Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3168885456', 'doi': 'https://doi.org/10.1111/cpr.13081', 'title': 'A novel multikinase inhibitor SKLB‐YTH‐60 ameliorates inflammation and fibrosis in bleomycin‐induced lung fibrosis mouse models', 'display_name': 'A novel multikinase inhibitor SKLB‐YTH‐60 ameliorates inflammation and fibrosis in bleomycin‐induced lung fibrosis mouse models', 'publication_year': 2021, 'publication_date': '2021-06-14', 'ids': {'openalex': 'https://openalex.org/W3168885456', 'doi': 'https://doi.org/10.1111/cpr.13081', 'mag': '3168885456', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/34121240', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/8249783'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/cpr.13081', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S86484535', 'display_name': 'Cell Proliferation', 'issn_l': '0960-7722', 'issn': ['0960-7722', '1365-2184'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8249783', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101515172', 'display_name': 'Hongyao Liu', 'orcid': 'https://orcid.org/0000-0002-4442-6340'}, 'institutions': [{'id': 'https://openalex.org/I24185976', 'display_name': 'Sichuan University', 'ror': 'https://ror.org/011ashp19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24185976']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Hongyao Liu', 'raw_affiliation_strings': ['Sichuan University-Oxford University Huaxi Gastrointestinal Cancer Centre State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu China'], 'affiliations': [{'raw_affiliation_string': 'Sichuan University-Oxford University Huaxi Gastrointestinal Cancer Centre State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu China', 'institution_ids': ['https://openalex.org/I24185976']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003447311', 'display_name': 'Xiuli Wu', 'orcid': 'https://orcid.org/0000-0002-5202-6515'}, 'institutions': [{'id': 'https://openalex.org/I24185976', 'display_name': 'Sichuan University', 'ror': 'https://ror.org/011ashp19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24185976']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Xiuli Wu', 'raw_affiliation_strings': ['Sichuan University-Oxford University Huaxi Gastrointestinal Cancer Centre State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu China'], 'affiliations': [{'raw_affiliation_string': 'Sichuan University-Oxford University Huaxi Gastrointestinal Cancer Centre State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu China', 'institution_ids': ['https://openalex.org/I24185976']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102337377', 'display_name': 'Cailing Gan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I24185976', 'display_name': 'Sichuan University', 'ror': 'https://ror.org/011ashp19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24185976']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Cailing Gan', 'raw_affiliation_strings': ['Sichuan University-Oxford University Huaxi Gastrointestinal Cancer Centre State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu China'], 'affiliations': [{'raw_affiliation_string': 'Sichuan University-Oxford University Huaxi Gastrointestinal Cancer Centre State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu China', 'institution_ids': ['https://openalex.org/I24185976']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100622736', 'display_name': 'Liqun Wang', 'orcid': 'https://orcid.org/0000-0001-8624-4046'}, 'institutions': [{'id': 'https://openalex.org/I24185976', 'display_name': 'Sichuan University', 'ror': 'https://ror.org/011ashp19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24185976']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Liqun Wang', 'raw_affiliation_strings': ['West China School of Public Health and Heathy Food Evaluation Research Center and West China Fourth Hospital Sichuan University Chengdu China'], 'affiliations': [{'raw_affiliation_string': 'West China School of Public Health and Heathy Food Evaluation Research Center and West China Fourth Hospital Sichuan University Chengdu China', 'institution_ids': ['https://openalex.org/I24185976']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100325273', 'display_name': 'Guan Wang', 'orcid': 'https://orcid.org/0000-0001-9974-4867'}, 'institutions': [{'id': 'https://openalex.org/I24185976', 'display_name': 'Sichuan University', 'ror': 'https://ror.org/011ashp19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24185976']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Guan Wang', 'raw_affiliation_strings': ['Sichuan University-Oxford University Huaxi Gastrointestinal Cancer Centre State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu China'], 'affiliations': [{'raw_affiliation_string': 'Sichuan University-Oxford University Huaxi Gastrointestinal Cancer Centre State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu China', 