Publication Information

{'id': 'https://openalex.org/W2275976839', 'doi': 'https://doi.org/10.1055/s-0042-102883', 'title': 'Higher Plasma ApoE Levels are Associated with Low-Normal Thyroid Function: Studies in Diabetic and Nondiabetic Subjects', 'display_name': 'Higher Plasma ApoE Levels are Associated with Low-Normal Thyroid Function: Studies in Diabetic and Nondiabetic Subjects', 'publication_year': 2016, 'publication_date': '2016-02-25', 'ids': {'openalex': 'https://openalex.org/W2275976839', 'doi': 'https://doi.org/10.1055/s-0042-102883', 'mag': '2275976839', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26916531'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1055/s-0042-102883', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S131832911', 'display_name': 'Hormone and Metabolic Research', 'issn_l': '0018-5043', 'issn': ['0018-5043', '1439-4286'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320000', 'host_organization_name': 'Thieme Medical Publishers (Germany)', 'host_organization_lineage': ['https://openalex.org/P4310320000'], 'host_organization_lineage_names': ['Thieme Medical Publishers (Germany)'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5068530239', 'display_name': 'Lynnda van Tienhoven-Wind', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1334415907', 'display_name': 'University Medical Center Groningen', 'ror': 'https://ror.org/03cv38k47', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334415907']}, {'id': 'https://openalex.org/I169381384', 'display_name': 'University of Groningen', 'ror': 'https://ror.org/012p63287', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I169381384']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'L. van Tienhoven-Wind', 'raw_affiliation_strings': ['Department of Endocrinology, University of Groningen and University Medical Center, Groningen, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Endocrinology, University of Groningen and University Medical Center, Groningen, The Netherlands', 'institution_ids': ['https://openalex.org/I1334415907', 'https://openalex.org/I169381384']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060583173', 'display_name': 'Geesje M. Dallinga‐Thie', 'orcid': 'https://orcid.org/0000-0001-5412-5923'}, 'institutions': [{'id': 'https://openalex.org/I2802928900', 'display_name': 'Academic Medical Center', 'ror': 'https://ror.org/03t4gr691', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802928900', 'https://openalex.org/I4210151833']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'G. Dallinga-Thie', 'raw_affiliation_strings': ['Department of Experimental Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Experimental Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I2802928900']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5059663377', 'display_name': 'Robin P.F. Dullaart', 'orcid': 'https://orcid.org/0000-0003-4520-1239'}, 'institutions': [{'id': 'https://openalex.org/I1334415907', 'display_name': 'University Medical Center Groningen', 'ror': 'https://ror.org/03cv38k47', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334415907']}, {'id': 'https://openalex.org/I169381384', 'display_name': 'University of Groningen', 'ror': 'https://ror.org/012p63287', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I169381384']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'R. Dullaart', 'raw_affiliation_strings': ['Department of Endocrinology, University of Groningen and University Medical Center, Groningen, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Endocrinology, University of Groningen and University Medical Center, Groningen, The Netherlands', 'institution_ids': ['https://openalex.org/I1334415907', 'https://openalex.org/I169381384']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.45, 'has_fulltext': False, 'cited_by_count': 8, 'citation_normalized_percentile': {'value': 0.742876, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 84, 'max': 85}, 'biblio': {'volume': '48', 'issue': '07', 'first_page': '462', 'last_page': '467'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10293', 'display_name': 'Thyroid Disorders and Treatments', 'score': 0.9961, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10293', 'display_name': 'Thyroid Disorders and Treatments', 'score': 0.9961, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11839', 