Title: Effects of HbA1C on insulin resistance and islet function in newly diagnosed type 2 diabetic patients
Abstract: Objective To provide theoretical support for for reasonable selection of hypoglycemic agents and effective control of blood glucose by investigating the relationship between HbA1C level and islet function in newly diagnosed type 2 diabetic patients.Methods Height,body weight,blood lipids,fasting blood glucose and insulin,and HbA1C level were detected in 126 ( 76 male and 50 female )newly diagnosed type 2 diabetic patients.The patients were then divided into group A ( HbA1C < 7.0% ),group B ( 7.0% ≤ HbA1C < 9.0% ),and group C ( HbA1C ≥ 9.0%) based on HbA1C level.HOMA-IR,HOMA-β,and ISI were determined.Results The mean age and BMI did not differ significantly among the three groups (P> 0.05 ).With an elevation in HbA1C, TC increased and HDL-C decreased accordingly.Fasting glucose level was significantly higher in group C than in groups A and B ( P< 0.05 ).HOMA-IR significantly increased and ISI declined in group B.As compared with other groups,HOMA-β was significantly decreased in group C ( P < 0.05 ).Conclusions With an increase in HbA1C,the sensitivity to insulin declines level and β- cell function is weakened in newly diagnosed type 2 diabetic patients.
Key words:
HbA1C; Type 2 diabetes; Insulin resistance; β-cell function
Publication Year: 2012
Publication Date: 2012-03-01
Language: en
Type: article
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