Title: Biosynthesis,Transferer and Assembly of Pterin-based Molybdenum Cofactors: Potential Drug Targets
Abstract:As a crucial molecule participating in catalyzing reduction-oxidation(redox) reactions,molybdenum cofactors involve in the redox metabolism of sulphur,nitrogen and carbon.Molybdenum cofactors are gene...As a crucial molecule participating in catalyzing reduction-oxidation(redox) reactions,molybdenum cofactors involve in the redox metabolism of sulphur,nitrogen and carbon.Molybdenum cofactors are generally divided into two groups: the iron-sulphur-cluster-based iron-molybdenum cofactor(FeMo-co) and the pterin-based molybdenum cofactor(Moco).Mo-bis-molybdopterin guanine dinucleotide(Mo-bis-MGD) is one member of Moco,which is important cofactor of nitrate reductase.Membrane-bound nitrate reductase mediating the reduction of nitrate provides bacteria with energy and nitrogen source,which is related with latent tuberculosis infection.Moreover,membrane-bound nitrate reductase contributes significantly to the virulence of Mycobacterium bovis BCG in immunodeficient mice.The difference of biosynthesis,transference and assembly of Moco between human and bacteria indicates that the steps of biosyntheis of Mo-bis-MGD might be developed as novel drug targets to screen novel antibiotics against pathogens,particularly the(multi)drug-resistant Mycobcterium tuberculosis.Read More
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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