Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3154003478', 'doi': 'https://doi.org/10.3389/fcell.2021.649433', 'title': 'The Wdr1-LIMK-Cofilin Axis Controls B Cell Antigen Receptor-Induced Actin Remodeling and Signaling at the Immune Synapse', 'display_name': 'The Wdr1-LIMK-Cofilin Axis Controls B Cell Antigen Receptor-Induced Actin Remodeling and Signaling at the Immune Synapse', 'publication_year': 2021, 'publication_date': '2021-04-13', 'ids': {'openalex': 'https://openalex.org/W3154003478', 'doi': 'https://doi.org/10.3389/fcell.2021.649433', 'mag': '3154003478', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/33928084', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/8076898'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3389/fcell.2021.649433', 'pdf_url': 'https://www.frontiersin.org/articles/10.3389/fcell.2021.649433/pdf', 'source': {'id': 'https://openalex.org/S2596924766', 'display_name': 'Frontiers in Cell and Developmental Biology', 'issn_l': '2296-634X', 'issn': ['2296-634X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320527', 'host_organization_name': 'Frontiers Media', 'host_organization_lineage': ['https://openalex.org/P4310320527'], 'host_organization_lineage_names': ['Frontiers Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.frontiersin.org/articles/10.3389/fcell.2021.649433/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5051387247', 'display_name': 'Madison Bolger-Munro', 'orcid': 'https://orcid.org/0000-0002-8176-4824'}, 'institutions': [{'id': 'https://openalex.org/I141945490', 'display_name': 'University of British Columbia', 'ror': 'https://ror.org/03rmrcq20', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I141945490']}], 'countries': ['CA'], 'is_corresponding': True, 'raw_author_name': 'Madison Bolger-Munro', 'raw_affiliation_strings': ['Department of Microbiology & Immunology and Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology & Immunology and Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada', 'institution_ids': ['https://openalex.org/I141945490']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047592756', 'display_name': 'Kate Choi', 'orcid': 'https://orcid.org/0000-0002-7959-1944'}, 'institutions': [{'id': 'https://openalex.org/I141945490', 'display_name': 'University of British Columbia', 'ror': 'https://ror.org/03rmrcq20', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I141945490']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Kate Choi', 'raw_affiliation_strings': ['Department of Microbiology & Immunology and Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology & Immunology and Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada', 'institution_ids': ['https://openalex.org/I141945490']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5043655202', 'display_name': 'Faith Cheung', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I141945490', 'display_name': 'University of British Columbia', 'ror': 'https://ror.org/03rmrcq20', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I141945490']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Faith Cheung', 'raw_affiliation_strings': ['Department of Microbiology & Immunology and Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology & Immunology and Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada', 'institution_ids': ['https://openalex.org/I141945490']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101968036', 'display_name': 'Jason Liu', 'orcid': 'https://orcid.org/0000-0002-1864-8281'}, 'institutions': [{'id': 'https://openalex.org/I141945490', 'display_name': 'University of British Columbia', 'ror': 'https://ror.org/03rmrcq20', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I141945490']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Yi Tian Liu', 'raw_affiliation_strings': ['Department of Microbiology & Immunology and Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology & Immunology and Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada', 'institution_ids': ['https://openalex.org/I141945490']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079321958', 'display_name': 'May Dang-Lawson', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I141945490', 'display_name': 'University of British Columbia', 'ror': 'https://ror.org/03rmrcq20', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I141945490']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'May Dang-Lawson', 'raw_affiliation_strings': ['Department of Microbiology & Immunology and Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology & Immunology and Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada', 'institution_ids': ['https://openalex.org/I141945490']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055780363', 'display_name': 'Nikola Deretic', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I141945490', 'display_name': 'University of British Columbia', 