'institution_ids': ['https://openalex.org/I24185976']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101183789', 'display_name': 'Yue Lin', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I24185976', 'display_name': 'Sichuan University', 'ror': 'https://ror.org/011ashp19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24185976']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Lin Yue', 'raw_affiliation_strings': ['Sichuan University-Oxford University Huaxi Gastrointestinal Cancer Centre State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu China'], 'affiliations': [{'raw_affiliation_string': 'Sichuan University-Oxford University Huaxi Gastrointestinal Cancer Centre State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu China', 'institution_ids': ['https://openalex.org/I24185976']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100421210', 'display_name': 'Zhihao Liu', 'orcid': 'https://orcid.org/0000-0002-0246-8761'}, 'institutions': [{'id': 'https://openalex.org/I24185976', 'display_name': 'Sichuan University', 'ror': 'https://ror.org/011ashp19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24185976']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Zhihao Liu', 'raw_affiliation_strings': ['Sichuan University-Oxford University Huaxi Gastrointestinal Cancer Centre State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu China'], 'affiliations': [{'raw_affiliation_string': 'Sichuan University-Oxford University Huaxi Gastrointestinal Cancer Centre State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu China', 'institution_ids': ['https://openalex.org/I24185976']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100323835', 'display_name': 'Wei Wei', 'orcid': 'https://orcid.org/0000-0003-4066-0081'}, 'institutions': [{'id': 'https://openalex.org/I24185976', 'display_name': 'Sichuan University', 'ror': 'https://ror.org/011ashp19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24185976']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Wei Wei', 'raw_affiliation_strings': ['Sichuan University-Oxford University Huaxi Gastrointestinal Cancer Centre State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu China'], 'affiliations': [{'raw_affiliation_string': 'Sichuan University-Oxford University Huaxi Gastrointestinal Cancer Centre State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu China', 'institution_ids': ['https://openalex.org/I24185976']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072146814', 'display_name': 'Xingping Su', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I24185976', 'display_name': 'Sichuan University', 'ror': 'https://ror.org/011ashp19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24185976']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Xingping Su', 'raw_affiliation_strings': ['Sichuan University-Oxford University Huaxi Gastrointestinal Cancer Centre State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu China'], 'affiliations': [{'raw_affiliation_string': 'Sichuan University-Oxford University Huaxi Gastrointestinal Cancer Centre State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu China', 'institution_ids': ['https://openalex.org/I24185976']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010105082', 'display_name': 'Qianyu Zhang', 'orcid': 'https://orcid.org/0000-0002-0758-2432'}, 'institutions': [{'id': 'https://openalex.org/I24185976', 'display_name': 'Sichuan University', 'ror': 'https://ror.org/011ashp19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24185976']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Qianyu Zhang', 'raw_affiliation_strings': ['West China School of Public Health and Heathy Food Evaluation Research Center and West China Fourth Hospital Sichuan University Chengdu China'], 'affiliations': [{'raw_affiliation_string': 'West China School of Public Health and Heathy Food Evaluation Research Center and West China Fourth Hospital Sichuan University Chengdu China', 'institution_ids': ['https://openalex.org/I24185976']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102764184', 'display_name': 'Zui Tan', 'orcid': 'https://orcid.org/0000-0002-3583-6989'}, 'institutions': [{'id': 'https://openalex.org/I24185976', 'display_name': 'Sichuan University', 'ror': 'https://ror.org/011ashp19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24185976']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Zui Tan', 'raw_affiliation_strings': ['Sichuan University-Oxford University Huaxi Gastrointestinal Cancer Centre State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu China'], 'affiliations': [{'raw_affiliation_string': 'Sichuan University-Oxford University Huaxi Gastrointestinal Cancer Centre State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu China', 'institution_ids': ['https://openalex.org/I24185976']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067588220', 'display_name': 'Yuqin Yao', 'orcid': 'https://orcid.org/0000-0003-2097-6978'}, 'institutions': [{'id': 'https://openalex.org/I24185976', 