Title: Expression of epidermal growth factor receptor in colon cancer with different pathological characteristics and its clinical significance
Abstract: Objective
To investigate the relationship between epidermal growth factor receptor (EGFR) expression in colon cancer and its clinicopathological characteristics and survival.
Methods
The express of EGFR in 400 colon were evaluated by using immunohistochemistry, the relationship between EGFR and clinicopathological factors was analyzed by χ2 test; Kaplan Meier method was used to calculate the survival rate of patients and the parallel log-rank test was performed; Cox proportional risk regression model was used to analyze prognostic factors.
Results
The positive expression of EGFR in colon cancer tissues was 52.50% (210/400). Up-expression of EGFR was not significant correlated with patients’ age, nor with sex, lymphnode metastasis, tumor size and differentiation grade (the χ2 values were respectively 2.673, 1.095, 0.047, 0.73 and 0.058, the P values were all >0.05), but clear related with tumor-node-metastasis (TNM) stage, 5-years survival of patients, the depth of invasion, lymphatic cancer thrombus and invasion of nerves or vessels (The χ2 values were respectively 57.165, 9.265, 4.375, 31.191 and 10.176, the P values were all <0.05).
Conclusion
High expression of EGFR may be distinct associated with the development and prognosis of colon cancer.
Key words:
Colon adenocarcinomas; Epidermal growth factor receptor; Immunohistochemistry
Publication Year: 2019
Publication Date: 2019-07-08
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot