Title: The Effects of Transient Intensive Insulin Treatment on Beta-cell Function in Newly Diagnosed Type II Diabetic Patients
Abstract: Objective To study the effect of short-term intensive insulin treatment on beta-cell function and plasma glucose in newly diagnosed type 2 diabetic patients.Methods Twenty-one newly diagnosed type 2 diabetic patients with FPG 11.1 mmol/L were treated by 2 weeks CSII.An intravenous glucose tolerance test(IVGTT) was performed before and after CSII.The levels of fasting plasma glucose(FPG),2 hours postprandial glucose(2hPG),glycosylated hemoglobin A1c(HbA1c),first-phase secretion of insulin,the mean area under the curve(AUC) of insulin,insulin sensitivity index(ISI),insulin resistance index(Homa IR) and insulin secretion index(Homa β) were compared.Results The excellent control of FPG and 2hPG in 20 out of 21 patients were achieved stably in 2.8±1.6 days and 7.8±1.9 days by CSII.After the treatment,FPG,2h PG and HbA1c were significantly decreased(P0.01);fasting and first-phase secretion of insulin,AUC of insulin and Homa β were significantly increased(P0.01);Homa IR was also significantly decreased(P0.01).Twelve patients were followed up for an average of 6 months with mean HbA1c of(5.86± 0.57)%,FPG of(5.8±1.0) mmol/L,2h PG of *7.6±2.2) mmol/L.Conclusion The excellent glycemic control and improvement of beta-cell function can be induced by short-term CSII intensive therapy in newly diagnosed type 2 diabetic patients.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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