Title: Evaluation of islet α-cell and β-cell function at different levels of HbA1C in patients with type 2 diabetes mellitus
Abstract: Objective To investigate the change of islet α-cell and β-cell function at different levels of HbA1C in patients with type 2 diabetes mellitus.Methods A total of 288 cases of type 2 diabetic patients were divided into four groups according to their HbA1C levels:HbA1C ≤ 7.0% (Group A),7.0% <HbA1CC ≤ 9.0% (Group B),9.0% <HbA1C ≤ 11.0% (Group C),and HbA1C>11.0% (Group D).Oral glucose tolerance test,insulin releasing test,and glucagon releasing test were performed to observe the differences in glucagon,glucagon/insulin,early insulin secretion index (△I30/△G30),and the second-phase insulin secretion index [using area under curve of insulin(AUC1)] among the four groups,and a correlation analysis was performed between glucagon and other indicators.Result (1) Glucagon,glucagon/insulin,and area under curve of glucagon increased significantly with the increase of HbA1C(all P<0.05).(2) Compared with group A,homeostasis model assessment for insulin resistance (HOMA-IR) in group B,C,and D were significantly higher(P<0.05),insulin sensitivity index,homeostasis model assessment for β cell function (HOMA-β),△I30/△G30,the AUC1 were significantly lower(all P<0.05).Compared with group A,△I30/△G30 in group B and C dropped about 50% (P<0.05),and △I30/△G30 in group D decreased 90% (P<0.05).(3) Person correlation analysis showed that glucagon had a negative correlation with △I30/△G30,HOMA-β,body mass index,insulin sensitivity index,AUC1 (all P<0.05),and a positive correlation with fasting plasma glucose,area under curve of glucose,HOMA-IR,HbA1C,course of diabetes (all P<0.05).Conclusions Abnormal function of islet α-cell and β-cell exist in patients with type 2 diabetes,especially in those with higher levels of HbA1C,indicating that regulation of glucagon will make the blood glucose target be reached more easily.
Key words:
Glucagon; Islet α-cell; Islet β-cell; HbA1C; Diabetes mellitus,type 2
Publication Year: 2013
Publication Date: 2013-04-25
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot