Publication Information

{'id': 'https://openalex.org/W2171672464', 'doi': 'https://doi.org/10.1021/bi0263558', 'title': 'The DNA-Dependent Protein Kinase Interacts with DNA To Form a Protein−DNA Complex That Is Disrupted by Phosphorylation', 'display_name': 'The DNA-Dependent Protein Kinase Interacts with DNA To Form a Protein−DNA Complex That Is Disrupted by Phosphorylation', 'publication_year': 2002, 'publication_date': '2002-09-25', 'ids': {'openalex': 'https://openalex.org/W2171672464', 'doi': 'https://doi.org/10.1021/bi0263558', 'mag': '2171672464', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12379113'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/bi0263558', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S104038378', 'display_name': 'Biochemistry', 'issn_l': '0006-2960', 'issn': ['0006-2960', '1520-4995', '1943-295X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5020583214', 'display_name': 'Dennis Merkle', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I168635309', 'display_name': 'University of Calgary', 'ror': 'https://ror.org/03yjb2x39', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I168635309']}, {'id': 'https://openalex.org/I2801317318', 'display_name': 'Hospital for Sick Children', 'ror': 'https://ror.org/057q4rt57', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801317318']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Dennis Merkle', 'raw_affiliation_strings': ['Department of Biochemistry & Molecular Biology, University of Calgary, 3300 Hospital Drive, Calgary AB, T2N 4N1, Canada, Departments of Biological Sciences and of Chemistry, University of Calgary, 2500 University Drive, N.W., Calgary AB, T2N 1N4, Canada, and Program in Cell Biology, Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry & Molecular Biology, University of Calgary, 3300 Hospital Drive, Calgary AB, T2N 4N1, Canada, Departments of Biological Sciences and of Chemistry, University of Calgary, 2500 University Drive, N.W., Calgary AB, T2N 1N4, Canada, and Program in Cell Biology, Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada', 'institution_ids': ['https://openalex.org/I168635309', 'https://openalex.org/I2801317318']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029706709', 'display_name': 'Pauline Douglas', 'orcid': 'https://orcid.org/0000-0001-6515-2310'}, 'institutions': [{'id': 'https://openalex.org/I168635309', 'display_name': 'University of Calgary', 'ror': 'https://ror.org/03yjb2x39', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I168635309']}, {'id': 'https://openalex.org/I2801317318', 'display_name': 'Hospital for Sick Children', 'ror': 'https://ror.org/057q4rt57', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801317318']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Pauline Douglas', 'raw_affiliation_strings': ['Department of Biochemistry & Molecular Biology, University of Calgary, 3300 Hospital Drive, Calgary AB, T2N 4N1, Canada, Departments of Biological Sciences and of Chemistry, University of Calgary, 2500 University Drive, N.W., Calgary AB, T2N 1N4, Canada, and Program in Cell Biology, Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry & Molecular Biology, University of Calgary, 3300 Hospital Drive, Calgary AB, T2N 4N1, Canada, Departments of Biological Sciences and of Chemistry, University of Calgary, 2500 University Drive, N.W., Calgary AB, T2N 1N4, Canada, and Program in Cell Biology, Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada', 'institution_ids': ['https://openalex.org/I168635309', 'https://openalex.org/I2801317318']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035368724', 'display_name': 'Greg B. G. Moorhead', 'orcid': 'https://orcid.org/0000-0003-3282-7590'}, 'institutions': [{'id': 'https://openalex.org/I168635309', 'display_name': 'University of Calgary', 'ror': 'https://ror.org/03yjb2x39', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I168635309']}, {'id': 'https://openalex.org/I2801317318', 'display_name': 'Hospital for Sick Children', 'ror': 