Apolipoprotein E Receptor 2 Interactions with the N-Methyl-D-aspartate Receptor

Name: Work Video:
Duration: 3 min 30 s
Hyang‐Sook Hoe; Ana Pocivavsek; Geetanjali Chakraborty; Zhanyan Fu; Stefano Vicini; Michael Ehlers; G. William Rebeck
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5536, 5542, 5558, 5574, 5593, 5609, 5623, 5636, 5647], 'activation': [16, 118, 196, 298, 520, 683, 2734], 'was': [17, 113, 197, 293, 689, 778, 1362, 1467, 1508, 1518, 1641, 1671, 1714, 1796, 1949, 2030, 2184, 2218, 2260, 2569, 2580, 2809, 2839, 2863, 2918, 2950, 3176, 3363, 4065, 4131, 4169, 4333, 4547, 4582, 4613, 5009, 5080], 'blocked': [18, 198, 690, 2128], 'by': [19, 115, 199, 295, 687, 691, 1510, 1520, 1643, 1798, 1813, 1872, 2152, 2236, 2248, 2303, 2313, 2571, 3047, 3228, 3580, 3982, 4030, 4036, 4092, 4094, 4361, 4378, 4396, 4422, 4549, 4616, 4824, 5143, 5175, 5290], 'with': [21, 93, 133, 174, 201, 273, 313, 354, 909, 1016, 1075, 1265, 1282, 1290, 1311, 1324, 1364, 1462, 1486, 1542, 1558, 1591, 1610, 1762, 1824, 1854, 2001, 2048, 2086, 2105, 2129, 2138, 2166, 2196, 2204, 2207, 2226, 2278, 2285, 2323, 2364, 2382, 2393, 2413, 2418, 2433, 2444, 2454, 2462, 2493, 2618, 2666, 2679, 2689, 2748, 2773, 2781, 2791, 2796, 2894, 2901, 2924, 2955, 2971, 2993, 3001, 3007, 3012, 3050, 3059, 3065, 3080, 3117, 3129, 3156, 3166, 3235, 3274, 3277, 3320, 3388, 3404, 3489, 3500, 3506, 3512, 3521, 3528, 3560, 3584, 3596, 3614, 3651, 3668, 3676, 3690, 3706, 3721, 3808, 3814, 3819, 3823, 3835, 3859, 3872, 3925, 3965, 4002, 4017, 4043, 4120, 4187, 4216, 4233, 4264, 4275, 4280, 4294, 4326, 4426, 4438, 4446, 4477, 4502, 4526, 4533, 4596, 4664, 4673, 4686, 4692, 4703, 4716, 4725, 4764, 4790, 4796, 5020, 5354, 5417, 5520, 5529, 5561], 'inhibitors': [22, 202, 1856, 1860], 'the': [24, 30, 46, 54, 58, 69, 83, 94, 127, 134, 204, 210, 226, 234, 238, 249, 263, 274, 307, 314, 472, 494, 577, 659, 695, 701, 856, 906, 913, 1047, 1051, 1057, 1082, 1277, 1291, 1312, 1370, 1407, 1468, 1570, 1616, 1681, 1715, 1803, 1825, 1869, 1991, 2040, 2087, 2090, 2505, 2508, 2539, 2547, 2557, 2560, 2565, 2584, 2589, 2602, 2605, 2609, 2614, 2621, 2774, 2789, 2803, 2842, 2865, 2899, 3063, 3069, 3092, 3102, 3106, 3119, 3124, 3220, 3243, 3253, 3278, 3297, 3302, 3328, 3368, 3389, 3504, 3513, 3529, 3542, 3569, 3575, 3585, 3597, 3608, 3715, 3763, 3774, 3785, 3797, 3829, 3839, 3855, 3881, 3910, 3934, 3948, 3968, 3988, 4055, 4068, 4095, 4137, 4146, 4154, 4172, 4175, 4188, 4197, 4234, 4285, 4295, 4319, 4327, 4356, 4411, 4420, 4485, 4490, 4493, 4541, 4556, 4560, 4574, 4577, 4585, 4633, 4640, 4659, 4704, 4717, 4732, 4743, 4760, 4772, 4786, 5012, 5028, 5176, 5203, 5212, 5229, 5232, 5236, 5244, 5247, 5279, 5291, 5360, 5381, 5426, 5495, 5500, 5516, 5548, 5553, 5559, 5570, 5579, 5599, 5644, 5652], 'low': [25, 47, 205, 227, 388, 473, 477, 484, 696, 858], 'density': [26, 48, 206, 228, 389, 474, 478, 485, 697, 859, 915, 1982], 'lipoprotein': [27, 49, 207, 229, 390, 475, 479, 486, 698, 860], 'receptor': [28, 33, 50, 117, 176, 208, 213, 230, 297, 356, 372, 489, 496, 699, 703, 861, 1049, 1627, 4360, 4661, 5134, 5161, 5170, 5207, 5308, 5607, 5621], 'family,': [29, 209, 700], 'N-methyl-d-aspartate': [31, 211, 377, 407], '(NMDA)': [32, 212], 'antagonist': [34, 214, 704, 4431], 'MK': [35, 215, 705, 2005, 4432, 4467], '801,': [36, 216, 706], 'calcium': [38, 218, 574, 708, 1343, 2740, 4806, 4826, 4939], 'channel': [39, 219, 579, 709], 'blockers.': [40, 220, 710], 'We': [41, 79, 123, 221, 259, 303, 711, 1285, 1327, 1440, 1480, 2889, 3055, 3306, 3325, 3646, 3678, 3788, 3804, 3906, 4103, 4300, 4408, 4496, 4510, 4537, 4554, 5165, 5584, 5614, 5626, 5638], 'hypothesized': [42, 222], 'an': [43, 66, 100, 120, 223, 246, 280, 300, 654, 692, 1524, 1632, 2437, 3133, 3213, 3364, 4517, 4677], 'interaction': [44, 67, 106, 224, 247, 286, 2862, 3134, 3214, 3298, 3775, 3856, 4412, 4487, 4518, 4542, 4634, 4679, 4787, 5353, 5517], 'between': [45, 68, 107, 225, 248, 287, 1165, 1335, 2559, 3135, 3215, 3299, 4355, 4413, 4519, 4543, 4635, 5130, 5591], 'family': [51, 231, 1153, 1171], 'members': [52, 232], 'NMDA': [55, 116, 140, 175, 235, 296, 320, 355, 578, 702, 766, 910, 999, 1048, 1266, 1283, 2015, 2037, 2737, 2749, 2775, 4359, 4381, 4428, 4470, 4494, 4503, 4665, 4757, 4775, 4809, 4942, 5133, 5206, 5294, 5307, 5521, 5594, 5606, 5620], 'receptor.': [56, 236, 4495], 'present': [59, 239, 1010, 3754], 'study,': [60, 240], 'confirmed': [62, 242, 1509, 1519, 2821, 3732, 4301], 'through': [63, 75, 243, 255, 576, 1071, 1305, 1318, 2501, 4676, 5310, 5323, 5394, 5419], 'co-immunoprecipitation': [64, 244, 2648], 'experiments': [65, 245, 2651, 2922, 2954, 3867, 3920, 4074, 4081], 'receptor,': [71, 251, 476, 487, 2776, 5237], 'ApoEr2,': [72, 252, 370, 1765, 3811, 3836, 3997, 4389], 'NMDAR1': [74, 254, 1288, 5348], 'their': [76, 256, 727, 1072, 1270, 5395, 5540], 'extracellular': [77, 257, 380, 660, 717, 1063, 1292, 2710, 3071, 3107, 3120, 3142, 3530, 3565, 4403, 4678, 5179, 5314, 5325, 5362, 5507], 'domains.': [78, 258, 3843], 'also': [80, 124, 260, 304, 525, 657, 712, 864, 1441, 1485, 3158, 3312, 3953, 4515, 4630, 4730, 5035, 5079, 5210, 5275, 5493], 'found': [81, 125, 261, 305, 713, 1079, 1302, 3326, 3647, 3701, 3893, 3946, 4464, 4498, 4657, 4971, 5010, 5201], 'PDZ1': [84, 264, 3663, 3716, 3798, 3825, 3830, 3912, 3929, 3949, 4177, 4192, 4198, 4365, 5370], 'domain': [85, 129, 265, 309, 1099, 1314, 2997, 3072, 3094, 3108, 3121, 3515, 3610, 3672, 3717, 3799, 3831, 3913, 3950, 4178, 4199, 4236, 4699, 4707, 4720, 5234, 5422, 5471], 'PSD95,': [87, 267, 1076, 1304, 1769, 3398, 3496, 3615, 4032, 4390, 4638, 4687, 5537], 'a': [88, 171, 268, 351, 416, 529, 1077, 1333, 1365, 1463, 1550, 1674, 1677, 1981, 2445, 2455, 2463, 2576, 2630, 2654, 2872, 2963, 2978, 3097, 3115, 3399, 3407, 3791, 4105, 4352, 4690, 4932, 5302, 5332, 5373, 5420, 5587], 'postsynaptic': [89, 269, 394, 914, 1083, 1177, 3400], 'scaffolding': [90, 270, 3401], 'protein,': [91, 271, 3402], 'interacted': [92, 132, 272, 312, 2772, 3000, 3403, 3595, 3613, 3675, 4501, 4663, 4672, 4685, 4702, 4715], 'C': [95, 275, 1073, 5427], 'terminus': [96, 276, 5428], 'ApoEr2': [98, 108, 121, 149, 158, 168, 278, 288, 301, 329, 338, 348, 863, 1280, 1295, 1316, 1336, 1361, 1398, 1447, 1689, 1755, 1795, 1828, 2167, 2686, 2770, 2782, 2794, 2878, 2908, 2934, 2949, 2991, 2999, 3008, 3074, 3161, 3191, 3218, 3238, 3247, 3249, 3259, 3269, 3271, 3291, 3314, 3338, 3340, 3345, 3357, 3372, 3384, 3405, 3493, 3517, 3533, 