Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2084616126', 'doi': 'https://doi.org/10.3892/ijo.2015.2860', 'title': 'CH5137291, an androgen receptor nuclear translocation-inhibiting compound, inhibits the growth of castration-resistant prostate cancer cells', 'display_name': 'CH5137291, an androgen receptor nuclear translocation-inhibiting compound, inhibits the growth of castration-resistant prostate cancer cells', 'publication_year': 2015, 'publication_date': '2015-01-30', 'ids': {'openalex': 'https://openalex.org/W2084616126', 'doi': 'https://doi.org/10.3892/ijo.2015.2860', 'mag': '2084616126', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25634071'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3892/ijo.2015.2860', 'pdf_url': 'https://www.spandidos-publications.com/10.3892/ijo.2015.2860/download', 'source': {'id': 'https://openalex.org/S169822654', 'display_name': 'International Journal of Oncology', 'issn_l': '1019-6439', 'issn': ['1019-6439'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320412', 'host_organization_name': 'Spandidos Publishing', 'host_organization_lineage': ['https://openalex.org/P4310320412'], 'host_organization_lineage_names': ['Spandidos Publishing'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.spandidos-publications.com/10.3892/ijo.2015.2860/download', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5045610622', 'display_name': 'Nobuyuki Ishikura', 'orcid': None}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'NOBUYUKI ISHIKURA', 'raw_affiliation_strings': ['Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa 247-8530, Japan'], 'affiliations': [{'raw_affiliation_string': 'Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa 247-8530, Japan', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086192831', 'display_name': 'Hiromitsu Kawata', 'orcid': None}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'HIROMITSU KAWATA', 'raw_affiliation_strings': ['Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa 247-8530, Japan'], 'affiliations': [{'raw_affiliation_string': 'Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa 247-8530, Japan', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026274537', 'display_name': 'Ayako Nishimoto', 'orcid': 'https://orcid.org/0000-0002-8654-7423'}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'AYAKO NISHIMOTO', 'raw_affiliation_strings': ['Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa 247-8530, Japan'], 'affiliations': [{'raw_affiliation_string': 'Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa 247-8530, Japan', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079301007', 'display_name': 'Ryo Nakamura', 'orcid': 'https://orcid.org/0000-0003-2531-4885'}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'RYO NAKAMURA', 'raw_affiliation_strings': ['Chugai Research Institute for Medical Science, Inc., Kamakura, Kanagawa 247-8530, Japan'], 'affiliations': [{'raw_affiliation_string': 'Chugai Research Institute for Medical Science, Inc., Kamakura, Kanagawa 247-8530, Japan', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071970421', 'display_name': 'Toshiaki Tsunenari', 'orcid': 'https://orcid.org/0009-0009-0055-6766'}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'TOSHIAKI TSUNENARI', 'raw_affiliation_strings': ['Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa 247-8530, Japan'], 'affiliations': [{'raw_affiliation_string': 'Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa 247-8530, Japan', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087572619', 'display_name': 'Miho Watanabe', 'orcid': 'https://orcid.org/0009-0002-0764-2287'}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'MIHO WATANABE', 'raw_affiliation_strings': ['Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa 247-8530, Japan'], 'affiliations': [{'raw_affiliation_string': 'Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa 247-8530, Japan', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100875865', 'display_name': 'Kazutaka Tachibana', 'orcid': None}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'KAZUTAKA TACHIBANA', 'raw_affiliation_strings': ['Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa 247-8530, Japan'], 'affiliations': [{'raw_affiliation_string': 'Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa 247-8530, Japan', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041964655', 'display_name': 'Takuya Shiraishi', 'orcid': 'https://orcid.org/0000-0003-3543-1874'}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'TAKUYA SHIRAISHI', 