'https://ror.org/057q4rt57', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801317318']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Greg B. G. Moorhead', 'raw_affiliation_strings': ['Department of Biochemistry & Molecular Biology, University of Calgary, 3300 Hospital Drive, Calgary AB, T2N 4N1, Canada, Departments of Biological Sciences and of Chemistry, University of Calgary, 2500 University Drive, N.W., Calgary AB, T2N 1N4, Canada, and Program in Cell Biology, Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry & Molecular Biology, University of Calgary, 3300 Hospital Drive, Calgary AB, T2N 4N1, Canada, Departments of Biological Sciences and of Chemistry, University of Calgary, 2500 University Drive, N.W., Calgary AB, T2N 1N4, Canada, and Program in Cell Biology, Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada', 'institution_ids': ['https://openalex.org/I168635309', 'https://openalex.org/I2801317318']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065551717', 'display_name': 'Zoya Leonenko', 'orcid': 'https://orcid.org/0000-0002-8674-7425'}, 'institutions': [{'id': 'https://openalex.org/I168635309', 'display_name': 'University of Calgary', 'ror': 'https://ror.org/03yjb2x39', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I168635309']}, {'id': 'https://openalex.org/I2801317318', 'display_name': 'Hospital for Sick Children', 'ror': 'https://ror.org/057q4rt57', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801317318']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Zoya Leonenko', 'raw_affiliation_strings': ['Department of Biochemistry & Molecular Biology, University of Calgary, 3300 Hospital Drive, Calgary AB, T2N 4N1, Canada, Departments of Biological Sciences and of Chemistry, University of Calgary, 2500 University Drive, N.W., Calgary AB, T2N 1N4, Canada, and Program in Cell Biology, Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry & Molecular Biology, University of Calgary, 3300 Hospital Drive, Calgary AB, T2N 4N1, Canada, Departments of Biological Sciences and of Chemistry, University of Calgary, 2500 University Drive, N.W., Calgary AB, T2N 1N4, Canada, and Program in Cell Biology, Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada', 'institution_ids': ['https://openalex.org/I168635309', 'https://openalex.org/I2801317318']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079162936', 'display_name': 'Yaping Yu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I168635309', 'display_name': 'University of Calgary', 'ror': 'https://ror.org/03yjb2x39', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I168635309']}, {'id': 'https://openalex.org/I2801317318', 'display_name': 'Hospital for Sick Children', 'ror': 'https://ror.org/057q4rt57', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801317318']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Yaping Yu', 'raw_affiliation_strings': ['Department of Biochemistry & Molecular Biology, University of Calgary, 3300 Hospital Drive, Calgary AB, T2N 4N1, Canada, Departments of Biological Sciences and of Chemistry, University of Calgary, 2500 University Drive, N.W., Calgary AB, T2N 1N4, Canada, and Program in Cell Biology, Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry & Molecular Biology, University of Calgary, 3300 Hospital Drive, Calgary AB, T2N 4N1, Canada, Departments of Biological Sciences and of Chemistry, University of Calgary, 2500 University Drive, N.W., Calgary AB, T2N 1N4, Canada, and Program in Cell Biology, Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada', 'institution_ids': ['https://openalex.org/I168635309', 'https://openalex.org/I2801317318']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021501097', 'display_name': 'David T. Cramb', 'orcid': 'https://orcid.org/0000-0003-2494-0091'}, 'institutions': [{'id': 'https://openalex.org/I168635309', 'display_name': 'University of Calgary', 'ror': 'https://ror.org/03yjb2x39', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I168635309']}, {'id': 'https://openalex.org/I2801317318', 'display_name': 'Hospital for Sick Children', 'ror': 