Publication Information

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483, 514, 532, 591, 618, 629, 683, 733, 769, 796, 805, 837, 902, 932, 976, 1021, 1038, 1053, 1082, 1091, 1140, 1170, 1300, 1327, 1355, 1374, 1393, 1408, 1426, 1458], 'radio-mimetic': [15], 'chemicals,': [16], 'mammalian': [19, 171], 'cells,': [20, 172], 'during': [21], 'the': [22, 82, 128, 134, 173, 177, 188, 221, 242, 245, 267, 283, 287, 372, 379, 386, 404, 425, 456, 491, 511, 524, 530, 550, 572, 575, 595, 603, 623, 652, 659, 662, 665, 672, 740, 744, 762, 779, 801, 857, 899, 911, 922, 926, 933, 947, 953, 994, 1000, 1051, 1080, 1101, 1110, 1117, 1138, 1154, 1186, 1189, 1202, 1206, 1234, 1259, 1293, 1304, 1308, 1311, 1317, 1332, 1340, 1358, 1379, 1388, 1396, 1404, 1409, 1455], 'V(D)J': [23, 166], 'chain': [24, 167], 'recombination': [25, 39, 168], 'events': [26], '[1].': [27, 58, 87], 'Repair': [28], 'DSB': [30, 56, 71], 'eukaryotic': [32, 512, 551, 596, 747, 861, 1139], 'cells': [33, 305], 'can': [34, 1461], 'occur': [35, 162], 'via': [36, 46], 'homologous': [38, 76], 'pathway': [40, 51, 90], 'involving': [41], 'RAD51': [42], 'RAD52,': [44], 'or': [45, 339], 'non-homologous': [48], 'double-strand': [49, 387], 'end-joining': [50, 302], '(NHEJ),': [52], 'form': [54, 712, 1262], 'repair': [57, 69, 80, 243, 390, 759, 1182, 1196, 1265], 'Although': [59, 999, 1050], 'both': [60, 627], 'pathways': [61], 'are': [62, 307, 312, 541, 554, 1016, 1056, 1088, 1123, 1147, 1213, 1329, 1347], 'present': [63, 1330], 'all': [65], 'eukaryotes,': [66], 'yeast,': [68, 280, 1086], 'is': [72, 81, 94, 133, 183, 211, 368, 585, 600, 620, 680, 709, 717, 791, 809, 867, 967, 979, 1073, 1256, 1278, 1290, 1367, 1376, 1399, 1443], 'primarily': [73], 'achieved': [74], 'recombination,': [77], 'whereas': [78], 'NHEJ': [79, 89], 'predominant': [83], 'mechanism': [84], 'vertebrates': [86], 'The': [88, 124, 248, 317, 392, 537, 559, 703, 746, 764, 864, 962, 1114, 1135, 1210], 'higher': [92, 1007, 1130], 'eukaryotes': [93, 1131], 'dependent': [95, 184], 'on': [96, 185, 201, 220, 698, 1331, 1450], 'multiprotein': [98], 'complex,': [99], 'DNA-dependent': [100], 'protein': [101, 196, 214, 252, 311, 348, 393, 406, 492, 829, 1003, 1122], 'kinase': [102, 197, 253], '(DNA-PK)': [103], '[1]': [104], 'which': [105, 161, 182, 694, 1087, 1157], 'consists': [106], 'DNA-binding': [109, 847, 853, 890, 1033], 'component,': [110], 'heterodimer': [112, 175, 190, 207, 289], 'two': [114, 690, 870, 1118, 1322], 'proteins,': [115, 234], 'Ku70': [116, 338, 448, 513, 531, 617, 768, 804, 862, 937, 1040, 1044, 1052, 1081], 'Ku80,': [118], 'catalytic': [121, 178], 'subunit,': [122, 209], 'DNA-PKcs.': [123], 'main': [125], 'function': [126], 'Ku70/80': [129], 'component': [130], 'DNA-PK,': [132, 181], 'primary': [135, 1013], 'recognition': [136], 'DSB.': [138], 'Ku': [139, 174, 206, 288, 310, 322, 347, 383, 500, 539, 552, 561, 577, 597, 643, 660, 667, 748, 913, 929, 997, 1002, 1112, 1121, 1142, 1191, 1208, 1211, 1260, 