Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2116909324', 'doi': 'https://doi.org/10.1111/j.1365-2958.2004.04438.x', 'title': 'Type III secretion chaperones of <i>Pseudomonas syringae</i> protect effectors from Lon‐associated degradation', 'display_name': 'Type III secretion chaperones of <i>Pseudomonas syringae</i> protect effectors from Lon‐associated degradation', 'publication_year': 2004, 'publication_date': '2004-12-02', 'ids': {'openalex': 'https://openalex.org/W2116909324', 'doi': 'https://doi.org/10.1111/j.1365-2958.2004.04438.x', 'mag': '2116909324', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15661015'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1365-2958.2004.04438.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S102549058', 'display_name': 'Molecular Microbiology', 'issn_l': '0950-382X', 'issn': ['0950-382X', '1365-2958'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5108462919', 'display_name': 'Liliana Losada', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I66946132', 'display_name': 'University of Maryland, College Park', 'ror': 'https://ror.org/047s2c258', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I66946132']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Liliana C. Losada', 'raw_affiliation_strings': ['Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, 20742 USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, 20742 USA.', 'institution_ids': ['https://openalex.org/I66946132']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5046294016', 'display_name': 'Steven W. Hutcheson', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I66946132', 'display_name': 'University of Maryland, College Park', 'ror': 'https://ror.org/047s2c258', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I66946132']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Steven W. Hutcheson', 'raw_affiliation_strings': ['Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, 20742 USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, 20742 USA.', 'institution_ids': ['https://openalex.org/I66946132']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4020, 'currency': 'USD', 'value_usd': 4020, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 4.923, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 56, 'citation_normalized_percentile': {'value': 0.896568, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '55', 'issue': '3', 'first_page': '941', 'last_page': '953'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11578', 'display_name': 'Plant Pathogenic Bacteria Studies', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1110', 'display_name': 'Plant Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11578', 'display_name': 'Plant Pathogenic Bacteria Studies', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1110', 'display_name': 'Plant Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12232', 'display_name': 'Yersinia bacterium, plague, ectoparasites research', 'score': 0.9886, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12475', 'display_name': 'Plant Parasitism and Resistance', 'score': 0.9874, 'subfield': {'id': 'https://openalex.org/subfields/1110', 'display_name': 'Plant Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/pseudomonas-syringae', 'display_name': 'Pseudomonas syringae', 'score': 0.9311703}, {'id': 'https://openalex.org/keywords/chaperone', 'display_name': 'Chaperone (clinical)', 'score': 0.8343994}, {'id': 'https://openalex.org/keywords/proteolysis', 'display_name': 'Proteolysis', 'score': 0.41954368}], 'concepts': [{'id': 'https://openalex.org/C51785407', 'wikidata': 'https://www.wikidata.org/wiki/Q2627568', 'display_name': 'Effector', 'level': 2, 'score': 0.96501434}, {'id': 'https://openalex.org/C2780381237', 'wikidata': 'https://www.wikidata.org/wiki/Q311202', 'display_name': 'Pseudomonas syringae', 'level': 3, 'score': 0.9311703}, {'id': 'https://openalex.org/C49039625', 'wikidata': 'https://www.wikidata.org/wiki/Q84230', 'display_name': 'Secretion', 'level': 2, 'score': 0.8723006}, {'id': 'https://openalex.org/C130211564', 'wikidata': 'https://www.wikidata.org/wiki/Q21199165', 'display_name': 'Type three secretion system', 'level': 4, 'score': 0.8538446}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.85227764}, {'id': 'https://openalex.org/C2775962898', 'wikidata': 'https://www.wikidata.org/wiki/Q5073152', 'display_name': 'Chaperone (clinical)', 'level': 2, 'score': 0.8343994}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5339315}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.4987104}, {'id': 'https://openalex.org/C2781307694', 'wikidata': 