Publication Information

{'id': 'https://openalex.org/W2067540329', 'doi': 'https://doi.org/10.1074/jbc.m708138200', 'title': 'Eliminating the Synthesis of Mature Lamin A Reduces Disease Phenotypes in Mice Carrying a Hutchinson-Gilford Progeria Syndrome Allele', 'display_name': 'Eliminating the Synthesis of Mature Lamin A Reduces Disease Phenotypes in Mice Carrying a Hutchinson-Gilford Progeria Syndrome Allele', 'publication_year': 2008, 'publication_date': '2008-01-06', 'ids': {'openalex': 'https://openalex.org/W2067540329', 'doi': 'https://doi.org/10.1074/jbc.m708138200', 'mag': '2067540329', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/18178963'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m708138200', 'pdf_url': 'http://www.jbc.org/article/S0021925820571482/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925820571482/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5110205957', 'display_name': 'Shao H. 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'https://openalex.org/W2143185290', 'https://openalex.org/W2148618665', 'https://openalex.org/W2149619603', 'https://openalex.org/W2153825396', 'https://openalex.org/W2154950275', 'https://openalex.org/W2157478214', 'https://openalex.org/W2165644047', 'https://openalex.org/W2172254982'], 'related_works': ['https://openalex.org/W4221022264', 'https://openalex.org/W4206098026', 'https://openalex.org/W3176419864', 'https://openalex.org/W2317718274', 'https://openalex.org/W2255523009', 'https://openalex.org/W2119526996', 'https://openalex.org/W2088983871', 'https://openalex.org/W2052034221', 'https://openalex.org/W1554973796', 'https://openalex.org/W1484768737'], 'abstract_inverted_index': {'Hutchinson-Gilford': [0, 234, 484, 896, 899, 910, 1422], 'progeria': [1, 235, 485, 492, 897, 911, 1350, 1503, 3928, 4817], 'syndrome': [2, 236, 486, 898, 912, 918], 'is': [3, 16, 21, 237, 250, 255, 643, 709, 913, 1064, 1178, 1722, 1868, 3346, 3773, 4253, 4281, 4305, 4332, 4340, 4523, 4580], 'caused': [4, 238, 1067], 'by': [5, 79, 86, 239, 313, 320, 646, 796, 1068, 1494, 1565, 1583, 1772, 1864, 1896, 2088, 2171, 2405, 3042, 3180, 3721, 4172, 4193, 4334, 4342, 4469], 'the': [6, 24, 31, 34, 73, 76, 80, 90, 122, 192, 216, 222, 228, 240, 258, 265, 268, 307, 310, 314, 324, 356, 426, 450, 456, 462, 632, 639, 720, 728, 779, 921, 1173, 1214, 1219, 1222, 1236, 1241, 1244, 1433, 1554, 1709, 1712, 1717, 1725, 1773, 1785, 1795, 1806, 1827, 1858, 1865, 1871, 1874, 1879, 2420, 2471, 2489, 2501, 2523, 2564, 2605, 2623, 2642, 2662, 2754, 2831, 2839, 2886, 2891, 2903, 3051, 3096, 3107, 3114, 3118, 3124, 3131, 3140, 3168, 3176, 3181, 3186, 3196, 3230, 3296, 3316, 3319, 3325, 3351, 3362, 3540, 3543, 3566, 3579, 3583, 3609, 3622, 3675, 3680, 3748, 3774, 3969, 3972, 3977, 3981, 4016, 4082, 4118, 4128, 4146, 4165, 4169, 4194, 4201, 4205, 4232, 4258, 4273, 4285, 4289, 4308, 4316, 4321, 4357, 4415, 4451, 4466, 4491, 4515, 4567, 4590, 4593, 4597, 4603, 4622, 4780, 4797, 4807, 4900, 4944, 4956, 4964], 'synthesis': [7, 241, 1342, 3173, 3982], 'of': [8, 12, 33, 66, 124, 157, 194, 225, 230, 242, 246, 267, 300, 358, 391, 428, 459, 464, 474, 586, 635, 719, 784, 799, 923, 927, 1083, 1243, 1340, 1349, 1440, 1447, 1497, 1502, 1509, 1568, 1575, 1586, 1631, 1711, 1719, 1805, 1808, 1829, 1860, 1873, 1881, 1886, 2328, 2355, 2430, 2661, 2682, 2701, 2785, 2818, 2852, 2861, 2885, 3033, 3053, 3070, 3085, 3093, 3142, 3149, 3155, 3170, 3188, 3227, 3242, 3298, 3327, 3343, 3364, 3415, 3443, 3462, 3570, 3582, 3592, 3602, 3624, 3654, 3677, 3684, 3752, 3847, 3858, 3920, 3927, 3971, 3983, 3987, 4141, 4168, 4186, 4209, 4221, 4235, 4269, 4272, 4288, 4301, 4323, 4345, 4352, 4359, 4379, 4453, 4518, 4569, 4592, 4600, 4669, 4686, 4782, 4840, 4902, 4946, 4959, 4966], 'a': [9, 50, 243, 284, 472, 576, 587, 705, 723, 781, 844, 914, 924, 1069, 1080, 1090, 1420, 1572, 1809, 1882, 2340, 2343, 2376, 2428, 2652, 2699, 2816, 2871, 3019, 3064, 3136, 3160, 3598, 3984, 4174, 4179, 4254, 4298, 4343, 4376, 4511, 4665, 4673, 4687, 4800, 4912], 'mutant': [10, 109, 244, 343, 925, 1081, 1434, 1774], 'form': [11, 245, 926, 1082, 4412, 4485, 4510], 'prelamin': [13, 247, 551, 636, 829, 928, 1084, 2732], 'A,': [14, 140, 248, 374, 1085, 1849, 3209, 4361], 'which': [15, 249, 581, 1425, 1814], 'generally': [17, 251], 'called': [18, 252, 1087], 'progerin.': [19, 253, 1428, 3603, 3988, 4142], 'Progerin': [20, 254, 1171, 1233, 1721, 3716], 'targeted': [22, 256, 1723], 'to': [23, 43, 257, 277, 791, 835, 1229, 1336, 1724, 2427, 2480, 2622, 2724, 2740, 2902, 3047, 3112, 3607, 3627, 3658, 3661, 3688, 3712, 4246, 4356, 4366, 4509, 4573, 4585, 4835, 4909], 'nuclear': [25, 35, 91, 217, 259, 269, 325, 451, 721, 730, 1237, 1245, 1713, 1726, 1733, 1786, 1883, 3383, 3584, 3852, 3973, 4170, 4290, 4467, 4492, 4808], 'rim,': [26, 260], 'where': [27, 261], 'it': [28, 262, 1759, 2578, 4280, 4339, 4579, 4831, 4905], 'interferes': [29, 263], 'with': [30, 133, 264, 367, 575, 920, 1029, 1089, 1345, 1571, 1635, 1731, 1900, 1987, 2174, 2299, 2334, 2342, 2470, 2488, 2522, 2581, 2641, 2651, 2666, 2679, 2688, 2713, 2737, 2759, 2768, 2776, 2858, 2890, 2919, 2923, 2929, 2978, 2993, 3018, 3026, 3058, 3063, 3089, 3135, 3159, 3420, 3460, 3614, 3980, 4178, 4368, 4502, 4556, 4575, 4664, 4672], 'integrity': [32, 266, 1242, 2660], 'lamina,': [36, 270, 722, 1246, 4171], 'causes': [37, 271], 'misshapen': [38, 176, 272, 410, 1249, 1448, 3034, 3054, 3347, 3365, 3416, 3444, 4103], 'cell': [39, 273, 2289, 3348, 4416], 'nuclei,': [40, 274], 'and': [41, 57, 104, 130, 143, 164, 199, 207, 227, 275, 291, 338, 364, 377, 398, 433, 441, 461, 483, 553, 584, 648, 708, 714, 787, 794, 831, 851, 1177, 1180, 1239, 1251, 1442, 1512, 1517, 1581, 1624, 1728, 1838, 1841, 1852, 2071, 2077, 2170, 2225, 2302, 2337, 2345, 2373, 2389, 2403, 2455, 2478, 2552, 2588, 2615, 2619, 2630, 2638, 2649, 2698, 2704, 2721, 2731, 2743, 2762, 2782, 2809, 2835, 2864, 2868, 2896, 2927, 3000, 3024, 3073, 3095, 3106, 3126, 3130, 3139, 3190, 3202, 3212, 3217, 3257, 3290, 3403, 3439, 3550, 3561, 3573, 3650, 3682, 3732, 3741, 3750, 3754, 3763, 3999, 4012, 4093, 4109, 