'raw_affiliation_strings': ['Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa 247-8530, Japan'], 'affiliations': [{'raw_affiliation_string': 'Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa 247-8530, Japan', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102899168', 'display_name': 'Hitoshi Yoshino', 'orcid': 'https://orcid.org/0000-0002-8498-0530'}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'HITOSHI YOSHINO', 'raw_affiliation_strings': ['Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa 247-8530, Japan'], 'affiliations': [{'raw_affiliation_string': 'Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa 247-8530, Japan', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004333804', 'display_name': 'Akie Honma', 'orcid': None}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'AKIE HONMA', 'raw_affiliation_strings': ['Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa 247-8530, Japan'], 'affiliations': [{'raw_affiliation_string': 'Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa 247-8530, Japan', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076807906', 'display_name': 'Takashi Emura', 'orcid': None}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'TAKASHI EMURA', 'raw_affiliation_strings': ['Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa 247-8530, Japan'], 'affiliations': [{'raw_affiliation_string': 'Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa 247-8530, Japan', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000011261', 'display_name': 'Masateru Ohta', 'orcid': 'https://orcid.org/0000-0002-6580-7185'}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'MASATERU OHTA', 'raw_affiliation_strings': ['Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa 247-8530, Japan'], 'affiliations': [{'raw_affiliation_string': 'Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa 247-8530, Japan', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108410969', 'display_name': 'Toshito Nakagawa', 'orcid': None}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'TOSHITO NAKAGAWA', 'raw_affiliation_strings': ['Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa 247-8530, Japan'], 'affiliations': [{'raw_affiliation_string': 'Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa 247-8530, Japan', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037145590', 'display_name': 'Takao Houjo', 'orcid': None}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'TAKAO HOUJO', 'raw_affiliation_strings': ['Chugai Research Institute for Medical Science, Inc., Kamakura, Kanagawa 247-8530, Japan'], 'affiliations': [{'raw_affiliation_string': 'Chugai Research Institute for Medical Science, Inc., Kamakura, Kanagawa 247-8530, Japan', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018745405', 'display_name': 'Eva Corey', 'orcid': 'https://orcid.org/0000-0002-9244-3807'}, 'institutions': [{'id': 'https://openalex.org/I201448701', 'display_name': 'University of Washington', 'ror': 'https://ror.org/00cvxb145', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I201448701']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'EVA COREY', 'raw_affiliation_strings': ['Department of Urology, University of Washington, Seattle WA 98195, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology, University of Washington, Seattle WA 98195, USA', 'institution_ids': ['https://openalex.org/I201448701']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108554327', 'display_name': 'Robert L. Vessella', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I201448701', 'display_name': 'University of Washington', 'ror': 'https://ror.org/00cvxb145', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I201448701']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'ROBERT L. VESSELLA', 'raw_affiliation_strings': ['Department of Urology, University of Washington, Seattle WA 98195, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology, University of Washington, Seattle WA 98195, USA', 'institution_ids': ['https://openalex.org/I201448701']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108748469', 'display_name': 'Yuko Aoki', 'orcid': None}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'YUKO AOKI', 'raw_affiliation_strings': ['Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa 247-8530, Japan'], 'affiliations': [{'raw_affiliation_string': 'Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa 247-8530, Japan', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5071794274', 'display_name': 'Haruhiko Sato', 'orcid': 