Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2045299216', 'doi': 'https://doi.org/10.1016/j.juro.2011.02.1466', 'title': '613 IMMEDIATE, COMPARED TO DEFERRED, COMBINED ANDROGEN BLOCKADE PROLONGS TIME TO CASTRATE-RESISTANT LNCAP PROSTATE CANCER PROGRESSION IN VIVO', 'display_name': '613 IMMEDIATE, COMPARED TO DEFERRED, COMBINED ANDROGEN BLOCKADE PROLONGS TIME TO CASTRATE-RESISTANT LNCAP PROSTATE CANCER PROGRESSION IN VIVO', 'publication_year': 2011, 'publication_date': '2011-04-01', 'ids': {'openalex': 'https://openalex.org/W2045299216', 'doi': 'https://doi.org/10.1016/j.juro.2011.02.1466', 'mag': '2045299216'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.juro.2011.02.1466', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S30525748', 'display_name': 'The Journal of Urology', 'issn_l': '0022-5347', 'issn': ['0022-5347', '1527-3792'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5034814953', 'display_name': 'Hidetoshi Kuruma', 'orcid': None}, 'institutions': [], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Hidetoshi Kuruma', 'raw_affiliation_strings': ['Vancouver, Canada'], 'affiliations': [{'raw_affiliation_string': 'Vancouver, Canada', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080606297', 'display_name': 'Kilian M. Gust', 'orcid': None}, 'institutions': [], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Kilian Gust', 'raw_affiliation_strings': ['Vancouver, Canada'], 'affiliations': [{'raw_affiliation_string': 'Vancouver, Canada', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045476512', 'display_name': 'Hiroaki Matsumoto', 'orcid': 'https://orcid.org/0000-0003-0568-1258'}, 'institutions': [], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Hiroaki Matsumoto', 'raw_affiliation_strings': ['Vancouver, Canada'], 'affiliations': [{'raw_affiliation_string': 'Vancouver, Canada', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081653545', 'display_name': 'Amina Zoubeidi', 'orcid': 'https://orcid.org/0000-0002-0498-142X'}, 'institutions': [], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Amina Zoubeidi', 'raw_affiliation_strings': ['Vancouver, Canada'], 'affiliations': [{'raw_affiliation_string': 'Vancouver, Canada', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032759627', 'display_name': 'C. Thomas', 'orcid': None}, 'institutions': [], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Chirstian Thomas', 'raw_affiliation_strings': ['Vancouver, Canada'], 'affiliations': [{'raw_affiliation_string': 'Vancouver, Canada', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011209723', 'display_name': 'François Lamoureux', 'orcid': 'https://orcid.org/0000-0002-2738-0758'}, 'institutions': [], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Francois Lamoureux', 'raw_affiliation_strings': ['Vancouver, Canada'], 'affiliations': [{'raw_affiliation_string': 'Vancouver, Canada', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5062125605', 'display_name': 'Martin Gleave', 'orcid': 'https://orcid.org/0000-0003-4235-0167'}, 'institutions': [], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Martin Gleave', 'raw_affiliation_strings': ['Vancouver, Canada'], 'affiliations': [{'raw_affiliation_string': 'Vancouver, Canada', 'institution_ids': []}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 66}, 'biblio': {'volume': '185', 'issue': '4S', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10543', 'display_name': 'Advancements in Prostate Cancer Research', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10543', 'display_name': 'Advancements in Prostate Cancer Research', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10124', 'display_name': 'Prostate Cancer Research and Treatment', 'score': 0.9627, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11146', 'display_name': 'Long-Term Effects of Testosterone on Health', 'score': 0.9453, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/bicalutamide', 'display_name': 'Bicalutamide', 'score': 0.7390314}, {'id': 'https://openalex.org/keywords/prostate-cancer', 'display_name': 'Prostate Cancer', 'score': 0.552607}, {'id': 'https://openalex.org/keywords/metastatic-prostate-cancer', 'display_name': 'Metastatic Prostate Cancer', 'score': 0.546148}], 'concepts': [{'id': 'https://openalex.org/C2779723316', 'wikidata': 