4114, 4153, 4188, 4226, 4229, 4241, 4265, 4295, 4348, 4364, 4382, 4410, 4457, 4462, 4482, 4506, 4520, 4560, 4610, 4615, 4648, 4790, 4816, 4843], 'leads': [42, 276, 790], 'multiple': [44, 278, 1038, 1252], 'aging-like': [45, 279], 'disease': [46, 232, 280, 466, 1039, 1253, 1638, 1769, 1790, 1830, 1861, 3177, 3354, 3995, 4070, 4190, 4625, 4678, 4792, 4818], 'phenotypes.': [47, 233, 281, 467, 4793, 4819], 'We': [48, 119, 282, 353, 3563, 4197, 4313], 'created': [49, 283, 1419], 'gene-targeted': [51, 285, 1421], 'allele': [52, 82, 103, 107, 110, 286, 316, 337, 341, 344, 847, 900, 903, 1435, 1867, 1876, 2834, 4004, 4018, 4177, 4916], 'yielding': [53, 287], 'exclusively': [54, 288, 1427, 4023], 'progerin': [55, 129, 195, 226, 289, 363, 429, 460, 1341, 1441, 1576, 1632, 1837, 2730, 2865, 3213, 3678, 3705, 3744, 3772, 3848, 3859, 3921, 4148, 4187, 4210, 4222, 4236, 4249, 4260, 4311, 4324, 4365, 4500, 4572, 4601, 4788, 4814], '(LmnaHG)': [56, 290], 'found': [58, 292], 'that': [59, 75, 111, 212, 293, 309, 345, 446, 726, 840, 1074, 1628, 1762, 1781, 1857, 2684, 3120, 3269, 3318, 3361, 3565, 3621, 3771, 3915, 4127, 4257, 4279, 4284, 4315, 4330, 4477, 4487, 4499, 4514, 4549, 4587, 4621, 4660, 4681, 4779, 4803], 'heterozygous': [60, 294, 1431], 'mice': [61, 99, 126, 136, 146, 295, 333, 360, 370, 380, 839, 1488, 1563, 1625, 1793, 1834, 1844, 1990, 3075, 3086, 3156, 3198, 3206, 3219, 3236, 3244, 3271, 3276, 3305, 3309, 3321, 3408, 3448, 3549, 3572, 3694, 3698, 3756, 4007, 4021, 4074, 4084, 4111, 4612, 4629, 4635, 4659, 4671], '(LmnaHG/+)': [62, 296, 1436], 'exhibit': [63, 297], 'many': [64, 298], 'phenotypes': [65, 77, 123, 299, 311, 357, 1040, 1254, 1639, 1770, 1791, 1831, 1862, 3178, 3187, 3355, 3546, 3569, 3978, 3996, 4071, 4191, 4626, 4679], 'progeria.': [67, 301, 4947, 4967], 'In': [68, 170, 302, 404, 778, 1776, 1822, 2498, 3957, 4097, 4494], 'this': [69, 95, 303, 329, 1777, 1800, 3283, 3379, 3605, 3958, 3991, 4144, 4353], 'study,': [70, 304, 1778, 3959], 'we': [71, 97, 305, 331, 1779, 1802, 1825, 3184, 3359, 3381, 3553, 3960, 3993, 4125, 4277, 4619], 'tested': [72, 306], 'hypothesis': [74, 308], 'elicited': [78, 312, 1771, 1863, 3179, 4192], 'LmnaHG': [81, 102, 315, 336, 1796, 1866, 2840, 3182, 4195, 4274], 'might': [83, 317, 1767, 1788, 3370, 3975], 'be': [84, 318, 836, 3371, 3608, 3662, 3710, 4137, 4244, 4326, 4824, 4833, 4907], 'modulated': [85, 319], 'compositional': [87, 213, 321, 447, 1782, 4804], 'changes': [88, 214, 322, 448, 1763, 1783, 3967, 4247, 4588, 4805], 'in': [89, 196, 204, 215, 323, 430, 438, 449, 469, 1072, 1079, 1248, 1515, 1553, 1557, 1621, 1708, 1764, 1784, 1792, 1832, 1870, 1878, 2352, 2375, 2506, 2514, 2526, 2571, 2599, 2830, 2838, 3050, 3152, 3234, 3254, 3287, 3303, 3307, 3338, 3356, 3367, 3374, 3386, 3426, 3430, 3446, 3453, 3547, 3586, 3597, 3631, 3638, 3664, 3668, 3679, 3692, 3696, 3704, 3727, 3747, 3777, 3923, 3968, 3997, 4005, 4019, 4072, 4079, 4150, 4160, 4211, 4224, 4238, 4248, 4262, 4292, 4310, 4414, 4420, 4465, 4490, 4589, 4602, 4624, 4627, 4657, 4806, 4826, 4963], 'lamina.': [92, 326, 4493], 'To': [93, 327, 1798, 2287, 3165, 3377, 3538, 3989], 'explore': [94, 328, 1799, 3990], 'hypothesis,': [96, 330, 1801], 'bred': [98, 332, 1986], 'harboring': [100, 334, 1794], 'one': [101, 105, 335, 339, 1703, 4403], 'LmnaLCO': [106, 340, 1875, 4017], '(a': [108, 342], 'produces': [112, 346, 1815, 4008, 4022], 'lamin': [113, 117, 131, 139, 141, 347, 351, 365, 373, 375, 554, 652, 785, 788, 832, 901, 1231, 1765, 1810, 1816, 1820, 1839, 1848, 1850, 1888, 2178, 2862, 2981, 3171, 3200, 3208, 3210, 3594, 3655, 4010, 4013, 4024, 4180, 4303, 4335, 4346, 4349, 4360, 4362, 4380, 4383, 4480, 4483, 4504, 4507, 4577, 4784, 4913, 4961], 'C': [114, 348, 555, 701, 715, 789, 1817, 3201, 4025, 4336, 4384, 4411, 4844], 'but': [115, 349, 1035, 1493, 1818, 4117, 4618, 4680], 'no': [116, 350, 1702, 1819, 4402], 'A).': [118, 352, 1889], 'then': [120, 354, 2350, 2387, 2424, 2722], 'compared': [121, 355, 1826, 3088, 3158, 3185, 3994], 'LmnaHG/LCO': [125, 145, 172, 197, 359, 379, 406, 431, 1833, 2078, 3074, 3189, 3197, 3216, 3235, 3270, 3304, 3320, 3357, 3368, 3391, 3427, 3548, 3551, 3571, 3587, 3632, 3669, 3685, 3693, 3728, 3753, 4000, 4020, 4073, 4083, 4099, 4108, 4151, 4212, 4227, 4239, 4263, 4293, 4611, 4628, 4634], '(which': [127, 137, 361, 371, 1835, 1845], 'produce': [128, 138, 362, 372, 1836, 1846, 3849], 'C)': [132, 366, 1840], 'littermate': [134, 368, 1842, 3191], 'LmnaHG/+': [135, 179, 205, 369, 413, 439, 1487, 1562, 1843, 1901, 2073, 3192, 3205, 3218, 3243, 3275, 3308, 3339, 3344, 3375, 3395, 3431, 3639, 3665, 3697, 3733, 3755, 3998, 4006, 4080, 4110, 4161, 4225, 4609, 4658, 4670], 'C,': [142, 376, 1851, 3211, 3656, 4014, 4363], 'progerin).': [144, 378, 1853], 'exhibited': [147, 381, 4085], 'improved': [148, 165, 382, 399, 4087, 4091, 4677], 'body': [149, 383, 3231, 4088, 4640], 'weight': [150, 384, 1506, 3080, 3232, 4089, 4641], 'curves': [151, 385, 3081, 3233, 3267], '(p': [152, 161, 167, 181, 386, 395, 401, 415, 3245, 3259, 3277, 3292, 3310, 3433, 3456, 3644, 3671], '<': [153, 162, 168, 182, 387, 396, 402, 416, 3246, 3260, 3278, 3293, 3311, 3434, 3457, 3645], '0.0001),': [154, 163, 388, 397], 'reduced': [155, 389, 3599, 4189, 4206, 4233, 4270], 'numbers': [156, 390], 'spontaneous': [158, 392, 1559, 4645], 'rib': [159, 393, 3143, 3150, 3299, 4095], 'fractures': [160, 394, 3144, 3151, 3300], 'survival': [166, 400, 3100, 3115, 3266], '0.0001).': [169, 183, 403, 417, 3294], 'addition,': [171, 405, 4098], 'fibroblasts': [173, 180, 198, 206, 407, 414, 432, 440, 1430, 2230, 2296, 2637, 2909, 3345, 3369, 3389, 3428, 3432, 3560, 3574, 3633, 3640, 3734, 4100, 4152], 'had': [174, 408, 2685, 4101, 4637, 4661], 'fewer': [175, 409, 4094, 4102], 'nuclei': [177, 411, 1250, 1449, 3035, 3055, 3366, 3417, 3419, 3445], 'than': [178, 203, 412, 437, 3240, 3274, 3306, 3373, 3429, 3452, 3637, 3667, 3695, 3855, 4077, 4158, 4337, 4372], 'A': [184, 418, 552, 573, 637, 653, 713, 786, 830, 833, 929, 2733, 2863, 2982, 3172, 3341, 3438, 3649, 3740, 4011, 4347, 4381, 4409, 4481, 4508, 4652, 4785, 