'display_name': 'Hormonal Regulation and Hypertension', 'score': 0.991, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11339', 'display_name': 'Metabolism, Diabetes, and Cancer', 'score': 0.985, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/apolipoprotein-e', 'display_name': 'Apolipoprotein E', 'score': 0.7782682}], 'concepts': [{'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.917339}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.8958439}, {'id': 'https://openalex.org/C2777195454', 'wikidata': 'https://www.wikidata.org/wiki/Q16399', 'display_name': 'Euthyroid', 'level': 3, 'score': 0.8639616}, {'id': 'https://openalex.org/C57089818', 'wikidata': 'https://www.wikidata.org/wiki/Q424728', 'display_name': 'Apolipoprotein E', 'level': 3, 'score': 0.7782682}, {'id': 'https://openalex.org/C2993291352', 'wikidata': 'https://www.wikidata.org/wiki/Q16399', 'display_name': 'Thyroid function', 'level': 3, 'score': 0.6739354}, {'id': 'https://openalex.org/C2778913445', 'wikidata': 'https://www.wikidata.org/wiki/Q186319', 'display_name': 'Triglyceride', 'level': 3, 'score': 0.5941985}, {'id': 'https://openalex.org/C62746215', 'wikidata': 'https://www.wikidata.org/wiki/Q14890615', 'display_name': 'Apolipoprotein B', 'level': 3, 'score': 0.52985734}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.4866684}, {'id': 'https://openalex.org/C2780072125', 'wikidata': 'https://www.wikidata.org/wiki/Q28350', 'display_name': 'Lipoprotein', 'level': 3, 'score': 0.4770305}, {'id': 'https://openalex.org/C2778163477', 'wikidata': 'https://www.wikidata.org/wiki/Q43656', 'display_name': 'Cholesterol', 'level': 2, 'score': 0.46284148}, {'id': 'https://openalex.org/C2910068830', 'wikidata': 'https://www.wikidata.org/wiki/Q3025883', 'display_name': 'Type 2 Diabetes Mellitus', 'level': 3, 'score': 0.46246073}, {'id': 'https://openalex.org/C555293320', 'wikidata': 'https://www.wikidata.org/wiki/Q12206', 'display_name': 'Diabetes mellitus', 'level': 2, 'score': 0.44848925}, {'id': 'https://openalex.org/C135763542', 'wikidata': 'https://www.wikidata.org/wiki/Q106016', 'display_name': 'Genotype', 'level': 3, 'score': 0.42809728}, {'id': 'https://openalex.org/C526584372', 'wikidata': 'https://www.wikidata.org/wiki/Q16399', 'display_name': 'Thyroid', 'level': 2, 'score': 0.4114337}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.3004805}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.082662016}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.045132846}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001057', 'descriptor_name': 'Apolipoproteins E', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D003924', 'descriptor_name': 'Diabetes Mellitus, Type 2', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': True}, {'descriptor_ui': 'D003924', 'descriptor_name': 'Diabetes Mellitus, Type 2', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D013960', 'descriptor_name': 'Thyroid Function Tests', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D013961', 'descriptor_name': 'Thyroid Gland', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': True}, {'descriptor_ui': 'D016632', 'descriptor_name': 'Apolipoprotein A-I', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D016632', 'descriptor_name': 'Apolipoprotein A-I', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001055', 'descriptor_name': 'Apolipoproteins B', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D001055', 'descriptor_name': 'Apolipoproteins B', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001057', 'descriptor_name': 'Apolipoproteins E', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016022', 'descriptor_name': 'Case-Control Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003924', 'descriptor_name': 'Diabetes Mellitus, Type 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016014', 'descriptor_name': 'Linear Models', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008055', 'descriptor_name': 'Lipids', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D008055', 'descriptor_name': 'Lipids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015999', 'descriptor_name': 'Multivariate Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013961', 'descriptor_name': 'Thyroid Gland', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014280', 