Publication Information

{'id': 'https://openalex.org/W2947679604', 'doi': 'https://doi.org/10.1002/2211-5463.12681', 'title': 'Genetic interaction between DNA repair factors <i>PAXX</i>, <i>XLF, XRCC4</i> and <i>DNA‐PKcs</i> in human cells', 'display_name': 'Genetic interaction between DNA repair factors <i>PAXX</i>, <i>XLF, XRCC4</i> and <i>DNA‐PKcs</i> in human cells', 'publication_year': 2019, 'publication_date': '2019-05-29', 'ids': {'openalex': 'https://openalex.org/W2947679604', 'doi': 'https://doi.org/10.1002/2211-5463.12681', 'mag': '2947679604', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/31141305', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6609761'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/2211-5463.12681', 'pdf_url': 'https://febs.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/2211-5463.12681', 'source': {'id': 'https://openalex.org/S2898225119', 'display_name': 'FEBS Open Bio', 'issn_l': '2211-5463', 'issn': ['2211-5463'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://febs.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/2211-5463.12681', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5006159493', 'display_name': 'Mengtan Xing', 'orcid': 'https://orcid.org/0009-0008-1512-2015'}, 'institutions': [{'id': 'https://openalex.org/I204778367', 'display_name': 'Norwegian University of Science and Technology', 'ror': 'https://ror.org/05xg72x27', 'country_code': 'NO', 'type': 'education', 'lineage': ['https://openalex.org/I204778367']}], 'countries': ['NO'], 'is_corresponding': False, 'raw_author_name': 'Mengtan Xing', 'raw_affiliation_strings': ['Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology, Trondheim, Norway'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology, Trondheim, Norway', 'institution_ids': ['https://openalex.org/I204778367']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5021491856', 'display_name': 'Valentyn Oksenych', 'orcid': 'https://orcid.org/0000-0002-5088-3791'}, 'institutions': [{'id': 'https://openalex.org/I204778367', 'display_name': 'Norwegian University of Science and Technology', 'ror': 'https://ror.org/05xg72x27', 'country_code': 'NO', 'type': 'education', 'lineage': ['https://openalex.org/I204778367']}], 'countries': ['NO'], 'is_corresponding': True, 'raw_author_name': 'Valentyn Oksenych', 'raw_affiliation_strings': ['Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology, Trondheim, Norway'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology, Trondheim, Norway', 'institution_ids': ['https://openalex.org/I204778367']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5021491856'], 'corresponding_institution_ids': ['https://openalex.org/I204778367'], 'apc_list': {'value': 1750, 'currency': 'USD', 'value_usd': 1750, 'provenance': 'doaj'}, 'apc_paid': {'value': 1750, 'currency': 'USD', 'value_usd': 1750, 'provenance': 'doaj'}, 'fwci': 1.889, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 29, 'citation_normalized_percentile': {'value': 0.999983, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '9', 'issue': '7', 'first_page': '1315', 'last_page': '1326'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10123', 'display_name': 'DNA Repair Mechanisms', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10123', 'display_name': 'DNA Repair Mechanisms', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10878', 'display_name': 'CRISPR and Genetic Engineering', 'score': 0.9917, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11914', 'display_name': 'PARP inhibition in cancer therapy', 'score': 0.9899, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ku80', 'display_name': 'Ku80', 'score': 0.8799832}, {'id': 'https://openalex.org/keywords/non-homologous-end-joining', 'display_name': 'Non-homologous end joining', 'score': 0.76823705}, {'id': 'https://openalex.org/keywords/dna-pkcs', 'display_name': 'DNA-PKcs', 'score': 