3552, 3562, 3612, 3621, 3659, 3707, 3722, 3736, 3766, 3821, 3860, 3873, 3885, 3887, 3900, 3902, 3916, 3926, 3938, 3940, 3956, 3958, 3966, 3977, 3986, 4003, 4027, 4044, 4051, 4063, 4088, 4122, 4130, 4152, 4164, 4168, 4357, 4363, 4375, 4414, 4439, 4453, 4478, 4500, 4520, 4534, 4544, 4597, 4636, 4662, 4671, 4684, 4701, 4737, 4755, 4765, 4778, 4789, 4973, 5008, 5131, 5215, 5305, 5318, 5335, 5345, 5365, 5415, 5473, 5481, 5492, 5498, 5514, 5519, 5592], 'via': [99, 279, 468, 4364, 4369, 4808, 4941, 5283, 5368], 'alternatively': [101, 281, 5029, 5475], 'spliced,': [102, 282, 5476], 'intracellular': [103, 283, 1065, 1313, 2705, 3093, 3514, 5233, 5312], 'exon.': [104, 284], 'This': [105, 285, 2638], 'PSD95': [110, 131, 143, 290, 311, 323, 917, 1085, 1166, 1330, 1461, 3386, 3510, 3544, 3559, 3594, 3649, 3666, 3674, 3683, 3704, 3712, 3747, 3770, 3792, 3824, 3833, 3844, 3858, 3876, 3896, 3911, 3928, 3952, 3963, 3975, 4005, 4037, 4099, 4127, 4176, 4183, 4189, 4201, 4204, 4214, 4238, 4266, 4283, 4317, 4349, 4373, 4416, 4455, 4476, 4522, 4531, 4546, 4595, 4709, 4729, 4763, 5367, 5382, 5393, 5418, 5483, 5489, 5512, 5645], 'in': [111, 154, 156, 291, 334, 336, 444, 528, 539, 748, 751, 762, 781, 790, 855, 868, 1011, 1014, 1081, 1369, 1539, 1549, 1563, 1577, 1597, 1605, 1673, 1773, 1791, 1806, 1834, 1997, 2024, 2039, 2053, 2089, 2110, 2172, 2232, 2326, 2377, 2389, 2423, 2479, 2504, 2524, 2556, 2601, 2702, 2841, 2851, 2871, 2882, 2905, 2920, 2940, 2952, 2984, 3179, 3242, 3288, 3367, 3406, 3739, 3755, 3784, 4067, 4072, 4133, 4153, 4171, 4257, 4338, 4449, 4505, 4523, 4528, 4651, 4667, 5011, 5037, 5088, 5146, 5149, 5157, 5163, 5566, 5596], 'modulated': [114, 294], 'ligand.': [122, 302], 'PDZ2': [128, 308, 3840, 4211, 4235, 4289, 4323, 5383], 'NR2A': [135, 315, 1730, 3349, 4217, 4229, 4296, 4306, 5021], 'NR2B': [137, 317, 1737, 3329, 4219, 4231, 4328, 4332], 'subunits': [138, 177, 318, 357, 1021, 1069, 3311, 3322, 3332, 3381, 4228, 4368, 4675, 4694, 4714, 4727, 5135, 5208], 'receptors.': [141, 321, 1284, 4407, 4810, 5295], 'Full-length': [142, 322, 1460, 2793, 4282], 'increased': [144, 324, 3267, 3334, 3898, 3954, 3983, 4029, 4091, 4592, 4615], 'cell': [145, 325, 1345, 1835, 2028, 2041, 2077, 2494, 2819, 3057, 3498, 3989, 3993, 4008, 4015, 4025, 4086, 4273, 5501], 'surface': [146, 326, 2200, 2309, 3994, 4009, 4026, 4087, 4110, 4163, 4206, 4744], 'levels': [147, 327, 2075, 2294, 2823, 3244, 3335, 3346, 3550, 3571, 3734, 3995, 4084, 4111, 4161, 4207, 4304, 4337, 4745], 'its': [151, 331, 1054, 1298, 1306, 1319, 3127, 5324, 5352, 5369, 5506, 5524], 'cleavage,': [152, 332], 'resulting': [153, 333], 'increases': [155, 335, 5494], 'secreted': [157, 337, 3246, 3268, 3337, 3369, 3884, 3899, 3937, 3955], 'C-terminal': [160, 340, 410, 728, 1366, 1446, 1464, 1487, 1829, 3025, 5397], 'fragments': [161, 341, 729, 1830], 'ApoEr2.': [163, 343, 1356, 3305, 3324, 3601, 3677, 3697, 3864, 3971, 4022, 4113, 4209, 4553, 4749], 'These': [164, 344, 453, 535, 951, 1257, 3293, 3375, 4345, 4481, 4625, 4768, 4792, 5544], 'suggest': [166, 346, 953, 1259, 1328, 3295, 3377, 4347, 4483, 4627, 4770], 'can': [169, 349, 961, 3382], 'form': [170, 350, 5018], 'multiprotein': [172, 352], 'complex': [173, 353, 4387], 'PSD95.': [179, 359, 4791], 'Apolipoprotein': [360], 'E': [361], '(apoE)': [362], '2The': [363], 'abbreviations': [364], 'used': [365, 1656], 'are:': [366], 'apoE,': [367, 5573], 'apolipoprotein': [368], 'E;': [369], '2;': [373], 'NMDA,': [374], 'N-methyl-d-aspartate;': [375], 'NR,': [376], 'receptor;': [378, 408], 'ERK,': [379], 'signal-regulated': [381, 661, 2711], 'kinase;': [382], 'LTP,': [383], 'long': [384, 774], 'term': [385, 775], 'potentiation;': [386], 'LRP,': [387], 'receptor-related': [391, 480], 'protein;': [392, 399], 'PSD,': [393], 'density;': [395], 'GFP,': [396], 'green': [397], 'fluorescent': [398], 'HA,': [400], 'hemagglutinin;': [401], 'FBS,': [402], 'fetal': [403, 1544], 'bovine': [404, 1545], 'serum;': [405], 'NMDAR,': [406], 'CTF,': [409], 'fragments.': [411], 'allows': [412], 'lipoproteins': [413, 463], 'to': [414, 421, 460, 694, 1050, 1151, 1569, 1620, 1819, 1956, 2033, 2124, 2156, 2186, 2220, 2262, 2361, 2485, 2507, 2536, 2546, 2562, 2582, 2587, 2699, 3042, 3096, 3987, 4108, 4402, 4648, 4754, 5017, 5140, 5151, 5241, 5246, 5321, 5375, 5380, 5491, 5513], 'introduce': [415], 'variety': [417, 530], 'lipophilic': [419], 'molecules': [420, 5560], 'cells': [422, 467, 1536, 1587, 1617, 1758, 1993, 2045, 2162, 2192, 2320, 2430, 2780, 2854, 3006, 3234, 3275, 3317, 3488, 3689, 3757, 3807, 3871, 3924, 4001, 4057, 4117, 4135, 4263], '(1Li': [423], 'Y.': [424, 1237, 1699, 5258], 'Cam': [425], 'J.': [426, 502, 503, 631, 672, 827, 883, 884, 939, 985, 1423, 1424, 1903, 2722, 2757, 3420, 3426, 3428, 3429, 3466, 4245, 4851, 4882, 4913, 4989, 4990, 5061, 5112, 5406, 5454], 'Bu': [427], 'G.': [428, 800, 1205, 3460, 4876, 5055, 5106, 5448], 'Mol.': [429, 736, 940, 986, 1112, 1133, 1702, 3202, 5187, 5261], 'Neurobiol.': [430], '2001;': [431, 1114, 1135, 1209, 1427, 4916], '23:': [432], '53-67Crossref': [433], 'PubMed': [434, 514, 569, 600, 617, 642, 677, 742, 817, 848, 895, 946, 992, 1039, 1122, 1143, 1193, 1217, 1252, 1435, 1708, 1914, 2727, 2762, 3208, 3440, 3476, 4250, 4840, 4856, 4892, 4924, 4964, 5001, 5071, 5122, 5193, 5267, 5411, 5464], 'Scopus': [435, 515, 570, 601, 618, 643, 678, 743, 818, 849, 896, 947, 993, 1040, 1123, 1144, 1218, 1253, 1436, 1709, 1915, 2728, 2763, 3209, 3441, 3477, 4841, 4857, 4893, 4925, 4965, 5002, 5072, 5123, 5194, 5268, 5465], '(118)': [436], 'Google': [437, 517, 572, 603, 620, 645, 680, 745, 820, 851, 898, 949, 995, 1042, 1125, 1146, 1194, 1220, 1255, 1438, 1711, 1917, 2730, 2765, 3211, 3443, 3479, 4251, 4843, 4859, 4895, 4927, 4967, 5004, 5074, 5125, 5196, 5270, 5412, 5467], 'Scholar).': [438, 518, 646, 681, 746, 852, 899, 950, 996, 1043, 1147, 1256, 1439, 1918, 2532, 2731, 2766, 3480, 4252, 4928, 4968, 5005, 5075, 5126, 5197, 5271, 5413, 5468], 'Cholesterol': [439], 'lipids': [441], 'are': [442, 464, 1002, 1059, 4794, 5155], 'essential': [443], 'remodeling': [445], 'neuronal': [446, 532, 540, 2887, 2937, 2986, 4457, 4805], 'membranes': [447], 'developing': [449], 'new': [450], 'growth': [451, 3148], 'terminals.': [452], 'processes': [454, 764], 'mediate': [455], 'synaptic': [456], 'plasticity': [457, 1223], 'responses': [459], 'neurodegeneration.': [461], 'ApoE-containing': [462], 'endocytosed': [465], 'into': [466, 4559, 4576], 