Title: Influence of Antibiotics and Copper on Micronucleus Rate of Root-Tip Cells of Vicia-faba
Abstract: In order to evaluate the degree of biological genetic injury induced by antibiotics and heavy metals,the genotoxic effects of oxytetracycline( OTC),chlortetracycline( CTC),tetracycline( TTC) and copper( Cu),as well as their individual and mixed pollutions in various proportions,and the degree of biological genetic injury were studied by micronucleus rate in root-tip cells of Vicia-faba. The results showed that: 1) When the concentrations of the tetracycline antibiotics and Cu were 0-1. 6 mmol/L,the micronucleus rates of Vicia-faba treated increased at different levels and were significantly different from the control group. All micronucleus rates were above3. 33‰,and all the micronucleus indexes were higher than 1. 5. The results also showed that the experimental samples had mutagenicity.With the increase of the concentrations of tetracycline antibiotics,the micronucleus rate in root-tip cells of Vicia-faba showed an increasing trend after the first reduction. 2) Compared with the single effect of tetracycline antibiotics and Cu,there was antagonism when they were mixed in some proportion,and the trend was similar with the individual effect. The most obvious concentration for the antagonism was1∶ 4. When the proportions were 1 ∶ 1 and 1 ∶ 2,the micronucleus rate declined,but it was adverse when the proportions were 1 ∶ 8and 1∶ 16. These results demonstrated that the tetracycline antibiotics and Cu can cause biological genetic injury to root-tip cells of Vicia-faba,but when they were mixed,the injury reduced because of the complex interaction of Cu and tetracycline antibiotics.
Publication Year: 2015
Publication Date: 2015-01-01
Language: en
Type: article
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