0.74863917}, {'id': 'https://openalex.org/keywords/ku70', 'display_name': 'Ku70', 'score': 0.7187563}], 'concepts': [{'id': 'https://openalex.org/C145803527', 'wikidata': 'https://www.wikidata.org/wiki/Q18032396', 'display_name': 'DNA repair protein XRCC4', 'level': 5, 'score': 0.9565165}, {'id': 'https://openalex.org/C193104389', 'wikidata': 'https://www.wikidata.org/wiki/Q18032397', 'display_name': 'Ku80', 'level': 5, 'score': 0.8799832}, {'id': 'https://openalex.org/C122917832', 'wikidata': 'https://www.wikidata.org/wiki/Q2065945', 'display_name': 'Non-homologous end joining', 'level': 4, 'score': 0.76823705}, {'id': 'https://openalex.org/C68748289', 'wikidata': 'https://www.wikidata.org/wiki/Q18030783', 'display_name': 'DNA-PKcs', 'level': 4, 'score': 0.74863917}, {'id': 'https://openalex.org/C2780919815', 'wikidata': 'https://www.wikidata.org/wiki/Q6440930', 'display_name': 'Ku70', 'level': 4, 'score': 0.7187563}, {'id': 'https://openalex.org/C134935766', 'wikidata': 'https://www.wikidata.org/wiki/Q210538', 'display_name': 'DNA repair', 'level': 3, 'score': 0.70326257}, {'id': 'https://openalex.org/C175114707', 'wikidata': 'https://www.wikidata.org/wiki/Q408483', 'display_name': 'DNA ligase', 'level': 3, 'score': 0.60945904}, {'id': 'https://openalex.org/C143425029', 'wikidata': 'https://www.wikidata.org/wiki/Q5205747', 'display_name': 'DNA damage', 'level': 3, 'score': 0.5586386}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5424813}, {'id': 'https://openalex.org/C178169997', 'wikidata': 'https://www.wikidata.org/wiki/Q2892636', 'display_name': 'Genome instability', 'level': 4, 'score': 0.5334492}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.44884428}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.41300336}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.3470615}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.31005996}, {'id': 'https://openalex.org/C60748783', 'wikidata': 'https://www.wikidata.org/wiki/Q2984243', 'display_name': 'DNA mismatch repair', 'level': 4, 'score': 0.20264187}, {'id': 'https://openalex.org/C94966510', 'wikidata': 'https://www.wikidata.org/wiki/Q2252764', 'display_name': 'DNA-binding protein', 'level': 4, 'score': 0.18910804}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.16904894}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.08762252}], 'mesh': [{'descriptor_ui': 'D045643', 'descriptor_name': 'DNA Repair Enzymes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D045643', 'descriptor_name': 'DNA Repair Enzymes', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D051747', 'descriptor_name': 'DNA-Activated Protein Kinase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D064007', 'descriptor_name': 'Ataxia Telangiectasia Mutated Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D064007', 'descriptor_name': 'Ataxia Telangiectasia Mutated Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D020134', 'descriptor_name': 'Catalytic Domain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020134', 'descriptor_name': 'Catalytic Domain', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D053903', 'descriptor_name': 'DNA Breaks, Double-Stranded', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D059766', 'descriptor_name': 'DNA End-Joining Repair', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D059766', 'descriptor_name': 'DNA End-Joining Repair', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D019175', 'descriptor_name': 'DNA Methylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019175', 'descriptor_name': 'DNA Methylation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004260', 'descriptor_name': 'DNA Repair', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004260', 'descriptor_name': 'DNA Repair', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D045643', 'descriptor_name': 'DNA Repair Enzymes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051747', 