'https://orcid.org/0000-0002-1744-2388'}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'HARUHIKO SATO', 'raw_affiliation_strings': ['Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa 247-8530, Japan'], 'affiliations': [{'raw_affiliation_string': 'Research Division, Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa 247-8530, Japan', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.212, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 8, 'citation_normalized_percentile': {'value': 0.801088, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 84, 'max': 85}, 'biblio': {'volume': '46', 'issue': '4', 'first_page': '1560', 'last_page': '1572'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11146', 'display_name': 'Hormonal and reproductive studies', 'score': 0.9837, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11395', 'display_name': 'Radiopharmaceutical Chemistry and Applications', 'score': 0.9803, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/bicalutamide', 'display_name': 'Bicalutamide', 'score': 0.952592}, {'id': 'https://openalex.org/keywords/growth-inhibition', 'display_name': 'Growth inhibition', 'score': 0.42079136}, {'id': 'https://openalex.org/keywords/mcf-7', 'display_name': 'MCF-7', 'score': 0.4196533}], 'concepts': [{'id': 'https://openalex.org/C2779723316', 'wikidata': 'https://www.wikidata.org/wiki/Q6459234', 'display_name': 'LNCaP', 'level': 4, 'score': 0.98133177}, {'id': 'https://openalex.org/C2780962315', 'wikidata': 'https://www.wikidata.org/wiki/Q1988832', 'display_name': 'Bicalutamide', 'level': 5, 'score': 0.952592}, {'id': 'https://openalex.org/C61367390', 'wikidata': 'https://www.wikidata.org/wiki/Q416601', 'display_name': 'Androgen receptor', 'level': 4, 'score': 0.82253605}, {'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.71215963}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.62112176}, {'id': 'https://openalex.org/C2777911890', 'wikidata': 'https://www.wikidata.org/wiki/Q62614', 'display_name': 'Androgen', 'level': 3, 'score': 0.5789453}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.54874456}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.47572187}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.44823262}, {'id': 'https://openalex.org/C62112901', 'wikidata': 'https://www.wikidata.org/wiki/Q189159', 'display_name': 'Cell growth', 'level': 2, 'score': 0.43531066}, {'id': 'https://openalex.org/C2779707156', 'wikidata': 'https://www.wikidata.org/wiki/Q5611758', 'display_name': 'Growth inhibition', 'level': 3, 'score': 0.42079136}, {'id': 'https://openalex.org/C109541995', 'wikidata': 'https://www.wikidata.org/wiki/Q1881253', 'display_name': 'MCF-7', 'level': 5, 'score': 0.4196533}, {'id': 'https://openalex.org/C96232424', 'wikidata': 'https://www.wikidata.org/wiki/Q4118072', 'display_name': 'Cancer cell', 'level': 3, 'score': 0.34390765}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.25534874}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.19643813}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.15246871}, {'id': 'https://openalex.org/C71315377', 'wikidata': 'https://www.wikidata.org/wiki/Q11364', 'display_name': 'Hormone', 'level': 2, 'score': 0.11037737}, {'id': 'https://openalex.org/C2994423619', 'wikidata': 'https://www.wikidata.org/wiki/Q9103', 'display_name': 'Human breast', 'level': 4, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D017430', 'descriptor_name': 'Prostate-Specific Antigen', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D064129', 'descriptor_name': 'Prostatic Neoplasms, Castration-Resistant', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D011944', 'descriptor_name': 'Receptors, Androgen', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D011944', 'descriptor_name': 'Receptors, Androgen', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D013449', 'descriptor_name': 'Sulfonamides', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D013867', 'descriptor_name': 'Thiohydantoins', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D000813', 'descriptor_name': 'Anilides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000813', 'descriptor_name': 'Anilides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002467', 'descriptor_name': 'Cell Nucleus', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002467', 'descriptor_name': 'Cell Nucleus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D062105', 'descriptor_name': 'Molecular Docking Simulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009570', 'descriptor_name': 'Nitriles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D009570', 