Title: Early spirometric changes in asymptomatic smokers; is it a time dependent?
Abstract:In health, the main site of airways resistance occurs in the 4th_8th airway generations. Thus, FEV1 largely reflects large airways obstruction, and a significant amount of small airways disease must a...In health, the main site of airways resistance occurs in the 4th_8th airway generations. Thus, FEV1 largely reflects large airways obstruction, and a significant amount of small airways disease must accumulate before FEV1 becomes abnormal. Examination of the mid-portion of expiratory flow may offer more information on small airway pathology The Forced Expiratory Flow between 25 and 75% of the FVC (FEF25_75) is one of the most commonly cited measures of small airways pathology. The Forced Expiratory Volume in 3 sec (FEV3) to FVC ratio has been suggested as an alternative measure. <b>Aim:</b> evaluation the early effects of smoking on small airways by spirometry <b>Results:</b> fifty asymptomatic smokers (Group 1) compared with 50 nonsmokers (Group 2)as a control.The subjects age was ranged from 18 to 75 years with mean age 43.12 ± 13 in smokers, 15-62years with mean age41.74 ± 14 in non-smokers. The majority of the smokers(62 %) were manual workers and 38 % were mental workers while the majority of non-smokers were mental workers 64 %. Smoking cigarette was most common (54 %), than marijuana (46 %) The mean values of all the spirometry function tests were significantly reduced in smokers compared to non smokers, although, they are within the normal range. The impaired PFTs in smokers was found to be statistically highly significant to FEF 25-75 (small airway). Otherwise; there were no significance to other values applying unpaired T test. The most affected age group in significant FEF25-75 reduction was found in 36-55years old, females were more affected than males. The duration of smoking was the most independent risk factor that affects the small airways, than the type of smoking and number of cigarettes or stones per day.Read More
Publication Year: 2016
Publication Date: 2016-09-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 2
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