Protection following BNT162b2 booster in adolescents substantially exceeds that of a fresh 2-dose vaccine

Name: Work Video:
Duration: 3 min 30 s
Ofra Amir; Yair Goldberg; Micha Mandel; Yinon M. Bar-On; Omri Bodenheimer; Nachman Ash; Sharon Alroy‐Preis; Amit Huppert; Ron Milo
{'id': 'https://openalex.org/W4223961516', 'doi': 'https://doi.org/10.1038/s41467-022-29578-w', 'title': 'Protection following BNT162b2 booster in adolescents substantially exceeds that of a fresh 2-dose vaccine', 'display_name': 'Protection following BNT162b2 booster in adolescents substantially exceeds that of a fresh 2-dose vaccine', 'publication_year': 2022, 'publication_date': '2022-04-13', 'ids': {'openalex': 'https://openalex.org/W4223961516', 'doi': 'https://doi.org/10.1038/s41467-022-29578-w', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/35418201'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/s41467-022-29578-w', 'pdf_url': 'https://www.nature.com/articles/s41467-022-29578-w.pdf', 'source': {'id': 'https://openalex.org/S64187185', 'display_name': 'Nature Communications', 'issn_l': '2041-1723', 'issn': ['2041-1723'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.nature.com/articles/s41467-022-29578-w.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5013873819', 'display_name': 'Ofra Amir', 'orcid': 'https://orcid.org/0000-0003-2303-3684'}, 'institutions': [{'id': 'https://openalex.org/I174306211', 'display_name': 'Technion – Israel Institute of Technology', 'ror': 'https://ror.org/03qryx823', 'country_code': 'IL', 'type': 'education', 'lineage': ['https://openalex.org/I174306211']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'Ofra Amir', 'raw_affiliation_strings': ['Technion—Israel Institute of Technology, Haifa, Israel'], 'affiliations': [{'raw_affiliation_string': 'Technion—Israel Institute of Technology, Haifa, Israel', 'institution_ids': ['https://openalex.org/I174306211']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020074803', 'display_name': 'Yair Goldberg', 'orcid': 'https://orcid.org/0000-0002-4544-0910'}, 'institutions': [{'id': 'https://openalex.org/I174306211', 'display_name': 'Technion – Israel Institute of Technology', 'ror': 'https://ror.org/03qryx823', 'country_code': 'IL', 'type': 'education', 'lineage': ['https://openalex.org/I174306211']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'Yair Goldberg', 'raw_affiliation_strings': ['Technion—Israel Institute of Technology, Haifa, Israel'], 'affiliations': [{'raw_affiliation_string': 'Technion—Israel Institute of Technology, Haifa, Israel', 'institution_ids': ['https://openalex.org/I174306211']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072256853', 'display_name': 'Micha Mandel', 'orcid': 'https://orcid.org/0000-0002-4270-9777'}, 'institutions': [{'id': 'https://openalex.org/I197251160', 'display_name': 'Hebrew University of Jerusalem', 'ror': 'https://ror.org/03qxff017', 'country_code': 'IL', 'type': 'education', 'lineage': ['https://openalex.org/I197251160']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'Micha Mandel', 'raw_affiliation_strings': ['The Hebrew University of Jerusalem, Jerusalem, Israel'], 'affiliations': [{'raw_affiliation_string': 'The Hebrew University of Jerusalem, Jerusalem, Israel', 'institution_ids': ['https://openalex.org/I197251160']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049867081', 'display_name': 'Yinon M. Bar-On', 'orcid': 'https://orcid.org/0000-0001-8477-609X'}, 'institutions': [{'id': 'https://openalex.org/I53964585', 'display_name': 'Weizmann Institute of Science', 'ror': 'https://ror.org/0316ej306', 'country_code': 'IL', 'type': 'education', 'lineage': ['https://openalex.org/I53964585']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'Yinon M. Bar-On', 'raw_affiliation_strings': ['Department of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, Israel'], 'affiliations': [{'raw_affiliation_string': 'Department of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, Israel', 'institution_ids': ['https://openalex.org/I53964585']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069288115', 'display_name': 'Omri Bodenheimer', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802540905', 'display_name': 'Israel Ministry of Health', 'ror': 'https://ror.org/016n0q862', 'country_code': 'IL', 'type': 'government', 'lineage': ['https://openalex.org/I2802540905']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'Omri Bodenheimer', 'raw_affiliation_strings': ['Israel Ministry of Health, Jerusalem, Israel'], 'affiliations': [{'raw_affiliation_string': 'Israel Ministry of Health, Jerusalem, Israel', 'institution_ids': ['https://openalex.org/I2802540905']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040838391', 'display_name': 'Nachman Ash', 'orcid': 'https://orcid.org/0000-0001-9557-7205'}, 'institutions': [{'id': 'https://openalex.org/I2802540905', 'display_name': 'Israel Ministry of Health', 'ror': 'https://ror.org/016n0q862', 