4842], 'likely': [185, 419, 4283], 'explanation': [186, 420, 4131], 'for': [187, 421, 843, 1221, 1432, 2291, 2380, 2395, 2433, 2441, 2451, 2457, 2509, 2529, 2540, 2554, 2568, 2727, 2796, 2801, 2806, 2812, 2815, 2845, 2911, 2975, 3082, 3262, 3542, 4132, 4204, 4307, 4320, 4799], 'these': [188, 422, 630, 4133, 4550, 4949], 'differences': [189, 423, 3251, 3703, 4106, 4135, 4607], 'was': [190, 201, 424, 435, 2086, 2349, 2401, 2468, 2504, 2520, 2579, 2633, 2664, 2757, 2774, 2827, 2847, 2899, 3040, 3110, 3133, 3145, 3157, 3285, 3301, 3424, 3449, 3629, 4120, 4145, 4630, 4655], 'uncovered;': [191, 425], 'amount': [193, 427, 3986], 'tissues': [200, 434, 2331, 2640, 4154, 4242, 4266, 4296], 'lower': [202, 436, 3302, 3372, 3425, 3630, 3663, 3691, 3856, 4157, 4259], 'tissues.': [208, 442, 3562], 'These': [209, 443, 3250, 4794], 'studies': [210, 444, 1620, 3464, 3766, 4497, 4555, 4795, 4951], 'suggest': [211, 445], 'lamina': [218, 452, 1714, 1787, 1884, 3585, 3974, 4291, 4594, 4809], 'can': [219, 453, 4822], 'influence': [220, 454, 1768, 4596, 4943], 'both': [221, 455, 1622, 3255, 3263, 3288, 4009, 4478, 4503], 'steady-state': [223, 457, 3600, 4139, 4184, 4207, 4598, 4787], 'levels': [224, 458, 1339, 1630, 3676, 3707, 3746, 3846, 3857, 3919, 4140, 4149, 4185, 4208, 4234, 4261, 4599, 4789, 4815], 'severity': [229, 463, 1718, 1828, 1859, 4901, 4945], 'progeria-like': [231, 465], 'Mutations': [468], 'LMNA': [470, 546, 1073, 1333, 3913], 'yield': [471, 3916, 4953], 'host': [473], 'different': [475, 3059, 3083, 3153, 3713, 3726, 4960], 'human': [476], 'diseases,': [477], 'including': [478], 'muscular': [479, 792], 'dystrophy,': [480], 'partial': [481], 'lipodystrophy,': [482], '(HGPS)': [487], '3The': [488], 'abbreviations': [489], 'used': [490, 2752, 3111], 'are:HGPSHutchinson-Gilford': [491], 'syndromeHGHutchinson-Gilford': [493], 'alleleLCOlamin': [494], 'C-only': [495, 902, 1811, 4181], 'alleleRTreverse': [496], 'transcriptionBisTris2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)propane-1,3-diolAAaliphatic': [497], 'amino': [498, 908], 'acid.': [499, 909], '(1Muchir': [500, 732], 'A.': [501, 733, 973, 997, 1013, 1116, 1140, 1156, 1204, 1232, 1276, 1300, 1316, 1362, 1410, 1478, 1651, 1821, 1976, 2062, 2161, 2212, 2252, 2278, 2948, 2963, 3822, 3903, 3940, 4718, 4889, 4933], 'Worman': [502, 558, 734, 4388], 'H.J.': [503, 532, 559, 735, 764, 4389], 'Physiology': [504, 736], '(Bethesda).': [505, 737], '2004;': [506, 738, 2964, 3823, 3904, 4934], '19:': [507, 739], '309-314Crossref': [508, 740], 'PubMed': [509, 526, 541, 569, 602, 624, 671, 695, 741, 758, 773, 823, 891, 947, 990, 1023, 1058, 1133, 1166, 1208, 1293, 1326, 1374, 1414, 1482, 1546, 1614, 1663, 1694, 1753, 1943, 1980, 2029, 2066, 2128, 2165, 2216, 2282, 2318, 2368, 2967, 3503, 3533, 3789, 3826, 3840, 3870, 3907, 3952, 4064, 4399, 4445, 4543, 4722, 4745, 4771, 4893, 4937], 'Scopus': [510, 527, 542, 603, 625, 672, 696, 742, 759, 774, 824, 892, 948, 991, 1024, 1059, 1134, 1167, 1209, 1294, 1327, 1375, 1415, 1483, 1547, 1615, 1664, 1695, 1754, 1944, 1981, 2030, 2067, 2129, 2166, 2217, 2283, 2319, 2369, 2968, 3504, 3534, 3790, 3827, 3841, 3871, 3908, 3953, 4065, 4446, 4544, 4723, 4746, 4772, 4894, 4938], '(51)': [511, 743], 'Google': [512, 529, 544, 570, 605, 627, 674, 698, 744, 761, 776, 826, 894, 950, 993, 1026, 1061, 1136, 1169, 1211, 1296, 1329, 1377, 1417, 1485, 1549, 1617, 1666, 1697, 1756, 1946, 1983, 2032, 2069, 2131, 2168, 2219, 2285, 2321, 2371, 2970, 3506, 3536, 3792, 3829, 3843, 3873, 3910, 3955, 4067, 4400, 4448, 4546, 4725, 4748, 4774, 4896, 4940], 'Scholar,': [513, 530, 606, 675, 745, 762, 951, 994, 1137, 1297, 1667, 1947, 2033, 2132, 3507, 3793, 3830, 3874, 4726, 4749], '2Burke': [514, 746], 'B.': [515, 747, 816, 866, 1047, 1746, 1918, 2004, 2103, 2242, 3478, 4039, 4438, 4536], 'Stewart': [516, 748, 813, 875, 1010, 1048, 1153, 1313, 1927, 2013, 2112, 2943, 3487, 3516, 4048], 'C.L.': [517, 749, 814, 876, 1011, 1049, 1154, 1314, 1352, 1641, 1928, 2014, 2113, 2944, 3488, 3517, 3930, 4049], 'Nat.': [518, 750, 3835], 'Rev.': [519, 751], 'Mol.': [520, 752, 1748, 3784, 3865, 4440, 4538, 4761], 'Cell': [521, 536, 597, 753, 768, 818, 2221], 'Biol.': [522, 561, 598, 754, 819, 3523, 4391], '2002;': [523, 755, 2279], '3:': [524, 756], '575-585Crossref': [525, 757], '(356)': [528, 760], '3Worman': [531, 763], 'Bonne': [533, 765], 'G.': [534, 766, 1360, 1649, 3938], 'Exp.': [535, 767], 'Res.': [537, 615, 662, 769, 938], '2007;': [538, 770, 1205, 1371, 1660, 3949], '313:': [539, 771], '2121-2133Crossref': [540, 772], '(492)': [543, 775], 'Scholar).': [545, 571, 628, 699, 777, 827, 895, 1027, 1062, 1170, 1212, 1330, 1378, 1486, 1550, 1618, 1698, 2220, 2286, 2322, 2971, 3537, 3844, 3911, 3956, 4068, 4547, 4775], 'yields': [547, 1426], 'two': [548, 3411], 'principal': [549], 'proteins,': [550, 4578], '(4Lin': [556, 4386], 'F.': [557, 4387, 4856], 'J.': [560, 596, 613, 660, 691, 817, 858, 885, 936, 961, 1005, 1050, 1104, 1148, 1264, 1308, 1529, 1540, 1597, 1608, 1677, 1688, 1910, 1937, 1996, 2023, 2095, 2122, 2244, 3470, 3497, 3509, 3522, 4031, 4058, 4390, 4860], 'Chem.': [562, 3524, 4392], '1993;': [563, 4393], '268:': [564, 4394], '16321-16326Abstract': [565, 4395], 'Full': [566, 619, 621, 666, 668, 942, 944, 1055, 3528, 3530, 4396, 4766, 4768], 'Text': [567, 620, 622, 667, 669, 943, 945, 1056, 3529, 3531, 4397, 4767, 4769], 'PDF': [568, 623, 670, 946, 1057, 3532, 4398, 4770], 'Prelamin': [572], 'terminates': [574], 'CAAX': [577, 706, 1175], 'motif': [578, 707, 1176], '(i.e.': [579, 1877, 3418, 3589, 4297], 'CSIM),': [580], 'triggers': [582], 'farnesylation': [583], 'methylation': [585], 'carboxyl-terminal': [588, 633, 1174], 'cysteine': [589], '(5Beck': [590], 'L.A.': [591], 'Hosick': [592], 'T.J.': [593], 'Sinensky': [594, 688, 1194, 2311, 2361], 'M.': [595, 808, 862, 953, 981, 1016, 1096, 1124, 1159, 1256, 1284, 1319, 1395, 1463, 1523, 1591, 1671, 1738, 1740, 1914, 1961, 2000, 2047, 2099, 2146, 2197, 2254, 2310, 2312, 2360, 2362, 2938, 3474, 3801, 3811, 3882, 3892, 4035, 4430, 4432, 4528, 4530, 4703, 4732, 4751, 4848, 