Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2018368842', 'doi': 'https://doi.org/10.1210/endo-122-5-1707', 'title': 'Sex Difference in Epidermal Growth Factor Receptor Levels in Rat Liver Plasma Membrane*', 'display_name': 'Sex Difference in Epidermal Growth Factor Receptor Levels in Rat Liver Plasma Membrane*', 'publication_year': 1988, 'publication_date': '1988-05-01', 'ids': {'openalex': 'https://openalex.org/W2018368842', 'doi': 'https://doi.org/10.1210/endo-122-5-1707', 'mag': '2018368842', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/3258816'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1210/endo-122-5-1707', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S157527038', 'display_name': 'Endocrinology', 'issn_l': '0013-7227', 'issn': ['0013-7227', '1945-7170'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5109187549', 'display_name': 'Masanori Kashimata', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I201389808', 'display_name': 'Josai University', 'ror': 'https://ror.org/021r6aq66', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I201389808']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'MASANORI KASHIMATA', 'raw_affiliation_strings': ['Department of Dental Pharmacology, Josai Dental UniversitySakado, Saitama 350–02, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Dental Pharmacology, Josai Dental UniversitySakado, Saitama 350–02, Japan', 'institution_ids': ['https://openalex.org/I201389808']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046788733', 'display_name': 'Masahiko Hiramatsu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I201389808', 'display_name': 'Josai University', 'ror': 'https://ror.org/021r6aq66', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I201389808']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'MASAHIKO HIRAMATSU', 'raw_affiliation_strings': ['Department of Dental Pharmacology, Josai Dental UniversitySakado, Saitama 350–02, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Dental Pharmacology, Josai Dental UniversitySakado, Saitama 350–02, Japan', 'institution_ids': ['https://openalex.org/I201389808']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5108428608', 'display_name': 'Naomi Minami', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I201389808', 'display_name': 'Josai University', 'ror': 'https://ror.org/021r6aq66', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I201389808']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'NAOMI MINAMI', 'raw_affiliation_strings': ['Department of Dental Pharmacology, Josai Dental UniversitySakado, Saitama 350–02, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Dental Pharmacology, Josai Dental UniversitySakado, Saitama 350–02, Japan', 'institution_ids': ['https://openalex.org/I201389808']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3400, 'currency': 'USD', 'value_usd': 3400, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 3.67, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 17, 'citation_normalized_percentile': {'value': 0.719304, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 84, 'max': 85}, 'biblio': {'volume': '122', 'issue': '5', 'first_page': '1707', 'last_page': '1714'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10375', 'display_name': 'Pharmacogenetics and Drug Metabolism', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10375', 'display_name': 'Pharmacogenetics and Drug Metabolism', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10748', 'display_name': 'Growth Hormone and Insulin-like Growth Factors', 'score': 0.9969, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11146', 'display_name': 'Hormonal and reproductive studies', 'score': 0.9937, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/hypophysectomy', 'display_name': 'Hypophysectomy', 'score': 0.6293694}], 'concepts': [{'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.91081464}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.9022523}, {'id': 'https://openalex.org/C2776362946', 'wikidata': 'https://www.wikidata.org/wiki/Q424374', 'display_name': 'Epidermal growth factor', 'level': 3, 'score': 0.8289406}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.7719761}, {'id': 'https://openalex.org/C2779279991', 