Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2018093685', 'doi': 'https://doi.org/10.1371/journal.pone.0049388', 'title': 'Structure of the Type III Secretion Effector Protein ExoU in Complex with Its Chaperone SpcU', 'display_name': 'Structure of the Type III Secretion Effector Protein ExoU in Complex with Its Chaperone SpcU', 'publication_year': 2012, 'publication_date': '2012-11-14', 'ids': {'openalex': 'https://openalex.org/W2018093685', 'doi': 'https://doi.org/10.1371/journal.pone.0049388', 'mag': '2018093685', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/23166655', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3498133'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0049388', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0049388&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0049388&type=printable', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5078365326', 'display_name': 'A.S. Halavaty', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210091204', 'display_name': 'Joint Center for Structural Genomics', 'ror': 'https://ror.org/00exr1241', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I4210091204']}, {'id': 'https://openalex.org/I111979921', 'display_name': 'Northwestern University', 'ror': 'https://ror.org/000e0be47', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I111979921']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Andrei S. Halavaty', 'raw_affiliation_strings': ['Center for Structural Genomics of Infectious Diseases (CSGID), Chicago, Illinois, United States of America', 'Department of Molecular Pharmacology and Biological Chemistry, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Center for Structural Genomics of Infectious Diseases (CSGID), Chicago, Illinois, United States of America', 'institution_ids': ['https://openalex.org/I4210091204']}, {'raw_affiliation_string': 'Department of Molecular Pharmacology and Biological Chemistry, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America', 'institution_ids': ['https://openalex.org/I111979921']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016335715', 'display_name': 'Dominika Borek', 'orcid': 'https://orcid.org/0000-0002-4321-6253'}, 'institutions': [{'id': 'https://openalex.org/I867280407', 'display_name': 'The University of Texas Southwestern Medical Center', 'ror': 'https://ror.org/05byvp690', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I867280407']}, {'id': 'https://openalex.org/I4210091204', 'display_name': 'Joint Center for Structural Genomics', 'ror': 'https://ror.org/00exr1241', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I4210091204']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Dominika Borek', 'raw_affiliation_strings': ['Center for Structural Genomics of Infectious Diseases (CSGID), Chicago, Illinois, United States of America', 'University of Texas Southwestern Medical Center, Dallas, Texas, United States of America'], 'affiliations': [{'raw_affiliation_string': 'University of Texas Southwestern Medical Center, Dallas, Texas, United States of America', 'institution_ids': ['https://openalex.org/I867280407']}, {'raw_affiliation_string': 'Center for Structural Genomics of Infectious Diseases (CSGID), Chicago, Illinois, United States of America', 'institution_ids': ['https://openalex.org/I4210091204']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001810058', 'display_name': 'Gregory H. Tyson', 'orcid': 'https://orcid.org/0000-0002-2729-5035'}, 'institutions': [{'id': 'https://openalex.org/I111979921', 'display_name': 'Northwestern University', 'ror': 'https://ror.org/000e0be47', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I111979921']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gregory H. Tyson', 'raw_affiliation_strings': ['Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America', 'institution_ids': ['https://openalex.org/I111979921']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050482494', 'display_name': 'Jeff L. Veesenmeyer', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I111979921', 'display_name': 'Northwestern University', 'ror': 'https://ror.org/000e0be47', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I111979921']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jeff L. Veesenmeyer', 'raw_affiliation_strings': ['Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America', 'institution_ids': ['https://openalex.org/I111979921']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000004179', 'display_name': 'L. Shuvalova', 'orcid': 'https://orcid.org/0000-0002-2570-371X'}, 'institutions': [{'id': 'https://openalex.org/I4210091204', 'display_name': 'Joint Center for Structural Genomics', 'ror': 'https://ror.org/00exr1241', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I4210091204']}, {'id': 'https://openalex.org/I111979921', 'display_name': 'Northwestern University', 'ror': 'https://ror.org/000e0be47', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I111979921']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ludmilla Shuvalova', 'raw_affiliation_strings': ['Center for Structural Genomics of Infectious Diseases (CSGID), Chicago, Illinois, United States of America', 'Department of Molecular Pharmacology and Biological Chemistry, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Center for Structural Genomics of Infectious Diseases (CSGID), Chicago, Illinois, United States of America', 'institution_ids': ['https://openalex.org/I4210091204']}, {'raw_affiliation_string': 'Department of Molecular Pharmacology and Biological Chemistry, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America', 'institution_ids': ['https://openalex.org/I111979921']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046083677', 'display_name': 'G. Minasov', 'orcid': 'https://orcid.org/0000-0001-5460-3462'}, 'institutions': [{'id': 'https://openalex.org/I4210091204', 'display_name': 'Joint Center for Structural Genomics', 'ror': 'https://ror.org/00exr1241', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I4210091204']}, {'id': 'https://openalex.org/I111979921', 'display_name': 'Northwestern University', 'ror': 'https://ror.org/000e0be47', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I111979921']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'George Minasov', 'raw_affiliation_strings': ['Center for Structural Genomics of Infectious Diseases (CSGID), Chicago, Illinois, United States of America', 'Department of Molecular Pharmacology and Biological Chemistry, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Center for Structural Genomics of Infectious Diseases (CSGID), Chicago, Illinois, United States of America', 'institution_ids': ['https://openalex.org/I4210091204']}, {'raw_affiliation_string': 'Department of Molecular Pharmacology and Biological Chemistry, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America', 'institution_ids': ['https://openalex.org/I111979921']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063625875', 'display_name': 'Zbyszek Otwinowski', 'orcid': 'https://orcid.org/0000-0003-3640-8545'}, 'institutions': [{'id': 'https://openalex.org/I867280407', 'display_name': 'The University of Texas Southwestern Medical Center', 'ror': 'https://ror.org/05byvp690', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I867280407']}, {'id': 'https://openalex.org/I4210091204', 'display_name': 'Joint Center for Structural Genomics', 'ror': 'https://ror.org/00exr1241', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I4210091204']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Zbyszek Otwinowski', 'raw_affiliation_strings': ['Center for Structural Genomics of Infectious Diseases (CSGID), Chicago, Illinois, United States of America', 'University of Texas Southwestern Medical Center, Dallas, Texas, United States of America'], 'affiliations': [{'raw_affiliation_string': 'University of Texas Southwestern Medical Center, Dallas, Texas, United States of America', 'institution_ids': ['https://openalex.org/I867280407']}, {'raw_affiliation_string': 'Center for Structural Genomics of Infectious Diseases (CSGID), Chicago, Illinois, United States of America', 'institution_ids': ['https://openalex.org/I4210091204']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036755430', 'display_name': 'Alan R. Hauser', 'orcid': 'https://orcid.org/0000-0003-4596-7939'}, 'institutions': [{'id': 'https://openalex.org/I111979921', 'display_name': 'Northwestern University', 'ror': 'https://ror.org/000e0be47', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I111979921']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Alan R. Hauser', 'raw_affiliation_strings': ['Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America', 'institution_ids': ['https://openalex.org/I111979921']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5057424046', 'display_name': 'W.F. Anderson', 'orcid': 'https://orcid.org/0000-0003-4181-8127'}, 'institutions': [{'id': 'https://openalex.org/I4210091204', 'display_name': 'Joint Center for Structural Genomics', 'ror': 'https://ror.org/00exr1241', 'country_code': 'US', 'type': 'other', 'lineage': ['https://openalex.org/I4210091204']}, {'id': 'https://openalex.org/I111979921', 'display_name': 'Northwestern University', 'ror': 'https://ror.org/000e0be47', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I111979921']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Wayne F. Anderson', 'raw_affiliation_strings': ['Center for Structural Genomics of Infectious Diseases (CSGID), Chicago, Illinois, United States of America', 'Department of Molecular Pharmacology and Biological Chemistry, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Center for Structural Genomics of Infectious Diseases (CSGID), Chicago, Illinois, United States of America', 'institution_ids': ['https://openalex.org/I4210091204']}, {'raw_affiliation_string': 'Department of Molecular Pharmacology and Biological Chemistry, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America', 'institution_ids': ['https://openalex.org/I111979921']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5057424046'], 'corresponding_institution_ids': ['https://openalex.org/I4210091204', 'https://openalex.org/I111979921'], 'apc_list': {'value': 1805, 'currency': 'USD', 'value_usd': 1805, 'provenance': 'doaj'}, 'apc_paid': {'value': 1805, 'currency': 'USD', 'value_usd': 1805, 'provenance': 