'country_code': 'IL', 'type': 'government', 'lineage': ['https://openalex.org/I2802540905']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'Nachman Ash', 'raw_affiliation_strings': ['Israel Ministry of Health, Jerusalem, Israel'], 'affiliations': [{'raw_affiliation_string': 'Israel Ministry of Health, Jerusalem, Israel', 'institution_ids': ['https://openalex.org/I2802540905']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055339900', 'display_name': 'Sharon Alroy‐Preis', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802540905', 'display_name': 'Israel Ministry of Health', 'ror': 'https://ror.org/016n0q862', 'country_code': 'IL', 'type': 'government', 'lineage': ['https://openalex.org/I2802540905']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'Sharon Alroy-Preis', 'raw_affiliation_strings': ['Israel Ministry of Health, Jerusalem, Israel'], 'affiliations': [{'raw_affiliation_string': 'Israel Ministry of Health, Jerusalem, Israel', 'institution_ids': ['https://openalex.org/I2802540905']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068865686', 'display_name': 'Amit Huppert', 'orcid': 'https://orcid.org/0000-0002-3306-185X'}, 'institutions': [{'id': 'https://openalex.org/I2799810450', 'display_name': 'Sheba Medical Center', 'ror': 'https://ror.org/020rzx487', 'country_code': 'IL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799810450']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'Amit Huppert', 'raw_affiliation_strings': ['The Bio-statistical and Bio-mathematical Unit, The Gertner Institute for Epidemiology & Health Policy Research, Sheba Medical Center, Ramat Gan, Israel'], 'affiliations': [{'raw_affiliation_string': 'The Bio-statistical and Bio-mathematical Unit, The Gertner Institute for Epidemiology & Health Policy Research, Sheba Medical Center, Ramat Gan, Israel', 'institution_ids': ['https://openalex.org/I2799810450']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5024451873', 'display_name': 'Ron Milo', 'orcid': 'https://orcid.org/0000-0003-1641-2299'}, 'institutions': [{'id': 'https://openalex.org/I53964585', 'display_name': 'Weizmann Institute of Science', 'ror': 'https://ror.org/0316ej306', 'country_code': 'IL', 'type': 'education', 'lineage': ['https://openalex.org/I53964585']}], 'countries': ['IL'], 'is_corresponding': False, 'raw_author_name': 'Ron Milo', 'raw_affiliation_strings': ['Department of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, Israel'], 'affiliations': [{'raw_affiliation_string': 'Department of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, Israel', 'institution_ids': ['https://openalex.org/I53964585']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 5, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3920, 'currency': 'GBP', 'value_usd': 4808, 'provenance': 'doaj'}, 'apc_paid': {'value': 3920, 'currency': 'GBP', 'value_usd': 4808, 'provenance': 'doaj'}, 'fwci': 1.452, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 11, 'citation_normalized_percentile': {'value': 0.682618, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '13', 'issue': '1', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10118', 'display_name': 'SARS-CoV-2 and COVID-19 Research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10118', 'display_name': 'SARS-CoV-2 and COVID-19 Research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10833', 'display_name': 'Vaccine Coverage and Hesitancy', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/3306', 'display_name': 'Health'}, 'field': {'id': 'https://openalex.org/fields/33', 'display_name': 'Social Sciences'}, 'domain': {'id': 'https://openalex.org/domains/2', 'display_name': 'Social Sciences'}}, {'id': 'https://openalex.org/T10976', 'display_name': 'Viral gastroenteritis research and epidemiology', 'score': 0.9925, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/booster', 'display_name': 'Booster (rocketry)', 'score': 0.9679898}, {'id': 'https://openalex.org/keywords/booster-dose', 'display_name': 'Booster dose', 'score': 0.87749565}], 'concepts': [{'id': 'https://openalex.org/C203165030', 'wikidata': 'https://www.wikidata.org/wiki/Q741745', 'display_name': 'Booster (rocketry)', 'level': 2, 'score': 0.9679898}, {'id': 'https://openalex.org/C12590561', 'wikidata': 'https://www.wikidata.org/wiki/Q2920497', 'display_name': 'Booster dose', 'level': 4, 'score': 0.87749565}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.64771223}, {'id': 'https://openalex.org/C22070199', 'wikidata': 'https://www.wikidata.org/wiki/Q192995', 'display_name': 'Vaccination', 'level': 2, 'score': 0.42313164}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.2984239}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.27119893}, {'id': 'https://openalex.org/C2780801004', 'wikidata': 'https://www.wikidata.org/wiki/Q1415366', 'display_name': 'Immunization', 'level': 3, 'score': 0.19413435}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C1276947', 'wikidata': 