Publication Information

{'id': 'https://openalex.org/W3032081167', 'doi': 'https://doi.org/10.3760/cma.j.issn.1006-7876.2018.12.008', 'title': 'The effect of melatonin on the proliferation of neural stem cells in rats with cerebral ischemia reperfusion and its mechanism', 'display_name': 'The effect of melatonin on the proliferation of neural stem cells in rats with cerebral ischemia reperfusion and its mechanism', 'publication_year': 2018, 'publication_date': '2018-12-08', 'ids': {'openalex': 'https://openalex.org/W3032081167', 'doi': 'https://doi.org/10.3760/cma.j.issn.1006-7876.2018.12.008', 'mag': '3032081167'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'http://rs.yiigle.com/CN113694201812/1080702.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306506121', 'display_name': 'Chin J Neurol', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': [], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100332644', 'display_name': 'Zhen Li', 'orcid': 'https://orcid.org/0000-0002-9783-169X'}, 'institutions': [{'id': 'https://openalex.org/I117331123', 'display_name': 'Weifang Medical University', 'ror': 'https://ror.org/03tmp6662', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I117331123']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhen Li', 'raw_affiliation_strings': ['Department of Medical Imaging, Weifang Medical University, Weifang, Shandong 261053, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Imaging, Weifang Medical University, Weifang, Shandong 261053, China.', 'institution_ids': ['https://openalex.org/I117331123']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102928935', 'display_name': 'Dandan Cheng', 'orcid': 'https://orcid.org/0000-0003-2560-177X'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Dandan Cheng', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100344537', 'display_name': 'Wei Chen', 'orcid': 'https://orcid.org/0000-0003-0903-7945'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Wei Chen', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064516205', 'display_name': 'Guangzu Li', 'orcid': 'https://orcid.org/0000-0003-0494-1732'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Guangzu Li', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034526048', 'display_name': 'Yu-Peng Xia', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Yupeng Xia', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5057342947', 'display_name': 'Rui Zhuo', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Rui Zhuo', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 62}, 'biblio': {'volume': '51', 'issue': '12', 'first_page': '977', 'last_page': '984'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T14144', 'display_name': 'Neurological Disease Mechanisms and Treatments', 'score': 0.9834, 'subfield': {'id': 'https://openalex.org/subfields/2808', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T14144', 'display_name': 'Neurological Disease Mechanisms and Treatments', 'score': 0.9834, 'subfield': {'id': 'https://openalex.org/subfields/2808', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/nestin', 'display_name': 'Nestin', 'score': 0.63844657}, {'id': 'https://openalex.org/keywords/dapi', 'display_name': 'DAPI', 'score': 0.6232826}, {'id': 'https://openalex.org/keywords/immunofluorescence', 'display_name': 'Immunofluorescence', 'score': 0.4900502}], 'concepts': [{'id': 'https://openalex.org/C2778182776', 'wikidata': 'https://www.wikidata.org/wiki/Q180912', 'display_name': 'Melatonin', 'level': 2, 'score': 0.90334177}, {'id': 'https://openalex.org/C136834591', 'wikidata': 'https://www.wikidata.org/wiki/Q2944097', 'display_name': 'Neural stem cell', 'level': 3, 'score': 0.6623764}, {'id': 'https://openalex.org/C2777738006', 'wikidata': 'https://www.wikidata.org/wiki/Q14906812', 'display_name': 'Nestin', 'level': 4, 'score': 0.63844657}, {'id': 'https://openalex.org/C2777527632', 'wikidata': 'https://www.wikidata.org/wiki/Q238382', 'display_name': 'DAPI', 'level': 3, 'score': 0.6232826}, {'id': 