Title: Efficacy of single bolus oxycodone infusion in patient-controlled intravenous analgesia after caesarean section
Abstract: Objective
To observe the efficacy of oxycodone under no background dose in patient-controlled intravenous analgesia(PCIA) after caesarean surgery.
Methods
Sixty patients undergoing selective cesarean section were randomly categorized into two groups using random schedule table(n=30): group morphine(group M) and group oxycodone(group O), all patients were aged between 20 to 35 years and of ASA classⅠ,Ⅱ. Fifty milligrams of morphine was delivered in group M, while 50 mg oxycodone was delivered in group O. Ondansetron 8 mg was added to each group. PCIA was set on demand mode without loading dose or background infusion. In both groups, drugs were diluted to 100 ml with normal saline, and 4 ml bolus dose with 5 min lockout interval was set. At 4, 8, 12 h and 48 h after surgery, VAS was assessed, including VAS at rest, VAS at motion and VAS at uterine contraction. Total doses of the drug delivery within postoperative 48 h and the number of patient controlled analgesia(PCA) were recorded, postoperative nausea and vomiting and patient satisfaction were also evaluated.
Results
At 4, 8, 12 h and 24 h after surgery, VAS at uterine contraction in group O was significantly lower than VAS of group M(P 0.05). At 48 h after surgery, total doses of PCIA drugs, the number of PCA and the incidences of side effects were significantly lower in group O than these parameters in group M(P<0.05). The overall patient satisfaction degree in group O was significantly higher than patient satisfaction degree in group O(P<0.05).
Conclusions
Both oxycodone and morphine are effective for pain relief after cesarean section when PCIA is set on bolus mode. However, compared with morphine, oxycodone exhibited significantly better effects on uterine contraction, pain relief and patient satisfaction.
Key words:
Caesarean section; Postoperative analgesia; Oxycodone; Patient-controlled intravenous analgesia
Publication Year: 2018
Publication Date: 2018-04-15
Language: en
Type: article
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