Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1983951183', 'doi': 'https://doi.org/10.1021/bi0263715', 'title': 'Structure of a Nitric Oxide Synthase Heme Protein from <i>Bacillus subtilis</i><sup>,</sup>', 'display_name': 'Structure of a Nitric Oxide Synthase Heme Protein from <i>Bacillus subtilis</i><sup>,</sup>', 'publication_year': 2002, 'publication_date': '2002-08-21', 'ids': {'openalex': 'https://openalex.org/W1983951183', 'doi': 'https://doi.org/10.1021/bi0263715', 'mag': '1983951183', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12220171'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/bi0263715', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S104038378', 'display_name': 'Biochemistry', 'issn_l': '0006-2960', 'issn': ['0006-2960', '1520-4995', '1943-295X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5075708630', 'display_name': 'K. Pant', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I36373038', 'display_name': 'Cleveland Clinic Lerner College of Medicine', 'ror': 'https://ror.org/02x4b0932', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1316902750', 'https://openalex.org/I36373038']}, {'id': 'https://openalex.org/I205783295', 'display_name': 'Cornell University', 'ror': 'https://ror.org/05bnh6r87', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I205783295']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kartikeya Pant', 'raw_affiliation_strings': ['The Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, and The Department of Immunology, Lerner Research Institute, The Cleveland Clinic, Cleveland, Ohio 44195'], 'affiliations': [{'raw_affiliation_string': 'The Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, and The Department of Immunology, Lerner Research Institute, The Cleveland Clinic, Cleveland, Ohio 44195', 'institution_ids': ['https://openalex.org/I36373038', 'https://openalex.org/I205783295']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072298588', 'display_name': 'A.M. Bilwes', 'orcid': 'https://orcid.org/0000-0001-9922-0692'}, 'institutions': [{'id': 'https://openalex.org/I36373038', 'display_name': 'Cleveland Clinic Lerner College of Medicine', 'ror': 'https://ror.org/02x4b0932', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1316902750', 'https://openalex.org/I36373038']}, {'id': 'https://openalex.org/I205783295', 'display_name': 'Cornell University', 'ror': 'https://ror.org/05bnh6r87', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I205783295']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Alexandrine M. Bilwes', 'raw_affiliation_strings': ['The Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, and The Department of Immunology, Lerner Research Institute, The Cleveland Clinic, Cleveland, Ohio 44195'], 'affiliations': [{'raw_affiliation_string': 'The Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, and The Department of Immunology, Lerner Research Institute, The Cleveland Clinic, Cleveland, Ohio 44195', 'institution_ids': ['https://openalex.org/I36373038', 'https://openalex.org/I205783295']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007713390', 'display_name': 'Subrata Adak', 'orcid': 'https://orcid.org/0000-0001-7376-4755'}, 'institutions': [{'id': 'https://openalex.org/I205783295', 'display_name': 'Cornell University', 'ror': 'https://ror.org/05bnh6r87', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I205783295']}, {'id': 'https://openalex.org/I36373038', 'display_name': 'Cleveland Clinic Lerner College of Medicine', 'ror': 'https://ror.org/02x4b0932', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1316902750', 'https://openalex.org/I36373038']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Subrata Adak', 'raw_affiliation_strings': ['The Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, and The Department of Immunology, Lerner Research Institute, The Cleveland Clinic, Cleveland, Ohio 44195'], 'affiliations': [{'raw_affiliation_string': 'The Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, and The Department of Immunology, Lerner Research Institute, The Cleveland Clinic, Cleveland, Ohio 44195', 'institution_ids': ['https://openalex.org/I205783295', 'https://openalex.org/I36373038']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067430639', 'display_name': 'Dennis J. Stuehr', 'orcid': 'https://orcid.org/0000-0002-0960-6848'}, 