openalex.org/keywords/tetramer', 'display_name': 'Tetramer', 'score': 0.8742346}, {'id': 'https://openalex.org/keywords/zipper', 'display_name': 'Zipper', 'score': 0.7788059}, {'id': 'https://openalex.org/keywords/helix', 'display_name': 'Helix (gastropod)', 'score': 0.42900604}, {'id': 'https://openalex.org/keywords/sequence', 'display_name': 'Sequence (biology)', 'score': 0.42087525}], 'concepts': [{'id': 'https://openalex.org/C156860981', 'wikidata': 'https://www.wikidata.org/wiki/Q2565229', 'display_name': 'Leucine zipper', 'level': 4, 'score': 0.94244266}, {'id': 'https://openalex.org/C55988834', 'wikidata': 'https://www.wikidata.org/wiki/Q903650', 'display_name': 'Coiled coil', 'level': 2, 'score': 0.89923346}, {'id': 'https://openalex.org/C122146531', 'wikidata': 'https://www.wikidata.org/wiki/Q16920125', 'display_name': 'Heptad repeat', 'level': 4, 'score': 0.8939035}, {'id': 'https://openalex.org/C2778886173', 'wikidata': 'https://www.wikidata.org/wiki/Q53832', 'display_name': 'Tetramer', 'level': 3, 'score': 0.8742346}, {'id': 'https://openalex.org/C105782903', 'wikidata': 'https://www.wikidata.org/wiki/Q6577686', 'display_name': 'Zipper', 'level': 2, 'score': 0.7788059}, {'id': 'https://openalex.org/C2779546866', 'wikidata': 'https://www.wikidata.org/wiki/Q531306', 'display_name': 'Dimer', 'level': 2, 'score': 0.6899392}, {'id': 'https://openalex.org/C8010536', 'wikidata': 'https://www.wikidata.org/wiki/Q160398', 'display_name': 'Crystallography', 'level': 1, 'score': 0.5539071}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.52496594}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.52205586}, {'id': 'https://openalex.org/C47701112', 'wikidata': 'https://www.wikidata.org/wiki/Q735188', 'display_name': 'Protein structure', 'level': 2, 'score': 0.4861707}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.47003573}, {'id': 'https://openalex.org/C515207424', 'wikidata': 'https://www.wikidata.org/wiki/Q8066', 'display_name': 'Amino acid', 'level': 2, 'score': 0.45415276}, {'id': 'https://openalex.org/C167625842', 'wikidata': 'https://www.wikidata.org/wiki/Q899763', 'display_name': 'Peptide sequence', 'level': 3, 'score': 0.43684962}, {'id': 'https://openalex.org/C2778530040', 'wikidata': 'https://www.wikidata.org/wiki/Q1937315', 'display_name': 'Helix (gastropod)', 'level': 3, 'score': 0.42900604}, {'id': 'https://openalex.org/C2778112365', 'wikidata': 'https://www.wikidata.org/wiki/Q3511065', 'display_name': 'Sequence (biology)', 'level': 2, 'score': 0.42087525}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.34466898}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.32280755}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.2626087}, {'id': 'https://openalex.org/C18903297', 'wikidata': 'https://www.wikidata.org/wiki/Q7150', 'display_name': 'Ecology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C11413529', 'wikidata': 'https://www.wikidata.org/wiki/Q8366', 'display_name': 'Algorithm', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C2779965526', 'wikidata': 'https://www.wikidata.org/wiki/Q308841', 'display_name': 'Snail', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D005656', 'descriptor_name': 'Fungal Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D016350', 'descriptor_name': 'Leucine Zippers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D011494', 'descriptor_name': 'Protein Kinases', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D029701', 'descriptor_name': 'Saccharomyces cerevisiae Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018360', 'descriptor_name': 'Crystallography, X-Ray', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005656', 'descriptor_name': 'Fungal Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D005656', 'descriptor_name': 'Fungal Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006860', 'descriptor_name': 'Hydrogen Bonding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011487', 'descriptor_name': 'Protein Conformation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011494', 'descriptor_name': 'Protein Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011494', 'descriptor_name': 'Protein Kinases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D017433', 'descriptor_name': 'Protein Structure, Secondary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1126/science.8248779', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S3880285', 'display_name': 'Science', 'issn_l': '0036-8075', 'issn': ['0036-8075', '1095-9203'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315823', 'host_organization_name': 'American Association for the Advancement of Science', 'host_organization_lineage': ['https://openalex.org/P4310315823'], 'host_organization_lineage_names': ['American Association for the Advancement of