1296, 1324, 1344, 1362, 1456], 'displays': [140], 'high': [141, 518], 'affinity': [142], 'vitro': [144], 'for': [145, 194, 231, 398, 626, 658, 832, 1185, 1246, 1411, 1430], 'variety': [147], 'ends': [150, 331], 'including': [151, 855, 1175], 'blunt': [152], 'ends,': [153, 295, 1306], '5′': [154], '3′': [156], 'overhangs,': [157], 'hairpins': [160], 'intermediates': [164], '[2].': [169, 632, 1035, 1049], 'In': [170, 279, 424, 548, 651, 1316], 'recruits': [176], 'subunit': [179, 1022], 'association': [186, 1187], 'with': [187, 400, 418, 444, 517, 647, 729, 1193, 1267], 'Ku70/Ku80': [189], 'bound': [191, 219], 'to': [192, 272, 291, 314, 363, 370, 403, 416, 447, 564, 711, 755, 822, 885, 946, 981, 1061, 1167, 1274, 1280, 1303, 1351, 1356, 1391, 1418, 1434, 1439, 1447], 'DNA,': [193], 'its': [195, 205], 'activity.': [198], 'When': [199], 'localised': [200], 'damaged': [202], 'targeting': [208], 'DNA-PK': [210, 223, 256], 'an': [212, 419, 696, 730], 'active': [213], 'kinase,': [215], 'preferentially': [216], 'phosphorylating': [217], 'proteins': [218, 376, 384, 399, 435, 457, 501, 516, 540, 553, 578, 661, 668, 749, 821, 854, 1143, 1192, 1197, 1261, 1363], 'DNA.': [222], 'may': [224, 260, 323, 1198], 'also': [225, 261, 324, 508, 636, 644, 814, 942, 1107, 1228], 'act': [226], 'binding': [229, 631], 'site': [230], 'recruiting': [232], 'other': [233, 648, 820, 895, 995, 1128, 1173, 1194], 'such': [235, 897, 1251], 'ligases,': [238, 1177, 1233], 'directly': [239], 'involved': [240, 326, 983], 'double-stranded': [246], 'breaks.': [247], 'presence': [249, 268, 1235], 'activity': [254, 285, 320], 'suggests': [257, 1144, 1241], 'that': [258, 306, 613, 639, 811, 892, 1026, 1145, 1164, 1258, 1282, 1292], 'it': [259, 634], 'have': [262, 350, 611, 750, 1009, 1027, 1031, 1062], 'role': [264, 381, 760, 817, 1245, 1359], 'signaling': [266], 'cell-cycle': [273], 'checkpoint': [274], 'apoptosis': [276], 'regulating': [277], 'systems.': [278], 'vivo,': [282], 'end-binding': [284, 319], 'appears': [290, 884], 'significantly': [292], 'stabilise': [293], 'promotes': [297], 'efficient': [298], 'accurate': [300], 'illegitimate': [301], 'repair.': [303, 835], 'Mammalian': [304], 'deficient': [308, 336], 'sensitive': [313], 'radiation.': [316], 'be': [325, 982, 1199, 1275, 1462], 'protection': [328], 'chromosomal': [330], 'from': [332, 701, 894, 1064, 1076, 1126, 1149, 1201, 1313, 1387], 'nucleases,': [333], 'yeast': [335, 359, 1048], 'Ku80': [340, 405, 450, 515, 533, 619, 770, 806, 1054, 1083], 'display': [341], 'marked': [342], 'telomere': [343], 'attrition': [344], '[1,': [345], '2].': [346], 'homologues': [349, 528, 562, 1004, 1025, 1212, 1297], 'been': [351, 637, 798, 1028], 'identified': [352, 840, 918], 'vertebrates,': [354], 'insects,': [355], 'Caenorhabditis': [356], 'elegans': [357], '[2]': [360], 'but': [361, 507, 1271], 'not,': [362], 'date,': [364], 'prokaryotes.': [366], 'It': [367, 808, 1255, 1277, 1289], 'important': [369], 'understand': [371], 