'https://openalex.org/C2777542384', 'wikidata': 'https://www.wikidata.org/wiki/Q937403', 'display_name': 'Subventricular zone', 'level': 4, 'score': 0.59517455}, {'id': 'https://openalex.org/C74864618', 'wikidata': 'https://www.wikidata.org/wiki/Q2332446', 'display_name': 'Staining', 'level': 2, 'score': 0.52816314}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5109584}, {'id': 'https://openalex.org/C2778236600', 'wikidata': 'https://www.wikidata.org/wiki/Q592324', 'display_name': 'Immunofluorescence', 'level': 3, 'score': 0.4900502}, {'id': 'https://openalex.org/C34688535', 'wikidata': 'https://www.wikidata.org/wiki/Q418732', 'display_name': 'Proliferating cell nuclear antigen', 'level': 3, 'score': 0.47640812}, {'id': 'https://openalex.org/C204232928', 'wikidata': 'https://www.wikidata.org/wiki/Q899285', 'display_name': 'Immunohistochemistry', 'level': 2, 'score': 0.45716962}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.39247668}, {'id': 'https://openalex.org/C28328180', 'wikidata': 'https://www.wikidata.org/wiki/Q48196', 'display_name': 'Stem cell', 'level': 2, 'score': 0.373029}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.36589867}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.3452344}, {'id': 'https://openalex.org/C16685009', 'wikidata': 'https://www.wikidata.org/wiki/Q335057', 'display_name': 'Andrology', 'level': 1, 'score': 0.3357187}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.26347113}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.25028113}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.20824668}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.16327065}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'http://rs.yiigle.com/CN113694201812/1080702.htm', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306506121', 'display_name': 'Chin J Neurol', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3032508915', 'https://openalex.org/W3031917537', 'https://openalex.org/W3031050965', 'https://openalex.org/W3030621666', 'https://openalex.org/W3029988239', 'https://openalex.org/W3029087628', 'https://openalex.org/W3028832593', 'https://openalex.org/W3028808900', 'https://openalex.org/W3028522922', 'https://openalex.org/W3013489948', 'https://openalex.org/W3000529316', 'https://openalex.org/W2996800546', 'https://openalex.org/W2767448195', 'https://openalex.org/W2473803399', 'https://openalex.org/W2433505384', 'https://openalex.org/W2391990258', 'https://openalex.org/W2372571705', 'https://openalex.org/W2372173536', 'https://openalex.org/W2356854944', 'https://openalex.org/W2349487338'], 'abstract_inverted_index': {'Objective\r\nTo': [0], 'investigate': [1], 'the': [2, 7, 23, 31, 45, 52, 75, 83, 92, 104, 132, 139, 152, 155, 160, 171, 174, 177, 180, 191, 202, 205, 229, 246, 260, 273, 282, 285, 310, 350, 358, 370, 385, 393, 406, 415, 423, 432, 444, 452, 461, 471], 'effects': [3, 93, 105], 'of': [4, 9, 82, 94, 106, 157, 179, 193, 204, 242, 275, 284, 372, 405, 434, 443, 463, 473], 'melatonin': [5, 40, 56, 95, 107, 172, 209, 247, 290, 351, 388, 416, 453], 'on': [6, 96, 108], 'proliferation': [8, 98, 472], 'neural': [10], 'stem': [11, 486], 'cells': [12, 153, 175, 200, 244, 280, 342, 436, 446, 450, 487], '(NSCs)': [13], 'in': [14, 51, 154, 159, 164, 168, 176, 201, 245, 259, 281, 349, 357, 384, 414, 422, 451, 476], 'cerebral': [15, 477], 'ischemia': [16, 478], 'reperfusion': [17, 479], '(IR)': [18], 'rats,': [19], 'and': [20, 39, 55, 69, 113, 125, 135, 166, 208, 214, 277, 289, 296, 339, 376, 387, 408, 447, 465], 'to': [21, 44, 74], 'explore': [22], 'possible': [24], 'mechanisms.