Science'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8248779', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 54, 'referenced_works': ['https://openalex.org/W1574312817', 'https://openalex.org/W1964771243', 'https://openalex.org/W1966480910', 'https://openalex.org/W1968673134', 'https://openalex.org/W1969222787', 'https://openalex.org/W1975511017', 'https://openalex.org/W1975914851', 'https://openalex.org/W1980581336', 'https://openalex.org/W1983007565', 'https://openalex.org/W1983611815', 'https://openalex.org/W1984412128', 'https://openalex.org/W1984527736', 'https://openalex.org/W1985204165', 'https://openalex.org/W1985374711', 'https://openalex.org/W1988110468', 'https://openalex.org/W1990000982', 'https://openalex.org/W1995938191', 'https://openalex.org/W2001838626', 'https://openalex.org/W2003697928', 'https://openalex.org/W2005393972', 'https://openalex.org/W2007385914', 'https://openalex.org/W2011273569', 'https://openalex.org/W2011495938', 'https://openalex.org/W2014853910', 'https://openalex.org/W2017774235', 'https://openalex.org/W2019419950', 'https://openalex.org/W2030852504', 'https://openalex.org/W2041654633', 'https://openalex.org/W2045412127', 'https://openalex.org/W2050888116', 'https://openalex.org/W2053621664', 'https://openalex.org/W2055257235', 'https://openalex.org/W2055290772', 'https://openalex.org/W2057443486', 'https://openalex.org/W2057984729', 'https://openalex.org/W2059510901', 'https://openalex.org/W2060967383', 'https://openalex.org/W2064089886', 'https://openalex.org/W2064517997', 'https://openalex.org/W2070724021', 'https://openalex.org/W2073548049', 'https://openalex.org/W2079961768', 'https://openalex.org/W2081645347', 'https://openalex.org/W2083761143', 'https://openalex.org/W2085087848', 'https://openalex.org/W2091477850', 'https://openalex.org/W2094455792', 'https://openalex.org/W2107392414', 'https://openalex.org/W2116441099', 'https://openalex.org/W2119586900', 'https://openalex.org/W2162166182', 'https://openalex.org/W2213239053', 'https://openalex.org/W29841679', 'https://openalex.org/W4246356731'], 'related_works': ['https://openalex.org/W4229738240', 'https://openalex.org/W2741370137', 'https://openalex.org/W2739613058', 'https://openalex.org/W2165499430', 'https://openalex.org/W2051181331', 'https://openalex.org/W2029101025', 'https://openalex.org/W2007639221', 'https://openalex.org/W2001525537', 'https://openalex.org/W1994537350', 'https://openalex.org/W1988350384'], 'abstract_inverted_index': {'Coiled-coil': [0], 'sequences': [1], 'in': [2, 20, 77, 86, 96, 117, 133], 'proteins': [3], 'consist': [4], 'of': [5, 15, 24, 32, 39, 55, 72, 111, 129, 139], 'heptad': [6, 79], 'repeats': [7], 'containing': [8], 'two': [9, 74], 'characteristic': [10], 'hydrophobic': [11, 18, 75, 112], 'positions.': [12], 'The': [13, 51], 'role': [14], 'these': [16], 'buried': [17, 40, 94, 130], 'residues': [19, 41, 95], 'determining': [21], 'the': [22, 33, 56, 65, 68, 73, 78, 87, 97, 109, 127, 140], 'structures': [23, 48], 'coiled': [25, 62, 134], 'coils': [26, 135], 'was': [27], 'investigated': [28], 'by': [29], 'studying': [30], 'mutants': [31], 'GCN4': [34, 98], 'leucine': [35, 99], 'zipper.': [36], 'When': [37], 'sets': [38], 'were': [42, 49], 'altered,': [43], 'two-,': [44], 'three-,': [45], 'and': [46, 113], 'four-helix': [47], 'formed.': [50], 'x-ray': [52], 'crystal': [53], 'structure': [54], 'tetramer': [57, 66], 'revealed': [58], 'a': [59, 118], 'parallel,': [60], 'four-stranded': [61], 'coil.': [63], 'In': [64, 104], 'conformation,': [67], 'local': [69], 'packing': [70], 'geometry': [71], 'positions': [76], 'repeat': [80], 'is': [81, 121], 'reversed': [82], 'relative': [83], 'to': [84, 106, 123], 'that': [85, 92, 108], 'dimer.': [88], 'These': [89], 'studies': [90], 'demonstrate': [91], 'conserved,': [93], 'zipper': [100], 'direct': [101], 'dimer': [102], 'formation.': [103], 'contrast': [105], 'proposals': [107], 'pattern': [110], 'polar': [114], 'amino': [115], 'acids': [116], 'protein': [119], 'sequence': [120], 'sufficient': [122], 'determine': [124], 'three-dimensional': [125], 'structure,': [126], 'shapes': [128], 'side': [131], 'chains': [132], 'are': [136], 'essential': [137], 'determinants': [138], 'global': [141], 'fold.': [142]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2165499430', 'counts_by_year': [{'year': 2024, 'cited_by_count': 17}, {'year': 2023, 'cited_by_count': 28}, {'year': 2022, 'cited_by_count': 21}, {'year': 2021, 'cited_by_count': 43}, {'year': 2020, 'cited_by_count': 47}, {'year': 2019, 'cited_by_count': 34}, {'year': 2018, 'cited_by_count': 35}, {'year': 2017, 'cited_by_count': 43}, {'year': 2016, 'cited_by_count': 38}, {'year': 2015, 'cited_by_count': 38}, {'year': 2014, 'cited_by_count': 32}, {'year': 2013, 'cited_by_count': 58}, {'year': 2012, 'cited_by_count': 57}], 'updated_date': '2024-12-22T21:45:06.331130', 'created_date': '2016-06-24'}