'institutions': [{'id': 'https://openalex.org/I36373038', 'display_name': 'Cleveland Clinic Lerner College of Medicine', 'ror': 'https://ror.org/02x4b0932', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1316902750', 'https://openalex.org/I36373038']}, {'id': 'https://openalex.org/I205783295', 'display_name': 'Cornell University', 'ror': 'https://ror.org/05bnh6r87', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I205783295']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Dennis J. Stuehr', 'raw_affiliation_strings': ['The Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, and The Department of Immunology, Lerner Research Institute, The Cleveland Clinic, Cleveland, Ohio 44195'], 'affiliations': [{'raw_affiliation_string': 'The Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, and The Department of Immunology, Lerner Research Institute, The Cleveland Clinic, Cleveland, Ohio 44195', 'institution_ids': ['https://openalex.org/I36373038', 'https://openalex.org/I205783295']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5071526287', 'display_name': 'Brian R. Crane', 'orcid': 'https://orcid.org/0000-0001-8234-9991'}, 'institutions': [{'id': 'https://openalex.org/I36373038', 'display_name': 'Cleveland Clinic Lerner College of Medicine', 'ror': 'https://ror.org/02x4b0932', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1316902750', 'https://openalex.org/I36373038']}, {'id': 'https://openalex.org/I205783295', 'display_name': 'Cornell University', 'ror': 'https://ror.org/05bnh6r87', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I205783295']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Brian R. Crane', 'raw_affiliation_strings': ['The Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, and The Department of Immunology, Lerner Research Institute, The Cleveland Clinic, Cleveland, Ohio 44195'], 'affiliations': [{'raw_affiliation_string': 'The Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, and The Department of Immunology, Lerner Research Institute, The Cleveland Clinic, Cleveland, Ohio 44195', 'institution_ids': ['https://openalex.org/I36373038', 'https://openalex.org/I205783295']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.333, 'has_fulltext': False, 'cited_by_count': 129, 'citation_normalized_percentile': {'value': 0.999806, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '41', 'issue': '37', 'first_page': '11071', 'last_page': '11079'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12094', 'display_name': 'Hemoglobin structure and function', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12094', 'display_name': 'Hemoglobin structure and function', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10155', 'display_name': 'Nitric Oxide and Endothelin Effects', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11884', 'display_name': 'Redox biology and oxidative stress', 'score': 0.9965, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/pterin', 'display_name': 'Pterin', 'score': 0.68107}, {'id': 'https://openalex.org/keywords/hemeprotein', 'display_name': 'Hemeprotein', 'score': 0.44213519}], 'concepts': [{'id': 'https://openalex.org/C2776055822', 'wikidata': 'https://www.wikidata.org/wiki/Q386702', 'display_name': 'Pterin', 'level': 4, 'score': 0.68107}, {'id': 'https://openalex.org/C2776217839', 'wikidata': 'https://www.wikidata.org/wiki/Q189621', 'display_name': 'Heme', 'level': 3, 'score': 0.65658}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.6010046}, {'id': 'https://openalex.org/C2777272437', 'wikidata': 'https://www.wikidata.org/wiki/Q131238', 'display_name': 'Bacillus subtilis', 'level': 3, 'score': 0.5718306}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.52906805}, {'id': 'https://openalex.org/C519581460', 'wikidata': 'https://www.wikidata.org/wiki/Q207843', 'display_name': 'Nitric oxide', 'level': 2, 'score': 0.4955169}, {'id': 'https://openalex.org/C2777622882', 'wikidata': 'https://www.wikidata.org/wiki/Q417619', 'display_name': 'Nitric oxide synthase', 'level': 3, 'score': 0.44933057}, {'id': 'https://openalex.org/C20705724', 'wikidata': 'https://www.wikidata.org/wiki/Q902628', 'display_name': 'Hemeprotein', 'level': 4, 'score': 0.44213519}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.43755287}, {'id': 'https://openalex.org/C197957613', 'wikidata': 'https://www.wikidata.org/wiki/Q407280', 