Title: Expression of COX-2 and its prognostic significance in non-small cell lung cancer
Abstract: Objective To investigate the expression of COX-2 and its relation to clinical pathophysiological features and prognosis in non-small cell lung cancer (NSCLC). Methods The expression of COX-2 protein was detected in 52 NSCLC tissues by immunohistochemical (S-P) method. Results The positive COX-2 expression was observed in 25 (48.1%) cases of NSCLC tissues. The positive rate of COX-2 expression was 76.5% and 34.3% in adenocarcinoma and squamous cell carcinoma respectively (P0.01). The positive rate of COX-2 expression in T3+T4 disease (92.3%) was remarkably higher than that in stage T1+T2 (33.3%) (P0.01). There was a remarkable difference in COX-2 expression rate between clinical stage Ⅰ+Ⅱ (28.1%) and clinical stage Ⅲ+Ⅳ (80.0%) groups (P0.01). The positive rate of COX-2 expression was 83.3% in those with lymph node metastasis, but only 17.9% in those without lymph node metastasis (P 0.01). In addition, there were significant differences in positive rate of COX-2 expression among patients with ≤2, 2 but 5, ≥5 years of survival span respectively (P0.01). Conclusion Overexpression of COX-2 in NSCLC, especially in adenocarcinoma, is closely related to invasion, lymph node metastasis and clinical stage of lung cancer. It may play a role in development of NSCLC, and also may be a prognostic marker.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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Cited By Count: 1
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