'wikidata': 'https://www.wikidata.org/wiki/Q6058681', 'display_name': 'Testosterone (patch)', 'level': 2, 'score': 0.6294619}, {'id': 'https://openalex.org/C2780104272', 'wikidata': 'https://www.wikidata.org/wiki/Q933496', 'display_name': 'Hypophysectomy', 'level': 3, 'score': 0.6293694}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.58125454}, {'id': 'https://openalex.org/C2779256933', 'wikidata': 'https://www.wikidata.org/wiki/Q58929', 'display_name': 'Castration', 'level': 3, 'score': 0.417284}, {'id': 'https://openalex.org/C71315377', 'wikidata': 'https://www.wikidata.org/wiki/Q11364', 'display_name': 'Hormone', 'level': 2, 'score': 0.31228706}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.13215294}], 'mesh': [{'descriptor_ui': 'D066246', 'descriptor_name': 'ErbB Receptors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D007425', 'descriptor_name': 'Intracellular Membranes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008862', 'descriptor_name': 'Microsomes, Liver', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004815', 'descriptor_name': 'Epidermal Growth Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004815', 'descriptor_name': 'Epidermal Growth Factor', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D066246', 'descriptor_name': 'ErbB Receptors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066246', 'descriptor_name': 'ErbB Receptors', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D004958', 'descriptor_name': 'Estradiol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004958', 'descriptor_name': 'Estradiol', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007016', 'descriptor_name': 'Hypophysectomy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007425', 'descriptor_name': 'Intracellular Membranes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008862', 'descriptor_name': 'Microsomes, Liver', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009919', 'descriptor_name': 'Orchiectomy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010052', 'descriptor_name': 'Ovariectomy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012016', 'descriptor_name': 'Reference Values', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012737', 'descriptor_name': 'Sex Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013739', 'descriptor_name': 'Testosterone', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D013739', 'descriptor_name': 'Testosterone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1210/endo-122-5-1707', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S157527038', 'display_name': 'Endocrinology', 'issn_l': '0013-7227', 'issn': ['0013-7227', '1945-7170'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/3258816', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.8, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 47, 'referenced_works': ['https://openalex.org/W1492298052', 'https://openalex.org/W1498071142', 'https://openalex.org/W1501383613', 'https://openalex.org/W1508994608', 'https://openalex.org/W1512982676', 'https://openalex.org/W153068354', 'https://openalex.org/W1542431954', 'https://openalex.org/W1548707319', 'https://openalex.org/W1548966243', 'https://openalex.org/W1559210673', 'https://openalex.org/W1567148937', 'https://openalex.org/W1580023435', 'https://openalex.org/W1595351294', 'https://openalex.org/W1606919023', 'https://openalex.org/W1674445303', 'https://openalex.org/W1775749144', 'https://openalex.org/W1860820699', 'https://openalex.org/W1894641937', 'https://openalex.org/W1965584996', 'https://openalex.org/W1976890482', 'https://openalex.org/W1977849926', 'https://openalex.org/W1982251557', 'https://openalex.org/W1987172957', 'https://openalex.org/W1991445027', 'https://openalex.org/W1994341785', 'https://openalex.org/W1997342108', 'https://openalex.org/W2005747351', 'https://openalex.org/W2008761713', 'https://openalex.org/W2010394496', 'https://openalex.org/W2026358418', 'https://openalex.org/W2032436900', 'https://openalex.org/W2045372146', 'https://openalex.org/W2052435478', 'https://openalex.org/W2059388074', 'https://openalex.org/W2059623509', 'https://openalex.org/W2072680969', 'https://openalex.org/W2074545422', 'https://openalex.org/W2078494160', 'https://openalex.org/W2088046252', 