'doaj'}, 'fwci': 2.388, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 37, 'citation_normalized_percentile': {'value': 0.886281, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '7', 'issue': '11', 'first_page': 'e49388', 'last_page': 'e49388'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12232', 'display_name': 'Genetic and Pathogenic Study of Plague Bacteria', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12232', 'display_name': 'Genetic and Pathogenic Study of Plague Bacteria', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12477', 'display_name': 'Immunotoxin Therapy for Cancer Treatment', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11288', 'display_name': 'Clostridium difficile Infection and Treatment', 'score': 0.9975, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/chaperone', 'display_name': 'Chaperone (clinical)', 'score': 0.86750436}, {'id': 'https://openalex.org/keywords/type-iii-secretion-system', 'display_name': 'Type III Secretion System', 'score': 0.599056}, {'id': 'https://openalex.org/keywords/bacterial-pathogenesis', 'display_name': 'Bacterial Pathogenesis', 'score': 0.514976}], 'concepts': [{'id': 'https://openalex.org/C51785407', 'wikidata': 'https://www.wikidata.org/wiki/Q2627568', 'display_name': 'Effector', 'level': 2, 'score': 0.9492325}, {'id': 'https://openalex.org/C49039625', 'wikidata': 'https://www.wikidata.org/wiki/Q84230', 'display_name': 'Secretion', 'level': 2, 'score': 0.8938169}, {'id': 'https://openalex.org/C2775962898', 'wikidata': 'https://www.wikidata.org/wiki/Q5073152', 'display_name': 'Chaperone (clinical)', 'level': 2, 'score': 0.86750436}, {'id': 'https://openalex.org/C130211564', 'wikidata': 'https://www.wikidata.org/wiki/Q21199165', 'display_name': 'Type three secretion system', 'level': 4, 'score': 0.7527959}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.65191185}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5944425}, {'id': 'https://openalex.org/C98539663', 'wikidata': 'https://www.wikidata.org/wiki/Q220599', 'display_name': 'Cytosol', 'level': 3, 'score': 0.47875232}, {'id': 'https://openalex.org/C2777637488', 'wikidata': 'https://www.wikidata.org/wiki/Q31856', 'display_name': 'Pseudomonas aeruginosa', 'level': 3, 'score': 0.42912188}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.4235733}, {'id': 'https://openalex.org/C523546767', 'wikidata': 'https://www.wikidata.org/wiki/Q10876', 'display_name': 'Bacteria', 'level': 2, 'score': 0.3980744}, {'id': 'https://openalex.org/C60987743', 'wikidata': 'https://www.wikidata.org/wiki/Q1460232', 'display_name': 'Virulence', 'level': 3, 'score': 0.24075854}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.19496208}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.13837212}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.06275165}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.06184429}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001426', 'descriptor_name': 'Bacterial Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D058947', 'descriptor_name': 'Bacterial Secretion Systems', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D008958', 'descriptor_name': 'Models, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D018832', 'descriptor_name': 'Molecular Chaperones', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D046912', 'descriptor_name': 'Multiprotein Complexes', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D011487', 'descriptor_name': 'Protein Conformation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D001426', 'descriptor_name': 'Bacterial Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001426', 'descriptor_name': 'Bacterial Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001703', 'descriptor_name': 'Biophysics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018360', 'descriptor_name': 'Crystallography, X-Ray', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019281', 'descriptor_name': 'Dimerization', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018832', 'descriptor_name': 'Molecular Chaperones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018832', 'descriptor_name': 'Molecular Chaperones', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D046912', 'descriptor_name': 'Multiprotein Complexes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D046912', 'descriptor_name': 'Multiprotein Complexes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 6, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0049388', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0049388&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/9bfff080941a4f26be5d32471e777c5d', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3498133', 'pdf_url': 'https://europepmc.org/articles/pmc3498133?