'https://ror.org/057q4rt57', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801317318']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'David Cramb', 'raw_affiliation_strings': ['Department of Biochemistry & Molecular Biology, University of Calgary, 3300 Hospital Drive, Calgary AB, T2N 4N1, Canada, Departments of Biological Sciences and of Chemistry, University of Calgary, 2500 University Drive, N.W., Calgary AB, T2N 1N4, Canada, and Program in Cell Biology, Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry & Molecular Biology, University of Calgary, 3300 Hospital Drive, Calgary AB, T2N 4N1, Canada, Departments of Biological Sciences and of Chemistry, University of Calgary, 2500 University Drive, N.W., Calgary AB, T2N 1N4, Canada, and Program in Cell Biology, Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada', 'institution_ids': ['https://openalex.org/I168635309', 'https://openalex.org/I2801317318']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022101184', 'display_name': 'David P. Bazett‐Jones', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I168635309', 'display_name': 'University of Calgary', 'ror': 'https://ror.org/03yjb2x39', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I168635309']}, {'id': 'https://openalex.org/I2801317318', 'display_name': 'Hospital for Sick Children', 'ror': 'https://ror.org/057q4rt57', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801317318']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'David P. Bazett-Jones', 'raw_affiliation_strings': ['Department of Biochemistry & Molecular Biology, University of Calgary, 3300 Hospital Drive, Calgary AB, T2N 4N1, Canada, Departments of Biological Sciences and of Chemistry, University of Calgary, 2500 University Drive, N.W., Calgary AB, T2N 1N4, Canada, and Program in Cell Biology, Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry & Molecular Biology, University of Calgary, 3300 Hospital Drive, Calgary AB, T2N 4N1, Canada, Departments of Biological Sciences and of Chemistry, University of Calgary, 2500 University Drive, N.W., Calgary AB, T2N 1N4, Canada, and Program in Cell Biology, Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada', 'institution_ids': ['https://openalex.org/I168635309', 'https://openalex.org/I2801317318']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5035453779', 'display_name': 'Susan P. Lees‐Miller', 'orcid': 'https://orcid.org/0000-0001-5809-2516'}, 'institutions': [{'id': 'https://openalex.org/I168635309', 'display_name': 'University of Calgary', 'ror': 'https://ror.org/03yjb2x39', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I168635309']}, {'id': 'https://openalex.org/I2801317318', 'display_name': 'Hospital for Sick Children', 'ror': 'https://ror.org/057q4rt57', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801317318']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Susan P. Lees-Miller', 'raw_affiliation_strings': ['Department of Biochemistry & Molecular Biology, University of Calgary, 3300 Hospital Drive, Calgary AB, T2N 4N1, Canada, Departments of Biological Sciences and of Chemistry, University of Calgary, 2500 University Drive, N.W., Calgary AB, T2N 1N4, Canada, and Program in Cell Biology, Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry & Molecular Biology, University of Calgary, 3300 Hospital Drive, Calgary AB, T2N 4N1, Canada, Departments of Biological Sciences and of Chemistry, University of Calgary, 2500 University Drive, N.W., Calgary AB, T2N 1N4, Canada, and Program in Cell Biology, Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada', 'institution_ids': ['https://openalex.org/I168635309', 'https://openalex.org/I2801317318']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 5.421, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 149, 'citation_normalized_percentile': {'value': 0.999975, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '41', 'issue': '42', 'first_page': '12706', 'last_page': '12714'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10123', 'display_name': 'DNA Repair