'ror': 'https://ror.org/03rmrcq20', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I141945490']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Nikola Deretic', 'raw_affiliation_strings': ['Department of Microbiology & Immunology and Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology & Immunology and Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada', 'institution_ids': ['https://openalex.org/I141945490']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049563650', 'display_name': 'Connor Keane', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I141945490', 'display_name': 'University of British Columbia', 'ror': 'https://ror.org/03rmrcq20', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I141945490']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Connor Keane', 'raw_affiliation_strings': ['Department of Microbiology & Immunology and Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology & Immunology and Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada', 'institution_ids': ['https://openalex.org/I141945490']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5007781157', 'display_name': 'Michael R. Gold', 'orcid': 'https://orcid.org/0000-0003-1222-3191'}, 'institutions': [{'id': 'https://openalex.org/I141945490', 'display_name': 'University of British Columbia', 'ror': 'https://ror.org/03rmrcq20', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I141945490']}], 'countries': ['CA'], 'is_corresponding': True, 'raw_author_name': 'Michael R. Gold', 'raw_affiliation_strings': ['Department of Microbiology & Immunology and Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology & Immunology and Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada', 'institution_ids': ['https://openalex.org/I141945490']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5051387247', 'https://openalex.org/A5007781157'], 'corresponding_institution_ids': ['https://openalex.org/I141945490', 'https://openalex.org/I141945490'], 'apc_list': {'value': 2950, 'currency': 'USD', 'value_usd': 2950, 'provenance': 'doaj'}, 'apc_paid': {'value': 2950, 'currency': 'USD', 'value_usd': 2950, 'provenance': 'doaj'}, 'fwci': 1.286, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 11, 'citation_normalized_percentile': {'value': 0.999851, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 88, 'max': 89}, 'biblio': {'volume': '9', 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10379', 'display_name': 'Cellular Mechanics and Interactions', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10379', 'display_name': 'Cellular Mechanics and Interactions', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10031', 'display_name': 'T-cell and B-cell Immunology', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10831', 'display_name': 'Cell Adhesion Molecules Research', 'score': 0.9956, 'subfield': {'id': 'https://openalex.org/subfields/2723', 'display_name': 'Immunology and Allergy'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cofilin', 'display_name': 'Cofilin', 'score': 0.9531257}, {'id': 'https://openalex.org/keywords/actin-remodeling', 'display_name': 'Actin remodeling', 'score': 0.77475935}, {'id': 'https://openalex.org/keywords/immunological-synapse', 'display_name': 'Immunological synapse', 'score': 0.6612456}], 'concepts': [{'id': 'https://openalex.org/C2776601116', 'wikidata': 'https://www.wikidata.org/wiki/Q24786722', 'display_name': 'Cofilin', 'level': 5, 'score': 0.9531257}, {'id': 'https://openalex.org/C3620293', 'wikidata': 'https://www.wikidata.org/wiki/Q14908027', 'display_name': 'Actin remodeling', 'level': 5, 'score': 0.77475935}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.71990347}, {'id': 'https://openalex.org/C9756297', 'wikidata': 'https://www.wikidata.org/wiki/Q126223', 'display_name': 'Immunological synapse', 'level': 5, 'score': 0.6612456}, {'id': 'https://openalex.org/C151000934', 'wikidata': 'https://www.wikidata.org/wiki/Q4676834', 'display_name': 'Actin remodeling of neurons', 'level': 5, 'score': 0.5420379}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.51431835}, {'id': 'https://openalex.org/C2993400109', 'wikidata': 'https://www.wikidata.org/wiki/Q329638', 'display_name': 'Actin cytoskeleton', 'level': 4, 'score': 0.48711705}, {'id': 'https://openalex.org/C125705527', 'wikidata': 'https://www.wikidata.org/wiki/Q185269', 'display_name': 'Actin', 'level': 2, 'score': 0.4704237}, {'id': 'https://openalex.org/C157695867', 'wikidata': 'https://www.wikidata.org/wiki/Q1100474', 'display_name': 'B-cell receptor', 'level': 4, 'score': 0.43801647}, {'id': 'https://openalex.org/C2776090121', 'wikidata': 'https://www.wikidata.org/wiki/Q193529', 'display_name': 'T cell', 'level': 3, 'score': 0.320016}, {'id': 'https://openalex.org/C2778453870', 'wikidata': 'https://www.wikidata.org/wiki/Q188930', 'display_name': 'B cell', 'level': 3, 'score': 0.2595138}, {'id': 