Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2013580891', 'doi': 'https://doi.org/10.1016/j.dnarep.2006.12.007', 'title': 'Interaction of the Ku heterodimer with the DNA ligase IV/Xrcc4 complex and its regulation by DNA-PK', 'display_name': 'Interaction of the Ku heterodimer with the DNA ligase IV/Xrcc4 complex and its regulation by DNA-PK', 'publication_year': 2007, 'publication_date': '2007-01-23', 'ids': {'openalex': 'https://openalex.org/W2013580891', 'doi': 'https://doi.org/10.1016/j.dnarep.2006.12.007', 'mag': '2013580891', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17241822'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.dnarep.2006.12.007', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S3892243', 'display_name': 'DNA repair', 'issn_l': '1568-7856', 'issn': ['1568-7856', '1568-7864'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5103518943', 'display_name': 'Silvia Costantini', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I91080651', 'display_name': 'International Centre for Genetic Engineering and Biotechnology', 'ror': 'https://ror.org/043bgf219', 'country_code': 'IT', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I91080651']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Silvia Costantini', 'raw_affiliation_strings': ['International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I-34012, Trieste, Italy'], 'affiliations': [{'raw_affiliation_string': 'International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I-34012, Trieste, Italy', 'institution_ids': ['https://openalex.org/I91080651']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087718296', 'display_name': 'Lisa Woodbine', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I162608824', 'display_name': 'University of Sussex', 'ror': 'https://ror.org/00ayhx656', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I162608824']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Lisa Woodbine', 'raw_affiliation_strings': ['Genome Damage and Stability Centre, University of Sussex, Sussex BN1 9RQ, UK'], 'affiliations': [{'raw_affiliation_string': 'Genome Damage and Stability Centre, University of Sussex, Sussex BN1 9RQ, UK', 'institution_ids': ['https://openalex.org/I162608824']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076748697', 'display_name': 'Lucia Andreoli', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I91080651', 'display_name': 'International Centre for Genetic Engineering and Biotechnology', 'ror': 'https://ror.org/043bgf219', 'country_code': 'IT', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I91080651']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Lucia Andreoli', 'raw_affiliation_strings': ['International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I-34012, Trieste, Italy'], 'affiliations': [{'raw_affiliation_string': 'International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I-34012, Trieste, Italy', 'institution_ids': ['https://openalex.org/I91080651']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078309099', 'display_name': 'Penny A. Jeggo', 'orcid': 'https://orcid.org/0000-0002-8481-1462'}, 'institutions': [{'id': 'https://openalex.org/I162608824', 'display_name': 'University of Sussex', 'ror': 'https://ror.org/00ayhx656', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I162608824']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Penny A. Jeggo', 'raw_affiliation_strings': ['Genome Damage and Stability Centre, University of Sussex, Sussex BN1 9RQ, UK'], 'affiliations': [{'raw_affiliation_string': 'Genome Damage and Stability Centre, University of Sussex, Sussex BN1 9RQ, UK', 'institution_ids': ['https://openalex.org/I162608824']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5102904208', 'display_name': 'Alessandro Vindigni', 'orcid': 'https://orcid.org/0000-0002-0568-5067'}, 'institutions': [{'id': 'https://openalex.org/I91080651', 'display_name': 'International Centre for Genetic Engineering and Biotechnology', 'ror': 'https://ror.org/043bgf219', 'country_code': 'IT', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I91080651']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Alessandro Vindigni', 'raw_affiliation_strings': ['International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I-34012, Trieste, Italy'], 'affiliations': [{'raw_affiliation_string': 'International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I-34012, Trieste, Italy', 