Mechanisms', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10123', 'display_name': 'DNA Repair Mechanisms', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10492', 'display_name': 'Microtubule and mitosis dynamics', 'score': 0.9965, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10432', 'display_name': 'DNA and Nucleic Acid Chemistry', 'score': 0.9856, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ku70', 'display_name': 'Ku70', 'score': 0.836045}, {'id': 'https://openalex.org/keywords/ku80', 'display_name': 'Ku80', 'score': 0.71381223}, {'id': 'https://openalex.org/keywords/dna-pkcs', 'display_name': 'DNA-PKcs', 'score': 0.6354213}, {'id': 'https://openalex.org/keywords/dna-polymerase-mu', 'display_name': 'DNA polymerase mu', 'score': 0.6230916}, {'id': 'https://openalex.org/keywords/dna-clamp', 'display_name': 'DNA clamp', 'score': 0.5855687}, {'id': 'https://openalex.org/keywords/ddb1', 'display_name': 'DDB1', 'score': 0.46599877}], 'concepts': [{'id': 'https://openalex.org/C2780919815', 'wikidata': 'https://www.wikidata.org/wiki/Q6440930', 'display_name': 'Ku70', 'level': 4, 'score': 0.836045}, {'id': 'https://openalex.org/C175114707', 'wikidata': 'https://www.wikidata.org/wiki/Q408483', 'display_name': 'DNA ligase', 'level': 3, 'score': 0.8359311}, {'id': 'https://openalex.org/C145803527', 'wikidata': 'https://www.wikidata.org/wiki/Q18032396', 'display_name': 'DNA repair protein XRCC4', 'level': 5, 'score': 0.76080805}, {'id': 'https://openalex.org/C193104389', 'wikidata': 'https://www.wikidata.org/wiki/Q18032397', 'display_name': 'Ku80', 'level': 5, 'score': 0.71381223}, {'id': 'https://openalex.org/C68748289', 'wikidata': 'https://www.wikidata.org/wiki/Q18030783', 'display_name': 'DNA-PKcs', 'level': 4, 'score': 0.6354213}, {'id': 'https://openalex.org/C116988904', 'wikidata': 'https://www.wikidata.org/wiki/Q18038809', 'display_name': 'DNA polymerase mu', 'level': 5, 'score': 0.6230916}, {'id': 'https://openalex.org/C150109051', 'wikidata': 'https://www.wikidata.org/wiki/Q3630494', 'display_name': 'Autophosphorylation', 'level': 4, 'score': 0.6026324}, {'id': 'https://openalex.org/C31254050', 'wikidata': 'https://www.wikidata.org/wiki/Q22328799', 'display_name': 'DNA clamp', 'level': 5, 'score': 0.5855687}, {'id': 'https://openalex.org/C134935766', 'wikidata': 'https://www.wikidata.org/wiki/Q210538', 'display_name': 'DNA repair', 'level': 3, 'score': 0.5333028}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5023756}, {'id': 'https://openalex.org/C140248907', 'wikidata': 'https://www.wikidata.org/wiki/Q17913449', 'display_name': 'DDB1', 'level': 5, 'score': 0.46599877}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.4428339}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.41900566}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.41566098}, {'id': 'https://openalex.org/C97029542', 'wikidata': 'https://www.wikidata.org/wiki/Q281417', 'display_name': 'Protein kinase A', 'level': 3, 'score': 0.3993147}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.37541237}, {'id': 'https://openalex.org/C58167604', 'wikidata': 'https://www.wikidata.org/wiki/Q5121654', 'display_name': 'Circular bacterial chromosome', 'level': 4, 'score': 0.33284366}, {'id': 'https://openalex.org/C185581394', 'wikidata': 'https://www.wikidata.org/wiki/Q145911', 'display_name': 'Base pair', 'level': 3, 'score': 0.29706192}, {'id': 'https://openalex.org/C11960822', 'wikidata': 'https://www.wikidata.org/wiki/Q242736', 'display_name': 'Phosphorylation', 'level': 2, 'score': 0.2295079}, {'id': 'https://openalex.org/C60748783', 'wikidata': 'https://www.wikidata.org/wiki/Q2984243', 'display_name': 'DNA mismatch repair', 'level': 4, 'score': 0.18799564}, {'id': 'https://openalex.org/C94966510', 'wikidata': 'https://www.wikidata.org/wiki/Q2252764', 'display_name': 'DNA-binding protein', 'level': 4, 'score': 0.1673013}, {'id': 'https://openalex.org/C134459356', 'wikidata': 'https://www.wikidata.org/wiki/Q4274835', 'display_name': 'Ubiquitin ligase', 'level': 4, 'score': 