'display_name': 'Sichuan University', 'ror': 'https://ror.org/011ashp19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24185976']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Yuqin Yao', 'raw_affiliation_strings': ['West China School of Public Health and Heathy Food Evaluation Research Center and West China Fourth Hospital Sichuan University Chengdu China'], 'affiliations': [{'raw_affiliation_string': 'West China School of Public Health and Heathy Food Evaluation Research Center and West China Fourth Hospital Sichuan University Chengdu China', 'institution_ids': ['https://openalex.org/I24185976']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038261237', 'display_name': 'Liang Ouyang', 'orcid': 'https://orcid.org/0000-0001-5537-8834'}, 'institutions': [{'id': 'https://openalex.org/I24185976', 'display_name': 'Sichuan University', 'ror': 'https://ror.org/011ashp19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24185976']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Liang Ouyang', 'raw_affiliation_strings': ['Sichuan University-Oxford University Huaxi Gastrointestinal Cancer Centre State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu China'], 'affiliations': [{'raw_affiliation_string': 'Sichuan University-Oxford University Huaxi Gastrointestinal Cancer Centre State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu China', 'institution_ids': ['https://openalex.org/I24185976']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065562045', 'display_name': 'Luoting Yu', 'orcid': 'https://orcid.org/0000-0001-9297-6665'}, 'institutions': [{'id': 'https://openalex.org/I24185976', 'display_name': 'Sichuan University', 'ror': 'https://ror.org/011ashp19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24185976']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Luoting Yu', 'raw_affiliation_strings': ['Sichuan University-Oxford University Huaxi Gastrointestinal Cancer Centre State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu China'], 'affiliations': [{'raw_affiliation_string': 'Sichuan University-Oxford University Huaxi Gastrointestinal Cancer Centre State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu China', 'institution_ids': ['https://openalex.org/I24185976']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5002925062', 'display_name': 'Tinghong Ye', 'orcid': 'https://orcid.org/0000-0002-3296-6753'}, 'institutions': [{'id': 'https://openalex.org/I24185976', 'display_name': 'Sichuan University', 'ror': 'https://ror.org/011ashp19', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I24185976']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Tinghong Ye', 'raw_affiliation_strings': ['Sichuan University-Oxford University Huaxi Gastrointestinal Cancer Centre State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu China'], 'affiliations': [{'raw_affiliation_string': 'Sichuan University-Oxford University Huaxi Gastrointestinal Cancer Centre State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu China', 'institution_ids': ['https://openalex.org/I24185976']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5101515172', 'https://openalex.org/A5003447311', 'https://openalex.org/A5102337377', 'https://openalex.org/A5100622736', 'https://openalex.org/A5100325273', 'https://openalex.org/A5101183789', 'https://openalex.org/A5100421210', 'https://openalex.org/A5100323835', 'https://openalex.org/A5072146814', 'https://openalex.org/A5010105082', 'https://openalex.org/A5102764184', 'https://openalex.org/A5067588220', 'https://openalex.org/A5038261237', 'https://openalex.org/A5065562045', 'https://openalex.org/A5002925062'], 'corresponding_institution_ids': ['https://openalex.org/I24185976', 'https://openalex.org/I24185976', 'https://openalex.org/I24185976', 'https://openalex.org/I24185976', 'https://openalex.org/I24185976', 'https://openalex.org/I24185976', 'https://openalex.org/I24185976', 'https://openalex.org/I24185976', 'https://openalex.org/I24185976', 'https://openalex.org/I24185976', 'https://openalex.org/I24185976', 'https://openalex.org/I24185976', 'https://openalex.org/I24185976', 'https://openalex.org/I24185976', 'https://openalex.org/I24185976'], 'apc_list': {'value': 2860, 'currency': 'USD', 'value_usd': 2860, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 2.99, 'has_fulltext': False, 'cited_by_count': 18, 'citation_normalized_percentile': {'value': 0.999974, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '54', 'issue': '7', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10870', 'display_name': 'Idiopathic Pulmonary Fibrosis: Diagnosis and Management', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10870', 'display_name': 'Idiopathic Pulmonary Fibrosis: Diagnosis and Management', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12287', 'display_name': 'Fibroblast Growth Factor Signaling Pathway', 'score': 0.9621, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11651', 'display_name': 'Pulmonary Drug Delivery Techniques', 'score': 