'receptors,': [470, 723, 960, 1267, 5285], 'including': [471, 1631, 2289, 2708], 'protein': [481, 916, 1078, 1679, 2093, 3116, 3175, 5158], '(LRP1),': [482], 'very': [483, 857], 'type': [490], '2': [491, 1984, 2082, 2253, 2625], '(ApoEr2),': [492], 'LR11': [495], '(2Beffert': [497], 'U.': [498, 594, 873, 933, 979, 1695, 3446, 4862, 4958, 4979, 5041, 5092, 5254, 5434], 'Stolt': [499], 'P.C.': [500], 'Herz': [501, 882, 938, 984, 3427, 3465, 4881, 4988, 5060, 5111, 5453], 'Lipid': [504], 'Res.': [505, 735, 738, 844, 3201, 3204, 5186, 5189], '2004;': [506, 634, 814, 943, 989], '45:': [507], '403-409Abstract': [508], 'Full': [509, 511, 564, 566, 637, 639, 890, 892, 1117, 1119, 1138, 1140, 1212, 1214, 1430, 1432, 1909, 1911, 3435, 3437, 3471, 3473, 4887, 4889, 4919, 4921, 4996, 4998, 5066, 5068, 5117, 5119, 5459, 5461], 'Text': [510, 512, 565, 567, 638, 640, 891, 893, 1118, 1120, 1139, 1141, 1213, 1215, 1431, 1433, 1910, 1912, 3436, 3438, 3472, 3474, 4888, 4890, 4920, 4922, 4997, 4999, 5067, 5069, 5118, 5120, 5460, 5462], 'PDF': [513, 568, 641, 894, 1121, 1142, 1216, 1434, 1913, 3439, 3475, 4891, 4923, 5000, 5070, 5121, 5463], '(127)': [516], 'Ligand': [519], 'these': [522, 722, 3866, 3919, 4255, 4406, 5024, 5297, 5556], 'receptors': [523, 536, 761, 911, 1000, 1262, 2038, 2701, 2738, 2746, 2750, 4666, 4758, 4776, 4803, 4819, 4937, 4943, 5224, 5522, 5527, 5557, 5595], 'has': [524, 1086], 'been': [526, 1155], 'implicated': [527], 'signaling': [533, 763, 4822, 5282], 'processes.': [534], 'play': [537], 'roles': [538, 756], 'migration': [541], 'during': [542], 'development': [543, 1178], '(3Dulabon': [544], 'L.': [545, 1415], 'Olson': [546], 'E.C.': [547], 'Taglienti': [548], 'M.G.': [549], 'Eisenhuth': [550], 'S.': [551, 595, 1027, 3452, 4868, 4959, 5047, 5098, 5440], 'McGrath': [552], 'B.': [553], 'Walsh': [554], 'C.A.': [555], 'Kreidberg': [556], 'J.A.': [557, 3422], 'Anton': [558], 'E.S.': [559, 802], 'Neuron.': [560, 1208, 3467, 4883, 5062, 5113, 5455], '2000;': [561, 597, 1190, 3432, 4961], '27:': [562], '33-44Abstract': [563], '(505)': [571], 'Scholar),': [573, 621, 821, 1712], 'influx': [575, 4807, 4827, 4940], '(4Bacskai': [580, 4944], 'B.J.': [581, 4945], 'Xia': [582, 4946], 'M.Q.': [583, 4947], 'Strickland': [584, 1897, 4948], 'D.K.': [585, 1898, 4949], 'Rebeck': [586, 611, 629, 670, 732, 1700, 1901, 2720, 2755, 3198, 4834, 4849, 4950, 5183, 5259], 'G.W.': [587, 612, 630, 671, 733, 1701, 1902, 2721, 2756, 3199, 4835, 4850, 4951, 5184, 5260], 'Hyman': [588, 609, 627, 1899, 4832, 4952], 'B.T.': [589, 610, 628, 1900, 4833, 4953], 'Proc.': [590, 4954], 'Natl.': [591, 4955], 'Acad.': [592, 4956], 'Sci.': [593, 4957], 'A.': [596, 829, 921, 967, 1101, 3450, 4866, 4904, 4960, 5045, 5096, 5438], '97:': [598, 4962], '11551-11556Crossref': [599, 4963], '(172)': [602, 4966], 'Scholar,': [604, 1126, 1195, 3444, 4844, 4860, 4896], '5Qui': [605], 'Z.': [606, 626, 1896, 4829], 'Crutcher': [607, 4830], 'K.A.': [608, 4831], 'Neuroscience.': [613, 4836], '2003;': [614, 1036, 4837], '122:': [615, 4838], '291-303Crossref': [616, 4839], '(78)': [619, 4842], 'neurite': [623], 'outgrowth': [624], '(6Qui': [625], 'Biol.': [632, 885, 942, 988, 1425, 1704, 1904, 3430, 4914, 4991, 5263], 'Chem.': [633, 886, 1426, 1905, 3431, 4915, 4992], '279:': [635], '34948-34956Abstract': [636], '(85)': [644], 'Our': [647], 'work': [649, 5039, 5357], 'apoE-derived': [655, 1633, 4557], 'peptide': [656, 1639, 2628, 4558, 4590, 4620], 'kinase': [662, 1098, 2706, 2712, 4821], '(ERK': [664, 2714], '1/2)': [665, 2715], '(7Hoe': [666, 2716, 2751], 'H.S.': [667, 731, 1691, 2717, 2752, 3197, 4846, 5182, 5250], 'Harris': [668, 2718, 2753, 4847], 'D.C.': [669, 2719, 2754, 4848], 'Neurochem.': [673, 2723, 2758, 4852], '2005;': [674, 739, 845, 1705, 2724, 2759, 3205, 3468, 4853, 4884, 5063, 5114, 5190, 5264, 5456], '93:': [675, 2725, 2760, 4854], '145-155Crossref': [676, 2726, 2761, 4855], '(97)': [679, 2729, 2764, 4858], 'The': [682, 997, 1006, 1044, 1067, 1160, 1397, 1635, 2098, 2114, 2134, 2521, 2574, 3539, 3555, 3662, 3760, 3972, 4142, 4210, 4697, 4723, 5127, 5220, 5272], 'inhibitor': [693], 'promoted': [716, 3967, 4205, 5174], 'intramembranous': [719], 'cleavages': [720], 'affecting': [724, 1269, 3343, 4825, 5306], 'metabolism': [725, 5549], '(8Hoe': [730, 3196, 5181], 'Brain': [734, 737, 843, 1919, 2523, 3200, 3203, 5185, 5188], '137:': [740, 3206, 5191], '31-39Crossref': [741, 3207, 5192], '(81)': [744, 3210, 5195], 'Several': [747], 'vivo': [749, 5150], 'vitro': [752, 1998, 4529, 5147], 'have': [754, 865, 1154, 4647, 4815, 5200, 5300, 5387, 5585], 'supported': [755], 'for': [757, 1174, 1764, 1781, 1787, 1925, 2009, 2018, 2081, 2143, 2213, 2241, 2366, 2385, 2402, 2635, 2676, 3114, 3767, 4579, 4782, 5082, 5228, 5278, 5619, 5633, 5643, 5651], 'involving': [765], 'channels.': [767, 1005], 'ApoE': [768, 4384, 4589, 5526], 'targeted': [769], 'replacement': [770], 'mice': [771, 825, 1891, 5090], 'revealed': [772], 'potentiation': [776], '(LTP)': [777], 'significantly': [779, 4090, 4614], 'greater': [780, 3099, 4160], 'animals': [782], 'expressing': [783], 'mouse': [784, 1360, 1688, 1879, 2891, 4506], 'or': [786, 823, 1019, 1455, 1768, 2012, 2453, 3088, 3637, 3695, 3841, 4157, 4181, 4383, 4429, 4756, 4784, 5160], 'human': [787, 1533], 'apoE3': [788], 'than': [789, 3101], 'knock-out': [792], '(9Trommer': [793], 'B.L.': [794], 'Shah': [795], 'C.': [796, 833, 841, 875, 1197, 1413, 4981], 'Yun': [797], 'S.H.': [798], 'Gamkrelidze': [799], 'Pasternak': [801, 809], 'Ye': [803], 'G.L.': [804], 'Sotak': [805], 'M.': [806, 1203, 1207, 1225, 1229, 1235, 3414, 3416, 3462, 4240, 4244, 4878, 4902, 4912, 5057, 5108, 5401, 5405, 5450], 'Sullivan': [807, 834], 'P.M.': [808, 835], 'J.F.': [810], 'Ladu': [811], 'M.J.': [812], 'Neuroreport.': [813], '15:': [815], '2655-2658Crossref': [816], '(100)': [819], 'apoE2,': [822], 'apoE4': [824], '(10Grootendorst': [826], 'Bour': [828], 'Vogel': [830], 'E.': [831, 879, 1130, 1182, 4242, 4985, 5403], 'Kelche': [832], 'Dodart': [836], 'J.C.': [837], 'Bales': [838], 'K.': [839, 925, 971, 1025], 'Mathis': [840], 'Behav.': [842], '159:': [846], '1-14Crossref': [847], '(116)': [850], 'Mice': [853], 'deficient': [854], 'moderate': [866], 'defects': [867], 'LTP': [869, 963, 4975, 5084], '(11Weeber': [870, 4976], 'E.J.': [871, 937, 983, 3448, 4864, 4977, 5043, 5094, 5436], 'Beffert': [872, 932, 978, 1694, 4978, 5253, 5650], 'Jones': [874, 4980], 'Christian': [876, 4982], 