Title: Comparison of clinicaopathological features of Henoch-Schönlein purpura nephritis with different proportions of crescent
Abstract: Objective
Comparison of clinical and pathological features of Henoch-Schonlein purpura nephritis with different proportions of crescent.
Methods
Patients with Henoch Schonlein nephritis diagnosed by renal biopsy in our hospital from 2012 to 2017 (proportions of crescent 24%-50%), their epidemiological , clinical manifestations, laboratory examination , clinicopathological features were compared.
Results
There was no significant difference between the three groups in sex, age and incidence of diabetes(P>0.05). The morbidity of hypertension in C group is higher than others (P 0.05), while the incidence of edema and gross hematuria was significantly higher in group C than others. There were more patients had Nephritic syndrome (38.8%) in C group than the other groups (P<0.05). There was no significant difference in 24 h urinary protein, C-reactive protein (CRP), urine red blood cell, eosinophil granulocyte and immunoglobulin E (IgE) in the 3 groups. The levels of serum creatinine, blood urea nitrogen (BUN), and low density lipoprotein (LDL) increased significantly in group C, and the level of glomerular filtration rate (GFR) and albumin decreased significantly(P<0.05). The tubulointerstitial lesions, mesangial cell proliferation and deposition of C1q levels, C group was significantly higher than the other two groups (P<0.05).
Conclusions
In Henoch Schonlein purpura nephritis, with the increase of the proportion of the crescent body, the renal function and pathological changes of the kidney are gradually aggravated. Therefore, the crescent is important for the pro-gnosis of Henoch Schonlein purpura nephritis.
Key words:
Purpura, Schoenlein-Henoch/CO; Nephritis/ET/PA
Publication Year: 2018
Publication Date: 2018-03-20
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot