Title: Hyperhomocysteine and Young Adults With lschemic Stroke
Abstract: Objective: To investigate the relationships of plasma homocysteine (Hcy)levels and ischemic stroke in young Adults. Methods: The plasma homocysteine(Hcy)among forty cases with young adult ischemic cerebral disease(age at first event,=45 years, CI group)were investigated,. Thirty age-and sex-matched healthy persons(Control group) and thirty persons with nervous system disease but vascular disease(NVD group) were used as controls.All the subjects underwent brain CT or MRI examination,serum vitaminB12 and folic acid examination,besides examination of plasma Hcy. The effects of age, sex, liver function, renal function, smoking,drinking, serum vitaminB12,and folic acid were analyzed. Results: The mean plasma Hcy was significantly higher in the CI group(21.4±18.8umol/L) compared with NVD group and control group(10.2±5.0umol/L and 12.9±8.6umol/L,P0.01). Plasma Hcy level was inversely related to serum folate and vitamin B 12 concentrations whereas positively related to serum creatinine and smoking in all the three groups. The Hcy concentration of males was significantly higher than females in all groups. Conclusion: In this population , elevated plasma homocysteine is strongly associated with an increased prevalence of cerebral infarction in young adult, plasma Hcy level was inversely related to serum folate and vitamin B12 concentrations whereas positively related to serum creatinine and smoking.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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