Publication Information

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'at': [116, 132, 181, 270, 294, 310, 361, 376, 498, 532, 559, 761, 779], 'inflammation': [117, 138, 312, 364, 576, 618, 781, 803, 825, 979, 998, 1182, 1205, 1223, 1241, 1448, 1489, 1500, 1644, 1667], 'spiller': [118, 139, 313, 783], 'betydelig': [120], 'rolle': [121, 142, 316, 787], 'udviklingen': [123, 789], 'sygdommen,': [125], 'men': [126], 'flere': [127, 173, 596], 'studier': [128, 306, 707, 732], 'tyder': [129], 'også': [130, 308, 558], 'systemiske': [133, 378, 398, 460], 'systemisk': [137, 363, 617, 780], 'vaesentlig': [141, 681, 785], 'patogenesen.': [144], 'Philadelphia-negative': [146, 1006], 'myeloproliferative': [147, 1007], 'neoplasier': [148], '(MPNs)': [149], 'gruppe': [152], 'haematologiske': [154], 'kraeftsygdomme': [155], 'erhvervet': [158], 'genetisk': [159], 'defekt': [160], 'pluripotente': [164], 'stamcelle': [165], 'medfører': [167, 250], 'overproduktion': [169], 'eller': [172], 'blodets': [175], 'modne': [176], 'celler.': [177], 'Sygdommene': [178], 'udvikle': [182], 'sig': [183, 819], 'et': [185, 282, 298, 571, 645], 'biologisk': [186], 'kontinuum': [187], 'fra': [188, 552, 753], 'tidligt': [189], 'cancerstadie,': [190], 'essentiel': [191], 'trombocytose': [192], '(ET)': [193], 'over': [194, 727, 1053, 1587, 1692], 'polycytaemi': [195], 'vera': [196, 1055], '(PV)': [197], 'endelig': [199], 'det': [201, 496, 728], 'sene': [202], 'myelofibrose': [203], 'stadie': [204], '(PMF).': [205, 1062], 'Symptomer': [206], 'hos': [207, 326, 385, 433, 658, 691, 715, 767], 'disse': [208], 'patienter': [209, 271, 386, 402, 435, 515, 519, 533, 600, 692], 'skyldes': [210], 'isaer': [211], 'aendrede': [213], 'sammensaetning': [214], 'blodet,': [216], 'hyperviskositet,': [217], 'kompromitteret': [218], 'mikrocirkulation': [219], 'nedsat': [221], 'vaevsgennemblødning.': [222], 'Den': [223], 'øgede': [224, 837], 'morbiditet': [225], 'mortalitet': [227], 'beror': [228], 'høj': [230], 'grad': [231, 615], 'tromboembolier,': [233], 'blødninger': [234], 'leukemisk': [236], 'transformation.': [237, 1100], 'En': [238], 'raekke': [239], 'mutationer': [240], 'driver': [242], 'MPN': [243, 338, 404, 409, 437, 517, 535, 768, 1277, 1282, 1316, 1589, 1632], 'sygdommene': [244, 339], 'identificeret,': [246], 'bl.a.': [247, 256], 'JAK2V617F-mutationen': [248], 'deregulering': [252], 'JAK/STAT': [253, 1122], 'signalvejen,': [254], 'der': [255], 'betydning': [258], 'cellers': [260], 'vaekst': [261], 'overlevelse.': [263], 'Et': [264], 'tidligere': [265, 382, 546, 706, 793], 'stort': [266], 'registerstudie': [267], 'vist': [269, 285, 309, 625], 'MPNs': [273, 327, 1108, 1144, 1213, 1386, 1403], 'øget': [276, 286, 770, 823], 'risiko': [277, 838], 'pilotstudie': [283], 'forekomst': [287, 368, 560], 'intermediaer': [289, 481, 831], 'AMD.': [290, 832, 846, 1163, 1697, 1711], 'Dette': [291, 623, 701, 833], 'ønsker': [292], 'vi': [293, 358, 373, 395, 425, 457, 531, 595, 606, 612, 653, 679, 720, 759], 'undersøge': [295, 362], 'naermere': [296], 'større': [299, 670, 786], 'studie': [300, 526, 587], 'dette': [302, 355], 'Ph.d.