'descriptor_name': 'Triglycerides', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D014280', 'descriptor_name': 'Triglycerides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1055/s-0042-102883', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S131832911', 'display_name': 'Hormone and Metabolic Research', 'issn_l': '0018-5043', 'issn': ['0018-5043', '1439-4286'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320000', 'host_organization_name': 'Thieme Medical Publishers (Germany)', 'host_organization_lineage': ['https://openalex.org/P4310320000'], 'host_organization_lineage_names': ['Thieme Medical Publishers (Germany)'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26916531', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.71, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W2748952813', 'https://openalex.org/W2275976839', 'https://openalex.org/W2118738696', 'https://openalex.org/W2090982939', 'https://openalex.org/W2080164112', 'https://openalex.org/W2068768710', 'https://openalex.org/W2036452436', 'https://openalex.org/W2033921535', 'https://openalex.org/W2004682325', 'https://openalex.org/W1981780460'], 'abstract_inverted_index': {'Low-normal': [0], 'thyroid': [1, 40, 223], 'function': [2], 'within': [3, 231], 'the': [4, 25, 110, 114, 117, 135, 173, 176, 181, 208, 232, 237], 'euthyroid': [5, 50, 233], 'range': [6], 'may': [7, 235], 'confer': [8], 'higher': [9, 89, 123, 228], 'plasma': [10, 15, 37, 70, 145], 'triglycerides,': [11, 193], 'but': [12, 93], 'relationships': [13, 35, 209], 'with': [14, 39, 52, 164, 185, 212], 'apolipoprotein': [16], '(apo)': [17, 214], 'E,': [18], 'which': [19], 'plays': [20], 'an': [21], 'important': [22], 'role': [23], 'in': [24, 49, 68, 90, 124], 'metabolism': [26, 238], 'of': [27, 36, 113, 175, 183, 203, 210, 239], 'triglyceride-rich': [28, 240], 'apoB-containing': [29], 'lipoproteins,': [30], 'are': [31], 'unknown.': [32], 'We': [33], 'determined': [34], 'apoE': [38, 65, 129, 155, 186, 244], 'stimulating': [41], 'hormone': [42], '(TSH)': [43], 'and': [44, 53, 64, 75, 128, 154, 161, 172], 'free': [45, 61], 'thyroxine': [46], '(free': [47], 'T4)': [48], 'subjects': [51, 74, 139], 'without': [54], 'Type': [55], '2': [56], 'diabetes': [57], 'mellitus': [58], '(T2DM).': [59], 'TSH,': [60], 'T4,': [62], 'lipids,': [63], 'were': [66, 96, 122, 131, 158], 'measured': [67], 'fasting': [69], 'from': [71], '72': [72], 'T2DM': [73, 91, 125, 171, 204], '82': [76], 'nondiabetic': [77, 100], 'subjects.': [78, 101], 'The': [79, 102, 201], 'APOE': [80, 103, 177], 'genotype': [81, 104], 'was': [82, 87, 106], 'also': [83], 'determined.': [84], 'Free': [85], 'T4': [86], 'slightly': [88], '(p=0.030),': [92, 153], 'TSH': [94, 165, 184, 211, 229], 'levels': [95, 130, 156, 230], 'not': [97, 107, 132, 206], 'different': [98, 108, 133], 'vs.': [99], 'distribution': [105], 'between': [109, 134], 'groups.': [111, 136], 'None': [112], 'participants': [115], 'had': [116], 'ε2/ε2': [118], 'genotype.': [119], 'Plasma': [120], 'triglycerides': [121, 146], '(p=0.037).': [126], 'ApoB': [127], 'In': [137, 220], 'all': [138], 'combined,': [140], 'multivariable': [141], 'analysis': [142], 'showed': [143], 'that': [144], '(p=0.039),': [147], 'non-high': [148], 'density': [149], 'lipoprotein': [150, 215], '(non-HDL)': [151], 'cholesterol': [152], '(p=0.002)': [157], 'each': [159], 'independently': [160], 'positively': [162], 'associated': [163], 'after': [166, 189], 'adjustment': [167, 190], 'for': [168, 191], 'age,': [169], 'sex,': [170], 'presence': [174, 202], 'ε3': [178], 'allele.': [179], 'Furthermore,': [180], 'associations': [182], 'remained': [187], 'present': [188], 'either': [192], 'non-HDL': [194], 'cholesterol,': [195], 'or': [196], 'apoB': [197], '(p=0.005': [198], 'to': [199, 218], '0.023).': [200], 'did': [205], 'modify': [207], 'these': [213], 'variables': [216], '(p=0.11': [217], '0.36).': [219], 'conclusion,': [221], 'low-normal': [222], 'function,': [224], 'as': [225], 'indicated': [226], 'by': [227, 242], 'range,': [234], 'influence': [236], 'lipoproteins': [241], 'affecting': [243], 'regulation.': [245]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2275976839', 'counts_by_year': [{'year': 2022, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 1}], 'updated_date': '2024-12-13T20:31:43.187720', 'created_date': '2016-06-24'}