0.14043796}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.12144849}, {'id': 'https://openalex.org/C25602115', 'wikidata': 'https://www.wikidata.org/wiki/Q407111', 'display_name': 'Ubiquitin', 'level': 3, 'score': 0.09179875}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.05903074}, {'id': 'https://openalex.org/C156719811', 'wikidata': 'https://www.wikidata.org/wiki/Q28774', 'display_name': 'Reverse transcriptase', 'level': 4, 'score': 0.0}, {'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D034961', 'descriptor_name': 'Antigens, Nuclear', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D020134', 'descriptor_name': 'Catalytic Domain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D004249', 'descriptor_name': 'DNA Damage', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D004265', 'descriptor_name': 'DNA Helicases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D010957', 'descriptor_name': 'Plasmids', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein Serine-Threonine Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000255', 'descriptor_name': 'Adenosine Triphosphate', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000255', 'descriptor_name': 'Adenosine Triphosphate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000255', 'descriptor_name': 'Adenosine Triphosphate', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D051747', 'descriptor_name': 'DNA-Activated Protein Kinase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007089', 'descriptor_name': 'Image Enhancement', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000072200', 'descriptor_name': 'Ku Autoantigen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D046911', 'descriptor_name': 'Macromolecular Substances', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008854', 'descriptor_name': 'Microscopy, Electron', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D009690', 'descriptor_name': 'Nucleic Acid Conformation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010749', 'descriptor_name': 'Phosphoprotein Phosphatases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010749', 'descriptor_name': 'Phosphoprotein Phosphatases', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D010749', 'descriptor_name': 'Phosphoprotein Phosphatases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010957', 'descriptor_name': 'Plasmids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010957', 'descriptor_name': 'Plasmids', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D010957', 'descriptor_name': 'Plasmids', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': False}, {'descriptor_ui': 'D011257', 'descriptor_name': 'Pregnancy Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011257', 'descriptor_name': 'Pregnancy Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011257', 'descriptor_name': 'Pregnancy Proteins', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': False}, {'descriptor_ui': 'D011257', 'descriptor_name': 'Pregnancy Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D011257', 'descriptor_name': 'Pregnancy Proteins', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D054645', 'descriptor_name': 'Protein Phosphatase 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein Serine-Threonine Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein Serine-Threonine Kinases', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein Serine-Threonine Kinases', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': False}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein Serine-Threonine Kinases', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D013057', 'descriptor_name': 'Spectrum Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/bi0263558', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S104038378', 'display_name': 'Biochemistry', 'issn_l': '0006-2960', 'issn': ['0006-2960', '1520-4995', '1943-295X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12379113', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 11, 'referenced_works': ['https://openalex.org/W1516845708', 