4852, 4920], '1990;': [599], '110:': [600], '1489-1499Crossref': [601], '(172)': [604], '6Young': [607], 'S.G.': [608, 655, 884, 931, 1366, 1401, 1469, 1537, 1605, 1655, 1685, 1936, 1967, 2022, 2053, 2121, 2152, 2203, 2271, 2956, 3496, 3519, 3944, 4057, 4709, 4759, 4924], 'Fong': [609, 656, 932, 1353, 1402, 1470, 1538, 1606, 1642, 1686, 1968, 2054, 2153, 2204, 3510, 3931, 4710, 4756], 'L.G.': [610, 657, 854, 933, 1354, 1403, 1471, 1539, 1607, 1643, 1687, 1906, 1969, 1992, 2055, 2091, 2154, 2205, 2934, 3466, 3511, 3932, 4027, 4711, 4757], 'Michaelis': [611, 658, 686, 934, 2266], 'S.': [612, 659, 687, 935, 977, 1009, 1120, 1152, 1203, 1280, 1312, 1393, 1409, 1461, 1477, 1533, 1601, 1681, 1959, 1975, 2045, 2061, 2144, 2160, 2195, 2211, 2267, 2277, 2950, 2962, 3809, 3821, 3890, 3902, 4701, 4717, 4736, 4740, 4864, 4872, 4888, 4932], 'Lipid': [614, 661, 937], '2005;': [616, 663, 692, 939, 1411, 1479, 1977, 2063, 2162, 2213, 3786, 3837, 3867, 4719], '46:': [617, 664, 940], '2531-2558Abstract': [618, 665, 941], '(183)': [626, 673, 949], 'Following': [629], 'modifications,': [631], 'portion': [634], '(including': [638], 'farnesylcysteine': [640], 'methyl': [641], 'ester)': [642], 'clipped': [644], 'off': [645], 'ZMPSTE24': [647], 'degraded,': [649], 'releasing': [650], 'mature': [651, 1230, 1847, 1887, 3593, 4302, 4783], '(6Young': [654, 930], '7Corrigan': [676], 'D.P.': [677, 683], 'Kuszczak': [678], 'D.': [679, 804, 1527, 1595, 1675, 4730, 4862], 'Rusinol': [680, 1188], 'A.E.': [681, 1189, 3803, 3884], 'Thewke': [682], 'Hrycyna': [684], 'C.A.': [685], 'M.S.': [689, 1195], 'Biochem.': [690], '387:': [693], '129-138Crossref': [694], '(146)': [697], 'Lamin': [700], 'does': [702], 'not': [703, 710, 3709, 3725, 4121, 4581], 'contain': [704], 'farnesylated.': [711], 'Lamins': [712], 'are': [716, 841, 849, 1343, 1578, 1633, 4267], 'important': [717], 'proteins': [718, 2422, 4962], 'filamentous': [724], 'meshwork': [725], 'lines': [727], 'inner': [729], 'membrane': [731, 2432, 2503, 2519, 2565], 'mouse,': [780], 'complete': [782, 3590, 4299, 4688], 'absence': [783, 3169, 3591, 4300, 4781], 'dystrophy': [793], 'death': [795, 3328], '6': [797], 'weeks': [798, 1496, 1567, 1585, 3226, 3332, 3337], 'age': [800, 1498, 1587], '(8Sullivan': [801], 'T.': [802, 1183, 1185, 2946, 3834], 'Escalante-Alcalde': [803], 'Bhatt': [805], 'H.': [806, 2256, 4866, 4868], 'Anver': [807], 'Bhat': [809], 'N.': [810, 864, 1018, 1161, 1321, 1916, 2002, 2101, 2263, 2940, 3476, 4037], 'Nagashima': [811], 'K.': [812, 2952, 3515, 4926], 'Burke': [815, 1046], '1999;': [820], '147:': [821], '913-919Crossref': [822], '(971)': [825], 'However,': [828, 1213, 4124, 4276], 'appear': [834, 1031, 1489], 'dispensable,': [837], 'as': [838, 2307, 2753, 2792, 3719], 'homozygous': [842], '"lamin': [845], 'C-only"': [846], '(LmnaLCO/LCO)': [848], 'healthy': [850], 'robust': [852], '(9Fong': [853, 1905, 1991, 2090, 3465, 4026], 'Ng': [855, 1907, 1993, 2092, 2935, 3467, 4028], 'J.K.': [856, 1908, 1994, 2093, 2936, 3468, 4029], 'Lammerding': [857, 1909, 1995, 2094, 3469, 4030], 'Vickers': [859, 1911, 1997, 2096, 3471, 4032], 'T.A.': [860, 1912, 1998, 2097, 3472, 4033], 'Meta': [861, 1394, 1462, 1522, 1590, 1670, 1913, 1960, 1999, 2046, 2098, 2145, 2196, 2253, 2937, 3473, 4034, 4702, 4731], 'Cote': [863, 1915, 2001, 2100, 2939, 3475, 4036], 'Gavino': [865, 1917, 2003, 2102, 2241, 3477, 4038], 'Qiao': [867, 1388, 1456, 1524, 1592, 1672, 1919, 1954, 2005, 2040, 2104, 2139, 2190, 3479, 4040, 4696, 4733], 'X.': [868, 1389, 1457, 1525, 1593, 1673, 1920, 1955, 2006, 2041, 2105, 2140, 2191, 3480, 4041, 4697, 4734, 4870], 'Chang': [869, 1921, 2007, 2106, 3481, 4042], 'S.Y.': [870, 1922, 2008, 2107, 3482, 4043], 'Young': [871, 883, 1365, 1400, 1468, 1536, 1604, 1654, 1684, 1923, 1935, 1966, 2009, 2021, 2052, 2108, 2120, 2151, 2202, 2270, 2955, 3483, 3495, 3518, 3943, 4044, 4056, 4708, 4739, 4758, 4923], 'S.R.': [872, 1924, 2010, 2109, 3484, 4045], 'Yang': [873, 1379, 1925, 2011, 2110, 2941, 3485, 4046, 4735, 4752], 'S.H.': [874, 1383, 1451, 1521, 1589, 1669, 1926, 1949, 2012, 2035, 2111, 2134, 2185, 2942, 3486, 4047, 4691, 4753], 'Lee': [877, 1929, 2015, 2114, 3489, 3520, 4050], 'R.T.': [878, 1930, 2016, 2115, 3490, 3521, 4051], 'Bennett': [879, 1931, 2017, 2116, 3491, 4052], 'C.F.': [880, 1932, 2018, 2117, 3492, 4053], 'Bergo': [881, 1384, 1452, 1534, 1602, 1682, 1933, 1950, 2019, 2036, 2118, 2135, 2186, 2953, 3493, 4054, 4692, 4754, 4921], 'M.O.': [882, 1385, 1453, 1535, 1603, 1683, 1934, 1951, 2020, 2037, 2119, 2136, 2187, 2240, 2954, 3494, 4055, 4693, 4755, 4922], 'Clin.': [886, 1541, 1609, 1689, 1938, 2024, 2123, 3498, 4059], 'Investig.': [887, 1542, 1610, 1690, 1939, 2025, 2124, 3499, 4060], '2006;': [888, 1543, 1611, 1691, 1750, 1940, 2026, 2125, 3500, 3525, 4061, 4442, 4540, 4742, 4763, 4890], '116:': [889, 1544, 1612, 1692, 1941, 2027, 2126, 3501, 4062], '743-752Crossref': [890, 1942, 2028, 2127, 3502, 4063], '(195)': [893, 1945, 2031, 2130, 3505, 4066], 'reverse': [904], 'transcription': [905], '2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)propane-1,3-diol': [906], 'aliphatic': [907], 'rare': [915, 1332], 'pediatric': [916], 'progeroid': [917], 'associated': [919, 1344, 1634, 3979], 'production': [922], '10Eriksson': [952], 'Brown': [954, 1097, 1257], 'W.T.': [955, 1098, 1258], 'Gordon': [956, 1099, 1259, 3804, 3885, 4873], 'L.B.': [957, 1100, 1260, 3805, 3886, 4874], 'Glynn': [958, 1101, 1261], 'M.W.': [959, 1102, 1262, 3780, 3861], 'Singer': [960, 1103, 1263], 'Scott': [962, 1105, 1265], 'L.': [963, 1106, 1266, 4728, 4918], 'Erdos': [964, 1107, 1267, 3798, 3879, 4849], 'M.R.': [965, 1108, 1268, 3799, 3880, 4850], 'Robbins': [966, 1109, 1269], 'C.M.': [967, 1110, 1270], 'Moses': [968, 1111, 1271], 'T.Y.': [969, 1112, 1272], 'Berglund': [970, 1113, 1273], 'P.': [971, 1001, 1114, 1144, 1274, 1304, 1397, 1465, 1963, 2049, 2148, 2199, 3832, 4705], 'Dutra': [972, 1115, 1275], 'Pak': [974, 1117, 1277], 'E.': [975, 1118, 1278, 1736, 4428, 4526], 'Durkin': [976, 1119, 1279], 'Csoka': [978, 1121, 1281], 'A.B.': [979, 1122, 