Title: Prognostic value of EGFR、VEGF and COX-2 expression in patients with non-small cell lung cancer
Abstract: Objective:To evaluate the relationship between expression of EGFR,VEGF and COX-2,and the relationship between expression and clinicopathologic parameters and survival in patients with non-small cell lung cancer(NSCLC).Methods:Expressions of EGFR,VEGF and COX-2 were accessed by immunohistochemical staining on tissue microarray sections made of 88 cases of NSCLC and 10 cases of normal lung samples.The results were compared with relevant clinical and pathologic data.All cases were followed up for more than 5 years.Results:Positive rates of EGFR,VEGF and COX-2 were 46.6%,67.0% and 71.6%,respectively.None of normal lung samples was expressed.There was no correlation between EGFR expression and any clinical characteristics(P0.05).Positive expression of VEGF was higher in female patients(P=0.035).Positive expression of COX-2 was significantly higher in groups of female,non-smokers,adenocarcinoma and lymph node metastasis(P0.05).A positive correlation was found between expression of EGFR and VEGF,VEGF and COX-2(γ=0.198,P=0.02 and γ=0.416,P=0.000).Patients with positive expression of COX-2 had worse survival(P=0.014).Multivariate analysis using Cox regression modal showed that none of the biomarkers was the important independent prognostic factor for survival.Conclusion:EGFR,VEGF and COX-2 are aberrant highly expressed in NSCLC with positive correlation,which indicate they might act synergistically in angiogenesis of NSCLC.Aberrant expression of COX-2 is related with shorter survival and COX-2 may be useful as an indicator for prognosis in NSCLC.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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