Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2042658426', 'doi': 'https://doi.org/10.1039/c2ob27186a', 'title': 'Synthesis and evaluation of novel ellipticines as potential anti-cancer agents', 'display_name': 'Synthesis and evaluation of novel ellipticines as potential anti-cancer agents', 'publication_year': 2013, 'publication_date': '2013-01-01', 'ids': {'openalex': 'https://openalex.org/W2042658426', 'doi': 'https://doi.org/10.1039/c2ob27186a', 'mag': '2042658426', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/23314103'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1039/c2ob27186a', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S179810352', 'display_name': 'Organic & Biomolecular Chemistry', 'issn_l': '1477-0520', 'issn': ['1477-0520', '1477-0539'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320556', 'host_organization_name': 'Royal Society of Chemistry', 'host_organization_lineage': ['https://openalex.org/P4310320556'], 'host_organization_lineage_names': ['Royal Society of Chemistry'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5056872570', 'display_name': 'Fiona M. Deane', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I27577105', 'display_name': 'University College Cork', 'ror': 'https://ror.org/03265fv13', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I27577105']}], 'countries': ['IE'], 'is_corresponding': False, 'raw_author_name': 'Fiona M. Deane', 'raw_affiliation_strings': ['Department of Chemistry and Analytical & Biological Chemistry Research Facility, University College Cork, Cork, Ireland'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry and Analytical & Biological Chemistry Research Facility, University College Cork, Cork, Ireland', 'institution_ids': ['https://openalex.org/I27577105']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015218602', 'display_name': 'E. O’Sullivan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I27577105', 'display_name': 'University College Cork', 'ror': 'https://ror.org/03265fv13', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I27577105']}], 'countries': ['IE'], 'is_corresponding': False, 'raw_author_name': "Elaine C. O'Sullivan", 'raw_affiliation_strings': ['Department of Chemistry and Analytical & Biological Chemistry Research Facility, University College Cork, Cork, Ireland'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry and Analytical & Biological Chemistry Research Facility, University College Cork, Cork, Ireland', 'institution_ids': ['https://openalex.org/I27577105']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024349179', 'display_name': 'Anita R. Maguire', 'orcid': 'https://orcid.org/0000-0001-8306-1893'}, 'institutions': [{'id': 'https://openalex.org/I27577105', 'display_name': 'University College Cork', 'ror': 'https://ror.org/03265fv13', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I27577105']}], 'countries': ['IE'], 'is_corresponding': False, 'raw_author_name': 'Anita R. Maguire', 'raw_affiliation_strings': ['Department of Chemistry and School of Pharmacy, Analytical and Biological Chemistry Research Facility, University College Cork , Cork, Ireland.'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry and School of Pharmacy, Analytical and Biological Chemistry Research Facility, University College Cork , Cork, Ireland.', 'institution_ids': ['https://openalex.org/I27577105']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066777834', 'display_name': 'Jayne Gilbert', 'orcid': 'https://orcid.org/0000-0001-5034-386X'}, 'institutions': [{'id': 'https://openalex.org/I1316052090', 'display_name': 'Mater Health Services', 'ror': 'https://ror.org/03mjtdk61', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1316052090']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Jayne Gilbert', 'raw_affiliation_strings': ['Department of Medical Oncology, Calvary Mater Newcastle Hospital, Edith Street,Waratah,Australia'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Oncology, Calvary Mater Newcastle Hospital, Edith Street,Waratah,Australia', 'institution_ids': ['https://openalex.org/I1316052090']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078927759', 'display_name': 'Jennette A. Sakoff', 'orcid': 'https://orcid.org/0000-0002-7009-5792'}, 'institutions': [{'id': 'https://openalex.org/I1316052090', 'display_name': 'Mater Health Services', 'ror': 