'https://www.wikidata.org/wiki/Q6459234', 'display_name': 'LNCaP', 'level': 4, 'score': 0.85121673}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.8464147}, {'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.7976295}, {'id': 'https://openalex.org/C2780962315', 'wikidata': 'https://www.wikidata.org/wiki/Q1988832', 'display_name': 'Bicalutamide', 'level': 5, 'score': 0.7390314}, {'id': 'https://openalex.org/C2779256933', 'wikidata': 'https://www.wikidata.org/wiki/Q58929', 'display_name': 'Castration', 'level': 3, 'score': 0.700508}, {'id': 'https://openalex.org/C2777911890', 'wikidata': 'https://www.wikidata.org/wiki/Q62614', 'display_name': 'Androgen', 'level': 3, 'score': 0.6719208}, {'id': 'https://openalex.org/C2778468042', 'wikidata': 'https://www.wikidata.org/wiki/Q273976', 'display_name': 'Blockade', 'level': 3, 'score': 0.6293429}, {'id': 'https://openalex.org/C2777899217', 'wikidata': 'https://www.wikidata.org/wiki/Q4759439', 'display_name': 'Androgen deprivation therapy', 'level': 4, 'score': 0.45455515}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.42756456}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.37059593}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.35012686}, {'id': 'https://openalex.org/C61367390', 'wikidata': 'https://www.wikidata.org/wiki/Q416601', 'display_name': 'Androgen receptor', 'level': 4, 'score': 0.20824856}, {'id': 'https://openalex.org/C71315377', 'wikidata': 'https://www.wikidata.org/wiki/Q11364', 'display_name': 'Hormone', 'level': 2, 'score': 0.092130184}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.juro.2011.02.1466', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S30525748', 'display_name': 'The Journal of Urology', 'issn_l': '0022-5347', 'issn': ['0022-5347', '1527-3792'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4220880667', 'https://openalex.org/W2911495509', 'https://openalex.org/W2609867172', 'https://openalex.org/W2350150322', 'https://openalex.org/W2165911768', 'https://openalex.org/W2090356696', 'https://openalex.org/W2084616126', 'https://openalex.org/W2065658150', 'https://openalex.org/W2063882679', 'https://openalex.org/W2031154402'], 'abstract_inverted_index': {'You': [0], 'have': [1], 'accessJournal': [2], 'of': [3, 170, 181, 186, 251, 267, 419], 'UrologyProstate': [4], 'Cancer:': [5], 'Basic': [6], 'Research1': [7], 'Apr': [8], '2011613': [9], 'IMMEDIATE,': [10], 'COMPARED': [11], 'TO': [12, 19], 'DEFERRED,': [13], 'COMBINED': [14], 'ANDROGEN': [15], 'BLOCKADE': [16], 'PROLONGS': [17], 'TIME': [18], 'CASTRATE-RESISTANT': [20], 'LNCAP': [21], 'PROSTATE': [22], 'CANCER': [23], 'PROGRESSION': [24], 'IN': [25], 'VIVO': [26], 'Hidetoshi': [27, 42, 478], 'Kuruma,': [28], 'Kilian': [29, 53, 487], 'Gust,': [30], 'Hiroaki': [31, 64, 496], 'Matsumoto,': [32], 'Amina': [33, 75, 505], 'Zoubeidi,': [34], 'Chirstian': [35, 86, 514], 'Thomas,': [36], 'Francois': [37, 97, 523], 'Lamoureux,': [38], 'and': [39, 108, 216, 231, 269, 313, 330, 340, 382, 400, 410, 434, 456, 474], 'Martin': [40, 109, 532], 'Gleave': [41, 111, 533], 'KurumaHidetoshi': [43], 'Kuruma': [44, 479], 'Vancouver,': [45, 56, 67, 78, 89, 100, 112, 480, 489, 498, 507, 516, 525, 534], 'Canada': [46, 57, 68, 79, 90, 101, 113, 481, 490, 499, 508, 517, 526, 535], 'More': [47, 58, 69, 80, 91, 102, 114, 482, 491, 500, 509, 518, 527, 536], 'articles': [48, 59, 70, 81, 92, 103, 115, 483, 492, 501, 510, 519, 528, 537], 'by': [49, 60, 71, 82, 93, 104, 116, 309, 397, 451, 469, 484, 493, 502, 511, 520, 529, 538], 'this': [50, 61, 72, 83, 94, 105, 117, 176, 264, 485, 494, 503, 512, 521, 530, 539], 'author': [51, 62, 73, 84, 95, 106, 118, 486, 495, 504, 513, 522, 531, 540], ',': [52, 63, 74, 85, 96, 107], 'GustKilian': [54], 'Gust': [55, 488], 'MatsumotoHiroaki': [65], 'Matsumoto': [66, 497], 'ZoubeidiAmina': [76], 'Zoubeidi': [77, 506], 'ThomasChirstian': [87], 'Thomas': [88, 515], 'LamoureuxFrancois': [98], 'Lamoureux': [99, 524], 'GleaveMartin': [110], 'View': [119], 'All': [120, 542], 'Author': [121], 'Informationhttps://doi.org/10.1016/j.juro.2011.02.1466AboutPDF': [122], 'ToolsAdd': [123], 'to': [124, 148, 192, 242, 275, 288, 297, 315, 386, 424, 438], 'favoritesDownload': [125], 'CitationsTrack': [126], 'CitationsPermissionsReprints': [127], 'ShareFacebookTwitterLinked': [128], 'InEmail': [129], 'INTRODUCTION': [130], 'AND': [131], 