'https://www.wikidata.org/wiki/Q33123', 'display_name': 'Proteolysis', 'level': 3, 'score': 0.41954368}, {'id': 'https://openalex.org/C190062978', 'wikidata': 'https://www.wikidata.org/wiki/Q79899', 'display_name': 'Cytoplasm', 'level': 2, 'score': 0.4100114}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.39601892}, {'id': 'https://openalex.org/C2776460866', 'wikidata': 'https://www.wikidata.org/wiki/Q170065', 'display_name': 'Pathogen', 'level': 2, 'score': 0.29181778}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.24947563}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.065289885}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.053331584}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001426', 'descriptor_name': 'Bacterial Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015964', 'descriptor_name': 'Gene Expression Regulation, Bacterial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D018832', 'descriptor_name': 'Molecular Chaperones', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D049070', 'descriptor_name': 'Protease La', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D044224', 'descriptor_name': 'Pseudomonas syringae', 'qualifier_ui': 'Q000472', 'qualifier_name': 'pathogenicity', 'is_major_topic': True}, {'descriptor_ui': 'D001426', 'descriptor_name': 'Bacterial Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D001426', 'descriptor_name': 'Bacterial Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004268', 'descriptor_name': 'DNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004926', 'descriptor_name': 'Escherichia coli', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004926', 'descriptor_name': 'Escherichia coli', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004926', 'descriptor_name': 'Escherichia coli', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018832', 'descriptor_name': 'Molecular Chaperones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014026', 'descriptor_name': 'Nicotiana', 'qualifier_ui': 'Q000382', 'qualifier_name': 'microbiology', 'is_major_topic': False}, {'descriptor_ui': 'D014026', 'descriptor_name': 'Nicotiana', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010935', 'descriptor_name': 'Plant Diseases', 'qualifier_ui': 'Q000382', 'qualifier_name': 'microbiology', 'is_major_topic': False}, {'descriptor_ui': 'D010935', 'descriptor_name': 'Plant Diseases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018515', 'descriptor_name': 'Plant Leaves', 'qualifier_ui': 'Q000382', 'qualifier_name': 'microbiology', 'is_major_topic': False}, {'descriptor_ui': 'D018515', 'descriptor_name': 'Plant Leaves', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049070', 'descriptor_name': 'Protease La', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044224', 'descriptor_name': 'Pseudomonas syringae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044224', 'descriptor_name': 'Pseudomonas syringae', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D044224', 'descriptor_name': 'Pseudomonas syringae', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012808', 'descriptor_name': 'Sigma Factor', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012808', 'descriptor_name': 'Sigma Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1365-2958.2004.04438.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S102549058', 'display_name': 'Molecular Microbiology', 'issn_l': '0950-382X', 'issn': ['0950-382X', '1365-2958'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/15661015', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 74, 'referenced_works': ['https://openalex.org/W1135507724', 'https://openalex.org/W1498516814', 'https://openalex.org/W1501920547', 'https://openalex.org/W1515015726', 'https://openalex.org/W1524666565', 'https://openalex.org/W1536529129', 'https://openalex.org/W1545600129', 'https://openalex.org/W1546783991', 'https://openalex.org/W1549613283', 'https://openalex.org/W1550786580', 'https://openalex.org/W1581054924', 'https://openalex.org/W1640177329', 'https://openalex.org/W1732098708', 'https://openalex.org/W1760848733', 'https://openalex.org/W1838285010', 'https://openalex.org/W1964633546', 'https://openalex.org/W1965970815', 'https://openalex.org/W1972010400', 'https://openalex.org/W1972825620', 'https://openalex.org/W1973578316', 'https://openalex.org/W1978028607', 'https://openalex.org/W1978338354', 'https://openalex.org/W1980671137', 'https://openalex.org/W1981423406', 'https://openalex.org/W1987587550', 'https://openalex.org/W2002875716', 'https://openalex.org/W2005528863', 'https://openalex.org/W2006101350', 