1282], 'Boehnke': [980, 1123, 1283], 'Glover': [982, 1125, 1285, 3781, 3862], 'T.W.': [983, 1126, 1286, 3782, 3863], 'Collins': [984, 1127, 1287, 3814, 3895, 4881], 'F.S.': [985, 1128, 1288, 3815, 3896, 4882], 'Nature.': [986, 1129, 1289], '2003;': [987, 1020, 1130, 1163, 1290, 1323], '423:': [988, 1131, 1291], '293-298Crossref': [989, 1132, 1292], '(1633)': [992, 1135, 1295], '11Sandre-Giovannoli': [995, 1138, 1298], 'de': [996, 1139, 1299], 'Bernard': [998, 1141, 1301], 'R.': [999, 1142, 1302, 3813, 3894, 4846, 4876], 'Cau': [1000, 1143, 1303], 'Navarro': [1002, 1145, 1305], 'C.': [1003, 1146, 1306, 1531, 1599, 1679, 1742, 2248, 4350, 4434, 4532, 4738], 'Amiel': [1004, 1147, 1307], 'Boccaccio': [1006, 1149, 1309], 'I.': [1007, 1150, 1310, 4854], 'Lyonnet': [1008, 1151, 1311], 'Munnich': [1012, 1155, 1315], 'Merrer': [1014, 1157, 1317], 'Le': [1015, 1158, 1318], 'Lévy': [1017, 1160, 1320], 'Science.': [1019, 1162, 1322, 4741], '300:': [1021, 1164, 1324], '2055Crossref': [1022, 1165, 1325], '(1112)': [1025, 1168, 1328], 'Patients': [1028], 'HGPS': [1030, 1063, 3778], 'normal': [1032, 1490], 'at': [1033, 1235, 1491, 2391, 2532, 3222, 3324, 4582], 'birth': [1034], 'soon': [1036], 'develop': [1037], 'resembling': [1041], 'premature': [1042], 'aging': [1043], '(12Debusk': [1044], 'F.L.': [1045], 'Pediatr.': [1051], '1972;': [1052], '80:': [1053], '697-724Abstract': [1054], '(288)': [1060], 'almost': [1065], 'always': [1066], 'point': [1070], 'mutation': [1071], 'alters': [1075], 'pre-mRNA': [1076], 'splicing,': [1077], 'resulting': [1078, 1247], 'commonly': [1086], 'progerin,': [1088, 3203, 3625], '50-amino': [1091, 1215], 'acid': [1092, 1216, 2879], 'internal': [1093, 2755], 'deletion': [1094, 1217], '(10Eriksson': [1095, 1255], 'retains': [1172], 'farnesylated': [1179], 'methylated': [1181], '(13Dechat': [1182], 'Shimi': [1184], 'Adam': [1186], 'S.A.': [1187], 'Andres': [1190], 'D.A.': [1191], 'Spielmann': [1192], 'H.P.': [1193], 'Goldman': [1196, 3802, 3883], 'R.D.': [1197, 3795, 3876], 'Proc.': [1198, 1404, 1472, 1970, 2056, 2155, 2206, 2272, 2957, 3816, 3897, 4712, 4883, 4927], 'Natl.': [1199, 1405, 1473, 1971, 2057, 2156, 2207, 2273, 2958, 3817, 3898, 4713, 4884, 4928], 'Acad.': [1200, 1406, 1474, 1972, 2058, 2157, 2208, 2274, 2959, 3818, 3899, 4714, 4885, 4929], 'Sci.': [1201, 1407, 1475, 1973, 2059, 2158, 2209, 2275, 2960, 3819, 3900, 4715, 4886, 4930], 'U.': [1202, 1408, 1476, 1974, 2060, 2159, 2210, 2276, 2961, 3820, 3901, 4716, 4887, 4931], '104:': [1206], '4955-4960Crossref': [1207], '(214)': [1210], 'eliminates': [1218], 'site': [1220], 'ZMPSTE24-mediated': [1223], 'cleavage': [1224], 'reaction,': [1225], 'abrogating': [1226], 'further': [1227, 4489], 'processing': [1228], 'accumulates': [1234], 'rim': [1238, 1727], 'impairs': [1240], 'Importantly,': [1331], 'mutations': [1334, 3914], 'leading': [1335], 'particularly': [1337, 1346, 3917, 3924], 'high': [1338, 3918], 'severe': [1347, 1637, 3353, 3545, 3568, 3851, 3925], 'forms': [1348, 3926], '(14Moulson': [1351, 1640, 3929], 'Gardner': [1355, 1644, 3933], 'J.M.': [1356, 1645, 3934], 'Farber': [1357, 1646, 3935], 'E.A.': [1358, 1647, 3936], 'Go': [1359, 1648, 3937], 'Passariello': [1361, 1650, 3939], 'Grange': [1363, 1652, 3941], 'D.K.': [1364, 1653, 3797, 3878, 3942], 'Miner': [1367, 1656, 3945], 'J.H.': [1368, 1657, 3946], 'Hum.': [1369, 1658, 1747, 3783, 3864, 3947, 4439, 4537], 'Mutat.': [1370, 1659, 3948], '28:': [1372, 1661, 3950], '882-889Crossref': [1373, 1662, 3951], '(89)': [1376, 1665, 3954], 'et': [1380, 4425], 'al.': [1381, 4426], '(15Yang': [1382, 1450, 2184, 4690], 'Toth': [1386, 1454, 1952, 2038, 2137, 2188, 4694], 'J.I.': [1387, 1455, 1953, 2039, 2138, 2189, 4695], 'Hu': [1390, 1458, 1956, 2042, 2141, 2192, 4698], 'Y.': [1391, 1459, 1957, 2043, 2142, 2193, 2258, 3807, 3888, 4699], 'Sandoval': [1392, 1460, 1958, 2044, 2143, 2194, 4700], 'Bendale': [1396, 1464, 1962, 2048, 2147, 2198, 4704], 'Gelb': [1398, 1466, 1964, 2050, 2149, 2200, 4706], 'M.H.': [1399, 1467, 1965, 2051, 2150, 2201, 4707], '102:': [1412, 1480, 1978, 2064, 2163, 2214, 4720], '10291-10296Crossref': [1413, 1481, 1979, 2065, 2164, 2215, 4721], '(237)': [1416, 1484, 1982, 2068, 2167, 2218, 4724], 'Scholar)': [1418, 2169, 2372, 4449, 4897, 4941], 'allele,': [1423, 1812, 3183, 4182], 'LmnaHG,': [1424], 'Mouse': [1429, 3067], 'express': [1437], 'large': [1438], 'amounts': [1439, 4220], 'have': [1443, 1626, 3767, 4810], 'an': [1444, 2175, 2381, 2610, 2667, 3009, 3615, 3962], 'increased': [1445], 'frequency': [1446, 3363, 3414], 'birth,': [1492], '6-8': [1495], 'they': [1499], 'manifest': [1500], 'hallmarks': [1501], '(slow': [1504], 'growth,': [1505], 'loss,': [1507], 'loss': [1508], 'adipose': [1510], 'tissue,': [1511], 'osteolytic': [1513], 'lesions': [1514, 1552], 'ribs': [1516, 1555], 'other': [1518, 1732, 4576], 'bones)': [1519], '(16Yang': [1520, 1588], 'Frost': [1526, 1594, 1674, 4729], 'Bauch': [1528, 1596, 1676], 'Coffinier': [1530, 1598, 1678, 4737], 'Majumdar': [1532, 1600, 1680, 2949], '2115-2121Crossref': [1545, 1613, 1693], '(231)': [1548, 1616, 1696], 'Osteolytic': [1551], 'result': [1556, 3922], 'numerous': [1558], 'fractures.': [1560, 4096], 'Most': [1561], 'die': [1564, 1582], '∼28': [1566], 'age.': [1569], 'Mice': [1570], 'double': [1573], 'dose': [1574], '(LmnaHG/HG)': [1577], 'severely': [1579], 'affected': [1580], '3': [1584, 2770, 2797], 'Genetic': [1619], 'humans': [1623], 'shown': [1627], 'higher': [1629], 'more': [1636, 3850, 4282, 4327, 4827], '16Yang': [1668], 'Thus': [1699], 'far,': [1700], 'however,': [1701, 3229, 4423], 'has': [1704, 4404], 'investigated': [1705], 'whether': [1706, 3167, 3966, 4407, 4837, 4911], 'alterations': [1707, 4309], 'composition': [1710, 1766, 3581, 3970, 4167, 4287, 4591], 'could': [1715, 3708, 4325, 4595, 4952], 'affect': [1716, 3175, 4899], 'disease.': [1720, 4903], 'directly': [1729], 'interacts': [1730], 'lamins': [1734, 4408, 4464, 4522, 4564, 4841], '(17Delbarre': [1735, 4427, 4525], 'Tramier': [1737, 4429, 4527], 'Coppey-Moisan': [1739, 4431, 4529], 'Gaillard': [1741, 