-': [303], 'projekt.': [304], 'Flere': [305], 'kronisk': [311, 575], 'vigtig': [315], 'både': [318, 739], 'initiering': [319], 'udvikling': [321, 350, 840], 'maligne': [324], 'celleklon': [325], 'herfra': [329], '"Human': [332, 1204], 'Inflammationsmodel"': [333], 'blevet': [334, 340], 'udviklet.': [335], 'Siden': [336], 'anvendt': [341], '"model': [343], 'sygdomme"': [344], 'tilsvarende': [347, 359], 'inflammationsmodel': [348], 'Alzheimers': [352], 'sygdom.': [353], 'I': [354, 421, 525, 527, 586, 1295, 1395], 'Ph.d.-projekt': [356], 'vil': [357, 372, 494, 510], 'forsøge': [360], 'forhold': [366, 661, 772], 'druser.': [370, 585], 'gøre': [374, 495], 'sammenligne': [377, 390], 'immunologiske': [379, 399, 443, 597], 'markører': [380, 461, 608], 'undersøgt': [384], 'MPN.': [392, 1265], 'Specielt': [393], 'interesseret': [396], 'forskelle': [400, 489, 598], '(MPNd)': [407, 1280], 'normale': [411, 809], 'nethinder': [412], '(MPNn).': [413, 1286], 'Denne': [414], 'afhandling': [415, 757], 'består': [416], 'overordnede': [419], 'studier.': [420], 'Studie': [422, 440], 'I,': [423], 'undersøgte': [424, 458, 473, 607], 'forekomsten': [426, 762], 'retinale': [428], 'associeret': [430, 564], '200': [434, 1313], '(artikel': [438, 467], 'I).': [439, 1318], 'II,': [441, 468, 590, 1462], 'omhandlede': [442], 'ligheder': [444], 'MPN,': [448], 'var': [450, 563], 'opdelt': [451], 'yderligere': [453], 'tre': [454, 553], 'delstudier': [455], 'hhv.': [459], 'inflammation,': [463, 610, 1339, 1481, 1690], 'aldring': [464], 'angiogenese': [466, 749], 'III': [469, 591, 1463], 'IV).': [471], 'Vi': [472, 509, 556, 795], 'markørerne': [474], 'fire': [476], 'typer': [477], 'patienter:': [479], 'nAMD,': [480, 1352], '(iAMD),': [483, 1355], 'MPNd': [484, 491, 602, 620, 659, 698, 1356, 1362, 1473, 1491, 1532, 1567], 'MPNn.': [486, 604, 622, 700, 1358, 1475, 1493], 'Undersøgelsen': [487], 'mellem': [490, 599], 'MPNn,': [493, 663, 1364, 1535, 1569], 'muligt': [497], 'identificere': [499], 'immunsystemet': [502], 'kunne': [504], 'vaere': [505], 'relevante': [506], 'AMD-patogenesen.': [508], 'endvidere': [511], 'sammenholde': [512], 'resultaterne': [513, 754], 'iAMD': [522, 1390], 'nAMD.': [524, 1392], '(Artikel': [528, 589], 'I)': [529], 'fandt': [530, 557, 594, 611, 652, 678, 719], 'signifikant': [538], 'højere': [539, 566, 572, 614, 628, 639], 'praevalens': [540], 'store': [542, 554], 'livet': [548], 'sammenlignet': [549, 581, 695], 'estimater': [551], 'befolkningsundersøgelser.': [555], 'neutrofil-lymfocyt': [567, 640], 'ratio,': [568, 641, 1511], 'hvilket': [569, 664], 'indikerer': [570, 733], 'niveau': [573], 'patienterne': [578], 'dem': [583], 'uden': [584], 'II': [588, 1320, 1460], 'IV)': [593], 'Da': [605], 'end': [621, 714, 792], 'blev': [624], 'inflammationsscore': [629], '(udregnet': [630], 'baggrund': [632], 'niveauer': [634], 'pro-inflammatoriske': [636], 'markører),': [637], 'samt': [642], 'indikationer': [643], 'dereguleret': [646], 'komplementsystem.': [647], 'Ved': [648], 'undersøgelse': [649], 'aldringsmarkører': [651], 'tegn': [654], 'accelereret': [656], 'immunaldring': [657], 'kommer': [665], 'udtryk': [667], 'procentdel': [671], '"effector': [673], 'memory': [674, 1541], 'T': [675, 687, 1542, 1560], 'celler".': [676], 'Endelig': [677], 'lavere': [682, 713], 'ekspression': [683, 710, 724], 'CXCR3': [685, 709, 723, 737, 1555, 1585, 1595], 'monocytter': [690, 726], 'iAMD,': [697, 1566], 'overensstemmelse': [704], 'raske': [716], 