Title: The analysis of clinicopathological significance of renal interstitial vascular lesions in 210 patients with idiopathic IgA nephropathy
Abstract: Objectives To investigate the clinicopathological significance of renal interstitial vascular lesions in idiopathic IgA nephropathy.Methods The clinicopathological data of 210 biopsy - proven cases of idiopathic IgAN from Jan.1999 to Jun.2010 in our hospital was retrospectively analyzed and the relationship between renal vascular lesions and clinical manifestation and pathological features was studied.Results Amongst the 210 patients studied,33.8% ( 71 cases ) were with various vascular lesions,compared with other 139 cases without vascular lesions,the incidence of hypertension was higher(73.2% vs 24.5%,P <0.05],the Scr was higher [( 132.5±20.8) μmol/L vs (86.4 ±15.2) μmol/L,P <0.05],eGFR was lower[(59.7 ±9.2) ml/min vs (83.1 ± 12.6)ml/min,P <0.05],the differences had statistical significance.The distribution of renal vascular lesions in pathological subtypes of IgAN was 6.0% in Ⅰ type ( 2/33 cases); 43.9% in Ⅱ type ( 18/41 cases ); 6.9% in Ⅲ type (4/59 cases),40.8% in Ⅳ type (20/49 cases ) ; 93.1% in Ⅴ type (27/29 cases ).Chi -square test showed the difference of vascular lesions in different types of IgAN had statistical significance( P < 0.05 ),and indicate the vascular lesions increased as the exacerbation of pathological changes.Conclusions Renal vascular lesions were common in patients with idiopathic IgA nephropathy and were closely related with the clinical manifestation and pathological features.It was suggested that renal vascular lesions can be an important effecting factor on the progression of IgA nephropathy.
Key words:
Glomerulonephritis; IGA
Publication Year: 2012
Publication Date: 2012-05-15
Language: en
Type: article
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