'display_name': 'Cofactor', 'level': 3, 'score': 0.4188499}, {'id': 'https://openalex.org/C47701112', 'wikidata': 'https://www.wikidata.org/wiki/Q735188', 'display_name': 'Protein structure', 'level': 2, 'score': 0.41629162}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.31941718}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.26344782}, {'id': 'https://openalex.org/C523546767', 'wikidata': 'https://www.wikidata.org/wiki/Q10876', 'display_name': 'Bacteria', 'level': 2, 'score': 0.17326075}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001412', 'descriptor_name': 'Bacillus subtilis', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D001426', 'descriptor_name': 'Bacterial Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D006420', 'descriptor_name': 'Hemeproteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D019001', 'descriptor_name': 'Nitric Oxide Synthase', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001412', 'descriptor_name': 'Bacillus subtilis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001426', 'descriptor_name': 'Bacterial Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001426', 'descriptor_name': 'Bacterial Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001665', 'descriptor_name': 'Binding Sites', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002417', 'descriptor_name': 'Cattle', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018360', 'descriptor_name': 'Crystallography, X-Ray', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019281', 'descriptor_name': 'Dimerization', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004795', 'descriptor_name': 'Enzyme Stability', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006418', 'descriptor_name': 'Heme', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006418', 'descriptor_name': 'Heme', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D006420', 'descriptor_name': 'Hemeproteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006420', 'descriptor_name': 'Hemeproteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009569', 'descriptor_name': 'Nitric Oxide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009569', 'descriptor_name': 'Nitric Oxide', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019001', 'descriptor_name': 'Nitric Oxide Synthase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019001', 'descriptor_name': 'Nitric Oxide Synthase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011622', 'descriptor_name': 'Pterins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011622', 'descriptor_name': 'Pterins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D013379', 'descriptor_name': 'Substrate Specificity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013499', 'descriptor_name': 'Surface Properties', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/bi0263715', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S104038378', 'display_name': 'Biochemistry', 'issn_l': '0006-2960', 'issn': ['0006-2960', '1520-4995', '1943-295X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12220171', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Life on land', 'id': 'https://metadata.un.org/sdg/15', 'score': 0.52}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 46, 'referenced_works': ['https://openalex.org/W1479676079', 'https://openalex.org/W1541963905', 'https://openalex.org/W1556153644', 'https://openalex.org/W1669388010', 'https://openalex.org/W1800678382', 'https://openalex.org/W1969185821', 'https://openalex.org/W1975262546', 'https://openalex.org/W1986398709', 'https://openalex.org/W1990808614', 'https://openalex.org/W1997070952', 'https://openalex.org/W2004483690', 'https://openalex.org/W2005819238', 'https://openalex.org/W2005857572', 'https://openalex.org/W2015492400', 'https://openalex.org/W2023553716', 'https://openalex.org/W2024060265', 'https://openalex.org/W2028231353', 'https://openalex.org/W2040407936', 'https://openalex.org/W2043512525', 'https://openalex.org/W2043606464', 'https://openalex.org/W2045639174', 'https://openalex.org/W2048946635', 'https://openalex.org/W2052105247', 'https://openalex.org/W2052232788', 'https://openalex.org/W2055671467', 'https://openalex.org/W2056420994', 'https://openalex.org/W2060034829', 'https://openalex.org/W2069144072', 'https://openalex.org/W2069301590', 