'kontroller.': [717], 'Derudover': [718], 'faldende': [722], 'biologiske': [729], 'MPN-kontinuum.': [730], 'Disse': [731], 'involvering': [735], 'PMF,': [742, 1601], 'sygdomsstadier': [744], 'fibrose.': [751], 'Ud': [752], 'denne': [756], 'kan': [758, 804], 'konkludere': [760], 'baggrundsbefolkningen.': [774], 'Endvidere': [775], 'viser': [776], 'resultater': [778], 'muligvis': [782], 'antaget.': [794], 'foreslår': [796], 'derfor': [797], 'AMD-model': [799], '(Figur': [800], '18)': [801, 1665], 'initiere': [805], 'accelerere': [807], 'aldersafhaengige': [810], 'akkumulation': [811], 'affaldsstoffer': [813], 'nethinden,': [815], 'senere': [817], 'udvikler': [818], 'druser,': [821], 'medførende': [822], 'lokal': [824], 'tiden': [828], 'tidlig': [829], 'resulterer': [834], 'invaliderende': [843], 'senstadier': [844], 'ENGLISH': [847], 'SUMMARY:': [848], 'Age-related': [849], 'macular': [850], 'degeneration': [851], 'is': [853, 868, 896, 942, 950, 1627], 'the': [854, 877, 887, 922, 937, 951, 967, 976, 1003, 1022, 1032, 1058, 1073, 1076, 1107, 1113, 1121, 1189, 1194, 1212, 1226, 1297, 1306, 1373, 1421, 1588, 1611, 1621, 1635, 1672, 1679, 1701, 1706], 'most': [855, 952], 'common': [856], 'cause': [857], 'of': [858, 876, 886, 936, 1013, 1021, 1031, 1072, 1089, 1103, 1120, 1149, 1161, 1193, 1228, 1290, 1299, 1308, 1338, 1350, 1409, 1445, 1480, 1487, 1505, 1514, 1522, 1527, 1549, 1575, 1613, 1623, 1676, 1704, 1710], 'irreversible': [859], 'vision': [860, 909], 'loss': [861], 'and': [862, 903, 918, 929, 934, 960, 995, 1082, 1091, 1095, 1098, 1132, 1152, 1191, 1262, 1278, 1281, 1305, 1326, 1341, 1357, 1363, 1391, 1412, 1464, 1474, 1512, 1559, 1568, 1600, 1608, 1625, 1670, 1691, 1695], 'blindness': [863], 'in': [864, 921, 933, 945, 966, 975, 1002, 1043, 1065, 1075, 1118, 1129, 1170, 1187, 1198, 1242, 1258, 1270, 1312, 1347, 1372, 1449, 1490, 1531, 1562, 1570, 1597, 1629, 1652, 1678, 1687, 1700], 'high-income': [865], 'countries.': [866], 'It': [867], 'a': [869, 1011, 1044, 1070, 1153, 1171, 1203, 1221, 1405, 1437, 1442, 1484, 1498, 1508, 1515, 1547, 1553, 1647], 'progressive': [870], 'retinal': [871, 1300], 'disease': [872, 888, 1603], 'leading': [873], 'damage': [875], 'cells': [878, 1561], 'responsible': [879], 'central': [881], 'vision.': [882], 'The': [883, 940, 1005, 1036, 1063, 1086], 'early': [884, 925, 1048], 'stages': [885, 1311, 1604, 1709], 'are': [889, 964, 1010, 1068, 1093, 1267], 'often': [890, 1069], 'asymptomatic,': [891], 'while': [892, 927], 'late-stage': [893], 'which': [895, 949, 1116, 1681], 'divided': [897, 1331], 'into': [898, 1332, 1684], 'two': [899, 1291, 1602], 'entities,': [900], 'neovascular': [901, 1150], 'geographic': [904], 'atrophy': [905, 935], 'both': [907, 1188, 1598], 'show': [908, 931, 1641], 'loss,': [910], 'though': [911], 'generally': [912], 'with': [913, 1016, 1143, 1260, 1264, 1276, 1283, 1303, 1315, 1385, 1387, 1389, 1402, 1436, 1451, 1472, 1572, 1631], 'different': [914, 1309], 'progression': [915, 1192], 'rates.': [916], 'Drusen': [917], 'pigmentary': [919], 'abnormalities': [920], 'retina': [923], 'characterise': [924], 'angiogenesis': [932, 1607], 'retina,': [938, 1680], 'respectively.': [939, 1343], 'aetiology': [941], 'multifactorial': [943], 'and,': [944], 'addition': [946], 'ageing,': [948, 1523], 