Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2433505384', 'doi': None, 'title': '[Effect of Zhixin Formula on Gliocyte Protein Expressions, TLRs and NF-κB in Bone Cancer Pain Model Rats].', 'display_name': '[Effect of Zhixin Formula on Gliocyte Protein Expressions, TLRs and NF-κB in Bone Cancer Pain Model Rats].', 'publication_year': 2015, 'publication_date': '2015-06-01', 'ids': {'openalex': 'https://openalex.org/W2433505384', 'mag': '2433505384', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26242124'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26242124', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100392856', 'display_name': 'Bin Zhang', 'orcid': 'https://orcid.org/0000-0002-6286-6227'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Bin Zhang', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058973468', 'display_name': 'Songxian Sun', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Song-xian Sun', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100450914', 'display_name': 'Yi‐Chen Chen', 'orcid': 'https://orcid.org/0000-0002-4616-2115'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Yi-chen Chen', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5102398136', 'display_name': 'Chunxiang Zhou', 'orcid': 'https://orcid.org/0000-0003-0796-9554'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Chun-xiang Zhou', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.231, 'has_fulltext': False, 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.465489, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 66, 'max': 73}, 'biblio': {'volume': '35', 'issue': '6', 'first_page': '704', 'last_page': '11'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12626', 'display_name': 'Cancer, Stress, Anesthesia, and Immune Response', 'score': 0.9857, 'subfield': {'id': 'https://openalex.org/subfields/2738', 'display_name': 'Psychiatry and Mental health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12626', 'display_name': 'Cancer, Stress, Anesthesia, and Immune Response', 'score': 0.9857, 'subfield': {'id': 'https://openalex.org/subfields/2738', 'display_name': 'Psychiatry and Mental health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10631', 'display_name': 'Cancer, Hypoxia, and Metabolism', 'score': 0.9798, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10129', 'display_name': 'Glioma Diagnosis and Treatment', 'score': 0.973, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/bone-cancer', 'display_name': 'Bone cancer', 'score': 0.6586703}], 'concepts': [{'id': 'https://openalex.org/C2780495277', 'wikidata': 'https://www.wikidata.org/wiki/Q905442', 'display_name': 'Glial fibrillary acidic protein', 'level': 3, 'score': 0.6656152}, {'id': 'https://openalex.org/C2776035513', 'wikidata': 'https://www.wikidata.org/wiki/Q1328805', 'display_name': 'Bone cancer', 'level': 3, 'score': 0.6586703}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.55999935}, {'id': 'https://openalex.org/C2776415932', 'wikidata': 'https://www.wikidata.org/wiki/Q48743', 'display_name': 'Western blot', 'level': 3, 'score': 0.50659573}, {'id': 'https://openalex.org/C204232928', 'wikidata': 'https://www.wikidata.org/wiki/Q899285', 'display_name': 'Immunohistochemistry', 'level': 2, 'score': 0.47804886}, {'id': 'https://openalex.org/C2778904085', 'wikidata': 'https://www.wikidata.org/wiki/Q3712728', 'display_name': 'Cancer pain', 'level': 3, 'score': 0.46418208}, {'id': 'https://openalex.org/C2776164576', 'wikidata': 'https://www.wikidata.org/wiki/Q62736', 'display_name': 'Osteoarthritis', 'level': 3, 'score': 0.46031165}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.4458719}, {'id': 'https://openalex.org/C2777542381', 'wikidata': 'https://www.wikidata.org/wiki/Q502961', 'display_name': 'Astrocyte', 'level': 3, 'score': 0.42591953}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.4256584}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.42115235}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.35999477}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.347708}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.09853113}, {'id': 'https://openalex.org/C204787440', 'wikidata': 'https://www.wikidata.org/wiki/Q188504', 'display_name': 'Alternative medicine', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C529278444', 'wikidata': 'https://www.wikidata.org/wiki/Q47273', 'display_name': 'Central nervous system', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001859', 'descriptor_name': 'Bone Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D004365', 'descriptor_name': 'Drugs, Chinese Herbal', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D016328', 'descriptor_name': 'NF-kappa B', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001253', 'descriptor_name': 'Astrocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001859', 'descriptor_name': 'Bone Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001859', 'descriptor_name': 'Bone Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D004365', 'descriptor_name': 'Drugs, Chinese Herbal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005904', 'descriptor_name': 'Glial Fibrillary Acidic Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017628', 'descriptor_name': 'Microglia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016328', 'descriptor_name': 'NF-kappa B', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012516', 'descriptor_name': 'Osteosarcoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010146', 'descriptor_name': 'Pain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017207', 'descriptor_name': 'Rats, Sprague-Dawley', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26242124', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.63, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3125615148', 'https://openalex.org/W3031763687', 'https://openalex.org/W2422141130', 'https://openalex.org/W2160704957', 'https://openalex.org/W2135218854', 'https://openalex.org/W2115923002', 'https://openalex.org/W2100623527', 'https://openalex.org/W2098137442', 'https://openalex.org/W2003586793', 'https://openalex.org/W1984971014'], 'abstract_inverted_index': {'To': [0], 'explore': [1], 'the': [2, 58, 63, 92, 128, 132, 138, 141, 148, 153, 158, 164, 178, 241, 248, 278, 307, 318, 332, 340, 348], 'analgesic': [3, 376], 'effect': [4], 'of': [5, 25, 31, 288, 304, 326, 361, 388, 394], 'Zhixin': [6], 'Formula': [7], '(ZF)': [8], 'and': [9, 37, 39, 62, 99, 163, 181, 193, 220, 237, 253, 292, 298, 350, 363, 386, 396], 'its': [10], 'effects': [11], 'on': [12], 'spinal': [13], 'glial': [14], 'fibrillary': [15], 'acidic': [16, 20], 'protein': [17, 213, 359], '(glial': [18], 'fibillary': [19], 'protein,': [21], 'GFAP,': [22, 216], 'a': [23, 106, 202, 255], 'marker': [24], 'astrocyte)': [26], ',': [27], 'CD11b': [28, 343], '(a': [29], 'maker': [30], 'microglia),': [32], 'Toll': [33], 'like': [34], 'receptors': [35], '(TLR2': [36], 'TLR4)': [38], 'nuclear': [40], 'factor': [41], 'κB': [42], '(NF-κB)': [43], 'in': [44, 69, 125, 177, 247, 277, 301, 306, 317, 331, 347], 'bone': [45, 64, 73, 133, 302], 'cancer': [46, 65, 74, 134], 'pain': [47, 66, 75, 135, 263], 'model': [48, 76, 110, 139, 249, 279, 308, 319, 333, 341], 'rats.Totally': [49], '20': [50], 'male': [51, 115], 'SD': [52, 116], 'rats': [53, 117, 176, 305], 'were': [54, 102, 118, 186, 228], 'randomly': [55, 119], 'divided': [56, 120], 'into': [57, 121], 'blank': [59, 129, 242], 'control': [60, 130, 243], 'group': [61, 136, 145, 168, 250, 280, 320, 334], 'group,': [67, 131, 152, 157, 162, 244, 342], '10': [68, 124], 'each': [70, 126], 'group.': [71, 309], 'The': [72], 'was': [77, 111, 251], 'induced': [78], 'by': [79, 188, 230], 'injecting': [80], 'ascites': [81], 'tumor': [82], 'fluid': [83], 'containing': [84], '3': [85], 'x': [86], '10(3)': [87], 'Walker256': [88], 'cell': [89], 'line': [90], 'from': [91, 222], 'left': [93], 'tibia.': [94], 'Ethological': [95], 'tests,': [96], 'X-ray': [97, 291], 'test,': [98], 'HE': [100, 293], 'staining': [101, 294], 'performed': [103], 'to': [104, 383], 'confirm': [105], 'successful': [107], 'modeling.': [108], 'After': [109], 'successfully': [112], 'established,': [113], '70': [114], 'seven': [122, 205], 'groups,': [123], 'group:': [127], '(as': [137], 'group),': [140], 'Western': [142, 238], 'medicine': [143, 166], '(WM)': [144], '(Tramadol': [146], 'Hydrochloride),': [147], 'high': [149, 351], 'dose': [150, 155, 160, 183, 352], 'ZF': [151, 156, 161, 184, 196, 353], 'middle': [154, 349], 'low': [159, 182], 'Chinese': [165], '(CM)': [167], '(Wulin': [169], 'Zhitong': [170], 'Capsule).': [171], 'Fourteen': [172], 'days': [173], 'after': [174], 'modeling,': [175], 'high,': [179], 'middle,': [180], 'groups': [185, 354], 'administrated': [187], 'gastrogavage': [189], 'with': [190, 240, 339], '9,': [191], '4.5,': [192], '2.25': [194], 'g/kg': [195], 'water': [197], 'condensed': [198], 'preparation': [199], 'respectively,': [200], 'once': [201], 'day': [203, 209], 'for': [204], 'consecutive': [206], 'days.': [207], 'On': [208], '21': [210], 'MS': [211], 'typical': [212], 'expressions': [214, 344, 360], 'including': [215], 'CD11b,': [217], 'TLR': [218], '(2,4)': [219], 'NF-κB': [221, 327, 368], 'cornu': [223], 'dorsal': [224], 'medullae': [225], 'spindis': [226], 'L4-L5': [227], 'detected': [229], 'immunohistochemistry,': [231], 'reverse': [232], 'transcription-polymerase': [233], 'chain': [234], 'reaction': [235], '(RT-PCR)': [236], 'blot.Compare': [239], 'increased': [245, 267, 316, 330], 'weight': [246], 'slow': [252], 'showed': [254, 295, 311], 'decreasing': [256], 'trend': [257], '(P': [258, 268, 281, 321, 335, 355, 372], '<': [259, 269, 282, 285, 322, 336, 356, 373], '0.01),': [260, 270], 'spontaneous': [261], 'ambulatory': [262], 'score': [264], '(SAPS)': [265], 'obviously': [266, 275, 345, 370], 'paw': [271], 'withdrawal': [272], 'threshold': [273], '(PWT)': [274], 'decreased': [276, 346, 371], '0.05,': [283], 'P': [284], '0.01).': [286, 357], 'Results': [287], 'lateral': [289], 'tibial': [290], 'obvious': [296], 'changes': [297], 'damage': [299], 'occurred': [300], 'structures': [303], 'Immunohistochemistry': [310], 'that': [312], 'GFAP': [313], 'expression': [314], 'significantly': [315, 329], '0.05).': [323, 337], 'Protein': [324], 'levels': [325], 'also': [328, 369], 'Compared': [338], 'Meanwhile,': [358], 'TLR2': [362], 'TLR4,': [364], 'as': [365, 367, 390, 392], 'well': [366, 391], '0.05).ZF': [374], 'had': [375], 'effect,': [377], 'which': [378], 'might': [379], 'be': [380], 'probably': [381], 'related': [382], 'inhibiting': [384], 'proliferation': [385], 'activation': [387, 393], 'gliocytes,': [389], 'TLRs': [395], 'NF-κB.': [397]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2433505384', 'counts_by_year': [{'year': 2016, 'cited_by_count': 1}], 'updated_date': '2024-12-14T00:19:36.708813', 'created_date': '2016-06-24'}