'origins': [373], 'these': [375, 429, 498, 1226, 1237, 1247, 1268], 'because': [377], 'central': [380], 'break': [389], 'pathway.': [391], 'sequence': [394, 493], 'database': [395, 412, 494], 'was': [396, 669, 990, 1383], 'searched': [397], 'significant': [401, 445, 919], 'homology': [402, 446, 920], '(Arabidopsis': [407], 'thaliana)': [408], 'using': [409, 495, 671], 'iterative': [410], 'PSI-BLAST': [411, 916], 'searches': [413, 430, 489, 917], '[3]': [414], 'run': [415], 'convergence': [417], 'E': [420], 'value': [421], '0.01.': [423], 'third': [426], 'iteration': [427], 'number': [432, 607, 851], 'putative': [434, 846], 'were': [436], 'detected': [437, 943, 992], 'within': [438, 761], 'several': [439], 'bacterial': [440, 499, 538, 560, 666, 912, 954, 996, 1111, 1141, 1190, 1207, 1323, 1361], 'archael': [442], 'genomes': [443], '(Fig.': [451, 579, 786, 938, 1222, 1335], '1A': [452], ').': [453], 'These': [454], 'include': [455], 'encoded': [458], 'YkoV': [460], '(Bacillus': [461, 464], 'subtilis),': [462], 'BH2208': [463], 'halodurans),': [465], 'SC6G9.24c,': [466], 'SCP1.285c,': [467], 'SCF55.25c': [468, 931, 966], '(Streptomyces': [469], 'coelicolor),': [470], 'Rv0937c': [471], '(Mycobacterium': [472], 'tuberculosis),': [473], 'PA2150': [474], '(Pseudomonas': [475], 'aeruginosa),': [476], 'Mlr9623,': [477], 'Mlr9624,': [478], 'Mll4607,': [479], 'Mll2074': [480], '(Mesorhizobium': [481], 'loti)': [482], 'AFI1726': [484], '(Archaeoglobus': [485], 'fulgidus).': [486], 'Reverse': [487], 'PSI-blast': [488], 'each': [496, 505, 1127], 'retrieved': [502], 'not': [503, 991, 1444], 'only': [504], 'other,': [506], 'many': [509], 'accuracy.': [519], 'Our': [520], 'findings': [521, 604], 'strongly': [522], 'suggest': [523], 'existence': [525], 'prokaryotic': [527], 'family': [534], 'proteins.': [536, 598, 650, 745, 863], 'composed': [542, 868], 'approximately': [544, 593], '270–350': [545], 'amino': [546, 588], 'acids.': [547], 'contrast,': [549], 'much': [555, 721], 'larger': [556, 576, 828], '(70–80': [557], 'kDa).': [558], 'appear': [563, 1060], 'represent': [565, 886, 1339], 'previously': [567], 'undetected': [568], 'conserved': [569, 586, 724, 876, 1102], 'domain': [570, 785, 790, 813, 951, 978], 'at': [571, 739, 1464], 'centre': [573], '1B).': [580], 'This': [581, 599, 679, 716, 789, 882, 987, 1071, 1381], 'common': [582, 1066, 1151], 'core': [583], 'structure': [584, 657, 663, 674, 686, 738, 1204], 'between': [587, 921, 1137], 'acids': [589, 1105], '210': [590], '550': [592], 'supported': [601, 1377, 1384, 1400], 'groups': [609], 'who': [610], 'shown': [612], 'this': [614, 640, 812, 977, 1272, 1338, 1353, 1435], 'region': [615, 641, 705, 725, 766, 859, 1098, 1103], 'one': [621], 'major': [624], 'determinants': [625], 'heterodimerisation': [628, 802], 'Recently,': [633], 'has': [635, 797], 'reported': [638], 'mediates': [645], 'interactions': [646], 'nuclear': [649], 'absence': [653], 'any': [655], 'known': [656], 