Title: Protein Transport across the Bio–membranes by Bacterial Type III Secretion System
Abstract:Pathogenic bacteria deliver effector proteins directly into host cells via type III secretion system (T3SS) to prime the host cell environment for infection. Thus T3SS inhibitor would potently suppres...Pathogenic bacteria deliver effector proteins directly into host cells via type III secretion system (T3SS) to prime the host cell environment for infection. Thus T3SS inhibitor would potently suppress bacterial infection. For molecular design of T3SS inhibitor, clarification of the protein transport mechanism of T3SS is required. We previously demonstrated that T3SS needle rotates by proton–motive force (PMF) and effector transport of T3SS is suppressed by inhibition of needle rotation. In this review, we summarize the recent knowledge about effector transport of T3SS and introduce our novel model of effector transport mechanism of T3SS based on our findings.Read More
Publication Year: 2019
Publication Date: 2019-01-01
Language: en
Type: article
Indexed In: ['crossref']
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