'J.M.': [877, 4983], 'Forster': [878, 4984], 'Sweatt': [880, 934, 980, 3455, 4871, 4986, 5050, 5101, 5443], 'J.D.': [881, 927, 935, 973, 981, 3456, 4872, 4987, 5051, 5102, 5444], '2002;': [887, 1906, 4993], '277:': [888, 1907, 4994], '39944-39952Abstract': [889, 4995], '(513)': [897, 5003], 'Biochemical': [900], 'immunohistochemical': [902], 'LRP1': [907], 'interacts': [908, 1289, 1310, 1323, 3834, 5416], '(12May': [918, 964], 'P.': [919, 965, 1227, 2520], 'Rohlmann': [920, 966], 'Bock': [922, 968], 'H.H.': [923, 969], 'Zurhove': [924, 970], 'Marth': [926, 972], 'Schomburg': [928, 974], 'E.D.': [929, 975], 'Noebels': [930, 976], 'J.L.': [931, 977], 'Weeber': [936, 982, 3447, 4863, 5042, 5093, 5435], 'Cell': [941, 987, 1527, 1703, 1877, 2158, 2316, 3850, 4434, 5262], '24:': [944, 990], '8872-8883Crossref': [945, 991], '(171)': [948, 994], 'data': [952, 3294, 3376, 3726, 4346, 4482, 4769, 5298], 'LRP1,': [955], 'potentially': [957, 1268, 1341, 4688], 'other': [958, 2622, 5144], 'modulate': [962, 4632], 'heteromeric': [998], '(NMDAR)': [1001], 'ligand-gated': [1003], 'ion': [1004], 'NR1': [1007, 1724, 2797, 2826, 2850, 2880, 2902, 2910, 2917, 2943, 2968, 2982, 3081, 3130, 3174, 3186, 3216, 3236, 3266, 3300, 4674, 5322], 'subunit': [1008, 4297, 4329], 'is': [1009, 1172, 3131, 3776, 4417, 5341, 5424, 5474], 'all': [1012, 3086, 3180, 3740, 4339], 'NMDARs': [1013, 4392], 'combination': [1015], 'NR2': [1017, 1068, 3188, 3310, 3321, 3380, 4270, 4367, 4693, 4713, 4726, 5376, 5390], '(NR2A-NR2D)': [1018], 'NR3': [1020], '(13Wenthold': [1022], 'R.J.': [1023], 'Prybylowski': [1024], 'Standley': [1026], 'Sans': [1028], 'N.': [1029, 4898, 4900], 'Petralia': [1030], 'R.S.': [1031], 'Annu.': [1032], 'Rev.': [1033], 'Pharmacol.': [1034], 'Toxicol.': [1035], '43:': [1037], '335-358Crossref': [1038], '(293)': [1041], 'trafficking': [1045, 4735, 5159, 5349, 5541], 'synapse': [1052, 1058], 'location': [1055], 'within': [1056], 'dependent': [1060, 4418], 'on': [1061, 1972, 2118, 2238, 2244, 2436, 3356, 3976, 4419, 4489, 4938, 5027, 5499], 'various': [1062, 3379, 3875, 5530], 'interactions.': [1066, 5363], 'interact,': [1070], 'termini,': [1074], 'abundantly': [1080], 'density.': [1084], 'three': [1087, 1683, 2103, 2375], 'PDZ': [1088, 1308, 1321, 4706, 4719], 'domains,': [1089, 3577], 'one': [1090, 1096, 4124], 'Src': [1091], 'homology': [1092], '3': [1093, 4739, 5217], 'domain,': [1094, 1309, 1322, 5326, 5371], 'guanylate': [1097, 1158], '(14McGee': [1100], 'Dakoji': [1102], 'S.R.': [1103], 'Osen': [1104], 'O.': [1105], 'Bredt': [1106, 1187, 1474, 5642], 'D.S.': [1107, 1188], 'Lim': [1108], 'W.A.': [1109], 'Prehoda': [1110], 'K.E.': [1111], 'Cell.': [1113, 1134], '8:': [1115, 1136], '1291-1301Abstract': [1116], '(200)': [1124], '15Tavares': [1127], 'G.A.': [1128], 'Panepucci': [1129], 'Brunger': [1131], 'A.T.': [1132], '1313-1325Abstract': [1137], '(140)': [1145], 'Proteins': [1148, 1805, 1862, 3033], 'belong': [1150], 'this': [1152, 1170, 1273, 2861, 3223, 3483, 4644, 4654, 5038, 5077, 5338, 5470], 'termed': [1156], 'membrane-associated': [1157], 'kinases.': [1159], 'large': [1161], 'network': [1162], 'interactions': [1164, 1281, 3964, 4293, 4325, 4724, 5129, 5315], 'proteins': [1168, 1517, 2078, 2201, 2297, 2310, 2489, 2869, 3168, 3171, 3783, 4013, 5240, 5391], 'critical': [1173], 'regulation': [1175], '(16El-Husseini': [1179], 'A.E.': [1180], 'Schnell': [1181], 'Chetkovich': [1183], 'D.M.': [1184], 'Nicoll': [1185], 'R.A.': [1186], 'Science.': [1189], '290:': [1191], '1364-1368Crossref': [1192], '17Sala': [1196], 'Peich': [1198], 'V.': [1199], 'Wilson': [1200], 'N.R.': [1201], 'Passafaro': [1202], 'Liu': [1204], 'Shend': [1206], '31:': [1210], '115-130Abstract': [1211], '(581)': [1219], 'Scholar)': [1221], '(18Migaud': [1224], 'Charlesworth': [1226], 'Dempster': [1228], 'Webster': [1230], 'L.C.': [1231], 'Watabe': [1232], 'A.M.': [1233], 'Makhinson': [1234], 'He': [1236], 'Ramsay': [1238], 'M.F.': [1239, 3418], 'Morris': [1240], 'R.G.': [1241], 'Morrison': [1242], 'J.H.': [1243], "O'Dell": [1244], 'T.H.': [1245], 'Grant': [1246], 'S.G.': [1247], 'Nature.': [1248], '1998;': [1249], '396:': [1250], '433-439Crossref': [1251], '(971)': [1254], 'may': [1263, 4779, 5577], 'interact': [1264, 2747, 4042, 4232, 5528, 5564], 'activity.': [1271], 'work,': [1274, 4655], 'investigated': [1276], 'mechanisms': [1278, 5611], 'demonstrate': [1286], 'portion': [1293, 3599], 'affects': [1297, 3301, 5515], 'processing.': [1299, 3315, 3385, 3917, 5543], 'Furthermore,': [1300], 'first': [1307, 1682, 4705], 'and,': [1317], 'second': [1320, 4106, 4718], 'NMDAR2': [1325, 1338], 'subunits.': [1326], 'functions': [1331, 5087, 5554, 5571], 'as': [1332, 1892, 2608, 2682, 3045, 3578, 3592, 5534], 'link': [1334, 4354, 4691, 5374], 'subunits,': [1339, 5377], 'thus': [1340, 5287, 5351], 'modulating': [1342], 'influx,': [1344, 2741], 'LTP.': [1348], 'Vector': [1349], 'Construction—We': [1350], 'produced': [1351], 'several': [1352, 1443, 3618, 4126, 4813], 'deletion': [1353, 1483, 3009, 3680, 3691, 3793, 3877, 4286, 4320], 'constructs': [1354, 1399, 1444, 1763, 3010, 3018, 3029, 3490, 3545, 3619, 3681, 3692, 3748, 4038, 4267, 5346], 'Each': [1357], 'construct': [1358, 3041, 3103, 3111, 3628, 3635, 3644, 3713, 3794, 3802, 4190, 4287, 4321, 5646], 'generated': [1363, 1442, 1481, 3617, 3679, 3790, 5301], 'HA': [1367, 1870, 3586], 'tag': [1368, 1466], 'pcDNA': [1371], 'flux3': [1372], 'expression': [1373, 1513, 3540, 3573, 4303], 'vector:': [1374], '1)': [1375, 1490, 4291], 'residues': [1376, 1379, 1382, 1385, 1388, 1391, 1395, 1491, 1494, 1497, 1500], '1-214;': [1377], '2)': [1378, 1493], '215-401;': [1380], '3)': [1381, 1496], '402-614;': [1383], '4)': [1384, 1499, 3519], '615-842;': [1386], '5)': [1387, 1503, 3023], '1-614;': [1389], '6)': [1390], '1-826;': [1392], '7)': [1394, 3078], '1-842.': [1396], 'lacked': [1400], 'ligand': [1401, 1684, 2697, 3145], 'binding': [1402, 1685, 2698, 4362, 4397, 4751, 5490, 5510], 'repeats': [1403, 1686], '4-6': [1404], 'included': [1406], 'alternately': [1408], 'spliced': [1409, 5030], 'cytoplasmic': [1410, 3598, 3609, 4698, 5031, 5421], 'insert': [1411], '(19Brandes': [1412], 'Kahr': [1414], 'Stockinger': [1416, 3423], 'W.': [1417, 3424], 'Hiesberger': [1418], 'T.': [1419, 4908], 'Schneider': [1420], 'W.J.': [1421], 'Nimpf': [1422, 3425], '276:': [1428, 4917], '22160-22169Abstract': [1429], '(64)': [1437], 'containing': [1448, 1582, 1778, 