0.9246, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/idiopathic-pulmonary-fibrosis', 'display_name': 'Idiopathic Pulmonary Fibrosis', 'score': 0.499112}], 'concepts': [{'id': 'https://openalex.org/C2776232574', 'wikidata': 'https://www.wikidata.org/wiki/Q415571', 'display_name': 'Bleomycin', 'level': 3, 'score': 0.76861787}, {'id': 'https://openalex.org/C2780559512', 'wikidata': 'https://www.wikidata.org/wiki/Q605709', 'display_name': 'Fibrosis', 'level': 2, 'score': 0.6781675}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.66831076}, {'id': 'https://openalex.org/C2778341716', 'wikidata': 'https://www.wikidata.org/wiki/Q2290446', 'display_name': 'Idiopathic pulmonary fibrosis', 'level': 3, 'score': 0.6620443}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.56228447}, {'id': 'https://openalex.org/C2781244666', 'wikidata': 'https://www.wikidata.org/wiki/Q32446', 'display_name': 'Pulmonary fibrosis', 'level': 3, 'score': 0.5255422}, {'id': 'https://openalex.org/C189165786', 'wikidata': 'https://www.wikidata.org/wiki/Q193825', 'display_name': 'Extracellular matrix', 'level': 2, 'score': 0.5225922}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.489906}, {'id': 'https://openalex.org/C2781080636', 'wikidata': 'https://www.wikidata.org/wiki/Q700000', 'display_name': 'SMAD', 'level': 3, 'score': 0.4739031}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.4724788}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.45836008}, {'id': 'https://openalex.org/C2777714996', 'wikidata': 'https://www.wikidata.org/wiki/Q7886', 'display_name': 'Lung', 'level': 2, 'score': 0.44464648}, {'id': 'https://openalex.org/C76419328', 'wikidata': 'https://www.wikidata.org/wiki/Q74419', 'display_name': 'Epithelial–mesenchymal transition', 'level': 4, 'score': 0.41389745}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.38874924}, {'id': 'https://openalex.org/C118131993', 'wikidata': 'https://www.wikidata.org/wiki/Q423671', 'display_name': 'Transforming growth factor', 'level': 2, 'score': 0.27860224}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.22208762}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.20235837}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.1495733}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.117783934}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.11657879}, {'id': 'https://openalex.org/C2779013556', 'wikidata': 'https://www.wikidata.org/wiki/Q181876', 'display_name': 'Metastasis', 'level': 3, 'score': 0.06721616}], 'mesh': [{'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D011658', 'descriptor_name': 'Pulmonary Fibrosis', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D000072283', 'descriptor_name': 'A549 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001665', 'descriptor_name': 'Binding Sites', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001761', 'descriptor_name': 'Bleomycin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001761', 'descriptor_name': 'Bleomycin', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015195', 'descriptor_name': 'Drug Design', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058750', 'descriptor_name': 'Epithelial-Mesenchymal Transition', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058750', 'descriptor_name': 'Epithelial-Mesenchymal Transition', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D006207', 'descriptor_name': 'Half-Life', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D062105', 'descriptor_name': 'Molecular Docking Simulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D011658', 'descriptor_name': 'Pulmonary Fibrosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011658', 'descriptor_name': 'Pulmonary Fibrosis', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': False}, {'descriptor_ui': 'D011658', 'descriptor_name': 'Pulmonary Fibrosis', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017207', 'descriptor_name': 'Rats, Sprague-Dawley', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053773', 'descriptor_name': 'Transforming Growth Factor beta1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053773', 'descriptor_name': 'Transforming Growth Factor beta1', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/cpr.13081', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S86484535', 'display_name': 'Cell Proliferation', 'issn_l': '0960-7722', 'issn': ['0960-7722', '1365-2184'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8249783', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/34121240', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8249783', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.85, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [{'funder': 'https://openalex.org/F4320321001', 'funder_display_name': 'National Natural Science Foundation of China', 'award_id': '81500054'}], 'datasets': [], 'versions': [], 'referenced_works_count': 36, 'referenced_works': ['https://openalex.org/W1505584712', 'https://openalex.org/W1604428153', 