'descriptor_name': 'DNA-Activated Protein Kinase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051747', 'descriptor_name': 'DNA-Activated Protein Kinase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004843', 'descriptor_name': 'Epistasis, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004843', 'descriptor_name': 'Epistasis, Genetic', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000072200', 'descriptor_name': 'Ku Autoantigen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000072200', 'descriptor_name': 'Ku Autoantigen', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/2211-5463.12681', 'pdf_url': 'https://febs.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/2211-5463.12681', 'source': {'id': 'https://openalex.org/S2898225119', 'display_name': 'FEBS Open Bio', 'issn_l': '2211-5463', 'issn': ['2211-5463'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc6609761', 'pdf_url': 'https://europepmc.org/articles/pmc6609761?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609761', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/31141305', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/2211-5463.12681', 'pdf_url': 'https://febs.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/2211-5463.12681', 'source': {'id': 'https://openalex.org/S2898225119', 'display_name': 'FEBS Open Bio', 'issn_l': '2211-5463', 'issn': ['2211-5463'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.53, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [{'funder': 'https://openalex.org/F4320310758', 'funder_display_name': 'Kreftforeningen', 'award_id': '182355'}, {'funder': 'https://openalex.org/F4320311040', 'funder_display_name': 'Norges Teknisk-Naturvitenskapelige Universitet', 'award_id': None}, {'funder': 'https://openalex.org/F4320322752', 'funder_display_name': 'Helse Midt-Norge', 'award_id': None}, {'funder': 'https://openalex.org/F4320323299', 'funder_display_name': 'Norges Forskningsråd', 'award_id': '270491'}, {'funder': 'https://openalex.org/F4320323299', 'funder_display_name': 'Norges Forskningsråd', 'award_id': '291217'}], 'datasets': [], 'versions': [], 'referenced_works_count': 43, 'referenced_works': ['https://openalex.org/W1970827792', 'https://openalex.org/W1988157092', 'https://openalex.org/W1989877475', 'https://openalex.org/W2017351036', 'https://openalex.org/W2017550130', 'https://openalex.org/W2034718433', 'https://openalex.org/W2048421417', 'https://openalex.org/W2050086663', 'https://openalex.org/W2067228541', 'https://openalex.org/W2072007776', 'https://openalex.org/W2080576686', 'https://openalex.org/W2081375417', 'https://openalex.org/W2088857928', 'https://openalex.org/W2106087857', 'https://openalex.org/W2109879947', 'https://openalex.org/W2110951885', 'https://openalex.org/W2119274866', 'https://openalex.org/W2127111507', 'https://openalex.org/W2146204567', 'https://openalex.org/W2146355613', 'https://openalex.org/W2147539498', 'https://openalex.org/W2155169980', 'https://openalex.org/W2405114290', 'https://openalex.org/W2414273841', 'https://openalex.org/W2477626371', 'https://openalex.org/W2511852522', 'https://openalex.org/W2528384811', 'https://openalex.org/W2535039453', 'https://openalex.org/W2564629728', 'https://openalex.org/W2568353756', 'https://openalex.org/W2614952490', 'https://openalex.org/W2618543928', 'https://openalex.org/W2735269221', 'https://openalex.org/W2739256644', 'https://openalex.org/W2765426710', 'https://openalex.org/W2771730334', 'https://openalex.org/W2783460793', 'https://openalex.org/W2783951142', 'https://openalex.org/W2788085902', 'https://openalex.org/W2883643479', 'https://openalex.org/W2905107636', 'https://openalex.org/W2991419284', 'https://openalex.org/W2998349152'], 'related_works': ['https://openalex.org/W2552954439', 'https://openalex.org/W2169008015', 'https://openalex.org/W2119371129', 'https://openalex.org/W2094532656', 'https://openalex.org/W2047804529', 