'OBJECTIVES': [132], 'Androgen': [133, 198], 'deprivation': [134], 'therapy': [135], 'is': [136, 156, 164], 'standard': [137], 'for': [138, 299, 334, 405], 'advanced': [139], 'prostate': [140, 201], 'cancer': [141, 202], '(PCa).': [142], 'Combined': [143], 'androgen': [144, 159], 'blockade': [145, 160], '(CAB)': [146], 'refers': [147], 'surgical': [149], 'or': [150, 247], 'medical': [151], 'castration': [152, 189, 243, 276], 'plus': [153], 'an': [154, 256], 'anti-androgen': [155, 171], 'considered': [157], 'maximum': [158], 'therapy.': [161], 'However,': [162], 'there': [163], 'no': [165], 'consensus': [166], 'about': [167], 'optimal': [168], 'timing': [169], 'induction': [172], 'after': [173, 188, 240, 294, 311, 373, 392], 'castration.': [174], 'In': [175, 281, 301], 'study,': [177], 'we': [178], 'compared': [179, 296, 426], 'effects': [180], 'immediate': [182, 237, 283, 336, 348, 365, 406], 'vs.': [183], 'delayed': [184], 'administration': [185], 'bicalutamide': [187, 252], 'on': [190], 'time': [191, 418, 423], 'castrate-resistant': [193], 'LNCaP': [194, 203, 432], 'tumor': [195, 376, 394], 'growth.': [196], 'METHODS': [197], 'dependent': [199], 'human': [200], 'cells': [204], 'were': [205, 219, 229, 272, 327, 351], 'inoculated': [206], 'into': [207, 233], 'male': [208], 'athymic': [209], 'nude': [210], 'mice': [211, 228, 262], 'subcutaneously.': [212], 'Serum': [213], 'PSA': [214, 224, 268, 286, 306, 325, 344], 'level': [215], 'tumour': [217, 270], 'volumes': [218], 'followed': [220], 'weekly.': [221], 'When': [222], 'serum': [223], 'values': [225], 'reached': [226], '50ng/ml,': [227], 'castrated': [230], 'divided': [232], '3': [234], 'groups': [235, 384], 'including': [236], 'CAB,': [238, 295, 337, 374, 407, 416], 'CAB': [239, 284, 304, 339, 349, 356, 366, 381, 409, 428], 'progression': [241], 'resistance': [244], '(deferred': [245], 'CAB),': [246], 'vehicle-only': [248, 383], 'dosing.': [249], '50mg/kg': [250], 'was': [253], 'used': [254], 'as': [255, 442], 'anti-': [257], 'androgen.': [258], 'RESULTS': [259], 'Forty': [260], 'one': [261], 'entered': [263], 'study.': [265], 'Averages': [266], 'volume': [271, 362, 377, 395], 'similar': [273], 'prior': [274], 'in': [277, 346, 363, 378, 429], 'all': [278], 'three': [279], 'groups.': [280], 'the': [282, 302, 335, 347, 364, 379, 430, 439], 'group,': [285, 305], 'declined': [287, 307], '−91.2%': [289], 'from': [290, 332, 402], 'baseline': [291, 333], '2': [292, 371], 'weeks': [293, 323, 372, 391], '−64.6%': [298], 'vehicle.': [300], 'deferred': [303, 338, 355, 380, 408, 427], '−50.4%': [308], '1W': [310], 'castration,': [312, 393, 421], 'returned': [314], 'pre-castration': [316], 'levels': [317, 326, 345], 'at': [318, 358, 370, 417], '4': [319], 'weeks.': [320], 'By': [321, 389], '12': [322, 359, 390], 'post-castration,': [324], '−29.0%,': [328], '+197.0%': [329], '+118.1%': [331], 'vehicle': [341, 411], 'groups,': [342, 412], 'respectively.': [343, 413], 'group': [350, 367], 'significantly': [352], 'lower': [353], 'than': [354], '(p=0.04': [357], 'weeks).': [360], 'Tumor': [361], 'decreased': [368], '−10.2%': [369], 'while': [375], 'continued': [385], 'increase': [387], 'post-castration.': [388], 'increased': [396], '+98.2%,': [398], '+307.4%': [399], '+546.9%': [401], 'base': [403], 'line': [404], 'CONCLUSIONS': [414], 'Immediate': [415], 'first-line': [420], 'prolonged': [422], 'recurrence': [425], 'androgen-sensitive': [431], 'models,': [433], 'has': [435], 'ongoing': [436], 'implications': [437], 'clinical': [440], 'disease': [441], 'more': [443], 'potent': [444], 'anti-androgens': [445], 'are': [446], 'under': [447], 'development.': [448], '©': [449], '2011': [450, 468], 'American': [452, 470], 'Urological': [453, 471], 'Association': [454, 472], 'Education': [455, 473], 'Research,': [457, 475], 'Inc.FiguresReferencesRelatedDetails': [458], 'Volume': [459], '185Issue': [460], '4SApril': [461], '2011Page:': [462], 'e247': [463], 'Advertisement': [464, 543, 544], 'Copyright': [465], '&': [466], 'Permissions©': [467], 'Inc.MetricsAuthor': [476], 'Information': [477], 'Expand': [541], 'PDF': [545], 'DownloadLoading': [546], '...': [547]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2045299216', 'counts_by_year': [], 'updated_date': '2024-08-22T09:02:25.492543', 'created_date': '2016-06-24'}