'https://openalex.org/W2014216245', 'https://openalex.org/W2017728221', 'https://openalex.org/W2018910670', 'https://openalex.org/W2019978236', 'https://openalex.org/W2042840404', 'https://openalex.org/W2050887121', 'https://openalex.org/W2052570866', 'https://openalex.org/W2057238625', 'https://openalex.org/W2063292959', 'https://openalex.org/W2067878709', 'https://openalex.org/W2070880631', 'https://openalex.org/W2082887128', 'https://openalex.org/W2089772414', 'https://openalex.org/W2092245702', 'https://openalex.org/W2096893680', 'https://openalex.org/W2097912852', 'https://openalex.org/W2099196052', 'https://openalex.org/W2099689497', 'https://openalex.org/W2101783575', 'https://openalex.org/W2102547044', 'https://openalex.org/W2105179222', 'https://openalex.org/W2106132559', 'https://openalex.org/W2107543403', 'https://openalex.org/W2110062470', 'https://openalex.org/W2113790807', 'https://openalex.org/W2115997854', 'https://openalex.org/W2116833173', 'https://openalex.org/W2122351989', 'https://openalex.org/W2123513957', 'https://openalex.org/W2132589339', 'https://openalex.org/W2132755374', 'https://openalex.org/W2134392367', 'https://openalex.org/W2136524485', 'https://openalex.org/W2142262094', 'https://openalex.org/W2144264917', 'https://openalex.org/W2146113572', 'https://openalex.org/W2146218685', 'https://openalex.org/W2148742847', 'https://openalex.org/W2157708426', 'https://openalex.org/W2160178001', 'https://openalex.org/W2161940955', 'https://openalex.org/W2320327426', 'https://openalex.org/W2320462907', 'https://openalex.org/W2425774778', 'https://openalex.org/W2804007336', 'https://openalex.org/W4254281572'], 'related_works': ['https://openalex.org/W2808185338', 'https://openalex.org/W2791163639', 'https://openalex.org/W2133411779', 'https://openalex.org/W2131507570', 'https://openalex.org/W2126981014', 'https://openalex.org/W2116909324', 'https://openalex.org/W2115997854', 'https://openalex.org/W2113745586', 'https://openalex.org/W2018093685', 'https://openalex.org/W1988945052'], 'abstract_inverted_index': {'Summary': [0], 'The': [1, 34, 84, 162], 'hrp': [2, 32], 'type': [3], 'III': [4], 'secretion': [5, 106], 'system': [6, 43], '(TTSS)': [7], 'of': [8, 17, 21, 47, 55, 86, 107, 124, 176, 182, 184, 189], 'Pseudomonas': [9], 'syringae': [10, 179], 'translocates': [11], 'effector': [12, 61, 190], 'proteins': [13], 'into': [14], 'the': [15, 31, 41, 48, 74, 87, 174, 177, 185], 'cytoplasm': [16], 'host': [18], 'cells.': [19], 'Proteolysis': [20], 'HrpR': [22], 'by': [23, 44], 'Lon': [24, 58, 113, 166], 'has': [25], 'been': [26], 'shown': [27], 'to': [28, 36, 73, 79, 82, 121, 130], 'negatively': [29], 'regulate': [30], 'TTSS.': [33], 'inability': [35], 'bypass': [37], 'Lon‐associated': [38, 127], 'effects': [39], 'on': [40], 'regulatory': [42], 'ectopic': [45], 'expression': [46], 'known': [49], 'regulators': [50], 'suggested': [51], 'a': [52], 'second': [53], 'site': [54], 'action': [56], 'for': [57, 118], 'in': [59, 101, 149, 160, 173], 'TTSS‐dependent': [60, 69, 105], 'secretion.': [62, 83, 131, 191], 'In': [63], 'this': [64], 'study': [65], 'we': [66], 'report': [67], 'that': [68, 77, 165], 'effectors': [70, 88, 109, 125], 'are': [71], 'subject': [72], 'proteolytic': [75], 'degradation': [76, 128], 'appears': [78, 120], 'be': [80, 122], 'rate‐limiting': [81], 'half‐lives': [85], 'AvrPto,': [89], 'AvrRpt2,': [90], 'HopPsyA,': [91], 'HopPsyB1,': [92, 138], 'HopPtoB2,': [93], 'HopPsyV1,': [94], 'HopPtoG': [95], 'and': [96, 140, 155, 187], 'HopPtoM': [97, 141], 'were': [98, 142, 158], 'substantially': [99], 'higher': [100], 'bacteria': [102], 'lacking': [103], 'Lon.': [104, 152], 'several': [108], 'was': [110], 'enhanced': [111], 'from': [112, 126], 'mutants.': [114], 'A': [115], 'primary': [116], 'role': [117], 'chaperones': [119], 'protection': [123], 'prior': [129], 'When': [132], 'coexpressed': [133], 'with': [134], 'their': [135], 'cognate': [136], 'chaperone,': [137], 'HopPsyV1': [139], 'at': [143, 169], 'least': [144], '10': [145], 'times': [146], 'more': [147], 'stable': [148], 'strains': [150], 'expressing': [151], 'Distinct': [153], 'Lon‐targeting': [154], 'chaperone‐binding': [156], 'domains': [157], 'identified': [159], 'HopPtoM.': [161], 'results': [163], 'imply': [164], 'is': [167], 'involved': [168], 'two': [170], 'distinct': [171], 'levels': [172], 'regulation': [175, 181], 'P.': [178], 'TTSS:': [180], 'assembly': [183], 'secreton': [186], 'modulation': [188]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2116909324', 'counts_by_year': [{'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-12-11T05:34:12.505379', 'created_date': '2016-06-24'}