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3498133', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://figshare.com/articles/dataset/Structure_of_the_Type_III_Secretion_Effector_Protein_ExoU_in_Complex_with_Its_Chaperone_SpcU__/117197', 'pdf_url': 'https://figshare.com/ndownloader/files/290474', 'source': {'id': 'https://openalex.org/S4306402621', 'display_name': 'INDIGO (University of Illinois at Chicago)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I39422238', 'host_organization_name': 'University of Illinois at Chicago', 'host_organization_lineage': ['https://openalex.org/I39422238'], 'host_organization_lineage_names': ['University of Illinois at Chicago'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/23166655', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0049388', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0049388&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 62, 'referenced_works': ['https://openalex.org/W1482207933', 'https://openalex.org/W1486597108', 'https://openalex.org/W1524666565', 'https://openalex.org/W1539422958', 'https://openalex.org/W1539796472', 'https://openalex.org/W1566039206', 'https://openalex.org/W1603881247', 'https://openalex.org/W1869516088', 'https://openalex.org/W1964284806', 'https://openalex.org/W1965305501', 'https://openalex.org/W1965910641', 'https://openalex.org/W1968252808', 'https://openalex.org/W1973784356', 'https://openalex.org/W1976977329', 'https://openalex.org/W1984106312', 'https://openalex.org/W1985629904', 'https://openalex.org/W1987587550', 'https://openalex.org/W1987672004', 'https://openalex.org/W1991855809', 'https://openalex.org/W1992655510', 'https://openalex.org/W1997917899', 'https://openalex.org/W1999590520', 'https://openalex.org/W2001641653', 'https://openalex.org/W2005248681', 'https://openalex.org/W2006693036', 'https://openalex.org/W2014795040', 'https://openalex.org/W2015706065', 'https://openalex.org/W2016432709', 'https://openalex.org/W2030776726', 'https://openalex.org/W2030798502', 'https://openalex.org/W2045469920', 'https://openalex.org/W2047429752', 'https://openalex.org/W2050330741', 'https://openalex.org/W2058189914', 'https://openalex.org/W2067906280', 'https://openalex.org/W2084695380', 'https://openalex.org/W2089772414', 'https://openalex.org/W2099327891', 'https://openalex.org/W2100619015', 'https://openalex.org/W2103503400', 'https://openalex.org/W2108285818', 'https://openalex.org/W2110397834', 'https://openalex.org/W2114356152', 'https://openalex.org/W2119236186', 'https://openalex.org/W2119420633', 'https://openalex.org/W2129595885', 'https://openalex.org/W2131350133', 'https://openalex.org/W2140831051', 'https://openalex.org/W2142489999', 'https://openalex.org/W2143815085', 'https://openalex.org/W2143938791', 'https://openalex.org/W2144081223', 'https://openalex.org/W2144998676', 'https://openalex.org/W2146300096', 'https://openalex.org/W2150704159', 'https://openalex.org/W2152388941', 'https://openalex.org/W2155511306', 'https://openalex.org/W2155826484', 'https://openalex.org/W2158102238', 'https://openalex.org/W2159211495', 'https://openalex.org/W2170037427', 'https://openalex.org/W2978539654'], 'related_works': ['https://openalex.org/W3175155005', 'https://openalex.org/W2913564413', 'https://openalex.org/W2808185338', 'https://openalex.org/W2791163639', 'https://openalex.org/W2133411779', 'https://openalex.org/W2131507570', 'https://openalex.org/W2116909324', 'https://openalex.org/W2046398622', 'https://openalex.org/W2018093685', 'https://openalex.org/W1990008102'], 'abstract_inverted_index': {'Disease': [0], 'causing': [1], 'bacteria': [2, 18], 'often': [3], 'manipulate': [4], 'host': [5, 50, 125], 'cells': [6, 126], 'in': [7, 81, 104], 'a': [8, 38, 99, 115, 129], 'way': [9], 'that': [10], 'facilitates': [11], 'the': [12, 45, 49, 64, 90, 96, 119], 'infectious': [13], 'process.': [14], 'Many': [15], 'pathogenic': [16], 'gram-negative': [17], 'accomplish': [19], 'this': [20, 139], 'by': [21, 121], 'using': [22], 'type': [23, 67, 101], 'III': [24, 68, 102], 'secretion': [25, 30, 40, 69], 'systems.': [26], 'In': [27], 'these': [28], 'complex': [29, 105], 'pathways,': [31], 'bacterial': [32], 'chaperones': [33], 'direct': [34], 'effector': [35, 46, 54, 103], 'proteins': [36], 'to': [37], 'needle-like': [39], 'apparatus,': [41], 'which': [42, 122], 'then': [43], 'delivers': [44], 'protein': [47, 55], 'into': [48], 'cell': [51], 'cytosol.': [52], 'The': [53], 'ExoU': [56, 73, 123], 'and': [57, 84, 127], 'its': [58, 107], 'chaperone': [59], 'SpcU': [60], 'are': [61], 'components': [62], 'of': [63, 72, 95, 118, 138], 'Pseudomonas': [65], 'aeruginosa': [66], 'system.': [70], 'Secretion': [71], 'has': [74], 'been': [75], 'associated': [76], 'with': [77, 106], 'more': [78], 'severe': [79], 'infections': [80], 'both': [82], 'humans': [83], 'animal': [85], 'models.': [86], 'Here': [87], 'we': [88], 'describe': [89], '1.92': [91], 'Å': [92], 'X-ray': [93], 'structure': [94], 'ExoU–SpcU': [97], 'complex,': [98], 'full-length': [100, 108], 'cognate': [109], 'chaperone.': [110], 'Our': [111], 'crystallographic': [112], 'data': [113], 'allow': [114], 'better': [116], 'understanding': [117], 'mechanism': [120], 'kills': [124], 'provides': [128], 'foundation': [130], 'for': [131], 'future': [132], 'studies': [133], 'aimed': [134], 'at': [135], 'designing': [136], 'inhibitors': [137], 'potent': [140], 'toxin.': [141]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2018093685', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 5}], 'updated_date': '2024-08-15T05:50:41.307567', 'created_date': '2016-06-24'}