'https://openalex.org/W1989425995', 'https://openalex.org/W2003196136', 'https://openalex.org/W2023579322', 'https://openalex.org/W2033270381', 'https://openalex.org/W2042645510', 'https://openalex.org/W2067488984', 'https://openalex.org/W2075250295', 'https://openalex.org/W2148760839', 'https://openalex.org/W2166625995', 'https://openalex.org/W4233418242'], 'related_works': ['https://openalex.org/W2187303774', 'https://openalex.org/W2171672464', 'https://openalex.org/W2092920840', 'https://openalex.org/W2072671463', 'https://openalex.org/W2056001365', 'https://openalex.org/W2046572356', 'https://openalex.org/W2039921012', 'https://openalex.org/W2025447131', 'https://openalex.org/W1977976903', 'https://openalex.org/W1966254852'], 'abstract_inverted_index': {'DNA': [0, 22, 44, 99, 109, 122, 170, 184, 196, 237], 'double-strand': [1, 23, 123, 238], 'breaks': [2, 24], 'are': [3, 49, 102, 119], 'a': [4, 61, 67], 'serious': [5], 'threat': [6], 'to': [7, 82, 90, 172], 'genome': [8], 'stability': [9], 'and': [10, 32, 47, 66, 71, 98, 112, 142, 146, 165, 192, 245], 'cell': [11], 'viability.': [12], 'One': [13], 'of': [14, 21, 52, 60, 69, 84, 107, 117, 134, 152, 182, 188, 195, 208, 212, 229, 247], 'the': [15, 19, 38, 53, 78, 92, 108, 113, 131, 180, 193, 216, 243, 248], 'major': [16], 'pathways': [17], 'for': [18, 105, 121], 'repair': [20, 240], 'in': [25, 236], 'human': [26], 'cells': [27], 'is': [28, 58, 128], 'nonhomologous': [29, 54], 'end-joining.': [30], 'Biochemical': [31], 'genetic': [33], 'studies': [34], 'have': [35, 137], 'shown': [36, 139], 'that': [37, 77, 140, 147, 163, 177, 205, 227], 'DNA-dependent': [39], 'protein': [40, 94, 114, 153, 190, 217], 'kinase': [41, 95, 115, 154], '(DNA-PK),': [42], 'XRCC4,': [43], 'ligase': [45, 100], 'IV,': [46], 'Artemis': [48], 'essential': [50, 120], 'components': [51], 'end-joining': [55], 'pathway.': [56], 'DNA-PK': [57, 214, 230], 'composed': [59], 'large': [62, 174, 189], 'catalytic': [63, 220], 'subunit,': [64], 'DNA-PKcs,': [65], 'heterodimer': [68, 80], 'Ku70': [70], 'Ku80': [72], 'subunits.': [73], 'Current': [74], 'models': [75], 'predict': [76], 'Ku': [79, 143, 166], 'binds': [81], 'ends': [83], 'double-stranded': [85], 'DNA,': [86], 'then': [87], 'recruits': [88], 'DNA-PKcs': [89, 118, 141, 164], 'form': [91, 173], 'active': [93], 'complex.': [96, 250], 'XRCC4': [97], 'IV': [101], 'subsequently': [103], 'required': [104], 'ligation': [106], 'ends.': [110], 'Magnesium-ATP': [111], 'activity': [116], 'break': [124, 239], 'repair.': [125], 'However,': [126], 'little': [127], 'known': [129], 'about': [130], 'physiological': [132], 'targets': [133], 'DNA-PK.': [135, 209], 'We': [136, 225], 'previously': [138], 'undergo': [144], 'autophosphorylation,': [145], 'this': [148], 'correlates': [149], 'with': [150, 168, 198, 215], 'loss': [151], 'activity.': [155], 'Here': [156], 'we': [157], 'show,': [158], 'using': [159], 'electron': [160], 'spectroscopic': [161], 'imaging,': [162], 'interact': [167], 'multiple': [169, 183], 'molecules': [171], 'protein−DNA': [175], 'complexes': [176, 191], 'converge': [178], 'at': [179], 'base': [181], 'loops.': [185], 'The': [186], 'number': [187], 'amount': [194], 'associated': [197], 'them': [199], 'were': [200], 'dramatically': [201], 'reduced': [202], 'under': [203], 'conditions': [204], 'promote': [206], 'phosphorylation': [207], 'Moreover,': [210], 'treatment': [211], 'autophosphorylated': [213], 'phosphatase': [218], '1': [219], 'subunit': [221], 'restored': [222], 'complex': [223], 'formation.': [224], 'propose': [226], 'autophosphorylation': [228], 'plays': [231], 'an': [232], 'important': [233], 'regulatory': [234], 'role': [235], 'by': [241], 'regulating': [242], 'assembly': [244], 'disassembly': [246], 'DNA-PK−DNA': [249]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2171672464', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 8}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 8}, {'year': 2012, 'cited_by_count': 12}], 'updated_date': '2024-12-14T20:55:59.998251', 'created_date': '2016-06-24'}