1959, 2055, 2177, 3085, 3104, 3622, 3795, 4288, 4322], 'only': [1449, 1452, 3105, 3118, 3623, 3630, 3768, 3796, 4144], 'exon': [1450, 1453, 3624, 3631, 3652, 3656, 5032, 5078], '18,': [1451], '19,': [1454], 'exons': [1456, 3638], '18': [1457, 3625, 3639, 3657], '19.': [1459], 'GFP': [1465, 1488], 'kind': [1469, 1716], 'gift': [1470, 1717], 'Dr.': [1472, 1719, 1747, 5616, 5628, 5640, 5648], 'David': [1473, 5641], '(University': [1475], 'California,': [1477], 'San': [1478, 2529], 'Francisco).': [1479], 'five': [1482], 'constructs,': [1484, 3878, 4006, 4271], 'tags:': [1489], '337-2175;': [1492], '735-2175;': [1495], '1047-2175;': [1498], '1-336;': [1501], '1-2175': [1504], 'residues.': [1505], 'Recombinant': [1506], 'DNA': [1507], 'sequencing': [1511], 'correctly': [1515], 'sized': [1516], 'Western': [1521, 1799, 1873, 2814, 3048, 3581, 4602], 'blot': [1522, 1800, 2815, 3582], 'using': [1523, 1868, 2662, 2671, 4136], 'anti-GFP': [1525, 1662, 3507], 'antibody.': [1526, 1827, 2903, 5654], 'Lines': [1528], 'Culture': [1530], 'Conditions—COS7': [1531], 'embryonic': [1534, 1880, 1887, 2318, 4115], 'kidney': [1535, 2319, 4116], 'were': [1537, 1555, 1588, 1618, 1629, 1743, 1759, 1785, 1811, 1832, 1863, 1884, 1921, 1943, 1953, 1970, 1999, 2022, 2046, 2079, 2100, 2116, 2136, 2150, 2163, 2193, 2202, 2223, 2230, 2274, 2300, 2311, 2321, 2373, 2410, 2416, 2431, 2469, 2477, 2499, 2542, 2554, 2598, 2616, 2652, 2660, 2827, 3037, 3284, 3318, 3737, 3752, 4028, 4034, 4052, 4089, 4118, 4165, 4307, 4436, 4444], 'maintained': [1538, 1786], 'Opti-MEM': [1540, 1621], '(Invitrogen)': [1541, 1624], '10%': [1543, 1551, 1583, 1611, 1779, 2178], 'serum': [1546, 1961, 2187, 2926, 2957], '(FBS,': [1547], 'Invitrogen)': [1548], 'CO2': [1552], 'incubator.': [1553], 'Cells': [1554, 1784, 1952, 2021, 2229, 2372, 2415], 'transiently': [1556, 1760, 2164], 'transfected': [1557, 1590, 1761, 2165, 2778, 2852, 2906, 3004, 3486, 3756, 4056, 4119, 4261, 4450], '0.5-1': [1559, 1592], 'μg': [1560, 1593], 'plasmid': [1562, 1596], 'FuGENE': [1564, 1598], '6': [1565, 1599], '(Roche': [1566], 'Diagnostics)': [1567], 'according': [1568], "manufacturer's": [1571], 'protocol': [1572], 'cultured': [1574, 1602, 1772, 2169], '24': [1575, 1603, 1614, 1782, 1789, 2170, 2181, 2190], 'h': [1576, 1604, 1615, 1790, 2083, 2171, 2269, 2284], "Dulbecco's": [1578, 1606, 1774, 2173], 'modified': [1579, 1607, 1775, 2174], "Eagle's": [1580, 1608, 1776, 2175], 'medium': [1581, 1609, 1777, 1958, 2176, 2183], 'FBS.': [1584, 1612, 2179], 'For': [1585, 1988, 2072, 3865, 3918], 'co-transfections,': [1586], 'similarly': [1589, 3177], 'each': [1595, 3040, 3711, 4580], '(Roche)': [1600, 1857], 'After': [1613, 1931, 2180, 2189], 'transferred': [1619, 1818, 1955, 2122], 'serum-free': [1622, 1792], 'media': [1623, 1808], 'then': [1626, 1771, 1954, 2101, 2301, 2380, 3307, 3789, 3907, 4538], 'ligands': [1628, 4550, 4753, 5180], 'added,': [1630], 'peptide.': [1634], 'tandem': [1637], 'repeat': [1638], '(LRKLRKRLLLRKLRKRLL)': [1640], 'synthesized': [1642], 'Johns': [1644], 'Hopkins': [1645], 'University': [1646], 'Medicine': [1648], '(Biosynthesis': [1649], 'Sequencing': [1651], 'Facility,': [1652], 'Baltimore,': [1653], 'MD).': [1654], 'Antibodies—We': [1655], 'antibodies': [1657, 2088, 2139, 2149, 5622], 'anti-HA': [1658, 3051], '(Abcam),': [1659, 1661], 'anti-c-myc': [1660], '(Roche),': [1663], 'anti-FLAG': [1664], '(Sigma),': [1665], 'anti-PSD95': [1667], '(Abcam).': [1668], 'Antibody': [1669], '5810': [1670, 1826, 2895, 4138], 'raised': [1672, 3219], 'rabbit': [1675], 'against': [1676, 1723, 1732], 'recombinant': [1678], '(20Hoe': [1690, 5249], 'Wessner': [1692, 5251], 'D.': [1693, 5252], 'Becker': [1696, 5255], 'A.G.': [1697, 5256], 'Matsuoka': [1698, 5257], '25:': [1706, 5265], '9259-9268Crossref': [1707, 5266], '(101)': [1710, 5269], 'Uwe': [1720, 5649], 'Beffert.': [1721], 'Antibodies': [1722], '(monoclonal,': [1725, 1738], 'recognizing': [1726, 1739], 'amino': [1727, 1733, 1740, 5398], 'acids': [1728, 1734, 1741, 5399], '656-811),': [1729], '(polyclonal,': [1731], '934-1142),': [1735], '934-1457)': [1742], 'generous': [1744], 'gifts': [1745], 'Barry': [1748, 5617], 'Wolfe': [1749, 5618], 'at': [1750, 1928, 1980, 1994, 2084, 2140, 2210, 2270, 2369, 2405, 2604, 2629, 4335, 4584], 'Georgetown': [1751], 'University.': [1752], 'Quantification': [1753, 4078, 4600], 'Proteolytic': [1756], 'Fragments—COS7': [1757], 'NR1,': [1766, 2784, 2786, 2807, 3002, 3157], 'NR2,': [1767], 'FBS': [1780], 'h.': [1783, 2145], 'another': [1788], 'media.': [1793, 1804], 'Secreted': [1794], 'determined': [1797, 2681, 3046, 3579], 'analysis': [1801, 1989, 2663, 2816, 3583], 'from': [1802, 1886, 2358, 2471, 2511, 2935, 3039, 4014, 4456, 4604, 4812, 5243], 'conditioned': [1807], '(15': [1809], 'μl)': [1810], 'separated': [1812, 1864, 2117, 2302], '4-15%': [1814, 2119], 'polyacrylamide': [1815, 2120, 2304], 'gel': [1816, 2265, 2305], 'electrophoresis,': [1817, 2306], 'nitrocellulose': [1820, 2125], 'membranes,': [1821, 2126], 'probed': [1823, 2788, 2898, 2970, 3062, 3503, 3817, 4278, 4445], '(CTF)': [1831], 'measured': [1833, 2312, 3880, 3933], 'lysates': [1836, 2884, 2893, 3058, 3499, 3813, 4016, 4274, 4435, 4458, 4567], '(lysis': [1837], 'buffer:': [1838], '50': [1839, 1973, 2056, 2290], 'mm': [1840, 1845, 1852, 1941, 1964, 2057, 2062, 2291, 2329, 2332, 2335, 2338, 2341, 2344, 2347], 'Tris,': [1841], 'pH': [1842, 2362], '7.4,': [1843], '150': [1844, 2061], 'NaCl,': [1846, 2063, 2330], '0.25%': [1847], 'deoxycholate,': [1848], '1%': [1849, 2064], 'Nonidet-40,': [1850], '1': [1851, 1963, 2003, 2010, 2144, 2268, 2283, 2334, 2337, 2636, 3749, 4569], 'EDTA': [1853], 'protease': [1855, 2070], 'phosphatase': [1859, 2068], '(Sigma)).': [1861], 'electrophoretically': [1865, 2123], 'analyzed': [1867, 2661, 5142], 'antibody': [1871, 2325, 2384, 2401, 3587, 4139, 4143, 4440], 'blots.': [1874], 'Primary': [1875], 'Neuronal': [1876], 'Culture—Primary': [1878], 'cortical': [1881], 'neuron': [1882], 'cultures': [1883, 2938], 'prepared': [1885, 2478], 'day': [1888], '16': [1889], 'Swiss-Webster': [1890, 2474], 'previously': [1893, 5166], 'described': [1894], '(21Qiu': [1895], '14458-14466Abstract': [1908], '(68)': [1916], 'cortices': [1920], 'chopped': [1922], 'trypsinized': [1924], '10': [1926, 1995, 2019, 2354], 'min': [1927, 2243, 2368, 2404], '37': [1929], '°C.': [1930], 'trypsinization,': [1932], '0.4': [1933], 'μg/ml': [1934, 1974], 'trypsin': [1935], 'inhibitor,': [1936], '0.025%': [1937], 'DNase,': [1938], '12': [1940], 'MgSO4': [1942], 'added': [1944, 2219, 2261], 'mixed': [1946], 'until': [1947], 'tissue': [1948, 1977], 'thoroughly': [1950], 'homogenized.': [1951], 'Neurobasal': [1957], 'B27': [1960], 'supplement,': [1962], 'glutamine,': [1965], 'gentamycin,': [1966], 'Ara-C.': [1968], 'Neurons': [1969], 'seeded': [1971], 'poly-d-lysine-coated': [1975], '12-well': [1976], 'culture': [1978], 'plates': [1979], '×': [1985, 2251], '106': [1986], 'cells.': [1987, 2987, 3787], 'PSD95-ApoEr2,': [1992], 'days': [1996], 'treated': [2000], 'buffer,': [2002, 2026, 2234], 'μm': [2004, 2014, 2355, 2626], '801': [2006, 4468], '(in': [2007, 2016], 'Me2SO)': [2008], 'h,': [2011, 2182, 2191], '100': [2013], 'water)': [2017], 'min.': [2020, 2215], 'lysed': [2023, 2052], 'lysis': [2025, 2106, 2233, 2480], 'but': [2027, 3526, 3563, 3654, 3837, 4033], 'debris': [2029], 'not': [2031, 2483, 2810, 2856, 3053, 3132, 3154, 3163, 3257, 3262, 3527, 3547, 3564, 3589, 3655, 3719, 3727, 3777, 3838, 4041, 4076, 4150, 5330, 5425], 'centrifuged': [2032, 2484], 'prevent': [2034, 2486], 'loss': [2035, 2487], 'pellet.': [2042], 'Co-immunoprecipitations—Transfected': [2043], 'COS7': [2044, 2779, 2818, 2853, 3005, 3233, 3316, 3487, 3688, 3806, 3870, 3923, 4000, 4262, 4451], 'washed': [2047, 2102, 2194, 2224, 2275, 2374, 2388], 'phosphate-buffered': [2049, 2197], 'saline': [2050, 2619], 'buffer': [2054, 2107, 2280, 2288, 2481], 'Tris': [2058], '(pH': [2059], '8.0),': [2060], 'Nonidet': [2065], 'P-40,': [2066], 'inhibitors.': [2071], 'immunoprecipitations,': [2073], 'equal': [2074], 'incubated': [2080, 2137, 2240, 2267, 2282, 2322, 2381, 2392, 2890, 3056, 3497, 3812, 4272, 4437], '4°C': [2085], 'presence': [2091, 4096, 4173, 5177, 5204, 5292, 5496], 'G-Sepharose': [2094], 'beads': [2095], '(Amersham': [2096], 'Biosciences).': [2097], 'precipitates': [2099, 2790, 2900, 3064, 3505, 3818, 4279, 4443], 'times': [2104, 2277, 2376], 'resuspended': [2109], 'SDS': [2111], 'sample': [2112, 2287], 'buffer.': [2113], 'samples': [2115, 3181, 3741], 'gels,': [2121], '5%': [2130], 'nonfat': [2131], 'dry': [2132], 'milk.': [2133], 'blots': [2135, 3049, 4603], 'room': [2141, 2271, 2370, 2406], 'temperature': [2142], 'Horseradish': [2146], 'peroxidase-conjugated': [2147], 'secondary': [2148], 'visualized': [2151], 'chemiluminescence': [2153], 'exposed': [2155], 'film.': [2157], 'Surface': [2159, 3851, 4129], 'Protein': [2160], 'Labeling—COS7': [2161], 'changed': [2185], 'free.': [2188], 'twice': [2195, 2225], 'saline,': [2198], 'labeled': [2203, 4145], 'Sulfo-NHS-SS-biotin': [2205], '(Pierce)': [2206], 'gentle': [2208], 'shaking': [2209], '4': [2211, 2669, 3030, 5430], '°C': [2212], '30': [2214, 2242], 'Quenching': [2216], 'solution': [2217], 'cells,': [2221, 2907, 4452, 5597], 'which': [2222, 2996, 3605, 3671, 5378, 5538, 5562], 'Tris-buffered': [2227], 'saline.': [2228], 'collected': [2231, 4565], 'disrupted': [2235], 'sonication': [2237], 'ice,': [2239, 2245], 'clarified': [2247], 'centrifugation': [2249], '(10,000': [2250], 'g,': [2252], 'min).': [2254], 'To': [2255, 2533, 2767, 2858, 3481, 3602, 3991, 4253], 'isolate': [2256], 'biotin-labeled': [2257, 4007, 4012], 'proteins,': [2258, 4010, 5532], 'lysate': [2259], 'immobilized': [2263], 'NeutrAvidin®': [2264], 'temperature.': [2272, 2371, 2407], 'Gels': [2273], '5': [2276, 2331, 2340, 2343, 3112, 3751], 'wash': [2279], 'SDS-PAGE': [2286], 'dithiothreitol.': [2292], 'Equal': [2293], 'biotinylated': [2296], '(10-25': [2298], 'μg)': [2299], 'specific': [2308], 'immunoblotting.': [2314], 'Live': [2315], 'Staining—Human': [2317], 'primary': [2324, 2886, 2936, 2985, 4424], 'ECS': [2327, 2378], '(145': [2328], 'KCl,': [2333], 'MgCl2,': [2336], 'CaCl2,': [2339], 'HEPES,': [2342], 'glucose,': [2345], '15': [2346], 'sucrose,': [2348], '0.25': [2349], 'mg/liter': [2350], 'phenol': [2351], 'red,': [2352], 'd-serine': [2356], '(all': [2357], 'Sigma),': [2359], 'adjusted': [2360], '7.4': [2363], 'NaOH)': [2365], '8': [2367, 2386, 2403], 'anti-ApoEr2': [2383, 2848, 5653], 'min,': [2387], 'ECS,': [2390], 'Alexa': [2394], 'Fluor': [2395], '555': [2396], '(Molecular': [2397], 'Probes)': [2398], 'goat': [2399], 'anti-rabbit': [2400], 'Final': [2408], 'washes': [2409], 'carried': [2411], 'out': [2412], 'ECS.': [2414], 'fixed': [2417], '4%': [2419], 'paraformaldehyde': [2420], 'mounted': [2422], 'GVA': [2424], 'mount': [2425], '(Zymed': [2426], 'Laboratories': [2427], 'Inc.).': [2428], 'Stained': [2429], 'viewed': [2432], 'imaged': [2435], 'Axioskop': [2438], 'FS': [2439], 'microscope': [2440], '(Zeiss,': [2441], 'Germany)': [2442], 'equipped': [2443, 2461], '×63,': [2446], '0.9': [2447], 'NA,': [2448], 'Achroplan': [2449], 'water': [2450], 'immersion': [2451], 'objective': [2452], 'Nikon': [2456], 'E600': [2457], 'microscipe': [2458], '(Nikon,': [2459], 'Japan)': [2460], '×60,': [2464], '1.0': [2465], 'NA.': [2466], 'Mouse': [2467], 'Brains—Brains': [2468], 'isolated': [2470, 4011], '3-month-old': [2472], 'male': [2473], 'mice.': [2475], 'Lysates': [2476], 'preferentially': [2491], 'remained': [2492], 'densities.': [2495], 'Osmotic': [2496, 2592], 'Infusion—Guide': [2497], 'cannula': [2498, 2541, 2561, 2585, 4575], 'inserted': [2500], 'holes': [2502], 'drilled': [2503], 'skull': [2506, 2558], 'following': [2509], 'coordinates': [2510], 'bregma:': [2512], 'AP,': [2513], '-3.8;': [2514], 'ML,': [2515], '-2.2;': [2516], 'DV,': [2517], '-2.6': [2518], '(22Watson': [2519], 'Rat': [2522], 'Stereotaxic': [2525], 'Coordinates.': [2526], 'Academic': [2527], 'Press,': [2528], 'Diego,': [2530], 'CA1998Google': [2531], 'minimize': [2534], 'damage': [2535], 'target': [2537], 'structures,': [2538], 'guide': [2540], 'aimed': [2543], '1-mm': [2544], 'dorsal': [2545, 4562], 'intended': [2548], 'site': [2549], 'infusion.': [2551], 'Three': [2552], 'screws': [2553], 'anchored': [2555], 'help': [2563], 'anchor': [2564], 'protective': [2566], 'cap': [2567], 'formed': [2570], 'cranioplastic': [2572], 'cement.': [2573], 'cement,': [2575], 'two-part': [2577], 'acrylic-based': [2578], 'medium,': [2579], 'applied': [2581], 'secure': [2583], 'cover': [2588], 'incision': [2590], 'area.': [2591], 'minipumps': [2593], '(200': [2594], 'μl,': [2595], 'Alzet': [2596], '2001)': [2597], 'subcutaneously': [2599], 'implanted': [2600], 'rats': [2603, 2615], 'same': [2606, 3786], 'time': [2607, 4586], 