Publication Information

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[6, 11, 17, 104, 170, 186, 191, 197, 284, 350], 'trimeric': [7, 187], 'enzyme': [8, 188], 'consisting': [9, 189], 'of': [10, 26, 39, 45, 115, 120, 139, 155, 173, 190, 206, 219, 225, 295, 300, 319, 335, 353], '460-kDa': [12, 192], 'catalytic': [13, 41, 193, 221], 'subunit': [14, 194], '(DNA-PKcs)': [15, 195], 'and': [16, 29, 51, 93, 150, 196, 209, 231, 273, 330], 'heterodimeric': [18, 198], 'regulatory': [19, 199], 'complex': [20, 200], 'called': [21, 201], 'Ku,': [22, 202], 'which': [23, 203], 'comprised': [25, 205], '70': [27, 207], '(Ku70)': [28, 208], '86': [30, 210], '(Ku80)': [31, 211], 'kDa': [32, 212], 'subunits.': [33, 213], 'Mutations': [34, 214], 'that': [35, 62, 69, 133, 145, 165, 215, 242, 249, 313, 325, 345], 'affect': [36, 216], 'the': [37, 40, 84, 110, 113, 116, 134, 147, 151, 156, 163, 174, 217, 220, 264, 290, 293, 296, 314, 327, 331, 336, 343, 354], 'expression': [38, 152, 218, 332], 'or': [42, 153, 222, 333], 'Ku80': [43, 223], 'subunits': [44, 224], 'DNA-PK': [46, 226], 'disrupt': [47, 227], 'both': [48, 119, 228, 299], 'V(D)J': [49, 229], 'recombination': [50, 230], 'DNA': [52, 73, 85, 98, 175, 232, 253, 265, 278, 355], 'double-stranded': [53, 74, 86, 97, 176, 233, 254, 266, 277, 356], 'break': [54, 75, 87, 177, 234, 255, 267, 357], 'repair': [55, 76, 88, 178, 235, 256, 268, 358], 'pathways.': [56, 236], 'In': [57, 107, 237, 287], 'this': [58, 238], 'report,': [59, 239], 'we': [60, 240], 'show': [61, 241], 'two': [63, 243], 'previously': [64, 244], 'uncharacterized': [65, 245], 'rodent': [66, 246], 'cell': [67, 90, 122, 141, 247, 270, 302, 321], 'lines': [68, 91, 123, 142, 248, 271, 303, 322], 'are': [70, 250], 'defective': [71, 251], 'in': [72, 252], 'express': [77, 257], 'catalytically': [78, 258], 'inactive': [79, 259], 'DNA-PK.': [80, 260], 'DNA-PKcs': [82, 117, 135, 262, 297, 315], 'from': [83, 118, 137, 263, 298, 317], 'mutant': [89, 269], 'IRS-20': [92, 272], 'SX-9': [94, 274], 'assembles': [95, 275], 'on': [96, 276], 'but': [99, 279], 'fails': [100, 280], 'to': [101, 109, 127, 281, 289, 307], 'function': [102, 282], 'as': [103, 283], 'kinase.': [106, 286], 'addition': [108, 288], 'defect,': [112, 292], 'abundance': [114, 294], 'these': [121, 140, 301, 320], 'reduced': [125, 305], 'relative': [126, 306], 'wild-type': [128, 308], 'controls.': [129, 309], 'These': [130, 159, 310, 339], 'results': [131, 311], 'suggest': [132, 312], 'gene': [136, 157, 316, 337], 'each': [138, 318], 'contains': [143, 323], 'mutations': [144, 324], 'inactivate': [146, 326], 'enzymatic': [148, 328], 'activity': [149, 329], 'stability': [154, 334], 'product.': [158, 338], 'data': [160, 340], 'further': [161, 341], 'strengthen': [162, 342], 'hypothesis': [164, 344], 'DNA-PK-mediated': [166, 346], 'phosphorylation': [168, 348], 'necessary': [171, 351], 'component': [172, 352], 'pathway.': [179, 359]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1977976903', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-14T07:18:19.017877', 'created_date': '2016-06-24'}