'https://openalex.org/W2103130650', 'https://openalex.org/W2111794066', 'https://openalex.org/W2112964787', 'https://openalex.org/W2131934565', 'https://openalex.org/W2136531196', 'https://openalex.org/W2181184413', 'https://openalex.org/W2204518242', 'https://openalex.org/W2413670091'], 'related_works': ['https://openalex.org/W2993729724', 'https://openalex.org/W2944924574', 'https://openalex.org/W2883402525', 'https://openalex.org/W2409692580', 'https://openalex.org/W2404899404', 'https://openalex.org/W2381910020', 'https://openalex.org/W2157439642', 'https://openalex.org/W2021396541', 'https://openalex.org/W1985747461', 'https://openalex.org/W1978459015'], 'abstract_inverted_index': {'The': [0, 120, 209, 235], 'specific': [1], 'binding': [2, 28, 37, 65, 255], 'of': [3, 26, 74, 77, 92, 106, 123, 132, 144, 155, 160, 176, 193, 219, 233, 237, 242, 252], '[125I]epidermal': [4], 'growth': [5], 'factor': [6], '([126I]EGF)': [7], 'to': [8, 40, 49, 116], 'hepatic': [9], 'microsomal': [10], 'membranes': [11, 270], 'was': [12, 38, 66, 126, 226, 245], 'about': [13], '2-fold': [14], 'higher': [15], 'in': [16, 20, 35, 43, 52, 63, 180, 184, 188, 246, 266, 272], 'adult': [17, 21, 78, 93], 'male': [18, 79, 108, 190], 'than': [19, 48], 'female': [22, 118, 167], 'rats.': [23], 'Scatchard': [24], 'analysis': [25], 'the': [27, 32, 41, 56, 69, 85, 102, 111, 117, 124, 130, 152, 172, 177, 181, 189, 206, 231, 250, 253, 262, 276, 293], 'data': [29], 'showed': [30], 'that': [31, 261, 280], 'sex': [33, 61], 'difference': [34, 42, 62], 'EGF': [36, 44, 64, 86, 112, 156, 185, 207, 243, 254, 263], 'due': [39], 'receptor': [45, 53, 87, 113, 125, 264], 'concentration': [46], 'rather': [47], 'a': [50, 216], 'change': [51], 'affinity.': [54], 'From': [55], 'developmental': [57], 'study,': [58], 'an': [59], 'apparent': [60, 203], 'observed': [67, 164], 'from': [68], 'pubertal': [70, 135, 141], 'period': [71], '(4': [72], 'weeks': [73], 'age).': [75], 'Castration': [76], 'rats': [80, 109, 168, 178, 195], 'slightly,': [81], 'but': [82], 'significantly,': [83], 'decreased': [84, 110, 121, 153], 'level;': [88], 'and': [89, 134, 221, 279], 'moreover,': [90], 'treatment': [91, 142], 'females': [94], 'with': [95, 137, 171, 196, 213, 249], 'testosterone': [96, 161, 198], 'increased': [97], 'it': [98], 'only': [99, 187], 'slightly.': [100], 'On': [101], 'other': [103], 'hand,': [104], 'castration': [105], 'neonatal': [107, 133, 281], 'content': [114], 'almost': [115], 'level.': [119], 'level': [122, 154, 265], 'completely': [127], 'restored': [128], 'by': [129, 230, 275], 'combination': [131], 'treatments': [136], 'testosterone.': [138], 'Neonatal': [139], 'or': [140, 199, 229, 240], 'alone': [143], 'castrated': [145], 'animals': [146], 'had': [147, 201, 215], 'no': [148, 202], 'significant': [149], 'effect': [150, 204], 'on': [151, 205, 292], 'receptors.': [157, 208], 'These': [158, 257], 'effects': [159, 291], 'were': [162, 169], 'similarly': [163], 'when': [165], 'normal': [166], 'treated': [170], 'steroid.': [173], 'Moreover,': [174], 'hypophysectomy': [175], 'resulted': [179], 'marked': [182], 'decrease': [183], 'receptors': [186], 'animals.': [191], 'Treatment': [192], 'hypophysectomized': [194], 'either': [197], 'T3': [200], 'membrane': [210], 'protein,': [211], 'cross-linked': [212], '[125I]EGF,': [214], 'mol': [217], 'wt': [218], '170,000,': [220], 'this': [222, 286], 'protein': [223], '(EGF': [224], 'receptor)': [225], 'phosphorylated': [227], 'basally': [228], 'addition': [232], 'EGF.': [234], 'rate': [236], 'affinity': [238], 'labeling,': [239], 'phosphorylation': [241], 'receptors,': [244], 'good': [247], 'agreement': [248], 'results': [251, 258], 'study.': [256], 'strongly': [259], 'suggest': [260], 'rat': [267], 'liver': [268], 'plasma': [269], 'is': [271], 'part': [273], 'regulated': [274], 'hypothalamopituitary': [277], 'unit': [278], 'androgens': [282], 'are': [283], 'essential': [284], 'for': [285], 'regulation,': [287], 'probably': [288], 'through': [289], 'their': [290], 'hypothalamus.': [294], '(Endocrinology122:': [295], '1707–1714,': [296], '1988)': [297]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2018368842', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-08T19:31:24.068430', 'created_date': '2016-06-24'}