Title: Effects of simvastatin on the expression of NADPH oxidase subunits mRNA in high glucose-induced injury of cardiomyocytes in neonatal rat
Abstract: Ventricular myocytes from hearts of the neonatal SD rats were treated with 10-7,10-6,and 10-5 mol/L simvastatin for 72 hours under high glucose condition. Compared with control group,the viability of cadiomyocyte was significantly lower in high glucose group (P<0.01 ).The activity of lactate dehydrogenase,the relative expressions of NADPH oxidase subunits p22phox,p47phox mRNA,and reactive oxygen species level in the high glucose group were higher than those of control group ( all P<0.05).lndexes mentioned above were significantly improved by simvastatin treatment in a dose-dependent manner.These results suggest that simvastatin ameliorates high glucose-induced injury of cardiomyocytes via increasing the expression of NADPH oxidase mRNA.
Key words:
Simvastatin; High glucose; Cardiomyocytes; NADPH oxidase subunits; Reactive oxygen species
Publication Year: 2012
Publication Date: 2012-05-25
Language: en
Type: article
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