'institution_ids': ['https://openalex.org/I91080651']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3770, 'currency': 'USD', 'value_usd': 3770, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 3.04, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 127, 'citation_normalized_percentile': {'value': 0.999982, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '6', 'issue': '6', 'first_page': '712', 'last_page': '722'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10123', 'display_name': 'DNA Repair Mechanisms', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10123', 'display_name': 'DNA Repair Mechanisms', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11914', 'display_name': 'PARP inhibition in cancer therapy', 'score': 0.9902, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10433', 'display_name': 'Carcinogens and Genotoxicity Assessment', 'score': 0.9897, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ku80', 'display_name': 'Ku80', 'score': 0.7826662}, {'id': 'https://openalex.org/keywords/dna-polymerase-mu', 'display_name': 'DNA polymerase mu', 'score': 0.6397899}, {'id': 'https://openalex.org/keywords/dna-pkcs', 'display_name': 'DNA-PKcs', 'score': 0.55014527}, {'id': 'https://openalex.org/keywords/non-homologous-end-joining', 'display_name': 'Non-homologous end joining', 'score': 0.4424196}, {'id': 'https://openalex.org/keywords/dna-clamp', 'display_name': 'DNA clamp', 'score': 0.4357763}, {'id': 'https://openalex.org/keywords/ddb1', 'display_name': 'DDB1', 'score': 0.41113234}], 'concepts': [{'id': 'https://openalex.org/C175114707', 'wikidata': 'https://www.wikidata.org/wiki/Q408483', 'display_name': 'DNA ligase', 'level': 3, 'score': 0.9569367}, {'id': 'https://openalex.org/C193104389', 'wikidata': 'https://www.wikidata.org/wiki/Q18032397', 'display_name': 'Ku80', 'level': 5, 'score': 0.7826662}, {'id': 'https://openalex.org/C145803527', 'wikidata': 'https://www.wikidata.org/wiki/Q18032396', 'display_name': 'DNA repair protein XRCC4', 'level': 5, 'score': 0.73710215}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.70452833}, {'id': 'https://openalex.org/C116988904', 'wikidata': 'https://www.wikidata.org/wiki/Q18038809', 'display_name': 'DNA polymerase mu', 'level': 5, 'score': 0.6397899}, {'id': 'https://openalex.org/C68748289', 'wikidata': 'https://www.wikidata.org/wiki/Q18030783', 'display_name': 'DNA-PKcs', 'level': 4, 'score': 0.55014527}, {'id': 'https://openalex.org/C134935766', 'wikidata': 'https://www.wikidata.org/wiki/Q210538', 'display_name': 'DNA repair', 'level': 3, 'score': 0.5358829}, {'id': 'https://openalex.org/C134459356', 'wikidata': 'https://www.wikidata.org/wiki/Q4274835', 'display_name': 'Ubiquitin ligase', 'level': 4, 'score': 0.52269423}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.46894026}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.46462876}, {'id': 'https://openalex.org/C122917832', 'wikidata': 'https://www.wikidata.org/wiki/Q2065945', 'display_name': 'Non-homologous end joining', 'level': 4, 'score': 0.4424196}, {'id': 'https://openalex.org/C31254050', 'wikidata': 'https://www.wikidata.org/wiki/Q22328799', 'display_name': 'DNA clamp', 'level': 5, 'score': 0.4357763}, {'id': 'https://openalex.org/C140248907', 'wikidata': 'https://www.wikidata.org/wiki/Q17913449', 'display_name': 'DDB1', 'level': 5, 'score': 0.41113234}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.3939737}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.35519785}, {'id': 'https://openalex.org/C94966510', 'wikidata': 'https://www.wikidata.org/wiki/Q2252764', 'display_name': 'DNA-binding protein', 'level': 4, 'score': 0.25878012}, {'id': 'https://openalex.org/C2756471', 'wikidata': 'https://www.wikidata.org/wiki/Q206286', 'display_name': 'DNA polymerase', 'level': 3, 'score': 0.20247063}, {'id': 'https://openalex.org/C25602115', 'wikidata': 'https://www.wikidata.org/wiki/Q407111', 'display_name': 'Ubiquitin', 'level': 3, 'score': 0.19299078}, {'id': 'https://openalex.org/C104451858', 'wikidata': 'https://www.wikidata.org/wiki/Q2714458', 'display_name': 'Nucleotide excision repair', 'level': 4, 'score': 0.12167218}, {'id': 'https://openalex.org/C58167604', 'wikidata': 'https://www.wikidata.org/wiki/Q5121654', 'display_name': 'Circular bacterial chromosome', 'level': 4, 'score': 