'descriptor_name': 'Nitriles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017430', 'descriptor_name': 'Prostate-Specific Antigen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017430', 'descriptor_name': 'Prostate-Specific Antigen', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D064129', 'descriptor_name': 'Prostatic Neoplasms, Castration-Resistant', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D064129', 'descriptor_name': 'Prostatic Neoplasms, Castration-Resistant', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D064129', 'descriptor_name': 'Prostatic Neoplasms, Castration-Resistant', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D021381', 'descriptor_name': 'Protein Transport', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D021381', 'descriptor_name': 'Protein Transport', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011944', 'descriptor_name': 'Receptors, Androgen', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011944', 'descriptor_name': 'Receptors, Androgen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013449', 'descriptor_name': 'Sulfonamides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D013449', 'descriptor_name': 'Sulfonamides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013449', 'descriptor_name': 'Sulfonamides', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D013867', 'descriptor_name': 'Thiohydantoins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D013867', 'descriptor_name': 'Thiohydantoins', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D013867', 'descriptor_name': 'Thiohydantoins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014105', 'descriptor_name': 'Tosyl Compounds', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014105', 'descriptor_name': 'Tosyl Compounds', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D023041', 'descriptor_name': 'Xenograft Model Antitumor Assays', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3892/ijo.2015.2860', 'pdf_url': 'https://www.spandidos-publications.com/10.3892/ijo.2015.2860/download', 'source': {'id': 'https://openalex.org/S169822654', 'display_name': 'International Journal of Oncology', 'issn_l': '1019-6439', 'issn': ['1019-6439'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320412', 'host_organization_name': 'Spandidos Publishing', 'host_organization_lineage': ['https://openalex.org/P4310320412'], 'host_organization_lineage_names': ['Spandidos Publishing'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25634071', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3892/ijo.2015.2860', 'pdf_url': 'https://www.spandidos-publications.com/10.3892/ijo.2015.2860/download', 'source': {'id': 'https://openalex.org/S169822654', 'display_name': 'International Journal of Oncology', 'issn_l': '1019-6439', 'issn': ['1019-6439'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320412', 'host_organization_name': 'Spandidos Publishing', 'host_organization_lineage': ['https://openalex.org/P4310320412'], 'host_organization_lineage_names': ['Spandidos Publishing'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.79, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 48, 'referenced_works': ['https://openalex.org/W1486610297', 'https://openalex.org/W1948931726', 'https://openalex.org/W1974154130', 'https://openalex.org/W1974810481', 'https://openalex.org/W1985143543', 'https://openalex.org/W1995087335', 'https://openalex.org/W2003955264', 'https://openalex.org/W2004278446', 'https://openalex.org/W2006138763', 'https://openalex.org/W2008697485', 'https://openalex.org/W2014303129', 'https://openalex.org/W2018928665', 'https://openalex.org/W2018964568', 'https://openalex.org/W2022635468', 'https://openalex.org/W2034731532', 'https://openalex.org/W2037250487', 'https://openalex.org/W2041665462', 'https://openalex.org/W2061271065', 'https://openalex.org/W2063882679', 'https://openalex.org/W2075760937', 'https://openalex.org/W2079688281', 'https://openalex.org/W2090356696', 'https://openalex.org/W2092629109', 'https://openalex.org/W2101904881', 'https://openalex.org/W2101995865', 'https://openalex.org/W2112501269', 'https://openalex.org/W2113031878', 'https://openalex.org/W2114617539', 'https://openalex.org/W2117325725', 'https://openalex.org/W2118055719', 'https://openalex.org/W2118906905', 'https://openalex.org/W2119504728', 'https://openalex.org/W2119701025', 'https://openalex.org/W2131422252', 'https://openalex.org/W2133667885', 'https://openalex.org/W2134825260', 'https://openalex.org/W2138067290', 