4433, 4531], 'Courvalin': [1743, 4435, 4533], 'J.C.': [1744, 4436, 4534], 'Buendia': [1745, 4437, 4535], 'Genet.': [1749, 3785, 3866, 4441, 4539], '15:': [1751, 4443, 4541], '1113-1122Crossref': [1752, 4444, 4542], '(102)': [1755, 4447, 4545], 'Scholar);': [1757], 'hence,': [1758], 'seemed': [1760], 'possible': [1761], 'allele.': [1775, 1797, 2841, 4196], 'hypothesized': [1780, 3360], 'modulate': [1789, 3976], 'took': [1803], 'advantage': [1804], 'existence': [1807], 'LmnaLCO,': [1813], 'our': [1823], 'studies,': [1824], 'Our': [1854], 'data': [1855], 'indicate': [1856], 'diminished': [1869], 'setting': [1872, 1880], 'devoid': [1885], 'Genetically': [1890], 'Modified': [1891], 'Mice—Male': [1892], 'chimeric': [1893], 'mice,': [1894, 3358, 3686], 'generated': [1895], 'injecting': [1897], 'C57BL/6': [1898], 'blastocysts': [1899], 'embryonic': [1902, 2229, 2234, 3388], 'stem': [1903], 'cells': [1904, 2990, 3057, 3455, 3588, 3666, 3670, 4228, 4240, 4264, 4294], '15Yang': [1948, 2034, 2133], 'Scholar),': [1984, 2070, 4401], 'were': [1985, 2083, 2231, 2297, 2305, 2332, 2386, 2411, 2423, 2439, 2485, 2538, 2607, 2617, 2676, 2711, 2735, 2766, 2791, 2856, 2888, 2914, 2973, 2991, 3006, 3061, 3076, 3087, 3104, 3128, 3237, 3252, 3322, 3690, 3724, 3757, 4075, 4112, 4155, 4613], 'LmnaLCO/+': [1988, 3399, 3447], 'female': [1989], 'Lmna+/+,': [2072, 3071], '(n': [2074, 2079, 3392, 3396, 3400, 3405, 3634, 3641, 3729, 3735], '=': [2075, 2080, 3393, 3397, 3401, 3406, 3635, 3642, 3672, 3730, 3736], '16),': [2076], '26)': [2081], 'offspring': [2082], 'analyzed.': [2084], 'Genotyping': [2085], 'performed': [2087, 2775, 3554], 'PCR': [2089, 2854, 2866], 'Western': [2172, 2226, 2292, 2406, 2434, 2483, 3555, 3611], 'blotting': [2173], 'antibody': [2176, 2437, 2536, 2587, 2594, 2979, 2997], 'against': [2177, 2980], 'A/C': [2179, 2443, 2542], '(sc-6215,': [2180, 2446], 'Santa': [2181, 2447, 2463, 2546, 2549, 2559, 2985], 'Cruz': [2182, 2448, 2464, 2547, 2560, 2986], 'Biotechnology)': [2183], 'Culture,': [2222], 'Protein': [2223], 'Extraction,': [2224, 2627], 'Blotting—Primary': [2227], 'mouse': [2228, 2237, 2330, 2639, 3122, 3559], 'prepared': [2232, 2306], 'from': [2233, 2596, 2635, 3390, 3410], 'day': [2235], '13.5': [2236], 'embryos': [2238], '(18Bergo': [2239], 'Ross': [2243], 'Schmidt': [2245], 'W.K.': [2246], 'Hong': [2247], 'Kendall': [2249], 'L.V.': [2250], 'Mohr': [2251], 'Genant': [2255], 'Jiang': [2257], 'Wisner': [2259], 'E.R.': [2260], 'Bruggen': [2261], 'van': [2262], 'Carano': [2264], 'R.A.D.': [2265], 'Griffey': [2268], 'S.M.': [2269], '99:': [2280], '13049-13054Crossref': [2281], '(352)': [2284], 'generate': [2288], 'extracts': [2290, 2304, 2410], 'blots,': [2293], 'early': [2294], 'passage': [2295, 2908, 2912], 'washed': [2298], 'phosphate-buffered': [2300, 2507, 2572], 'saline,': [2301], 'urea-soluble': [2303], 'described': [2308], '(19Dalton': [2309, 2359], 'Methods': [2313, 2363], 'Enzymol.': [2314, 2364], '1995;': [2315, 2365], '250:': [2316, 2366], '134-148Crossref': [2317, 2367], '(17)': [2320, 2370], 'For': [2323, 3099, 4829], 'tissue': [2324, 2378], 'extraction,': [2325], '150': [2326], 'mg': [2327], 'fresh': [2329], 'frozen': [2333], 'liquid': [2335], 'nitrogen': [2336], 'ground': [2338, 2374], 'into': [2339, 4200], 'powder': [2341, 2348], 'mortar': [2344], 'pestle.': [2346], 'The': [2347, 2398, 2408, 2436, 2518, 2535, 2659, 2708, 2729, 2772, 2787, 2821, 2842, 3031, 3147, 3413, 3441, 3652, 3702, 4002, 4069, 4105, 4214, 4605, 4633], 'resuspended': [2351], '0.5': [2353], 'ml': [2354], 'urea': [2356], 'solubilization': [2357], 'buffer': [2358], 'glass': [2377], 'grinder': [2379], 'additional': [2382], '2': [2383], 'min.': [2384, 2397], 'Samples': [2385], 'sonicated': [2388], 'centrifuged': [2390], '14,000': [2392], '×': [2393], 'g': [2394], '10': [2396, 2569, 2725, 2742, 2850], 'supernatant': [2399], 'fluid': [2400], 'collected': [2402], 'analyzed': [2404, 2487, 2620], 'blotting.': [2407, 2435], 'protein': [2409, 4166, 4237, 4331], 'electrophoresed': [2412], 'on': [2413, 2609, 2916, 3008, 3558, 4813], '4-12%': [2414], 'gradient': [2415], 'polyacrylamide': [2416], 'BisTris': [2417], 'gels': [2418, 2887], '(Invitrogen);': [2419], 'size-fractionated': [2421], 'electrophoretically': [2425], 'transferred': [2426], 'sheet': [2429], 'nitrocellulose': [2431, 2502], 'dilutions': [2438, 2537], '1:400': [2440, 2539], 'anti-lamin': [2442, 2541], 'goat': [2444, 2453, 2556], 'IgG': [2445, 2461, 2544, 2557, 2586, 2593], 'Biotechnology),': [2449], '1:1000': [2450, 2553], 'anti-actin': [2452, 2555], 'IgG,': [2454], '1:6000': [2456], 'horseradish': [2458], 'peroxidase-labeled': [2459], 'anti-goat': [2460, 2585], '(sc-2020,': [2462], 'Biotechnology).': [2465, 2561, 2987], 'Antibody': [2466], 'binding': [2467], 'detected': [2469], 'ECL': [2472], 'Plus': [2473], 'chemiluminescence': [2474], 'system': [2475, 2493, 3619], '(GE': [2476], 'Healthcare)': [2477], 'exposure': [2479], 'x-ray': [2481], 'film.': [2482], 'blots': [2484, 3612], 'also': [2486], 'Odyssey': [2490, 2515, 2600, 2611, 2892, 3616], 'infrared': [2491, 2612, 2893, 3617], 'imaging': [2492, 2613, 2894, 3618], '(LI-COR': [2494], 'Biosciences,': [2495], 'Lincoln,': [2496], 'NE).': [2497], 'those': [2499, 3241, 4078, 4159], 'experiments,': [2500], 'rinsed': [2505], 'saline': [2508, 2573], '5': [2510], 'min': [2511, 2570, 2977], 'before': [2512], 'incubation': [2513], 'blocking': [2516, 2527, 2601], 'buffer.': [2517, 2602], 'incubated': [2521, 2580, 2712, 2974], 'primary': [2524, 2636, 3387], 'antibodies': [2525], 'solution': [2528], '1': [2530, 2680], 'h': [2531], 'room': [2533], 'temperature.': [2534], 'rabbit': [2543], '(sc-20681,': [2545], 'Biotechnology,': [2548], 'Cruz,': [2550], 'CA)': [2551, 2648, 2720, 2781], '(sc-1616,': [2558], 'After': [2562, 2603, 2988], 'washing': [2563], 'three': [2566, 3043], 'times': [2567], 'containing': [2574, 2875], '0.1%': [2575], 'Tween': [2576], '20,': [2577], '1:5000': [2582, 2589], 'IRDye': [2583, 2590], '700': [2584], '800': [2591], 'anti-rabbit': [2592, 2994], '(both': [2595], 'Rockland': [2597], 