\r\n\r\n\r\nMethods\r\nSeventy-two': [25], 'rats': [26, 50, 158, 249], 'were': [27, 58, 87, 99, 120, 163, 183, 225, 306, 330, 437], 'randomly': [28], 'divided': [29, 59], 'into': [30, 60], 'normal': [32, 230, 311, 394], 'control': [33, 231, 312, 395], 'group': [34, 37, 41, 54, 57, 162, 232, 248, 262, 313, 352, 360, 396, 417, 425, 454], '(n=12),': [35], 'model': [36, 53, 161, 206, 261, 286, 359, 386, 424], '(n=30)': [38, 42], 'according': [43, 73], 'random': [46], 'number': [47, 192, 241], 'table.': [48], 'The': [49, 79, 129, 240, 403], 'four': [61], 'subgroups:': [62], '6': [63], 'h,': [64, 66], '24': [65], '72': [67], 'h': [68], '7': [70, 222, 301], 'd': [71, 302], 'subgroups': [72], 'time': [76, 252, 363], 'after': [77, 219, 303], 'IR.': [78], 'morphological': [80], 'changes': [81], 'subventricular': [84], 'zone': [85], '(SVZ)': [86], 'examined': [88, 100, 121], 'by': [89, 101, 122, 145], 'HE': [90], 'staining;': [91, 103], 'NSCs': [97, 134, 475], 'immunofluorescence': [102], 'toll-like': [109], 'receptor': [110], '4': [111], '(TLR4)': [112], 'nuclear': [114, 196], 'factor': [115], '(NF)': [116], '-κB': [117], 'p65': [118, 141, 378, 410, 467], 'protein': [119, 137, 142, 381, 411], 'immunohistochemistry': [123], 'staining': [124, 149, 188, 270], 'Western': [126, 365], 'blotting': [127, 366], 'analysis.': [128], 'correlation': [130], 'between': [131], 'proliferating': [133, 194], 'TLR4': [136, 373, 407, 464], 'or': [138], 'NF-κB': [140, 278, 340, 377, 409, 448, 466], 'was': [143, 254, 382, 412], 'analyzed': [144], 'linear': [146], 'regression': [147, 428], 'analysis.\r\n\r\n\r\nResults\r\nHE': [148], 'showed': [150, 189, 271, 368, 430], 'that': [151, 190, 258, 272, 369, 421, 431, 442], 'SVZ': [156, 178, 203, 283], 'disorder': [165], 'irregular': [167], 'shape.': [169], 'In': [170], 'group,': [173], 'injured': [181], 'side': [182], 'relatively': [184], 'well': [185], 'arranged.': [186], 'Immunofluorescence': [187], 'cell': [195], 'antigen': [197], '(PCNA)+Nestin+4′,6-diamidino-2-phenylindole': [198], '(DAPI)+': [199], '(498.47±26.44/mm2)': [207], 'groups': [210, 291, 389], '(623.10±39.70/mm2)': [211], 'increased': [212, 294], 'gradually,': [213, 295], 'reached': [215, 297], 'a': [216, 298], 'higher': [217, 227, 256, 299, 308, 383], 'level': [218, 300], 'IR': [220], 'for': [221], 'days,': [223], 'which': [224, 305], 'significantly': [226, 255, 307], 'than': [228, 257, 309], '(203.91±32.23/mm2)': [233], '(F=35.193,': [234], '170.344,': [235], '277.536,': [236], '285.947,': [237], 'all': [238, 267, 321, 327, 337, 347, 438], 'P<0.01).': [239, 268, 328, 402], 'PCNA+Nestin+DAPI+': [243, 435], 'at': [250, 361], 'each': [251, 362], 'points': [253], '(F=102.561,': [263], '91.244,': [264], '168.502,': [265], '38.013,': [266], 'Immunohistochemistry': [269], 'numbers': [274], 'TLR4+': [276, 332, 445], 'p65+': [279, 341, 449], '(740.02±31.63/mm2;': [287], '710.01±26.59/mm2)': [288], '(555.57±25.28/mm2;': [292], '528.85±30.60/mm2)': [293], 'IR,': [304], '(107.97±12.84/mm2;': [314], '109.80±13.89/mm2)': [315], '(F=21.413,': [316], '263.059,': [317], '873.691,': [318], '1': [319], '037.098,': [320], 'P<0.01;': [322], 'F=26.374,': [323], '372.940,': [324], '854.826,': [325], '929.018,': [326], 'There': [329], 'less': [331], '(F=7.641,': [333], '25.135,': [334], '66.094,': [335], '103.753,': [336], 'P<0.05)': [338], '(F=18.612,': [343], '69.597,': [344], '113.113,': [345], '119.814,': [346], 'P<0.01)': [348], 'as': [353, 390, 418], 'compared': [354, 391, 419], 'with': [355, 392, 420, 441], 'those': [356], 'points.': [364], 'analysis': [367, 429], 'expression': [371, 404, 462], '(0.87±0.08;': [374], '0.68±0.06)': [375], '(0.72±0.05;': [379], '0.58±0.05)': [380], '(0.35±0.04,': [397], '0.31±0.03;': [398], 'F=107.43,': [399], 'F=132.51,': [400], 'both': [401, 457], 'lower': [413], '(P<0.01).': [426], 'Linear': [427], 'differences': [433], 'negatively': [439], 'correlated': [440], '(r2=0.838,': [455], 'r2=0.813,': [456], 'P<0.01).\r\n\r\n\r\nConclusion\r\nMelatonin': [458], 'can': [459], 'inhibit': [460], 'protein,': [468], 'thus': [469], 'promote': [470], 'endogenous': [474], 'rats.\r\n\r\n\r\nKey': [480], 'words:': [481], '\r\nBrain': [482], 'ischemia;\xa0Reperfusion': [483], 'injury;\xa0NF-kappa': [484], 'B;\xa0Neural': [485]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3032081167', 'counts_by_year': [], 'updated_date': '2024-12-13T03:05:28.966200', 'created_date': '2020-06-05'}