'https://openalex.org/W2139726760', 'https://openalex.org/W2143618467', 'https://openalex.org/W2152631280', 'https://openalex.org/W2161550802', 'https://openalex.org/W2163839067', 'https://openalex.org/W2166918329', 'https://openalex.org/W2168011358', 'https://openalex.org/W2168108459', 'https://openalex.org/W2171041379', 'https://openalex.org/W2615718476', 'https://openalex.org/W4243767567'], 'related_works': ['https://openalex.org/W4220880667', 'https://openalex.org/W2911495509', 'https://openalex.org/W2350150322', 'https://openalex.org/W2165911768', 'https://openalex.org/W2095873383', 'https://openalex.org/W2090356696', 'https://openalex.org/W2084616126', 'https://openalex.org/W2076586151', 'https://openalex.org/W2065658150', 'https://openalex.org/W2063882679'], 'abstract_inverted_index': {'Resistance': [0], 'of': [1, 24, 53, 61, 98, 120, 123, 134, 179, 202, 214, 221, 243, 252, 257, 272, 296], 'prostate': [2, 83, 298], 'cancer': [3, 84], 'to': [4, 58, 228, 287], 'castration': [5, 62], 'is': [6, 285], 'currently': [7], 'an': [8, 35], 'unavoidable': [9], 'problem.': [10], 'The': [11], 'major': [12, 294], 'mechanisms': [13, 60], 'underlying': [14], 'such': [15], 'resistance': [16, 63], 'are': [17], 'androgen': [18], 'receptor': [19], '(AR)': [20], 'overexpression,': [21], 'androgen-independent': [22, 73], 'activation': [23], 'AR,': [25], 'and': [26, 45, 49, 70, 77, 105, 137, 157, 165, 182, 192, 198, 246, 263, 276], 'AR': [27, 36, 41, 68, 74, 258], 'mutation.': [28], 'To': [29], 'address': [30], 'this': [31], 'problem,': [32], 'we': [33], 'developed': [34], 'pure': [37, 114], 'antagonist,': [38], 'CH5137291,': [39], 'with': [40, 51, 210, 239], 'nuclear': [42, 96, 132], 'translocation-inhibiting': [43], 'activity,': [44, 260], 'compared': [46], 'its': [47], 'activity': [48, 119], 'characteristics': [50], 'that': [52, 92, 224, 235], 'bicalutamide.': [54], 'Cell': [55], 'lines': [56], 'corresponding': [57], 'the': [59, 95, 117, 131, 144, 176, 211, 219, 240, 250, 269], 'were': [64, 79], 'used:': [65], 'LNCaP-BC2': [66, 164, 197], 'having': [67, 72], 'overexpression': [69], 'LNCaP-CS10': [71, 166, 199], 'activation.': [75], 'VCaP': [76, 156], 'LNCaP': [78, 158, 191, 222], 'used': [80], 'as': [81, 101, 103, 112, 160, 162], 'hormone-sensitive': [82], 'cells.': [85], 'In': [86, 108, 125, 170, 266], 'vitro': [87], 'functional': [88], 'assay': [89], 'clearly': [90], 'showed': [91, 138, 186], 'CH5137291': [93, 147, 173, 217, 236, 273, 284], 'inhibited': [94, 148, 175, 218, 249], 'translocation': [97, 133], 'wild-type': [99, 262], 'ARs': [100], 'well': [102, 161, 209], 'W741C-': [104], 'T877A-mutant': [106], 'ARs.': [107, 124, 265], 'addition,': [109], 'it': [110], 'acted': [111], 'a': [113, 139, 187, 255, 289], 'antagonist': [115], 'on': [116, 143], 'transcriptional': [118, 145], 'these': [121, 135], 'types': [122, 295], 'contrast,': [126], 'bicalutamide': [127, 154, 185, 229], 'did': [128], 'not': [129], 'inhibit': [130], 'ARs,': [136], 'partial/full': [140], 'agonistic': [141], 'effect': [142, 189, 195, 213], 'activity.': [146], 'cell': [149], 'growth': [150, 178, 220], 'more': [151], 'strongly': [152, 174, 248], 'than': [153], 'in': [155, 163, 168, 190, 196, 206, 261], 'cells': [159, 167], 'vitro.': [169], 'xenograft': [171], 'models,': [172], 'tumor': [177], 'LNCaP,': [180], 'LNCaP-BC2,': [181], 'LNCaP-CS10,': [183], 'whereas': [184], 'weaker': [188], 'almost': [193], 'no': [194], 'xenografts.': [200], 'Levels': [201], 'prostate-specific': [203], 'antigen': [204], '(PSA)': [205], 'plasma': [207], 'correlated': [208], 'antitumor': [212], 'both': [215], 'agents.': [216], 'tumors': [223], 'had': [225], 'become': [226], 'resistant': [227], 'treatment.': [230], 'A': [231], 'docking': [232], 'model': [233], 'suggested': [234], 'intensively': [237], 'collided': [238], 'M895': [241], 'residue': [242], 'helix': [244, 253], '12,': [245, 254], 'therefore': [247], 'folding': [251], 'cause': [256], 'agonist': [259], 'W741C-mutant': [264], 'cynomolgus': [267], 'monkeys,': [268], 'serum': [270], 'concentration': [271], 'increased': [274], 'dose-dependently': [275], 'PSA': [277], 'level': [278], 'decreased': [279], '80%': [280], 'at': [281], '100': [282], 'mg/kg.': [283], 'expected': [286], 'offer': [288], 'novel': [290], 'therapeutic': [291], 'approach': [292], 'against': [293], 'castration-resistant': [297], 'cancers.': [299]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2084616126', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 2}], 'updated_date': '2024-12-13T21:41:33.988309', 'created_date': '2016-06-24'}