Title: Study for MMP-2 level in patients with acute coronary syndrome
Abstract: Objective:To explore role of serum matrix metalloproteinase-2(MMP-2) in onset of acute coronary syndrome(ACS) and its relationship with diseased degree of coronary heart disease(CHD).Methods:A total of100 CHD patients were selected,including 50 cases with stable angina pectoris(SAP,SAP group) and 50 ACS patients(ACS group).Another 20 healthy subjects were enrolled as healthy control group.Levels of blood lipids,serum high sensitive C reactive protein(hsCRP),cardiac troponin I(cTnI) and MMP-2 were measured,compared and analyzed in all groups.Results:(1) Compared with healthy control group,there was significant increase in triglyceride level,significant decrease in high density lipoprotein level;and significant increase in cTnI[(0.011 ±0.024) μg/L vs.(0.019 ± 0.026) μg/L vs.(1.113 ± 4.220) μg/L]in SAP group and ACS group,furthermore the cTnI level of ACS group was more than that of SAP group P0.05~0.01;(2) Compared with healthy control group and SAP group,the hsCRP[(0.59 ±0.32) pg/ml,(1.40 ± 1.90) pg/ml vs.(4.79 ±4.31) pg/ml],MMP-2[(0.30 ±0.14) μg/L,(0.38±0.78) μg/L vs.(0.58±0.54) μg/L]level significantly increased(P0.01 all)in ACS group;(3) Pearson rectilinear correlation analysis indicated that serum MMP-2 was positively correlated with serum hsCRP(r = 0.374,P0.01) in all groups.Conclusion:Increased MMP-2 level may be related with occurrence of acute coronary syndrome,and its detection possesses certain application value for early diagnosis and treatment of acute coronary syndrome.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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