'https://openalex.org/W1678482413', 'https://openalex.org/W1750560289', 'https://openalex.org/W1902159756', 'https://openalex.org/W2001154241', 'https://openalex.org/W2014689880', 'https://openalex.org/W2018716033', 'https://openalex.org/W2031450475', 'https://openalex.org/W2043449217', 'https://openalex.org/W2057292199', 'https://openalex.org/W2069775532', 'https://openalex.org/W2075400164', 'https://openalex.org/W2085060090', 'https://openalex.org/W2093024396', 'https://openalex.org/W2115141581', 'https://openalex.org/W2116241430', 'https://openalex.org/W2142474078', 'https://openalex.org/W2143370737', 'https://openalex.org/W2155413391', 'https://openalex.org/W2167383172', 'https://openalex.org/W2190389820', 'https://openalex.org/W2208096782', 'https://openalex.org/W2272059546', 'https://openalex.org/W2315538569', 'https://openalex.org/W2503069845', 'https://openalex.org/W2573628710', 'https://openalex.org/W2610199736', 'https://openalex.org/W2612572443', 'https://openalex.org/W2613737538', 'https://openalex.org/W2791214769', 'https://openalex.org/W2984691924', 'https://openalex.org/W3011528304', 'https://openalex.org/W3021543659', 'https://openalex.org/W3033778067', 'https://openalex.org/W3168885456'], 'related_works': ['https://openalex.org/W3196482013', 'https://openalex.org/W307228711', 'https://openalex.org/W2383309780', 'https://openalex.org/W2380651012', 'https://openalex.org/W2374993091', 'https://openalex.org/W2365811023', 'https://openalex.org/W2364204753', 'https://openalex.org/W2359640985', 'https://openalex.org/W2121729413', 'https://openalex.org/W2102239057'], 'abstract_inverted_index': {'Abstract': [0], 'Objectives': [1], 'Idiopathic': [2], 'pulmonary': [3, 52], 'fibrosis': [4, 76, 140, 158], '(IPF)': [5], 'is': [6, 39], 'marked': [7], 'by': [8, 115, 141], 'the': [9, 32, 72, 85, 95, 102, 133, 155, 163, 166, 183], 'excessive': [10], 'accumulation': [11], 'of': [12, 20, 35, 89, 98, 135, 149, 157, 165, 185], 'extracellular': [13], 'matrix,': [14], 'which': [15], 'participates': [16], 'in': [17, 92, 159, 180], 'a': [18, 41, 221], 'variety': [19], 'chronic': [21], 'diseases': [22], 'or': [23], 'injuries': [24], 'and': [25, 46, 55, 67, 79, 101, 111, 126, 138, 144, 161, 199], 'seriously': [26], 'threatens': [27], 'human': [28], 'health.': [29], 'Due': [30], 'to': [31, 43, 50, 83], 'side': [33], 'effects': [34], 'clinical': [36], 'drugs,': [37], 'there': [38], 'still': [40], 'need': [42], 'develop': [44], 'novel': [45], 'less': [47], 'toxic': [48], 'drugs': [49], 'treat': [51], 'fibrosis.': [53, 186], 'Materials': [54], 'Methods': [56], 'SKLB‐YTH‐60': [57], 'was': [58, 113], 'developed': [59], 'through': [60], 'computer‐aided': [61], 'drug': [62, 223], 'design,': [63], 'de': [64], 'novo': [65], 'synthesis': [66], 'high‐throughput': [68], 'screening.': [69], 'We': [70], 'employed': [71], 'bleomycin': [73], '(BLM)‐induced': [74], 'lung': [75], 'animal': [77], 'models': [78], 'used': [80], 'TGF‐β': [81], '1': [82], 'induce': [84], 'epithelial‐mesenchymal': [86], 'transition': [87], '(EMT)': [88], 'A549': [90, 127, 136], 'cells': [91, 137], 'vitro.': [93], 'Meanwhile,': [94], 'protein': [96], 'expression': [97], 'collagen': [99], 'I': [100], 'α‐smooth': [103], 'muscle': [104], 'actin': [105], '(α‐SMA),': [106], 'E‐cadherin,': [107], 'p‐FGFR1,': [108], 'p‐PLCγ,': [109], 'p‐Smad2/3': [110], 'p‐Erk1/2': [112], 'detected': [114], 'western': [116], 'blot.': [117], 'Results': [118], 'YTH‐60': [119, 130, 151, 175, 188, 218], 'has': [120, 189], 'obvious': [121], 'anti‐proliferative': [122], 'activity': [123], 'on': [124], 'fibroblasts': [125], 'cells.': [128], 'Moreover,': [129], 'could': [131, 152, 219], 'impair': [132], 'EMT': [134], 'suppressed': [139], 'inhibiting': [142], 'FGFR': [143], 'TGF‐β/Smad‐dependent': [145], 'pathways.': [146], 'Intraperitoneal': [147], 'administration': [148], 'preventive': [150], 'significantly': [153], 'reduce': [154], 'degree': [156], 'mice': [160, 181], 'regulate': [162], 'imbalance': [164], 'immune': [167], 'microenvironment.': [168], 'In': [169], 'addition,': [170], 'we': [171], 'observed': [172], 'that': [173, 217], 'therapeutic': [174], 'treatment': [176], 'attenuated': [177], 'fibrotic': [178], 'changes': [179], 'during': [182], 'period': [184], 'Importantly,': [187], 'shown': [190], 'an': [191], 'acceptable': [192], 'oral': [193], 'bioavailability': [194], '(': [195, 204], 'F': [196], '=': [197, 207], '17.86%)': [198], 'appropriate': [200], 'eliminated': [201], 'half‐life': [202], 'time': [203], 'T': [205], '1/2': [206], '8.03': [208], 'hours).': [209], 'Conclusions': [210], 'Taken': [211], 'together,': [212], 'these': [213], 'preclinical': [214], 'evaluations': [215], 'suggested': [216], 'be': [220], 'promising': [222], 'candidate': [224], 'for': [225], 'treating': [226], 'IPF.': [227]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3168885456', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 3}], 'updated_date': '2024-09-20T01:17:13.884517', 'created_date': '2021-06-22'}