Title: STUDY ON MISMATCH NEGATIVITY OF PATIENT WITH SCHIZOPHRENIA
Abstract: Objectives:To investigate the characteristic of mismatch negativity (MMN) in patitnts with first-episode schizophrenia and its variation after treatment. Methods:MMN and P_ 300 were recorded from 45 schizophrenics and 40 normal controls with American Brova instrument, and assessea their psychotic symptoms with PANSS. Results:Compared with NC, schizophrenics showed delayed MMN latency (NC: 199.7±29.9ms, Sch: 221.4±32.6ms, P0.01), decreased MMN amplitude (NC: 7.8±3.8μV, Sch: 4.5±3.3μV, P0.01), and delayed latency of P_ 300 (P0.01). Delayed MMN latency and decreased MMN amplitude correlated negatively with positive symptoms and thought disorder. After 12 weeks of treatment, abnormal MMN was improved with improving psychotic symptoms.Conclusions:MMN could reflect the automatic processing of schizophrenics, and might be useful markers applying into schizophrenics.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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Cited By Count: 3
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