Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2169225653', 'doi': 'https://doi.org/10.1677/joe.0.1070041', 'title': 'Homologous ligand regulation of gonadotrophin-releasing hormone receptors in vivo: relationship to gonadotrophin secretion and gonadal steroids', 'display_name': 'Homologous ligand regulation of gonadotrophin-releasing hormone receptors in vivo: relationship to gonadotrophin secretion and gonadal steroids', 'publication_year': 1985, 'publication_date': '1985-10-01', 'ids': {'openalex': 'https://openalex.org/W2169225653', 'doi': 'https://doi.org/10.1677/joe.0.1070041', 'mag': '2169225653', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/2995531'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1677/joe.0.1070041', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S34842069', 'display_name': 'Journal of Endocrinology', 'issn_l': '0022-0795', 'issn': ['0022-0795', '1479-6805'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319937', 'host_organization_name': 'Bioscientifica', 'host_organization_lineage': ['https://openalex.org/P4310319937'], 'host_organization_lineage_names': ['Bioscientifica'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5054940173', 'display_name': 'Sharda Naik', 'orcid': 'https://orcid.org/0000-0002-6634-5090'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'S. I. Naik', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054517895', 'display_name': 'G. Saade', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'G. Saade', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006660087', 'display_name': 'A. Detta', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'A. Detta', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5068727596', 'display_name': 'Richard N. Clayton', 'orcid': 'https://orcid.org/0000-0003-0873-1548'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'R. N. Clayton', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.135, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 9, 'citation_normalized_percentile': {'value': 0.576146, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 78, 'max': 79}, 'biblio': {'volume': '107', 'issue': '1', 'first_page': '41', 'last_page': '47'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11510', 'display_name': 'Reproductive System and Pregnancy', 'score': 0.7503, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11510', 'display_name': 'Reproductive System and Pregnancy', 'score': 0.7503, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.8255786}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.8248075}, {'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.6836076}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.6732662}, {'id': 'https://openalex.org/C49039625', 'wikidata': 'https://www.wikidata.org/wiki/Q84230', 'display_name': 'Secretion', 'level': 2, 'score': 0.61759824}, {'id': 'https://openalex.org/C64894306', 'wikidata': 'https://www.wikidata.org/wiki/Q849622', 'display_name': 'Homologous chromosome', 'level': 3, 'score': 0.5857381}, {'id': 'https://openalex.org/C71315377', 'wikidata': 'https://www.wikidata.org/wiki/Q11364', 'display_name': 'Hormone', 'level': 2, 'score': 0.5225972}, {'id': 'https://openalex.org/C116569031', 'wikidata': 'https://www.wikidata.org/wiki/Q899107', 'display_name': 'Ligand (biochemistry)', 'level': 3, 'score': 0.45622808}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.42220426}, {'id': 'https://openalex.org/C23589133', 'wikidata': 'https://www.wikidata.org/wiki/Q412005', 'display_name': 'Hormone receptor', 'level': 4, 'score': 0.41628397}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.40066028}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.30956364}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.08632231}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.08504394}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.05917555}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C530470458', 'wikidata': 'https://www.wikidata.org/wiki/Q128581', 'display_name': 'Breast cancer', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D007987', 'descriptor_name': 'Gonadotropin-Releasing Hormone', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D010902', 'descriptor_name': 'Pituitary Gland', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D010906', 'descriptor_name': 'Pituitary Hormone-Releasing Hormones', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D011956', 'descriptor_name': 'Receptors, Cell Surface', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003513', 'descriptor_name': 'Cycloheximide', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D003513', 'descriptor_name': 'Cycloheximide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005640', 'descriptor_name': 'Follicle Stimulating Hormone', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D005640', 'descriptor_name': 'Follicle Stimulating Hormone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007987', 'descriptor_name': 'Gonadotropin-Releasing Hormone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007006', 'descriptor_name': 'Hypogonadism', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007006', 'descriptor_name': 'Hypogonadism', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007986', 'descriptor_name': 'Luteinizing Hormone', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D007986', 'descriptor_name': 'Luteinizing