'https://www.wikidata.org/wiki/Q333', 'display_name': 'Astronomy', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000090982', 'descriptor_name': 'BNT162 Vaccine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000086382', 'descriptor_name': 'COVID-19', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000293', 'descriptor_name': 'Adolescent', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000086382', 'descriptor_name': 'COVID-19', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007117', 'descriptor_name': 'Immunization, Secondary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007557', 'descriptor_name': 'Israel', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000086402', 'descriptor_name': 'SARS-CoV-2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/s41467-022-29578-w', 'pdf_url': 'https://www.nature.com/articles/s41467-022-29578-w.pdf', 'source': {'id': 'https://openalex.org/S64187185', 'display_name': 'Nature Communications', 'issn_l': '2041-1723', 'issn': ['2041-1723'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/5e798c9a54634be492c4de72f5ceb557', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9008037', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/2021.12.19.21267933', 'pdf_url': 'https://www.medrxiv.org/content/medrxiv/early/2021/12/21/2021.12.19.21267933.full.pdf', 'source': None, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/35418201', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/s41467-022-29578-w', 'pdf_url': 'https://www.nature.com/articles/s41467-022-29578-w.pdf', 'source': {'id': 'https://openalex.org/S64187185', 'display_name': 'Nature Communications', 'issn_l': '2041-1723', 'issn': ['2041-1723'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.74, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 22, 'referenced_works': ['https://openalex.org/W2171456100', 'https://openalex.org/W3127271954', 'https://openalex.org/W3154757366', 'https://openalex.org/W3163785571', 'https://openalex.org/W3201177512', 'https://openalex.org/W3208466650', 'https://openalex.org/W3209937564', 'https://openalex.org/W3210126657', 'https://openalex.org/W3212447088', 'https://openalex.org/W4200186202', 'https://openalex.org/W4200230275', 'https://openalex.org/W4200323635', 'https://openalex.org/W4200358703', 'https://openalex.org/W4200427886', 'https://openalex.org/W4200585097', 'https://openalex.org/W4206399312', 'https://openalex.org/W4225386205', 'https://openalex.org/W4225470021', 'https://openalex.org/W4226296959', 'https://openalex.org/W4226376477', 'https://openalex.org/W4226523965', 'https://openalex.org/W4296764556'], 'related_works': ['https://openalex.org/W4387965302', 'https://openalex.org/W4311793641', 'https://openalex.org/W4302774475', 'https://openalex.org/W4283826450', 'https://openalex.org/W4223961516', 'https://openalex.org/W4207003944', 'https://openalex.org/W4200574689', 'https://openalex.org/W3199092625', 'https://openalex.org/W2385876451', 'https://openalex.org/W2324037830'], 'abstract_inverted_index': {'Israel': [0], 'began': [1], 'administering': [2], 'a': [3, 22, 33, 48, 59, 67, 128], 'BNT162b2': [4], 'booster': [5, 24, 54, 115, 139], 'dose': [6, 25, 55], 'to': [7, 27, 32, 51, 76, 84, 135], 'restore': [8], 'protection': [9], 'following': [10], 'the': [11, 14, 44, 78, 90, 102, 114, 121, 138], 'waning': [12], 'of': [13, 47, 58, 66, 130], '2-dose': [15, 35, 61, 103], 'vaccine.': [16], 'Biological': [17], 'studies': [18], 'have': [19], 'shown': [20], 'that': [21, 57, 70, 73, 120], '"fresh"': [23], 'leads': [26], 'increased': [28, 40], 'antibody': [29], 'levels': [30], 'compared': [31, 89], 'fresh': [34, 49, 60], 'vaccine,': [36, 62], 'which': [37], 'may': [38], 'suggest': [39], 'effectiveness.': [41], 'To': [42], 'compare': [43], 'real-world': [45], 'effectiveness': [46], '(up': [50], '60': [52], 'days)': [53], 'with': [56], 'we': [63, 88], 'took': [64], 'advantage': [65], 'quasi-experimental': [68], 'study': [69], 'compares': [71], 'populations': [72], 'were': [74], 'eligible': [75], 'receive': [77], 'vaccine': [79, 104], 'at': [80], 'different': [81], 'times': [82], 'due': [83], 'age-dependent': [85], 'policies.': [86], 'Specifically,': [87], 'confirmed': [91, 122], 'infection': [92, 123], 'rates': [93], 'in': [94, 106, 137], 'adolescents': [95, 107], 'aged': [96, 108], '12-14': [97], '(215,653': [98], 'individuals)': [99, 111], 'who': [100, 112], 'received': [101, 113], 'and': [105], '16-18': [109], '(103,454': [110], 'dose.': [116], 'Our': [117], 'analysis': [118], 'shows': [119], 'rate': [124], 'was': [125], 'lower': [126], 'by': [127], 'factor': [129], '3.7': [131], '(95%': [132], 'CI:': [133], '2.7': [134], '5.2)': [136], 'group.': [140]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4223961516', 'counts_by_year': [{'year': 2023, 'cited_by_count': 7}, {'year': 2022, 'cited_by_count': 4}], 'updated_date': '2025-01-10T01:15:36.514143', 'created_date': '2022-04-19'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