0.11488539}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.08960897}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.07633072}, {'id': 'https://openalex.org/C156719811', 'wikidata': 'https://www.wikidata.org/wiki/Q28774', 'display_name': 'Reverse transcriptase', 'level': 4, 'score': 0.0}, {'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D034961', 'descriptor_name': 'Antigens, Nuclear', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D011088', 'descriptor_name': 'DNA Ligases', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D051747', 'descriptor_name': 'DNA-Activated Protein Kinase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034961', 'descriptor_name': 'Antigens, Nuclear', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034961', 'descriptor_name': 'Antigens, Nuclear', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000072481', 'descriptor_name': 'DNA Ligase ATP', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011088', 'descriptor_name': 'DNA Ligases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004260', 'descriptor_name': 'DNA Repair', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051747', 'descriptor_name': 'DNA-Activated Protein Kinase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000072200', 'descriptor_name': 'Ku Autoantigen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008954', 'descriptor_name': 'Models, Biological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D025941', 'descriptor_name': 'Protein Interaction Mapping', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.dnarep.2006.12.007', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S3892243', 'display_name': 'DNA repair', 'issn_l': '1568-7856', 'issn': ['1568-7856', '1568-7864'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17241822', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 51, 'referenced_works': ['https://openalex.org/W1750064874', 'https://openalex.org/W1861478519', 'https://openalex.org/W1963613246', 'https://openalex.org/W1966254852', 'https://openalex.org/W1969331397', 'https://openalex.org/W1972313386', 'https://openalex.org/W1977145510', 'https://openalex.org/W1979303367', 'https://openalex.org/W1979568780', 'https://openalex.org/W1985679430', 'https://openalex.org/W1985775217', 'https://openalex.org/W1986448084', 'https://openalex.org/W1992688638', 'https://openalex.org/W1995084314', 'https://openalex.org/W1996271528', 'https://openalex.org/W2000572584', 'https://openalex.org/W2001784394', 'https://openalex.org/W2002231685', 'https://openalex.org/W2006268714', 'https://openalex.org/W2007784993', 'https://openalex.org/W2011522975', 'https://openalex.org/W2014199526', 'https://openalex.org/W2014512941', 'https://openalex.org/W2015090136', 'https://openalex.org/W2019219567', 'https://openalex.org/W2022648619', 'https://openalex.org/W2028716923', 'https://openalex.org/W2039921012', 'https://openalex.org/W2049878642', 'https://openalex.org/W2051148032', 'https://openalex.org/W2051550009', 'https://openalex.org/W2058336786', 'https://openalex.org/W2060453248', 'https://openalex.org/W2061015483', 'https://openalex.org/W2063683246', 'https://openalex.org/W2064605123', 'https://openalex.org/W2064642458', 'https://openalex.org/W2078288351', 'https://openalex.org/W2082910780', 'https://openalex.org/W2084919692', 'https://openalex.org/W2086218293', 'https://openalex.org/W2088474558', 'https://openalex.org/W2092863175', 'https://openalex.org/W2092920840', 'https://openalex.org/W2103007290', 'https://openalex.org/W2111802021', 'https://openalex.org/W2116718924', 'https://openalex.org/W2135735491', 'https://openalex.org/W2144512576', 'https://openalex.org/W2147348417', 'https://openalex.org/W2149912948'], 'related_works': ['https://openalex.org/W2947679604', 'https://openalex.org/W2187303774', 'https://openalex.org/W2171672464', 'https://openalex.org/W2092920840', 'https://openalex.org/W2072671463', 'https://openalex.org/W2046572356', 'https://openalex.org/W2041529030', 'https://openalex.org/W2034353458', 'https://openalex.org/W2013580891', 'https://openalex.org/W1977976903'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2013580891', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 13}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 10}, {'year': 2014, 'cited_by_count': 9}, {'year': 2013, 'cited_by_count': 8}, {'year': 2012, 'cited_by_count': 13}], 'updated_date': '2024-12-16T06:56:35.069831', 'created_date': '2016-06-24'}