Hormone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010052', 'descriptor_name': 'Ovariectomy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010902', 'descriptor_name': 'Pituitary Gland', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D010902', 'descriptor_name': 'Pituitary Gland', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010906', 'descriptor_name': 'Pituitary Hormone-Releasing Hormones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011863', 'descriptor_name': 'Radioimmunoassay', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011869', 'descriptor_name': 'Radioligand Assay', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011956', 'descriptor_name': 'Receptors, Cell Surface', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011966', 'descriptor_name': 'Receptors, LHRH', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1677/joe.0.1070041', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S34842069', 'display_name': 'Journal of Endocrinology', 'issn_l': '0022-0795', 'issn': ['0022-0795', '1479-6805'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319937', 'host_organization_name': 'Bioscientifica', 'host_organization_lineage': ['https://openalex.org/P4310319937'], 'host_organization_lineage_names': ['Bioscientifica'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/2995531', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.64, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W747883771', 'https://openalex.org/W4388227751', 'https://openalex.org/W4386784867', 'https://openalex.org/W3143659456', 'https://openalex.org/W288505458', 'https://openalex.org/W2399746911', 'https://openalex.org/W2035029381', 'https://openalex.org/W167346798', 'https://openalex.org/W1500486059', 'https://openalex.org/W121435057'], 'abstract_inverted_index': {'ABSTRACT': [0], 'A': [1, 24], 'single': [2, 226], 'injection': [3, 33, 93, 228], 'of': [4, 34, 72, 94, 167, 180, 285], 'gonadotrophin-releasing': [5], 'hormone': [6], '(GnRH)': [7], '(60': [8, 229], 'ng': [9, 230], 's.c.,': [10], '42·9': [11], 'nmol)': [12], 'induced': [13], 'biphasic': [14], 'GnRH': [15, 35, 51, 73, 83, 95, 101, 108, 146, 166, 193, 205, 217, 227, 245, 255], 'receptor': [16, 27, 52, 74, 80, 87, 121, 128, 211, 218], 'regulation': [17], 'in': [18, 100, 145, 153, 159, 192, 195, 232, 247, 269, 275], 'normal': [19, 77, 237, 277], 'intact': [20, 154, 234], 'adult': [21], 'female': [22, 252, 278], 'mice.': [23, 239, 253], 'transient': [25, 79, 174], '22%': [26], 'decrease': [28, 53, 175], 'occurred': [29, 54, 176], '30–60': [30], 'min': [31], 'after': [32, 56, 92, 224], 'when': [36, 106], 'peak': [37, 58], 'serum': [38, 59, 107, 113, 183, 199], 'decapeptide': [39], 'concentrations': [40], 'were': [41, 110, 206], 'reached': [42], '(137': [43], '±': [44, 149, 157], '41': [45], '(': [46, 249], 's.e.m.': [47], ')': [48, 251], 'ng/l).': [49], 'This': [50, 120], 'shortly': [55], 'the': [57, 163, 172, 178, 181, 241, 270, 276], 'LH': [60, 114, 184], 'values': [61], 'at': [62], '15–30': [63], 'min.': [64], 'The': [65], 'subsequent': [66], 'rapid': [67], '(within': [68], '1': [69], 'h)': [70], 'return': [71], 'levels': [75, 109, 201], 'to': [76, 117, 126, 204, 257, 283], 'suggested': [78], 'occupancy': [81], 'by': [82, 133, 165, 262], 'rather': [84], 'than': [85], 'true': [86], 'loss.': [88], 'At': [89], '8': [90, 222], 'h': [91, 223], 'a': [96, 134, 142, 189, 225, 263, 286], 'significant': [97], '35%': [98], 'increase': [99, 122], 'receptors': [102, 147, 194, 246, 261], 'was': [103, 123, 131, 220], 'consistently': [104], 'observed,': [105], 'undetectable': [111], 'and': [112, 130, 185, 202, 213], 'had': [115], 'returned': [116], 'basal': [118], 'levels.': [119, 215], 'not': [124], 'due': [125], 'increased': [127, 198], 'affinity,': [129], 'prevented': [132], 'non-specific': [135], 'protein': [136], 'synthesis': [137], 'inhibitor.': [138], 'Ovariectomy,': [139], 'which': [140], 'caused': [141], '50%': [143, 190], 'fall': [144], '(59·4': [148], '4·9': [150], 'fmol/pituitary': [151], 'gland': [152], 'controls;': [155], '26·9': [156], '2·6': [158], 'ovariectomized': [160, 196], 'mice)': [161], 'abolished': [162], 'induction': [164], 'its': [168, 259, 273], 'own': [169, 260], 'receptors,': [170], 'although': [171], 'initial': [173], 'over': [177], 'period': [179], 'acute': [182], 'FSH': [186], 'rise.': [187], 'Despite': [188], 'reduction': [191], 'mice,': [197], 'gonadotrophin': [200, 214], 'responsiveness': [203], 'maintained,': [207], 'indicating': [208], 'dissociation': [209], 'between': [210], 'changes': [212], 'No': [216], 'up-regulation': [219], 'observed': [221], 's.c.)': [231], 'either': [233], 'or': [235], 'orchidectomized': [236], 'male': [238], 'However,': [240], 'same': [242], 'treatment': [243], 'doubled': [244], 'GnRH-deficient': [248, 271], 'hpg': [250], 'While': [254], 'appears': [256, 281], 'up-regulate': [258], 'direct': [264], 'action': [265, 274], 'on': [266], 'pituitary': [267, 280], 'gonadotrophs': [268], 'mouse': [272, 279], 'secondary': [282], 'stimulation': [284], 'gonadal': [287], 'product,': [288], 'presumably': [289], 'oestrogens.': [290], 'J.': [291], 'Endocr.': [292], '(1985)': [293], '107,': [294], '41–47': [295]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2169225653', 'counts_by_year': [{'year': 2021, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}], 'updated_date': '2024-12-08T19:53:51.528952', 'created_date': '2016-06-24'}