'https://openalex.org/C142669718', 'wikidata': 'https://www.wikidata.org/wiki/Q154626', 'display_name': 'Cytoskeleton', 'level': 3, 'score': 0.25234103}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.20211512}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.16818947}, {'id': 'https://openalex.org/C19317047', 'wikidata': 'https://www.wikidata.org/wiki/Q412037', 'display_name': 'T-cell receptor', 'level': 4, 'score': 0.14598247}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.108290404}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.09573445}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.058725417}], 'mesh': [], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3389/fcell.2021.649433', 'pdf_url': 'https://www.frontiersin.org/articles/10.3389/fcell.2021.649433/pdf', 'source': {'id': 'https://openalex.org/S2596924766', 'display_name': 'Frontiers in Cell and Developmental Biology', 'issn_l': '2296-634X', 'issn': ['2296-634X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320527', 'host_organization_name': 'Frontiers Media', 'host_organization_lineage': ['https://openalex.org/P4310320527'], 'host_organization_lineage_names': ['Frontiers Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/e9004ca4e69f462481ed809a38b90124', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076898', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3389/fcell.2021.649433', 'pdf_url': 'https://www.frontiersin.org/articles/10.3389/fcell.2021.649433/pdf', 'source': {'id': 'https://openalex.org/S2596924766', 'display_name': 'Frontiers in Cell and Developmental Biology', 'issn_l': '2296-634X', 'issn': ['2296-634X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320527', 'host_organization_name': 'Frontiers Media', 'host_organization_lineage': ['https://openalex.org/P4310320527'], 'host_organization_lineage_names': ['Frontiers Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320334506', 'funder_display_name': 'Canadian Institutes of Health Research', 'award_id': 'PJT-166196'}], 'datasets': [], 'versions': [], 'referenced_works_count': 114, 'referenced_works': ['https://openalex.org/W1831873206', 'https://openalex.org/W1833314573', 'https://openalex.org/W1945972342', 'https://openalex.org/W1963969404', 'https://openalex.org/W1967139887', 'https://openalex.org/W1967359088', 'https://openalex.org/W1967975220', 'https://openalex.org/W1978307034', 'https://openalex.org/W1978677736', 'https://openalex.org/W1980863018', 'https://openalex.org/W1981352846', 'https://openalex.org/W1983432630', 'https://openalex.org/W1986601054', 'https://openalex.org/W1993289560', 'https://openalex.org/W1994844322', 'https://openalex.org/W2003736664', 'https://openalex.org/W2009277812', 'https://openalex.org/W2013940103', 'https://openalex.org/W2019206924', 'https://openalex.org/W2023841575', 'https://openalex.org/W2025785462', 'https://openalex.org/W2027498023', 'https://openalex.org/W2028497798', 'https://openalex.org/W2033970156', 'https://openalex.org/W2034306306', 'https://openalex.org/W2035325286', 'https://openalex.org/W2036524475', 'https://openalex.org/W2038450971', 'https://openalex.org/W2045054556', 'https://openalex.org/W2045388973', 'https://openalex.org/W2056475154', 'https://openalex.org/W2057485569', 'https://openalex.org/W2070505228', 'https://openalex.org/W2072522584', 'https://openalex.org/W2073177357', 'https://openalex.org/W2073960853', 'https://openalex.org/W2078702573', 'https://openalex.org/W2080945459', 'https://openalex.org/W2082024168', 'https://openalex.org/W2086285294', 'https://openalex.org/W2087743724', 'https://openalex.org/W2089920144', 'https://openalex.org/W2099691755', 'https://openalex.org/W2103407592', 'https://openalex.org/W2104777481', 'https://openalex.org/W2105789974', 'https://openalex.org/W2113395636', 'https://openalex.org/W2116130782', 'https://openalex.org/W2117248853', 'https://openalex.org/W2118038068', 'https://openalex.org/W2120245870', 'https://openalex.org/W2126496496', 'https://openalex.org/W2133954646', 'https://openalex.org/W2134571046', 'https://openalex.org/W2135174117', 'https://openalex.org/W2135388013', 'https://openalex.org/W2136088887', 'https://openalex.org/W2138204597', 'https://openalex.org/W2144779659', 'https://openalex.org/W2152655368', 'https://openalex.org/W2153840405', 'https://openalex.org/W2154617002', 'https://openalex.org/W2155827443', 'https://openalex.org/W2160466201', 'https://openalex.org/W2162560056', 'https://openalex.org/W2167279371', 'https://openalex.org/W2168599205', 'https://openalex.org/W2168936544', 'https://openalex.org/W2238959460', 'https://openalex.org/W2268921967', 'https://openalex.org/W2331356571', 'https://openalex.org/W2396908022', 'https://openalex.org/W2397919450', 'https://openalex.org/W2511531163', 'https://openalex.org/W2536508826', 'https://openalex.org/W2544486379', 'https://openalex.org/W2560787367', 'https://openalex.org/W2562184414', 'https://openalex.org/W2566732684', 