'https://ror.org/03mjtdk61', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1316052090']}, {'id': 'https://openalex.org/I78757542', 'display_name': 'University of Newcastle Australia', 'ror': 'https://ror.org/00eae9z71', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I78757542']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Jennette A. Sakoff', 'raw_affiliation_strings': ['Centre for Chemical Biology, Chemistry, School of Environmental and Life Science, The University of Newcastle, University Drive,Callaghan NSW 2308,Australia', 'Department of Medical Oncology, Calvary Mater Newcastle Hospital, Edith Street,Waratah,Australia'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Oncology, Calvary Mater Newcastle Hospital, Edith Street,Waratah,Australia', 'institution_ids': ['https://openalex.org/I1316052090']}, {'raw_affiliation_string': 'Centre for Chemical Biology, Chemistry, School of Environmental and Life Science, The University of Newcastle, University Drive,Callaghan NSW 2308,Australia', 'institution_ids': ['https://openalex.org/I78757542']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026633618', 'display_name': 'Adam McCluskey', 'orcid': 'https://orcid.org/0000-0001-7125-863X'}, 'institutions': [{'id': 'https://openalex.org/I78757542', 'display_name': 'University of Newcastle Australia', 'ror': 'https://ror.org/00eae9z71', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I78757542']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Adam McCluskey', 'raw_affiliation_strings': ['Centre for Chemical Biology, Chemistry, School of Environmental and Life Science, The University of Newcastle, University Drive, Callaghan NSW 2308, Australia'], 'affiliations': [{'raw_affiliation_string': 'Centre for Chemical Biology, Chemistry, School of Environmental and Life Science, The University of Newcastle, University Drive, Callaghan NSW 2308, Australia', 'institution_ids': ['https://openalex.org/I78757542']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5026317418', 'display_name': 'Florence O. McCarthy', 'orcid': 'https://orcid.org/0000-0001-5837-1638'}, 'institutions': [{'id': 'https://openalex.org/I27577105', 'display_name': 'University College Cork', 'ror': 'https://ror.org/03265fv13', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I27577105']}], 'countries': ['IE'], 'is_corresponding': False, 'raw_author_name': 'Florence O. McCarthy', 'raw_affiliation_strings': ['Department of Chemistry and Analytical & Biological Chemistry Research Facility, University College Cork, Cork, Ireland'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry and Analytical & Biological Chemistry Research Facility, University College Cork, Cork, Ireland', 'institution_ids': ['https://openalex.org/I27577105']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.063, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 58, 'citation_normalized_percentile': {'value': 0.999985, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '11', 'issue': '8', 'first_page': '1334', 'last_page': '1334'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11845', 'display_name': 'Cancer therapeutics and mechanisms', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11845', 'display_name': 'Cancer therapeutics and mechanisms', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12172', 'display_name': 'Neutropenia and Cancer Infections', 'score': 0.9781, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12334', 'display_name': 'Lung Cancer Research Studies', 'score': 0.9749, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/camptothecin', 'display_name': 'Camptothecin', 'score': 0.6198026}, {'id': 'https://openalex.org/keywords/growth-inhibition', 'display_name': 'Growth inhibition', 'score': 0.58950454}], 'concepts': [{'id': 'https://openalex.org/C147897179', 'wikidata': 'https://www.wikidata.org/wiki/Q407828', 'display_name': 'Topoisomerase', 'level': 3, 'score': 0.9572741}, {'id': 'https://openalex.org/C2778119113', 'wikidata': 'https://www.wikidata.org/wiki/Q418817', 'display_name': 'Etoposide', 'level': 3, 'score': 0.8944447}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.845543}, {'id': 'https://openalex.org/C2779682216', 'wikidata': 'https://www.wikidata.org/wiki/Q419964', 'display_name': 'Camptothecin', 'level': 2, 'score': 0.6198026}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.59589773}, {'id': 'https://openalex.org/C2779707156', 'wikidata': 