'Immunochemicals)': [2598], 'washing,': [2604, 2989], 'membranes': [2606], 'scanned': [2608], 'system,': [2614, 2895], 'images': [2616], 'acquired': [2618, 2889], 'according': [2621, 2901], "manufacturer's": [2624, 2904], 'instructions.': [2625, 2905], 'RNA': [2626, 2632, 2663, 2683], 'cDNA': [2628, 2709], 'Synthesis,': [2629], 'RT-PCR—Total': [2631], 'extracted': [2634], 'RNeasy': [2643], 'mini': [2644], 'kit': [2645], '(Qiagen,': [2646], 'Valencia,': [2647], 'quantified': [2650, 2900, 3613], 'NanoDrop': [2653], 'Spectrophotometer': [2654], '(NanoDrop': [2655], 'Technologies,': [2656], 'Wilmington,': [2657], 'DE).': [2658], 'verified': [2665], 'ethidium': [2668], 'bromide-stained': [2669], '1.5%': [2670], 'agarose': [2671, 2873], 'gel.': [2672], 'Reverse': [2673], 'transcriptase': [2674], 'reactions': [2675], 'carried': [2677], 'out': [2678], 'μg': [2681], 'been': [2686, 4662], 'treated': [2687, 4663], 'DNase': [2689], '(DNA-Free,': [2690], 'Ambion,': [2691, 2717], 'Foster': [2692, 2718, 2779], 'City,': [2693, 2719, 2780], 'CA),': [2694], 'Superscript': [2695], 'III': [2696], '(Invitrogen),': [2697], 'mixture': [2700, 4344], 'oligo(dT)': [2702], '(Invitrogen)': [2703, 2881], 'random': [2705], 'primers': [2706, 2738, 2760, 2765], '(Invitrogen).': [2707], 'samples': [2710], 'RNase': [2714], '(RNase': [2715], 'H,': [2716], 'diluted': [2723], 'ng/μl': [2726], 'PCRs.': [2728], 'cDNAs': [2734], 'amplified': [2736, 2758], 'corresponding': [2739], 'exon': [2741, 2744, 2825], '12': [2745], 'sequences': [2746], '(forward,': [2747], '5′-CTGACCATGGTTGAGGACAA-3′;': [2748], 'reverse,': [2749], '5′-TTAGGAGAGCAGGCCTGAAG-3′).': [2750], 'Arbp,': [2751], 'control,': [2756], '5′-ACTGAGATTCGGGATATGCTGT-3′': [2761], '5′-TCCTAGACCAGTGTTCTGAGCTG-3′.': [2763], 'All': [2764], 'designed': [2767], 'Primer': [2769], 'software.': [2771], 'RT-PCR': [2773, 2822, 2843, 4216], 'AmpliTaq': [2777], '(ABI': [2778], '50': [2783], 'ng': [2784], 'cDNA.': [2786], 'thermal': [2788], 'cycling': [2789], 'conditions': [2790], 'follows:': [2793], '95': [2794, 2799], '°C': [2795, 2800, 2805, 2811], 'min,': [2798], '15': [2802, 2813, 4373], 's,': [2803, 2808, 2814], '60': [2804, 2877, 2976], '30': [2807], '72': [2810], 'total': [2817], '26': [2819], 'cycles.': [2820], 'fragment': [2823, 2844], 'spanning': [2824], '10-12': [2826], '456': [2828], 'bp': [2829, 2837], 'wild-type': [2832, 4003, 4175, 4461, 4479], 'Lmna': [2833, 4176], '306': [2836], 'Arbp': [2846, 2853], '108': [2848], 'bp.': [2849], 'μl': [2851, 2860], 'products': [2855, 2867], 'mixed': [2857], '25': [2859], 'loaded': [2869], 'onto': [2870], '1.3%': [2872], 'gel': [2874], 'SYTO': [2876], 'nucleic': [2878], 'stain': [2880], '(1:16,000': [2882], 'dilution).': [2883], 'Images': [2884, 3005], 'band': [2897], 'intensity': [2898], 'Immunofluorescence': [2906], 'Microscopy—Early': [2907], '(matched': [2910], 'number)': [2913], 'grown': [2915], 'coverslips,': [2917], 'fixed': [2918, 3985], '3%': [2920], 'paraformaldehyde,': [2921], 'permeabilized': [2922], '0.2%': [2924], 'Triton': [2925], 'X-100,': [2926], 'blocked': [2928], 'bovine': [2930], 'serum': [2931], 'albumin': [2932], '(20Fong': [2933], 'Sullivan': [2945], 'Burghardt': [2947], 'Reue': [2951, 3514, 4925], '101:': [2965, 3824, 3905, 4935], '18111-18116Crossref': [2966], '(164)': [2969], 'Cells': [2972], '(1:200,': [2983], 'sc-20680,': [2984], 'stained': [2992], 'Cy3-conjugated': [2995], 'secondary': [2996, 4811], '(Jackson': [2998], 'ImmunoResearch)': [2999], '4′,6-diamidino-2-phenylindole': [3001], '(to': [3002], 'visualize': [3003], 'DNA).': [3004], 'obtained': [3007], 'Axiovert': [3010], '200': [3011], 'MOT': [3012], 'microscope': [3013], '(Carl': [3014], 'Zeiss,': [3015], 'Thornwood,': [3016], 'NY)': [3017], '63×/1.25': [3020], 'oil': [3021], 'immersion': [3022], 'objective': [3023], 'processed': [3025], 'Axo-Vision': [3027], '4.2': [3028], 'software': [3029], '(Zeiss).': [3030], 'number': [3032, 3141, 3148, 3297, 3442], '(exhibiting': [3036], 'blebs': [3037], 'or': [3038, 3422, 4417], 'folds)': [3039], 'scored': [3041, 3382], 'independent': [3044], 'observers': [3045], 'blinded': [3046], 'genotype.': [3048], 'Differences': [3049], 'percentages': [3052], 'between': [3056, 4107, 4608], 'genotypes': [3060], 'assessed': [3062], 'χ2': [3065], 'test.': [3066, 3098, 3164], 'Phenotypes—Body': [3068], 'weights': [3069], 'LmnaHG/+,': [3072], 'monitored': [3077], 'weekly.': [3078], 'Body': [3079], 'groups': [3084, 3154], 'repeated': [3090], 'measures': [3091], 'analysis': [3092], 'variance': [3094], 'log-rank': [3097, 3108], 'analysis,': [3101], 'Kaplan-Meier': [3102, 3265], 'analyses': [3103, 3557], 'performed,': [3105], 'test': [3109, 3378], 'compare': [3113], 'curves.': [3116], 'At': [3117], 'time': [3119, 3326], 'each': [3121, 4369], 'died,': [3123], 'heart': [3125, 3681, 3749], 'lungs': [3127], 'removed,': [3129], 'thorax': [3132], 'photographed': [3134], 'digital': [3137], 'camera,': [3138], 'counted.': [3146], 'two-tailed': [3161], "Student's": [3162], 't': [3163], 'determine': [3166, 4836, 4910], 'would': [3174, 3575, 4136, 4832, 4898, 4906, 4942], 'mice.': [3193, 4001, 4162, 4213], 'As': [3194], 'expected,': [3195], 'synthesized': [3199], 'whereas': [3204, 4015], 'produced': [3207], '(Fig.': [3214, 3248, 3280, 3313, 3436, 3647, 3699, 3738, 3760], '1).': [3215], 'appeared': [3220], 'similar': [3221, 4653], 'weaning.': [3223], 'By': [3224], '10-15': [3225], 'age,': [3228], 'significantly': [3238, 4086, 4156, 4676], 'better': [3239], '0.0001)': [3247, 3279, 3312, 3435, 3646], '2A).': [3249], 'apparent': [3253], 'males': [3256, 3289], 'females': [3258, 3291], '0.0001': [3261], 'groups).': [3264], 'revealed': [3268, 3620, 4218], 'lived': [3272], 'longer': [3273], '2B).': [3281], 'Again,': [3282], 'difference': [3284], 'significant': [3286], 'Also,': [3295, 3743, 3912], '2C),': [3314], 'despite': [3315], 'fact': [3317], 'older': [3323], '(27': [3329], '±': [3330, 3335], '1.65': [3331], 'versus': [3333], '23': [3334], '0.70': [3336], 'mice).': [3340], 'hallmark': [3342], 'nuclei.': [3349, 