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'https://openalex.org/W3151975986', 'https://openalex.org/W3151832929', 'https://openalex.org/W3151561104', 'https://openalex.org/W3148023678', 'https://openalex.org/W3147063983', 'https://openalex.org/W3147050224', 'https://openalex.org/W3145860786', 'https://openalex.org/W3144075899', 'https://openalex.org/W3143759552', 'https://openalex.org/W3142620760', 'https://openalex.org/W3142355166', 'https://openalex.org/W3141536319', 'https://openalex.org/W3140082918', 'https://openalex.org/W3139722704', 'https://openalex.org/W3031079308', 'https://openalex.org/W2166373554', 'https://openalex.org/W2155650069', 'https://openalex.org/W2001699853', 'https://openalex.org/W1544839988'], 'abstract_inverted_index': {'RNA': [0, 23], '干扰(RNAi': [1], ')': [2, 25], '是在多重有机体的基因': [3], 'silencing': [4, 15], '的': [5, 20, 44, 52, 54], 'evolutionarily': [6], '保存的进程,它为由反向的遗传调查基因功能成为了一个强大的工具。最近,许多组报导了使用综合': [7], 'oligonucleotides': [8], '或': [9], 'siRNA': [10], '编码原生质标志由': [11], 'transfection': [12], '在哺乳动物的房间导致': [13], 'RNAi,但是这仍然在它的申请被限制,特别当产生长期的基因': [14], '体内是必要的时。避免这个问题,交付': [16], 'retrovirus': [17], '或交付': [18], 'lentivirus': [19], 'RNAi': [21, 29, 35, 58], '被开发了。这里,我们描述了为交付短发卡': [22], '(shRNA': [24], '的病毒的系统从': [26], 'H1': [27, 43, 49], '倡导者抄录了的二枚制动火箭。结果证明病毒的调停向量的': [28], '能实质地击倒的制动火箭在': [30], '293-T': [31], '房间调整人的': [32], 'p53': [33, 37, 47, 55], '的表示。而且,制动火箭在我们的转导系统的病毒的调停向量的': [34], '能稳定地很长时间使': [36], '基因失去活性。比作从': [38], 'U6': [39, 51], '倡导者,抄录的': [40], 'shRNAs': [41, 53], '驾驶': [42], 'shRNA': [45], '戏剧性地也减少了': [46], '的表示。驾驶': [48], '、驾驶': [50], 'down': [56], '规定效率是几乎相同的。结果显示病毒的交付向量的': [57], '将是的那枚制动火箭在功能的基因组学和基因治疗的一个有用工具。': [59]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3142917394', 'counts_by_year': [], 'updated_date': '2024-09-19T18:45:34.455625', 'created_date': '2021-04-13'}