'cannulation': [2610], 'procedure.': [2611], 'Half': [2612], 'infused': [2617, 4555], 'half': [2623], 'received': [2624], 'rate': [2631], '∼1': [2633], 'μl/h': [2634], 'week.': [2637, 4570], 'approach': [2639, 4107], 'delivered': [2640], 'approximately': [2641], '336': [2642], 'pmoles': [2643], 'apoE.': [2645, 5551], 'Statistical': [2646], 'Analyses—All': [2647], 'immunoblot': [2650], 'repeated': [2653], 'minimum': [2655], 'four': [2657, 3890, 3943], 'times.': [2658], 'Data': [2659], 'variance': [2665], 'Graphpad': [2667], 'Prism': [2668], 'software,': [2670], "Tukey's": [2672], 'Multiple': [2673], 'Comparison': [2674], 'test': [2675, 2768, 2859, 3482, 4254], 'post-hoc': [2677], 'analyses': [2678], 'significance': [2680], 'p': [2683], '<': [2684, 4101, 4623], '0.05.': [2685], 'Directly': [2687], 'Interacts': [2688, 2992, 3387, 3667, 4215], 'NMDAR1—In': [2690], 'altered': [2704, 3227, 4395, 4548, 4759], 'activation,': [2707], 'activating': [2709], 'required': [2735], 'active': [2736], 'suggesting': [2742], 'some': [2744, 5344, 5478, 5485], 'whether': [2769, 2860, 2876, 3309, 3854, 3909, 4410, 4512, 4540, 5153], 'directly': [2771, 5604], 'immunoprecipitated': [2785, 2967, 3705], 'anti-HA.': [2792, 3066, 3820], 'co-precipitated': [2795, 2849, 2881, 3079, 3095, 3511, 3650, 3822, 4459, 4532], '(Fig.': [2798, 2831, 2912, 2927, 2944, 2958, 2973, 3016, 3027, 3082, 3182, 3281, 3347, 3359, 3373, 3508, 3553, 3626, 3633, 3642, 3660, 3684, 3708, 3723, 3742, 3758, 3800, 3826, 3904, 3960, 4045, 4058, 4140, 4298, 4311, 4330, 4341, 4460, 4479, 4508, 4535, 4598, 4680, 4695, 4710, 4721, 4766, 5316, 5429], '1A,': [2799, 2832], 'upper': [2800], 'panel).': [2801, 2834, 3185, 4061, 4194, 4314, 4344], 'absence': [2804, 2843, 4069], 'co-expressed': [2806], 'co-precipitation': [2808, 2838, 3128, 3557, 3764, 4474, 4593, 4612, 4761], 'observed': [2811, 2840, 4066, 4166], '(lane': [2812], '3).': [2813, 3538, 3645], 'extracts': [2820], 'total': [2825, 3289, 3344, 3549, 4049], 'consistent': [2828, 4795], 'across': [2829, 4309], 'transfections': [2830, 4310, 4340], 'lower': [2833, 3184, 3744, 4060, 4313], 'As': [2835, 2904, 2962, 3698, 3729, 4448], 'controls,': [2836, 3730], 'no': [2837, 3285], 'precipitating': [2845], 'antibody,': [2846], '(data': [2855, 3052, 3261, 3588, 4075], 'shown).': [2857, 3054, 3263, 3590, 3728, 4077], 'merely': [2864], 'result': [2866], 'overexpressed': [2868, 3167], 'interacting': [2870], 'cell,': [2873], 'examined': [2875, 3670, 4409], 'native': [2877], 'brain': [2883, 2892, 4507, 4566, 4581], 'cultures.': [2888], '(α-ApoEr2),': [2896], 'co-immunoprecipitated': [2911, 3412], '1B,': [2913, 2928], 'lane': [2914, 2929, 2946, 2960, 2975], '2).': [2915, 2947], 'No': [2916, 2948, 4062], 'detected': [2919, 2951, 4132], 'control': [2921, 2953, 3279], 'performed': [2923], 'nonimmune': [2925, 2956], '1).': [2930, 2961, 4509], 'Similarly,': [2931, 4315], 'immunoprecipitation': [2932], 'resulted': [2939], 'precipitation': [2941], '1C,': [2945, 2959, 2974], 'positive': [2964], 'control,': [2965], 'anti-NR1': [2972, 3060], '3),': [2976], 'demonstrating': [2977], 'strong': [2979, 3556], 'band': [2980], 'immunoreactivity': [2983], 'Extracellular': [2988], 'Domain': [2989, 3391, 3664, 4212], 'NR1—To': [2994], 'determine': [2995, 5152], 'created': [3011], 'different': [3013, 3543], 'N-terminal': [3014], 'deletions': [3015, 3026], '2A,': [3017, 3028], '1,': [3019, 3535], '2,': [3020, 3536], '3,': [3021], '6).': [3032, 5219], 'expected': [3035], 'sizes': [3036], 'expressed': [3038, 3178, 4170, 4334], 'similar': [3043, 3738, 4053, 4308, 4336], 'levels,': [3044], 'Constructs': [3067, 3084], 'possessing': [3068], 'full': [3070], '(5,': [3075], '6,': [3076], '2B).': [3083], '(7)': [3087], 'most': [3089], '(6)': [3090], 'much': [3098], 'extent': [3100], '(5).': [3109], 'Importantly,': [3110], 'encoded': [3113], 'without': [3123, 3342], 'transmembrane': [3125, 3137], 'domain;': [3126], 'two': [3136, 3782, 4668], 'proteins.': [3138], 'Expression': [3139], 'individual': [3141, 3576], 'domains': [3143, 3531, 3566, 4404], '(the': [3144], 'binding,': [3146], 'epidermal': [3147], 'factor,': [3149], 'O-linked': [3151], 'domains),': [3152], 'did': [3153, 3162, 3256, 3546, 3718], 'immunoprecipitate': [3155], 'confirming': [3159], 'co-precipitate': [3164, 3720], 'nonspecifically': [3165], '(including': [3169], 'membrane': [3170, 4148, 5245], '(construct': [3172, 3518, 3524, 3930, 4290], '4)).': [3173], '2B,': [3183], 'Subunits': [3189], 'Affect': [3190], 'Processing—ApoEr2': [3192], 'undergoes': [3193], 'regulated': [3194], 'proteolysis': [3195, 3224, 3260], 'Scholar);': [3212], 'possibility': [3221, 5600], 'could': [3225, 3979, 4350, 4393, 4514, 4631, 5172, 5209, 5225, 5274, 5319, 5329], 'be': [3226, 3980, 4351, 4394, 4649, 4780, 5141, 5173, 5226, 5276, 5288], 'NR1.': [3229], 'Thus,': [3230, 3591, 3828, 3962, 4195, 5509], 'co-transfected': [3232, 3276, 3319, 3687, 3805, 3869, 3922, 3999], 'assessed': [3240], 'changes': [3241, 3287, 5156], 'CTF.': [3250, 3888, 3941], 'Transfection': [3251], 'vector': [3254, 3280], 'alone': [3255, 3914], 'alter': [3258, 3383, 5547], 'Co-expression': [3264], 'CTF': [3272, 3341, 3903, 3959], 'compared': [3273, 4186], '3A).': [3282], 'There': [3283], 'obvious': [3286], 'cellular': [3290], 'levels.': [3292], 'processing': [3303, 3358, 3862, 4733, 5171], 'asked': [3308, 3908, 4539], 'affected': [3313, 3861, 3915, 4731, 4974], 'NR2D': [3331], 'strongly': [3333, 3753, 3897], '3B).': [3348, 3374], 'NR2C': [3351], 'had': [3352, 4497], 'relatively': [3353], 'minor': [3354], 'effects': [3355, 3973], '3B),': [3360], 'although': [3361, 4639, 5327], 'there': [3362, 5154], 'apparent': [3365], 'decrease': [3366], 'forms': [3370, 5479, 5486], 'Cytoplasmic': [3390], 'ApoEr2—A': [3393], 'recent': [3394], 'study': [3395, 4930], 'yeast': [3408, 4222], 'two-hybrid': [3409, 4223], 'system': [3410, 4224], '(23Gotthardt': [3413], 'Trommsdorff': [3415], 'Nevitt': [3417], 'Shelton': [3419], 'Richardson': [3421], '275:': [3433], '25616-25624Abstract': [3434], '(398)': [3442], '24Beffert': [3445, 4861, 5433], 'Durudas': [3449, 4865, 5044, 5095, 5437], 'Qiu': [3451, 4867, 5046, 5097, 5439], 'Masiulis': [3453, 4869, 5048, 5099, 5441], 'I.': [3454, 4870, 5049, 5100, 5442], 'Li': [3457, 4873, 5052, 5103, 5445], 'W.P.': [3458, 4874, 5053, 5104, 5446], 'Adelmann': [3459, 4875, 5054, 5105, 5447], 'Frotscher': [3461, 4877, 5056, 5107, 5449], 'Hammer': [3463, 4879, 5058, 5109, 