'https://www.wikidata.org/wiki/Q5611758', 'display_name': 'Growth inhibition', 'level': 3, 'score': 0.58950454}, {'id': 'https://openalex.org/C164361826', 'wikidata': 'https://www.wikidata.org/wiki/Q177604', 'display_name': 'Alkylation', 'level': 3, 'score': 0.53683627}, {'id': 'https://openalex.org/C2780259306', 'wikidata': 'https://www.wikidata.org/wiki/Q412197', 'display_name': 'Irinotecan', 'level': 4, 'score': 0.53602827}, {'id': 'https://openalex.org/C137824038', 'wikidata': 'https://www.wikidata.org/wiki/Q175562', 'display_name': 'Intercalation (chemistry)', 'level': 2, 'score': 0.48016495}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.46200085}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.44679973}, {'id': 'https://openalex.org/C96232424', 'wikidata': 'https://www.wikidata.org/wiki/Q4118072', 'display_name': 'Cancer cell', 'level': 3, 'score': 0.4370948}, {'id': 'https://openalex.org/C62112901', 'wikidata': 'https://www.wikidata.org/wiki/Q189159', 'display_name': 'Cell growth', 'level': 2, 'score': 0.41731626}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.36970836}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.34663892}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.26799744}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.08883238}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.08553159}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.072013766}, {'id': 'https://openalex.org/C526805850', 'wikidata': 'https://www.wikidata.org/wiki/Q188874', 'display_name': 'Colorectal cancer', 'level': 3, 'score': 0.05692184}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C161790260', 'wikidata': 'https://www.wikidata.org/wiki/Q82264', 'display_name': 'Catalysis', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': True}, {'descriptor_ui': 'D004264', 'descriptor_name': 'DNA Topoisomerases, Type I', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D004250', 'descriptor_name': 'DNA Topoisomerases, Type II', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D004611', 'descriptor_name': 'Ellipticines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D059004', 'descriptor_name': 'Topoisomerase I Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D059005', 'descriptor_name': 'Topoisomerase II Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004264', 'descriptor_name': 'DNA Topoisomerases, Type I', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004250', 'descriptor_name': 'DNA Topoisomerases, Type II', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004354', 'descriptor_name': 'Drug Screening Assays, Antitumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004611', 'descriptor_name': 'Ellipticines', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': False}, {'descriptor_ui': 'D004611', 'descriptor_name': 'Ellipticines', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D004611', 'descriptor_name': 'Ellipticines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019073', 'descriptor_name': 'HT29 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D061986', 'descriptor_name': 'MCF-7 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015394', 'descriptor_name': 'Molecular Structure', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013329', 'descriptor_name': 'Structure-Activity Relationship', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D059004', 'descriptor_name': 'Topoisomerase I Inhibitors', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': False}, {'descriptor_ui': 'D059004', 'descriptor_name': 'Topoisomerase I Inhibitors', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D059004', 'descriptor_name': 'Topoisomerase I Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D059005', 'descriptor_name': 'Topoisomerase II Inhibitors', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': False}, {'descriptor_ui': 'D059005', 'descriptor_name': 'Topoisomerase II Inhibitors', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D059005', 'descriptor_name': 'Topoisomerase II Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1039/c2ob27186a', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S179810352', 'display_name': 'Organic & Biomolecular Chemistry', 'issn_l': '1477-0520', 'issn': ['1477-0520', '1477-0539'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320556', 'host_organization_name': 'Royal Society of Chemistry', 'host_organization_lineage': ['https://openalex.org/P4310320556'], 