Title: The role of serum uric acid in different types of coronary heart disease
Abstract: Objective To detect the mechanism of serum uric acid (UA) in different types of coronary heart disease (CHD).Methods 88 patients were divided into three groups:the control group,stable angina (SA) group and acute coronary syndrom (ACS) group.The levels of UA,alpha-granule membrane protein 140 (GMP-140),von Willebrand factor(vWF),plasminogen activator inhabitor typed (PAI-1),Thromboxane B_2 (TXB_2) and C-reacting protein(CRP) were measured.Results ①UA and CRP in ACS group were higher than that in SA group and control group [(392.1±68.57) μmol/L and (42.2±39.4) mg/L vs (370.50±58.80) μmol/L and (18.9±17.1) mg/L vs (286.00±65.31) μmol/L and (2.5±0.7) mg/L,P<0.05)].For UA,there was no difference between ACS and SA group(P>0.05);CRP was higher in ACS group than in SA group (P<0.05).②vWF and TXB_2 were higher in ACS[(1.65±0.48)%,(19.73±18.66)ng/L]and SA group[(1.35±0.49)%,(11.18±10.71) ng/L]than in control group[(1.07±0.26)%,(6.46±5.41) ng/L,P<0.05],and those were higher in ACS group than in SA group (P<0.05).③GMP-140 and PAI-1 were higher in ACS [(13.04±0.99) μg/L and (65.65±14.76) μg/L]and SA group[(12.55±0.74) μg/L and (62.69±12.24) μg/L]than in control group [(12.32±0.29) μg/L,(50.78±13.88) μg/L,P<0.05].There were no differences between ACS and SA group (P>0.05).④Comparing hyperuricemia group and non-hyperuricemia group in CHD patients:the CRP(71.3±18.9) mg/L,vWF(1.08±0.52) %,GMP-140(13.57±1.11) μg/L,TXB_2 (57.26±47.84)ng/L,PAI-1 (72.12±9.23) μg/L in ACS group possessing hyperuricemia were higher than non-hyperuricemia group [CRP (20.7±17.9) mg/L,vWF (0.84±0.54) %,GMP-140 (13.23±1.07) μg/L,TXB_2 (26.70 + 23.83) ng/L,PAI-1 (61.30±12.07) μg/L](t=7.394,0.008,0.227,7.605,0.421,P<0.05);CRP(31.1±18.9)mg/L and TXB2 (21.54±3.90) ng/L in SA group possessing hyperuricemia group were higher than non-hyperuricemia group[(10.9±10.1)mg/L and (5.02±4.93) ng/L,t=0.494,8.669,P<0.05].Logistic stepwise regression analysis indicated that the related factors with ACS were UA(OR=1.046),CRP(OR=7.615),PAI-1(OR=1.301),PT(OR=0.300)and TG(OR=2.243) (P<0.05).Conclusions UA is an important risk factor in CHD patients.UA can induce different types of CHD by damaging blood vessel endothelium function,activating platelet,changing coagulation and causing inflammatory.
Key words:
Coronary heart disease; Serum uric Acid
Publication Year: 2009
Publication Date: 2009-12-01
Language: en
Type: article
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