5451], 'R.E.': [3464, 4880, 5059, 5110, 5452], '47:': [3469, 4885, 5064, 5115, 5457], '567-579Abstract': [3470, 4886, 5065, 5116, 5458], '(377)': [3478, 4894, 5073, 5124, 5466], 'finding,': [3484], 'HA-tagged': [3492], 'GFP-tagged': [3495, 4265], 'anti-HA,': [3501], '4A).': [3509, 3554], 'full-length': [3522, 3561, 3696, 3703, 3769, 3895, 4031, 4098, 4121, 4182, 4203, 4316], 'ApoErR2': [3523], '7),': [3525], '(constructs': [3534, 3693], 'affect': [3548, 4804, 4820, 5347, 5539, 5578, 5605], 'occurred': [3567], 'despite': [3568], 'higher': [3570], 'hypothesized,': [3593], 'further': [3603, 5356], 'define': [3604, 5331], 'part': [3606], '4B,': [3627, 3634, 3643], '1),': [3629], '19': [3632, 3641, 3653], '2),': [3636, 4681], '4C).': [3661], 'ApoEr2—We': [3669, 3852], '5A),': [3685], '1-3)': [3694], 'expected,': [3699], '5B).': [3709], 'However,': [3710, 5414], 'lacking': [3714, 4191], '5B': [3724], '5B,': [3743], 'panel),': [3745], '5C).': [3759], 'specificity': [3761], 'again': [3771], 'demonstrated': [3772, 4082, 4609, 4800, 4816, 5388, 5586], 'because': [3778], 'overexpression': [3780], '5A,': [3801], '4).': [3803, 4696], 'PDZ1-GFP': [3809], 'anti-GFP,': [3815], '5D).': [3827], 'PDZ3': [3842], 'Increases': [3845], 'Processing': [3846], 'Levels': [3848, 4023, 4047], 'tested': [3853, 4511], 'amount': [3882, 3935], 'experiments,': [3891, 3944], '6A).': [3905], '4),': [3931], '6B).': [3961], 'cleavage': [3969, 3978, 4747, 5213, 5221, 5273, 5504], 'explained': [3981], 'movement': [3984], 'surface.': [3990], 'measure': [3992], 'avidin': [4018], 'beads,': [4019], 'immunoblotted': [4021], 'unaffected': [4035], 'do': [4040, 5487], '6C).': [4046], 'cell-associated': [4050], 'among': [4054], '6C,': [4059], 'signal': [4064], 'biotinylation': [4071], 'multiple': [4073, 4080], '210%': [4093], '(p': [4100, 4622], '0.05).': [4102], 'took': [4104], 'measuring': [4109], 'Human': [4114], 'constructs.': [4128], 'live': [4134], '6D).': [4141], 'plasma': [4147], 'internal': [4151], 'endoplasmic': [4155], 'reticulum': [4156], 'Golgi.': [4158], 'Visibly': [4159], 'when': [4167], '(top': [4179], 'panel)': [4180, 4185], '(bottom': [4184], '(middle': [4193], 'again,': [4196], 'Subunits—': [4220], 'A': [4221], 'NMDAR': [4227, 4421, 4430], '(25Niethammer': [4239, 5400], 'Kim': [4241, 5402], 'Sheng': [4243, 5404], 'Neurosci.': [4246, 5407], '1996;': [4247, 5408], '16:': [4248, 5409], '2157-2163Crossref': [4249, 5410], 'findings': [4256, 4626], 'system,': [4259], 'FLAG-tagged': [4269], 'anti-FLAG,': [4276], 'anti-GFP.': [4281], '7A).': [4299], '7A,': [4312], '7B).': [4331], '7B,': [4342], 'bottom': [4343], 'structural': [4353], 'PDZ2.': [4370], 'Co-precipitation': [4371], 'Is': [4376], 'Affected': [4377], 'Activation': [4379], 'Receptors': [4382], 'Receptors—The': [4385], 'potential': [4386, 5361], 'agonists': [4399], 'antagonists': [4401], 'treating': [4423], 'agonist': [4427], '801.': [4433], '5810,': [4441], 'anti-PSD95.': [4447], '8A).': [4461, 4480, 4536], 'Surprisingly,': [4462], 'both': [4466, 5311], 'treatments': [4471], 'markedly': [4472], 'reduced': [4473], 'PSD95-ApoEr2': [4486], 'depends': [4488], 'activity': [4491, 5608], 'R1': [4504], 'observe': [4516], 'vivo.': [4524, 4652], 'Consistent': [4525], 'studies,': [4530], 'bind': [4552, 5320, 5379, 5392, 5482], 'rat': [4561, 4607], 'hippocampus': [4563, 4578], 'after': [4568, 4618], 'Correct': [4571], 'insertion': [4572], 'noted': [4583], 'dissection.': [4588], '8B).': [4599], 'peptide-infused': [4606], 'brains': [4608], 'ApoEr2/PSD95': [4611], '103%': [4617], '0.01).': [4624], 'precise': [4641], 'mechanism': [4642], 'finding': [4645], 'will': [4646, 5138, 5358], 'explored': [4650], 'ways:': [4669], 'first,': [4670], 'second,': [4683], 'forming': [4689, 5372], '5),': [4711], 'whereas': [4712], '7).': [4722], '(Figs.': [4738, 5216], '6),': [4741], 'increasing': [4742], 'Finally,': [4750], '8).': [4767], 'conformations': [4773], 'important': [4781, 5081, 5227, 5277], 'promoting': [4783, 5503], 'inhibiting': [4785], 'results': [4793], 'numerous': [4797], 'Studies': [4811], 'groups': [4814], 'cascades': [4823], '(5Qui': [4828], '7Hoe': [4845], '26Ohkubo': [4897], 'Mitsuda': [4899], 'Tamatani': [4901], 'Yamaguchi': [4903], 'Lee': [4905], 'Y.D.': [4906], 'Ogihara': [4907], 'Vitek': [4909], 'M.P.': [4910], 'Tohyama': [4911], '3046-3053Abstract': [4918], '(82)': [4926], 'Another': [4929], 'direct': [4933], 'effect': [4934], 'Other': [4969], 'Most': [5006], 'recently,': [5007], 'post-synaptic': [5013], 'densities,': [5014], 'shown': [5016], 'complexes': [5019, 5025], 'PSD95;': [5023], 'depended': [5026], 'identified': [5036], '(24Beffert': [5040, 5091], 'Interestingly,': [5076, 5469], 'proper': [5083], 'memory': [5086], 'transgenic': [5089], 'physical': [5128, 5589], 'reported': [5136, 5167], 'here': [5137], 'need': [5139], 'techniques': [5145], 'localization': [5162], 'synapses.': [5164], 'Here': [5198], 'promote': [5211], 'release': [5230], 'allowing': [5238], 'associated': [5239], 'move': [5242], 'cytoplasm': [5248], 'cessation': [5280], 'influenced': [5289], 'From': [5296], 'model': [5303], 'function': [5309], '9).': [5317], 'subdomain': [5333], 'mediated': [5337], 'interaction.': [5339], 'It': [5340], 'possible': [5342], 'ApoEr2;': [5355], 'explore': [5359], 'Intracellularly,': [5364], 'binds': [5366], 'domain.': [5384, 5508], 'Previous': [5385], 'extreme': [5396], 'Ref.': [5432], 'so': [5477], 'not.': [5488], 'surface,': [5502], 'proteolysis.': [5525], 'adaptor': [5531], 'such': [5533], 'disabled': [5535], 'events': [5545], 'naturally': [5546], 'Understanding': [5552], 'they': [5563], 'aids': [5565], 'understanding': [5568], 'how': [5575], 'it': [5576], 'risk': [5580], 'Alzheimer': [5582], 'disease.': [5583], 'close': [5588], 'connection': [5590], 'raising': [5598], 'isoforms': [5603], 'molecular': [5610], 'memory.': [5613], 'thank': [5615, 5627, 5639], 'useful': [5624], 'discussions.': [5625], 'George': [5629], 'Augustine': [5630], '(Duke': [5631], 'University)': [5632], 'helpful': [5634], 'discussions': [5635], 'advice.': [5637]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2022736599', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 8}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 10}, {'year': 2013, 'cited_by_count': 5}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-12-14T16:22:35.220138', 'created_date': '2016-06-24'}
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