Title: FEV1 dynamics and total NO3-/ NO2- level in exhaled breath condensate of current smokers
Abstract:The study aim was to investigate pre- and post-exercise FEV1 level and the level of total NO3-/ NO2- in exhaled breath condensate (EBC) in smokers compared to non-smokers.
The control group included ...The study aim was to investigate pre- and post-exercise FEV1 level and the level of total NO3-/ NO2- in exhaled breath condensate (EBC) in smokers compared to non-smokers.
The control group included healthy non-smokers aged 18 - 35 years (those with no diagnosed respiratory diseases). The second group included current smokers aged 18 - 35 years (smoking history of ≥ 3 years) without respiratory pathology. Both groups were studied at rest, post-exercise FEV1 level was also measured after 10 minutes jogging.
The 1.6-fold reduced basal level of NO metabolites in EBC was found in smokers compared to non-smokers (1,42 ± 0,11 mkmol/l and 2,4 ± 0,26 mkmol/l respectively, p <0.05). Significant differences in post-exercise FEV1 level in smokers and non-smokers were not observed probably due to the small smoking history. Nevertheless, post-exercise FEV1 level in smokers was 1.3-fold lower than in non-smoking group.
Thus, in healthy smokers the reduced respiratory functional capacity was found to be associated with impaired NO synthesis in the lungs even at relatively small smoking history.Read More
Publication Year: 2014
Publication Date: 2014-09-01
Language: en
Type: article
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Cited By Count: 1
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