'significant': [953], 'risk': [954, 962, 1148, 1703], 'factor': [955], 'developing': [957, 1705], 'environmental-': [959], 'genetic': [961, 1019], 'factors': [963], 'implicated': [965], 'pathogenesis.': [968, 1004, 1379], 'Research': [969], 'has': [970, 980, 1109, 1139, 1156, 1207, 1214], 'focused': [971], 'on': [972, 1503, 1557], 'local': [973, 1689], 'changes': [974, 1074, 1301, 1371], 'eye': [977], 'where': [978, 1666], 'been': [981, 1039, 1110, 1208, 1215], 'found': [982, 1040, 1399, 1430, 1467, 1483, 1525, 1552, 1583], 'play': [984, 1646], 'an': [985, 1017, 1146, 1158, 1184, 1416, 1661], 'essential': [986, 1051, 1185, 1650], 'role,': [987], 'but': [988], 'studies': [989, 1176, 1574, 1593], 'also': [990, 1178, 1429], 'point': [991], 'systemic': [993, 997, 1181, 1240, 1253, 1271, 1336, 1488, 1643], 'alterations': [994], 'especially': [996], 'be': [1000], 'involved': [1001], 'neoplasms': [1008], '(MPN)': [1009], 'group': [1012, 1102], 'haematological': [1014], 'cancers': [1015], 'acquired': [1018], 'defect': [1020], 'pluripotent': [1023], 'haematopoietic': [1024], 'stem': [1025], 'cell,': [1026], 'characterised': [1027, 1605], 'by': [1028, 1251, 1497, 1537, 1606], 'excess': [1029], 'haematopoiesis': [1030], 'myeloid': [1033], 'cell': [1034, 1130, 1196], 'lineage.': [1035], 'diseases': [1037, 1219], 'have': [1038, 1145, 1177, 1404], 'evolve': [1042, 1683], 'biological': [1045, 1590], 'continuum': [1046], 'from': [1047, 1415, 1423], 'cancer': [1049], 'state,': [1050], 'thrombocythemia,': [1052], 'polycythaemia': [1054], '(PV),': [1056], 'advanced': [1059], 'myelofibrosis': [1060], 'stage': [1061], 'symptoms': [1064], 'these': [1066], 'patients': [1067, 1142, 1259, 1275, 1314, 1384, 1388, 1401, 1450, 1471, 1630], 'result': [1071], 'blood': [1077], 'composition,': [1078], 'hyperviscosity,': [1079], 'microvascular': [1080], 'disturbances,': [1081], 'reduced': [1083], 'tissue': [1084], 'perfusion.': [1085], 'major': [1087], 'causes': [1088], 'morbidity': [1090], 'mortality': [1092], 'thromboembolic-': [1094], 'haemorrhagic': [1096], 'events,': [1097], 'leukemic': [1099], 'A': [1101, 1134], 'mutations': [1104], 'that': [1105, 1141, 1180, 1400, 1431, 1620, 1642], 'drive': [1106], 'identified,': [1111], 'e.g.,': [1112], 'JAK2V617F': [1114], 'mutation,': [1115], 'results': [1117, 1612, 1640, 1699], 'deregulation': [1119], 'signal': [1123], 'transduction': [1124], 'pathway': [1125], 'important,': [1126], 'instance,': [1128], 'differentiation': [1131], 'survival.': [1133], 'previous': [1135, 1573], 'large': [1136, 1410, 1425], 'register': [1137], 'study': [1138, 1155, 1167, 1329, 1394, 1459], 'shown': [1140, 1157, 1179, 1536], 'increased': [1147, 1159, 1628, 1688, 1702], 'pilot': [1154], 'prevalence': [1160, 1298, 1307, 1408, 1433, 1622], 'intermediate': [1162, 1353, 1696], 'We': [1164, 1247, 1266, 1428], 'wish': [1165], 'this': [1168, 1201, 1232, 1250, 1614], 'further': [1169], 'larger': [1172], 'scale': [1173], 'study.': [1174], 'Several': [1175], 'plays': [1183], 'role': [1186, 1651], 'initiation': [1190], 'malignant': [1195], 'clone': [1197], 'MPNs.': [1199, 1327], 'From': [1200, 1610], 'knowledge,': [1202], 'model"': [1206], 'developed.': [1209], 'Since': [1210], 'then,': [1211], 'used': [1216], 'as': [1217], 'model': [1218, 1224, 1663], 'similar': [1222], 