'host_organization_lineage_names': ['Royal Society of Chemistry'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/23314103', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.55, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 29, 'referenced_works': ['https://openalex.org/W1536538430', 'https://openalex.org/W1884743999', 'https://openalex.org/W1970912130', 'https://openalex.org/W1972410555', 'https://openalex.org/W1974517960', 'https://openalex.org/W1976034958', 'https://openalex.org/W1977754686', 'https://openalex.org/W1990202861', 'https://openalex.org/W2004193642', 'https://openalex.org/W2009918106', 'https://openalex.org/W2010585267', 'https://openalex.org/W2028101098', 'https://openalex.org/W2034553072', 'https://openalex.org/W2059731771', 'https://openalex.org/W2077301074', 'https://openalex.org/W2082034956', 'https://openalex.org/W2089077361', 'https://openalex.org/W2092287241', 'https://openalex.org/W2093239725', 'https://openalex.org/W2094814066', 'https://openalex.org/W2108462936', 'https://openalex.org/W2121454394', 'https://openalex.org/W2124624490', 'https://openalex.org/W2124707826', 'https://openalex.org/W2132600317', 'https://openalex.org/W2146274229', 'https://openalex.org/W2152989464', 'https://openalex.org/W4211084461', 'https://openalex.org/W4236530034'], 'related_works': ['https://openalex.org/W2941541752', 'https://openalex.org/W2909523539', 'https://openalex.org/W2409654774', 'https://openalex.org/W2314333023', 'https://openalex.org/W2074902034', 'https://openalex.org/W2063989721', 'https://openalex.org/W2050951907', 'https://openalex.org/W2025290139', 'https://openalex.org/W1573325703', 'https://openalex.org/W1541204074'], 'abstract_inverted_index': {'Drugs': [0], 'that': [1, 78, 147], 'inhibit': [2, 110], 'DNA': [3, 7, 58, 112], 'topoisomerase': [4, 8, 34, 60, 73, 94, 123], 'I': [5, 35, 74, 95], 'and': [6, 36, 55, 62, 141, 154], 'II': [9, 37, 124], 'have': [10], 'been': [11], 'widely': [12], 'used': [13], 'in': [14, 155, 192], 'cancer': [15, 67], 'chemotherapy.': [16], 'We': [17], 'report': [18], 'herein': [19], 'the': [20, 51, 72, 102, 111, 133, 169, 193], 'results': [21], 'of': [22, 48, 90, 101, 118, 122, 127, 148, 181, 195], 'a': [23, 88, 116], 'focused': [24], 'medicinal': [25], 'chemistry': [26], 'effort': [27], 'around': [28], 'novel': [29, 80], 'ellipticinium': [30], 'salts': [31, 43], 'which': [32], 'target': [33], 'enzymes': [38], 'with': [39, 50, 189], 'improved': [40], 'solubility.': [41], 'The': [42], 'were': [44, 106], 'prepared': [45], 'by': [46], 'reaction': [47, 114], 'ellipticine': [49, 81, 128], 'required': [52], 'alkyl': [53], 'halide': [54], 'evaluated': [56], 'for': [57], 'intercalation,': [59], 'inhibition': [61, 64, 96, 136, 144], 'growth': [63, 135, 143, 172], 'against': [65], '12': [66], 'cell': [68, 139, 157], 'lines.': [69], 'Results': [70], 'from': [71], 'relaxation': [75], 'assay': [76], 'indicated': [77], 'all': [79, 138], 'derivatives': [82, 103], 'behaved': [83], 'as': [84], 'intercalating': [85], 'agents.': [86], 'At': [87], 'concentration': [89, 117], '100': [91, 119], 'μM,': [92, 120], 'specific': [93], 'was': [97, 129, 168, 183], 'not': [98], 'observed.': [99], 'Two': [100], 'under': [104], 'investigation': [105], 'found': [107, 130, 184], 'to': [108, 131, 146, 185], 'fully': [109], 'decatenation': [113], 'at': [115], 'indicative': [121], 'inhibition.': [125], 'N-Alkylation': [126, 180], 'enhance': [132], 'observed': [134], 'across': [137], 'lines': [140, 158], 'induce': [142], 'comparable': [145], 'Irinotecan': [149], '(CPT-11;': [150], 'GI50': [151, 163, 190], '1–18': [152], 'μM)': [153], 'some': [156], 'better': [159], 'than': [160], 'Etoposide': [161], '(VP-16;': [162], '=': [164, 177], '0.04–5.2': [165], 'μM).': [166, 179], '6-Methylellipticine': [167], 'most': [170], 'potent': [171], 'inhibitory': [173], 'compound': [174], 'assessed': [175], '(GI50': [176], '0.47–0.9': [178], '6-methylellipticine': [182], 'reduce': [186], 'this': [187], 'response': [188], 'values': [191], 'range': [194], '1.3–28': [196], 'μM.': [197]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2042658426', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 8}, {'year': 2018, 'cited_by_count': 9}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 7}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-12-08T08:49:02.905301', 'created_date': '2016-06-24'}