'analysed': [670], 'secondary': [673, 685], 'prediction': [675, 687], 'program,': [676], 'PSIPRED': [677], '[4].': [678], 'simple': [682], 'reliable': [684], 'method,': [688], 'incorporating': [689], 'feed-forward': [691], 'neural': [692], 'networks': [693], 'perform': [695], 'analysis': [697], 'output': [699], 'obtained': [700], 'PSI-BLAST.': [702], 'N-terminal': [704, 765, 949], '(aa': [706, 726, 771, 974], '1–80': [707], 'approx.)': [708, 728, 773], 'predicted': [710], 'β-sheet': [714], 'sub-domain.': [715], 'followed': [718], 'more': [722, 1124, 1243], 'highly': [723, 736], '80–170': [727], 'α/β': [731], 'fold': [732], 'finally,': [734], 'α-helical': [737, 950, 988], 'C-terminal': [741, 858, 923], 'end': [742, 924], 'acquired': [751], 'additional': [752, 1238], 'domains,': [753], 'presumably': [754, 1158], 'enhance': [756], 'their': [757], 'cell.': [763], '1–240': [772], 'comprises': [774], 'divergent': [776, 1125], 'member': [777], 'Von': [780], 'Willebrant': [781], 'factor': [782], 'A': [783], '(VWA)': [784], '1B)': [787, 939], '[5].': [788, 807], 'protein–protein': [793], 'interacting': [794], 'module': [795], 'implicated': [799], 'likely': [810, 980], 'plays': [815], 'sequestering': [819], 'sites': [823], 'damage,': [826], 'forming': [827, 1178], 'complexes': [830, 1266], 'required': [831], 'concerted': [833], 'Aravind': [836], 'Koonin': [838], 'recently': [839], 'SAP': [842, 865, 907, 934], 'motif': [843, 866, 883, 891, 935, 964, 989], '[6],': [844], 'module,': [848], 'amphipatic': [871], 'helices': [872], 'connected': [873], 'loop': [877], 'invariant': [879], 'length': [880], '[6].': [881, 940], 'new': [888], 'bi-helical': [889], 'differs': [893], 'motifs': [896, 908], 'Helix–hairpin–Helix': [900], '(HhH),': [901], 'Helix–turn–Helix': [903], '(HtH).': [904], 'Do': [905], 'similar': [906, 1017, 1032, 1093], 'exist': [909], 'proteins?': [914], 'Iterative': [915], 'S.': [927, 1283, 1424], 'coelicolor': [928, 1284], 'protein,': [930], 'We': [941, 1415, 1437], 'similarity': [945, 1136], 'extreme': [948], 'transcriptional': [955], 'terminator': [956], 'Rho': [957], '(PDB': [958], 'ID:': [959], '1a8v,': [960], '1a62).': [961], 'SAP-like': [963], 'located': [968, 1099], '40-amino': [971], 'acid': [972, 1097], 'extension': [973], '290–330)': [975], 'binding.': [986], 'homologues.': [998, 1113], 'eukaryote': [1001], 'various': [1006], 'organisms': [1008], 'diverged': [1010], 'substantially': [1011], 'sequence,': [1014], 'they': [1015, 1059, 1146], 'overall': [1019], 'size': [1020], 'structure.': [1023], 'Those': [1024], 'characterised': [1029], 'biochemically': [1030, 1057], 'properties': [1034], 'Moreover,': [1036], 'human': [1037], 'Drosophila': [1039], 'cDNAs': [1041], 'will': [1042], 'complement': [1043], 'null': [1045], 'mutations': [1046], 'subunits': [1055, 1084, 1119], 'distinct,': [1058], 'arisen': [1063], 'ancestral': [1067, 1152], 'gene': [1068], '[2,': [1069], '7].': [1070], 'relationship': [1072], 'most': [1074], 