Title: Event-related potential study of abnormal cognition processing in treatment-refractory schizophrenia
Abstract: Objective
To explore the characteristics of evoked potentials P300 and mismatched negativity (MMN) in treatment-refractory schizophrenia.
Methods
21 schizophrenia patients as case group and 26 healthy subjects as normal control group were measured events-related potential P300 and MMN, and the differences of P300 at F3, F4, Fz, Cz and MMN at Fz, Cz, Pz of the two groups were compared.
Results
① The reaction time of case group[(408.91±202.24) ms] was longer than normal control group((361.60±254.32) ms), and the difference was significant(P<0.05). ②P300 latency at F3, F4, Fz, Cz of case group((385.92±53.14)ms, (400.31±51.32)ms, (386.77±62.68)ms, (374.77±57.61)ms) were significantly longer than those of normal control group((341.00±30.42)ms, (335.23±29.71)ms, (338.65±30.09)ms, (344.42±30.86)ms). P300 amplitude at F4, Fz of case group((4.68±2.90) μV(5.83±3.73) μV) were significantly lower than those of normal control group((6.71±2.57)μV, (7.99±2.78)μV), P<0.05. ③MMN aptitude at Fz of case group((2.77±2.25) μV) was significantly lower than that of normal control group((5.87±3.28)μV)(P<0.05). The control group presented the expected reduction in the amplitude of the MMN from frontal to central and parietal locations. MMN amplitude of case group was contrary.
Conclusion
Treatment-refractory schizophrenia patients have cognitive function impairment.
Key words:
Treatment-refractory schizophrenia; Event-related potential; P300; Mismatch negativity
Publication Year: 2012
Publication Date: 2012-10-20
Language: en
Type: article
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