4104], 'Given': [3350], 'less': [3352, 3544, 3567], 'fibroblasts.': [3376], 'possibility,': [3380], 'shape': [3384, 3853], 'abnormalities': [3385, 3854], '5),': [3394, 3402], '3),': [3398], 'Lmna+/+': [3404, 3454], '2)': [3407], '(generated': [3409], 'litters).': [3412], 'folds': [3421], 'blebs)': [3423], '3,': [3437], 'B).': [3440, 3651], 'somewhat': [3450], 'greater': [3451], '0.001),': [3458], 'consistent': [3459], 'results': [3461], 'earlier': [3463], '21Lammerding': [3508], 'Ji': [3512], 'J.Y.': [3513], '281:': [3526], '25768-25780Abstract': [3527], '(457)': [3535], 'understand': [3539], 'mechanism': [3541, 4119], 'fibroblasts,': [3552], 'blot': [3556], 'reasoned': [3564, 4126], 'make': [3576], 'sense': [3577], 'if': [3578], 'altered': [3580, 4138, 4286], 'A)': [3595, 4304], 'resulted': [3596], 'level': [3601], 'Indeed,': [3604, 4143], 'proved': [3606], 'case.': [3610], 'expression': [3623, 3653, 3706], 'relative': [3626, 3657, 3687], 'actin,': [3628, 3659, 3689], '8)': [3636, 3643, 3731, 3737], '4,': [3648, 3700], 'tended': [3660], '0.057).': [3673], 'Similarly,': [3674, 4904], 'skin': [3683, 3751], 'C-F).': [3701], 'ascribed': [3711, 4245], 'mRNA': [3714, 3717, 3745], 'levels.': [3715, 4251, 4312], 'levels,': [3718], 'judged': [3720], 'quantitative': [3722, 4215], 'RT-PCR,': [3723], '5,': [3739, 3761], 'C).': [3742, 3764], 'virtually': [3758], 'identical': [3759], 'B': [3762], 'Previous': [3765], 'established,': [3768], 'quite': [3769], 'unequivocally,': [3770], 'culprit': [3775], 'molecule': [3776], '(22Glynn': [3779, 3860], '14:': [3787, 3868], '2959-2969Crossref': [3788, 3869], '(196)': [3791, 3872], '23Goldman': [3794, 3875], 'Shumaker': [3796, 3877], 'Eriksson': [3800, 3881, 4847], 'Gruenbaum': [3806, 3887], 'Khuon': [3808, 3889], 'Mendez': [3810, 3891], 'Varga': [3812, 3893], '8963-8968Crossref': [3825, 3906], '(832)': [3828, 3909], '24Scaffidi': [3831], 'Misteli': [3833], 'Med.': [3836, 4762], '11:': [3838], '440-445Crossref': [3839], '(463)': [3842], 'Higher': [3845], 'studied': [3961], 'entirely': [3963], 'new': [3964, 4801], 'issue,': [3965, 3992], 'milder': [4076], 'mice;': [4081], 'curves,': [4090, 4642], 'survival,': [4092], 'reproducible': [4113], 'highly': [4115, 4616], 'significant,': [4116, 4617], 'immediately': [4122], 'obvious.': [4123], 'most': [4129], 'parsimonious': [4130], 'phenotypic': [4134, 4606], 'case;': [4147], 'Thus,': [4163], 'changing': [4164], 'replacing': [4173], 'lowered': [4183], 'gained': [4198], 'insight': [4199], 'probable': [4202], 'mechanisms': [4203], 'experiments': [4217], 'equal': [4219], 'transcripts': [4223], 'tissues,': [4230], 'so': [4231, 4513], 'cannot': [4243], 'transcript': [4250], 'It': [4252], 'formal': [4255], 'possibility': [4256], 'because': [4268], 'translation': [4271], 'transcript.': [4275], 'believe': [4278], 'responsible': [4306, 4319], 'suspect': [4314], 'cellular': [4317], 'machinery': [4318], 'turnover': [4322], 'efficient': [4328], 'when': [4329, 4338], 'surrounded': [4333, 4341], 'Part': [4351], 'may': [4354], 'relate': [4355], 'abilities': [4358], 'interact': [4367, 4488, 4574], 'other.': [4370], 'More': [4371], 'years': [4374], 'after': [4375], 'molecular': [4377], 'understanding': [4378], 'biogenesis': [4385], 'conclusively': [4405], 'determined': [4406], 'heterodimers': [4413], 'exist': [4418], 'solely': [4419], 'homodimers.': [4421], 'Recently,': [4422], 'Delbarre': [4424], 'examined': [4450], 'polymerization': [4452], 'green': [4454, 4557], 'fluorescent': [4455, 4459, 4558, 4562], 'protein-tagged': [4456, 4460, 4559, 4563], 'red': [4458, 4561], 'mutated': [4463], 'envelope': [4468], 'measuring': [4470], 'fluorescence': [4471, 4551], 'resonance': [4472, 4552], 'energy': [4473, 4553], 'transfer.': [4474], 'They': [4475], 'concluded': [4476], 'B1': [4484, 4505, 4914], 'homopolymers': [4486], 'contrast,': [4495], 'their': [4496], 'suggested': [4498], 'co-assembles': [4501], 'heteropolymer,': [4512], 'usual': [4516], 'segregation': [4517], 'A-type': [4519], 'B-type': [4521], 'lost': [4524], 'Assuming': [4548], 'transfer': [4554], 'accurately': [4565], 'portray': [4566], 'ability': [4568], 'native': [4570], 'untagged': [4571], 'all': [4583], 'farfetched': [4584], 'imagine': [4586], 'cell.': [4604], 'unequivocal': [4614], 'emphasize': [4620], 'reduction': [4623], 'only': [4631], 'partial.': [4632], 'still': [4636, 4643, 4649], 'markedly': [4638], 'abnormal': [4639], 'developed': [4644], 'bone': [4646], 'fractures,': [4647], 'died': [4650], 'prematurely.': [4651], 'situation': [4654], 'observed': [4656], 'farnesyltransferase': [4666, 4674], 'inhibitor.': [4667], 'Treatment': [4668], 'inhibitor': [4675], 'treatment': [4682], 'fell': [4683], 'far': [4684], 'short': [4685], 'cure': [4689], '25Fong': [4727], '311:': [4743], '1621-1623Crossref': [4744], '(257)': [4747], '26Meta': [4750], 'Trends': [4760], '12:': [4764], '480-487Abstract': [4765], '(34)': [4773], 'This': [4776, 4820], 'study': [4777], 'shows': [4778], 'affects': [4786], 'progerin-induced': [4791], 'lay': [4796], 'foundation': [4798], 'concept': [4802, 4821], 'effects': [4812], 'now': [4823], 'explored': [4825], 'detail.': [4828], 'example,': [4830], 'intriguing': [4834], 'transgenic': [4838], 'overexpression': [4839], '(27Varga': [4845], 'Olive': [4851], 'Harten': [4853], 'Kolodgie': [4855], 'Capell': [4857], 'B.C.': [4858], 'Cheng': [4859], 'Faddah': [4861], 'Perkins': [4863], 'Avallone': [4865], 'San': [4867], 'Qu': [4869], 'Ganesh': [4871], 'Virmani': [4875], 'Wight': [4877], 'T.N.': [4878], 'Nabel': [4879], 'E.G.': [4880], '103:': [4891], '3250-3255Crossref': [4892], '(221)': [4895], 'interesting': [4908], 'knock-out': [4915], '(28Vergnes': [4917], 'Peterfy': [4919], '10428-10433Crossref': [4936], '(306)': [4939], 'Ultimately,': [4948], 'genetic': [4950], 'clues': [4954], 'regarding': [4955], 'functional': [4957], 'relevance': [4958], 'pathogenesis': [4965]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2067540329', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2025-01-06T04:36:47.560018', 'created_date': '2016-06-24'}