'evident': [1075, 1200], 'comparison': [1078], '22%': [1089], 'identical': [1090], '38%': [1092], 'over': [1094], '258-amino': [1096], '(amino': [1104], '250–550),': [1106], 'found': [1108, 1463], 'sequences': [1115], 'than': [1132], 'yeast.': [1134], 'derived': [1148], 'gene,': [1153], 'product': [1155], 'functioned': [1159], 'homodimeric': [1162], 'complex': [1163], 'could': [1165], 'bind': [1166, 1302], 'ends/breaks': [1169], 'possibly': [1171], 'sequester': [1172], 'factors,': [1174], 'primordial': [1180], 'complex.': [1183], 'Evidence': [1184], 'operon': [1203, 1334], 'genes.': [1209], 'often': [1214], 'organised': [1215], 'into': [1216], 'operons': [1217], 'containing': [1218], 'ATP-dependent': [1219, 1239], 'ligases': [1221, 1240, 1270], '1C).': [1223, 1336], 'All': [1224], 'bacteria': [1227], 'contain': [1229], 'essential': [1230], 'NAD+-dependent': [1231], 'specific': [1244], 'enzymes': [1248], 'vivo': [1250], 'repair/recombination.': [1254], 'possible': [1257, 1291], 'functional': [1263], 'remains': [1273], 'established.': [1276], 'interesting': [1279], 'note': [1281], 'contains': [1285], 'linear': [1287], 'genome.': [1288], 'three': [1294], 'Streptomyces': [1295], '(SC6G9.24c,': [1298], 'SCP1.285c': [1299], 'SCF55.25c)': [1301], 'protecting': [1307], 'termini': [1309], 'chromosome': [1312], 'nuclease': [1314], 'digestion.': [1315], 'M.': [1318], 'loti': [1319], 'plasmid': [1320], 'pMLb,': [1321], 'genes': [1325], '(Mlr9623': [1326], 'Mlr9624)': [1328], 'same': [1333], 'Could': [1337], 'first': [1341], 'primitive': [1342], 'hetrodimeric': [1343], 'complex?': [1345], 'Experiments': [1346], 'currently': [1348], 'progress': [1350], 'test': [1352], 'hypothesis': [1354], 'establish': [1357], 'vivo.': [1365], 'A.J.D.': [1366, 1392], 'Royal': [1369, 1389], 'Society': [1370, 1390], 'University': [1371], 'Research': [1372, 1406], 'Fellow': [1373], 'G.R.W.': [1375], 'MRC.': [1380], 'work': [1382, 1442], 'grants': [1386], 'research': [1394], 'S.P.J.': [1397], 'laboratory': [1398], 'part': [1402], 'Cancer': [1405, 1413], 'Campaign': [1407], 'Association': [1410], 'International': [1412], 'research.': [1414], 'would': [1416], 'like': [1417], 'thank': [1419], 'Dr': [1420, 1423, 1427], 'A.': [1421], 'Lesk,': [1422], 'Bell': [1425], 'C.': [1428], 'Ponting': [1429], 'helpful': [1431], 'discussions': [1432], 'relating': [1433], 'work.': [1436], 'apologise': [1438], 'authors': [1440], 'whose': [1441], 'cited': [1445], 'due': [1446], 'severe': [1448], 'restrictions': [1449], 'references.': [1451], 'Full': [1452], 'alignments': [1453], '(Ku78)': [1457], 'VWA': [1459], 'domains': [1460], 'http://SMART.embl-heidelberg.de/.': [1465]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2025447131', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 8}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 8}, {'year': 2019, 'cited_by_count': 10}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 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