Title: The analysis of plasma homocysteine among 1020 residents in community
Abstract: Objective To study the plasma homocysteine (Hcy) distributive characteristics in different sex and age groups of the community residents in Guangdong, and to analyze its associated factors as well as its effects on cerebral artery stenosis. Methods In this study, we presented data concerning 2500 residents who had undergone a systematic health checkup,including clinical and biologic examinations. Plasma was saved from 1020 residents who were asymptomatic but having TCD examination. Hcy concentration was measured by fluorescence ration biochemical assay kit. Results The average plasma Hcy levels of males (15.0μmol/L±5.8μmol/L ) were significantly higher than those of females (12. 4μmol/L±3. 9μmol/L, P 0. 05 ). Hcy level increased parallel with age. The prevalence rate of hyperhomocysteinemia in males (47.2%) was higher than in females (23.2%). Hcy levels in MCA stenosis group (18.3μmol/L±5.3μmol/L) were significantly higher than that in control group (12.9μmol/L±4.6μmol/L, P 0.05). Based on logistic regression analysis, Hcy was only associated with sex and age, but not with blood lipids etc. Conclusion Hcy levels were different in sex and age groups which emerged as independent predictors of hyperhomocysteinemia but had no association with blood lipids in the community residents, suggesting that hyperhomocysteinemia might worsen cerebral artery stenosis.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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