'https://openalex.org/W2586974243', 'https://openalex.org/W2592302348', 'https://openalex.org/W2592634893', 'https://openalex.org/W2604317589', 'https://openalex.org/W2604838489', 'https://openalex.org/W2605350170', 'https://openalex.org/W2626877998', 'https://openalex.org/W2759543907', 'https://openalex.org/W2766095317', 'https://openalex.org/W2766769159', 'https://openalex.org/W2770046820', 'https://openalex.org/W2789400319', 'https://openalex.org/W2794407505', 'https://openalex.org/W2799755880', 'https://openalex.org/W2800497993', 'https://openalex.org/W2892349970', 'https://openalex.org/W2893535784', 'https://openalex.org/W2894924203', 'https://openalex.org/W2901658403', 'https://openalex.org/W2902298238', 'https://openalex.org/W2914685386', 'https://openalex.org/W2938678047', 'https://openalex.org/W2970826594', 'https://openalex.org/W2981569223', 'https://openalex.org/W2983332703', 'https://openalex.org/W2984209763', 'https://openalex.org/W2984485347', 'https://openalex.org/W2988118358', 'https://openalex.org/W2990201239', 'https://openalex.org/W3033208177', 'https://openalex.org/W3041635606', 'https://openalex.org/W3081045667', 'https://openalex.org/W3092324095', 'https://openalex.org/W3127243979', 'https://openalex.org/W4243437939'], 'related_works': ['https://openalex.org/W3015719748', 'https://openalex.org/W3003751606', 'https://openalex.org/W2472516939', 'https://openalex.org/W2124497742', 'https://openalex.org/W2080945459', 'https://openalex.org/W2011545163', 'https://openalex.org/W2004043477', 'https://openalex.org/W2003529245', 'https://openalex.org/W1983813017', 'https://openalex.org/W1969950216'], 'abstract_inverted_index': {'When': [0], 'B': [1, 11, 23, 57, 73, 142, 190, 232], 'cells': [2, 24, 31], 'encounter': [3], 'membrane-bound': [4], 'antigens,': [5], 'the': [6, 27, 41, 63, 72, 87, 105, 184, 202, 209, 221], 'formation': [7], 'and': [8, 33, 66, 92, 130, 158, 162, 175, 193, 197, 230], 'coalescence': [9, 67], 'of': [10, 22, 29, 40, 68, 89, 97, 116, 183, 205], 'cell': [12, 58, 191, 233], 'antigen': [13], 'receptor': [14], '(BCR)': [15], 'microclusters': [16, 70], 'amplifies': [17], 'BCR': [18, 45, 69, 206], 'signaling.': [19], 'The': [20], 'ability': [21], 'to': [25, 35, 156, 167, 201, 235], 'probe': [26], 'surface': [28], 'antigen-presenting': [30], '(APCs)': [32], 'respond': [34], 'APC-bound': [36, 236], 'antigens': [37], 'requires': [38], 'remodeling': [39, 229], 'actin': [42, 53, 77, 82, 90, 98, 147, 157, 168, 186, 228], 'cytoskeleton.': [43], 'Initial': [44], 'signaling': [46, 207], 'stimulates': [47], 'actin-related': [48], 'protein': [49, 123], '(Arp)': [50], '2/3': [51], 'complex-dependent': [52], 'polymerization,': [54], 'which': [55, 85], 'drives': [56], 'spreading': [59], 'as': [60, 62, 120], 'well': [61], 'centripetal': [64], 'movement': [65], 'at': [71, 208], 'cell-APC': [74], 'synapse.': [75, 211], 'Sustained': [76], 'polymerization': [78], 'depends': [79], 'on': [80, 217], 'concomitant': [81], 'filament': [83], 'depolymerization,': [84], 'enables': [86], 'recycling': [88], 'monomers': [91], 'Arp2/3': [93], 'complexes.': [94], 'Cofilin-mediated': [95], 'severing': [96], 'filaments': [99], 'is': [100, 224], 'a': [101], 'rate-limiting': [102], 'step': [103], 'in': [104, 141, 180], 'morphological': [106], 'changes': [107], 'that': [108, 173, 188, 194], 'occur': [109], 'during': [110], 'immune': [111, 210], 'synapse': [112], 'formation.': [113], 'Hence,': [114], 'regulators': [115], 'cofilin': [117, 153, 161], 'activity': [118], 'such': [119], 'WD': [121], 'repeat-containing': [122], '1': [124, 132], '(Wdr1),': [125], 'LIM': [126], 'domain': [127], 'kinase': [128], '(LIMK),': [129], 'coactosin-like': [131], '(Cotl1)': [133], 'may': [134], 'also': [135], 'be': [136], 'essential': [137], 'for': [138, 154, 226, 231], 'actin-dependent': [139, 203], 'processes': [140], 'cells.': [143], 'Wdr1': [144, 174], 'enhances': [145], 'cofilin-mediated': [146], 'disassembly.': [148], 'Conversely,': [149], 'Cotl1': [150, 213], 'competes': [151], 'with': [152], 'binding': [155, 166], 'LIMK': [159, 176, 198], 'phosphorylates': [160], 'prevents': [163], 'it': [164], 'from': [165], 'filaments.': [169], 'We': [170], 'now': [171], 'show': [172], 'have': [177], 'distinct': [178], 'roles': [179], 'BCR-induced': [181, 227], 'assembly': [182], 'peripheral': [185], 'structures': [187], 'drive': [189], 'spreading,': [192], 'cofilin,': [195], 'Wdr1,': [196], 'all': [199], 'contribute': [200], 'amplification': [204], 'Depleting': [212], 'had': [214], 'no': [215], 'effect': [216], 'these': [218], 'processes.': [219], 'Thus,': [220], 'Wdr1-LIMK-cofilin': [222], 'axis': [223], 'critical': [225], 'responses': [234], 'antigens.': [237]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3154003478', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 1}], 'updated_date': '2024-12-12T20:43:19.142259', 'created_date': '2021-04-26'}