'https://openalex.org/W2046572356', 'https://openalex.org/W2041529030', 'https://openalex.org/W2025951531', 'https://openalex.org/W2007369689', 'https://openalex.org/W1873396772'], 'abstract_inverted_index': {'DNA': [0, 80, 86, 95], 'double-strand': [1], 'breaks': [2], '(DSBs)': [3], 'are': [4, 42], 'highly': [5], 'cytotoxic': [6], 'lesions,': [7], 'and': [8, 25, 40, 72, 76, 79, 124, 166, 196, 198, 224, 241], 'unrepaired': [9], 'or': [10, 155, 210], 'misrepaired': [11], 'DSBs': [12, 88], 'can': [13], 'lead': [14], 'to': [15, 181, 232, 246, 260], 'various': [16], 'human': [17, 139, 148, 204, 266], 'diseases,': [18], 'including': [19, 52, 109, 159], 'immunodeficiency,': [20], 'neurological': [21], 'abnormalities,': [22], 'growth': [23], 'retardation,': [24], 'cancer.': [26], 'Nonhomologous': [27], 'end': [28], 'joining': [29], '(NHEJ)': [30], 'is': [31, 141, 256], 'the': [32, 47, 91, 94, 128, 132, 170, 188, 247, 262], 'major': [33], 'DSB': [34, 43], 'repair': [35, 64], 'pathway': [36], 'in': [37, 99, 120, 138, 203, 230, 265], 'mammals.': [38], 'Ku70': [39], 'Ku80': [41], 'sensors': [44], 'that': [45, 202, 254], 'facilitate': [46], 'recruitment': [48], 'of': [49, 74, 93, 131, 173], 'downstream': [50], 'factors,': [51, 158], 'protein': [53, 56, 66, 101], 'kinase': [54, 102], 'DNA-dependent': [55], 'kinase,': [57], 'catalytic': [58], 'subunit': [59], '(DNA-PKcs),': [60], 'structural': [61], 'components': [62], '[X-ray': [63], 'cross-complementing': [65], '4': [67], '(XRCC4),': [68], 'XRCC4-like': [69], 'factor': [70], '(XLF),': [71], 'paralogue': [73], 'XRCC4': [75, 192], 'XLF': [77], '(PAXX)],': [78], 'ligase': [81], 'IV': [82], '(LIG4),': [83], 'which': [84, 100, 152], 'complete': [85], 'repair.': [87], 'also': [89], 'trigger': [90], 'activation': [92], 'damage': [96], 'response': [97, 231], 'pathway,': [98], 'ataxia-telangiectasia': [103], 'mutated': [104], '(ATM)': [105], 'phosphorylates': [106], 'multiple': [107], 'substrates,': [108], 'histone': [110], 'H2AX.': [111], 'Traditionally,': [112], 'research': [113], 'on': [114], 'NHEJ': [115, 136, 157], 'factors': [116, 137], 'was': [117], 'performed': [118], 'using': [119], 'vivo': [121], 'mouse': [122], 'models': [123], 'murine': [125], 'cells.': [126, 267], 'However,': [127], 'current': [129], 'knowledge': [130], 'genetic': [133, 189, 263], 'interactions': [134, 264], 'between': [135, 191], 'cells': [140, 237], 'incomplete.': [142], 'Here,': [143], 'we': [144, 186, 252], 'obtained': [145], 'genetically': [146, 212], 'modified': [147], 'HAP1': [149, 174, 236, 255], 'cell': [150], 'lines,': [151], 'lacked': [153], 'one': [154], 'two': [156], 'LIG4,': [160], 'XRCC4,': [161, 211, 225], 'XLF,': [162, 195, 206, 223], 'PAXX,': [163], 'DNA-PKcs,': [164, 222], 'DNA-PKcs/XRCC4,': [165], 'DNA-PKcs/PAXX.': [167], 'We': [168, 200], 'examined': [169], 'genomic': [171], 'instability': [172], 'cells,': [175, 205], 'as': [176, 178], 'well': [177], 'their': [179], 'sensitivity': [180], 'DSB-inducing': [182], 'agents.': [183], 'In': [184], 'addition,': [185], 'determined': [187], 'interaction': [190], 'paralogues': [193], '(XRCC4,': [194], 'PAXX)': [197], 'DNA-PKcs.': [199, 215], 'found': [201, 253], 'but': [207, 226], 'not': [208, 227], 'PAXX': [209, 229], 'interacts': [213], 'with': [214, 221, 228], 'Moreover,': [216], 'ATM': [217], 'possesses': [218], 'overlapping': [219], 'functions': [220], 'DSBs.': [233], 'Finally,': [234], 'NHEJ-deficient': [235], 'show': [238], 'increased': [239], 'chromosomal': [240], 'chromatid': [242], 'breaks,': [243], 'when': [244], 'compared': [245], 'WT': [248], 'parental': [249], 'control.': [250], 'Overall,': [251], 'a': [257], 'suitable': [258], 'model': [259], 'study': [261]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2947679604', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 4}], 'updated_date': '2024-12-17T03:11:21.082956', 'created_date': '2019-06-07'}