'https://openalex.org/W2069526662', 'https://openalex.org/W2077437981', 'https://openalex.org/W2080476827', 'https://openalex.org/W2080528351', 'https://openalex.org/W2089337124', 'https://openalex.org/W2094354723', 'https://openalex.org/W2098772291', 'https://openalex.org/W2100882223', 'https://openalex.org/W2108508060', 'https://openalex.org/W2115153703', 'https://openalex.org/W2124306294', 'https://openalex.org/W2160004875', 'https://openalex.org/W2166125504', 'https://openalex.org/W2169917527', 'https://openalex.org/W2173833672', 'https://openalex.org/W2896133428', 'https://openalex.org/W4234401654'], 'related_works': ['https://openalex.org/W2466287610', 'https://openalex.org/W2376188186', 'https://openalex.org/W2274197510', 'https://openalex.org/W2254668287', 'https://openalex.org/W2216269996', 'https://openalex.org/W2169490506', 'https://openalex.org/W2161928213', 'https://openalex.org/W2081623409', 'https://openalex.org/W2003982324', 'https://openalex.org/W1980347870'], 'abstract_inverted_index': {'Eukaryotic': [0], 'nitric': [1, 6, 40], 'oxide': [2, 7, 41], 'synthases': [3], '(NOSs)': [4], 'produce': [5, 39, 207], 'to': [8, 19, 38, 78, 90, 132, 179, 206], 'mediate': [9], 'intercellular': [10], 'signaling': [11], 'and': [12, 29, 47, 68, 108, 115, 128, 167, 171, 212, 222], 'protect': [13], 'against': [14], 'pathogens.': [15], 'Recently,': [16], 'proteins': [17, 158], 'homologous': [18], 'mammalian': [20, 94, 129], 'NOS': [21, 95, 228], 'oxygenase': [22, 96], 'domains': [23, 97], 'have': [24], 'been': [25, 36], 'found': [26], 'in': [27, 121, 159, 214, 233, 237], 'prokaryotes': [28], 'one': [30], 'from': [31, 177, 194, 210], 'Bacillus': [32], 'subtilis': [33, 235], '(bsNOS)': [34], 'has': [35], 'demonstrated': [37], '[Adak,': [42], 'S.,': [43, 46], 'Aulak,': [44], 'K.': [45], 'Stuehr,': [48], 'D.': [49], 'J.': [50, 52], '(2002)': [51], 'Biol.': [53], 'Chem.': [54], '277,': [55], '16167-16171].': [56], 'We': [57], 'present': [58], 'structures': [59, 200], 'of': [60, 92, 103, 123, 165, 191, 224], 'bsNOS': [61, 86, 166, 203], 'complexed': [62], 'with': [63, 113], 'the': [64, 69, 74, 93, 101, 117, 182, 187, 195, 220], 'active': [65], 'cofactor': [66], 'tetrahydrofolate': [67], 'substrate': [70, 183], 'L-arginine': [71], '(L-Arg)': [72], 'or': [73, 80], 'intermediate': [75], 'N(omega)-hydroxy-L-arginine': [76], '(NHA)': [77], '1.9': [79], '2.2': [81], 'A': [82], 'resolution,': [83], 'respectively.': [84], 'The': [85, 162], 'structure': [87], 'is': [88], 'similar': [89], 'those': [91], '(mNOS(ox))': [98], 'except': [99], 'for': [100, 136, 156], 'absence': [102], 'an': [104, 147], 'N-terminal': [105], 'beta-hairpin': [106], 'hook': [107], 'zinc-binding': [109], 'region': [110], 'that': [111, 202, 219], 'interact': [112], 'pterin': [114, 137], 'stabilize': [116], 'mNOS(ox)': [118, 168], 'dimer.': [119], 'Changes': [120], 'patterns': [122], 'residue': [124], 'conservation': [125, 141], 'between': [126], 'bacterial': [127, 196], 'NOSs': [130], 'correlate': [131], 'different': [133, 232], 'binding': [134], 'modes': [135], 'side': [138], 'chains.': [139], 'Residue': [140], 'on': [142], 'a': [143, 152, 175, 215], 'surface': [144], 'patch': [145], 'surrounding': [146], 'exposed': [148], 'heme': [149, 163], 'edge': [150], 'indicates': [151], 'likely': [153], 'interaction': [154], 'site': [155], 'reductase': [157], 'all': [160], 'NOSs.': [161], 'pockets': [164], 'recognize': [169], 'L-Arg': [170, 211], 'NHA': [172, 213], 'similarly,': [173], 'although': [174], 'change': [176], 'Val': [178], 'Ile': [180], 'beside': [181], 'guanidinium': [184], 'may': [185, 229], 'explain': [186], '10-20-fold': [188], 'slower': [189], 'dissociation': [190], 'product': [192], 'NO': [193, 225], 'enzyme.': [197], 'Overall,': [198], 'these': [199], 'suggest': [201], 'functions': [204], 'naturally': [205], 'nitrogen': [208], 'oxides': [209], 'pterin-dependent': [216], 'manner,': [217], 'but': [218], 'regulation': [221], 'purpose': [223], 'production': [226], 'by': [227], 'be': [230], 'quite': [231], 'B.': [234], 'than': [236], 'mammals.': [238]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1983951183', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 8}, {'year': 2013, 'cited_by_count': 9}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-12-09T05:18:49.197904', 'created_date': '2016-06-24'}