'development': [1227], "Alzheimer's": [1229], 'disease.': [1230], 'In': [1231, 1393, 1458], 'PhD': [1233, 1615], 'project,': [1234, 1616], 'we': [1235, 1381, 1398, 1466, 1477, 1482, 1524, 1551, 1582, 1617], 'would': [1236], 'like': [1237], 'investigate': [1239], 'relation': [1243], 'drusen': [1245, 1279, 1411, 1432, 1452, 1624], 'presence.': [1246], 'will': [1248, 1365, 1382], 'do': [1249], 'comparing': [1252], 'immunological': [1254, 1272, 1322, 1468], 'markers': [1255, 1337, 1479, 1521], 'previously': [1256, 1656], 'investigated': [1257, 1296, 1478], 'compare': [1263, 1383], 'primarily': [1268], 'interested': [1269], 'differences': [1273, 1360, 1469], 'between': [1274, 1324, 1361, 1470], 'normal': [1284, 1673], 'retinas': [1285], 'This': [1287, 1328, 1344, 1494, 1698], 'thesis': [1288], 'consists': [1289], 'main': [1292], 'studies.': [1293, 1427], 'Study': [1294, 1319], 'associated': [1302, 1435], '(paper': [1317], 'examined': [1321], 'similarities': [1323], 'was': [1330, 1345, 1434, 1495], 'three': [1333, 1424], 'substudies': [1334], 'exploring': [1335, 1546], 'ageing': [1340, 1530], 'angiogenesis,': [1342, 1550], 'done': [1346], 'four': [1348], 'types': [1349], 'patients:': [1351], 'Investigating,': [1359], 'make': [1366], 'it': [1367], 'possible': [1368], 'identify': [1370], 'immune': [1374, 1529], 'system,': [1375], 'relevant': [1376], 'Additionally,': [1380], '(Paper': [1396], 'I),': [1397], 'significantly': [1406], 'higher': [1407, 1438, 1443, 1485, 1499, 1509], 'consequently': [1413], 'earlier': [1417], 'age': [1418], 'compared': [1419, 1453, 1533, 1564, 1577, 1633], 'estimates': [1422], 'population-based': [1426], 'neutrophil-to-lymphocyte': [1439, 1510], 'ratio': [1440], 'indicating': [1441], 'level': [1444, 1486], 'chronic': [1446], 'low-grade': [1447], 'those': [1455], 'without': [1456], 'drusen.': [1457], '(papers': [1461], 'IV),': [1465], 'When': [1476, 1519], 'than': [1492, 1655], 'indicated': [1496], 'score': [1501], '(based': [1502], 'levels': [1504], 'pro-inflammatory': [1506], 'markers),': [1507], 'indications': [1513], 'deregulated': [1516], 'complement': [1517], 'system.': [1518], 'examining': [1520], 'signs': [1526], 'accelerated': [1528], 'more': [1538, 1649], 'senescent': [1539], 'effector': [1540], 'cells.': [1543], 'Finally,': [1544], 'when': [1545], 'marker': [1548], 'lower': [1554], 'expression': [1556, 1586], 'monocytes': [1558], 'line': [1571], 'healthy': [1579], 'controls.': [1580], 'Further,': [1581, 1638], 'decreasing': [1584], 'continuum.': [1591], 'These': [1592], 'indicate': [1594], 'involvement': [1596], 'fibrosis.': [1609], 'can': [1618, 1668], 'conclude': [1619], 'general': [1636], 'population.': [1637], 'our': [1639], 'may': [1645], 'far': [1648], 'pathogenesis': [1654], 'anticipated.': [1657], 'We,': [1658], 'therefore,': [1659], 'propose': [1660], '(Figure': [1664], 'initiate': [1669], 'accelerate': [1671], 'age-dependent': [1674], 'accumulation': [1675], 'debris': [1677], 'later': [1682], 'drusen,': [1685], 'resulting': [1686], 'time': [1693], 'early-': [1694], 'late': [1707], 'debilitating': [1708]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4302288361', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}], 'updated_date': '2024-12-12T18:43:42.708910', 'created_date': '2022-10-06'}